Результаты поиска

Microglial states associate with lesion dynamics in multiple sclerosis.

Multiple sclerosis (MS) is a neuroinflammatory disease of the CNS characterized by demyelinating lesions. Lesion expansion contributes to disability progression, whereas remyelination may restore neurological function. How these divergent outcomes relate to microglial states remains incompletely understood. Using single-cell-resolution spatial transcriptomics, we compare lesions containing foamy to those containing ramified microglia in postmortem human brain tissue. We find distinct cellular and molecular signatures spatially associated with microglial morphology. Lesions with ramified microg…

Intrathecal synthesis of antiviral IgG antibodies in multiple sclerosis.

The Measles-Rubella-Zoster (MRZ) reaction is a test for the intrathecal synthesis of IgG antibodies against measles, rubella and varicella zoster viruses. Since the 1990s, it has been used as an adjunctive test to support the diagnosis of multiple sclerosis (MS), although it has no formal role in current McDonald diagnostic criteria and its clinical relevance remains debated. While early studies considered a single elevated antibody index (M, R or Z) as a positive result, the practice today requires at least two elevated antibody indices (M+R, M+Z, or R+Z), referred to as a polyspecific MRZ re…

A novel small molecule remyelination therapy for multiple sclerosis.

We conducted a phenotypic screen of 20,000 central nervous system (CNS)-biased small molecules for their ability to stimulate differentiatio … e that CN045 is an attractive lead candidate for enhancing OPC differentiation and remyelination in multiple sclerosis patients.

Sex-dependent bioactive lipid mediator profiles in multiple sclerosis.

BACKGROUND: Pathophysiological drivers of sex differences in multiple sclerosis (MS) remain unclear. Potential candidates include bioactive lipid mediators (LMs), which are pivotal regulators of neuro-inflammatory responses. OBJECTIVE: To investigate sex-dependent LM differences in MS. METHODS: Plasma lipids were measured using targeted HPLC-MS/MS in a birth-year MS cohort (N = 410; n = 285 MS, n = 169 RRMS, n = 80 SPMS and n = 36 PPMS). Lipid profiles were compared between sexes and correlated with disability (Expanded Disability Status Scale (EDSS)), neuroaxonal damage (neurofilament light…

Multiomics integration prioritizes potential drug targets for multiple sclerosis.

Multiple sclerosis (MS) is an immune-mediated disease with no current cure. Drug discovery and repurposing are essential to enhance treatment efficacy and safety. We utilized summary statistics for protein quantitative trait loci (pQTL) of 2,004 plasma and 1,443 brain proteins, a genome-wide association study of MS susceptibility with 14,802 cases and 26,703 controls, both bulk and cell-type specific transcriptome data, and external pQTL data in blood and brain. Our integrative analysis included a proteome-wide association study to identify MS-associated proteins, followed by summary-data-base…

Accelerated grey matter degeneration in relapsing remitting multiple sclerosis.

BACKGROUND: Grey matter (GM) atrophy has been suggested as the most accurate marker of neurodegeneration in multiple sclerosis (MS) progression. However, long-term comparisons between MS and healthy controls (HC) are rare, and the most significantly atrophying brain regions and their clinical importance still need robust and longitudinal validation. METHODS: This multi-cohort longitudinal observational study used two relapsing remitting MS (RRMS) cohorts (N=386, T1w-scans=940) sampled for up to 12 years to map grey matter atrophy localisation and disease progression (Expanded Disability Statu…

Исследование нарушений сна, связанных с множественным склерозом.

Множественный склероз является распространенным демиелинизирующим заболеванием в неврологии, характеризующимся сложным и непредсказуемым патогенезом, а также различными клиническими проявлениями, которые создают значительное бремя для физического и психического здоровья пациентов. Повреждения сна, как широко распространенный, но зачастую игнорируемый симптом потери трудоспособности в этой болезни, имеют высокий уровень заболеваемости и значительно снижает качество жизни пациентов. В этой статье систематически анализируются недавние улучшения в расстройствах сна, связанных с множественным склер

Совпадение в аннотации оригинала
Multiple sclerosis is a common demyelinating disease in neurology, characterized by a complex and unpredictable pathogenesis, as well as diverse clinical manifestations, which impose a significant burden on the physical and mental health of patients. Sleep disturbances, as a prevalent yet often overlooked disabling symptom in this disease, have a high incide…

Пресимптоматический множественный склероз: Отличения от радиологически изолированного синдрома.

Радиоактивно изолированный синдром (РИС) представляет собой первоначальную фазу множественного склероза (МС) и, кстати, выявляется у асимптоматических лиц, которые демонстрируют типичные повреждения мозга или спинного мозга, указывающие на аутоиммунное воспалительное демиэлирование. Критерии РИС 2023 года повышают диагностическую точность в случае имитации изображений путем введения требования об одном взвешенном на Т2 гиперинтенсивном повреждении в двух из четырех указанных мест (перивентральном, яхтакортном/кортовом, инфекционном, спинном мозге) наряду по крайней мере с двумя из следующих: п

Совпадение в аннотации оригинала
Radiologically isolated syndrome (RIS) represents the initial phase of multiple sclerosis (MS) and is identified incidentally in asymptomatic individuals who display typical brain or spinal cord lesions indicative of autoimmune inflammatory demyelination. The 2023 RIS criteria enhance diagnostic precision against imaging mimics by requiring one T2-weighted h…

Описание рабочих мест южноафриканских работников с множественным склерозом.

ВАЖНЕЙШАЯ ПОМОЩЬ: Включение работников, страдающих хроническими заболеваниями, такими, как множественный склероз (МС), на рабочих местах по-прежнему является сложной задачей из-за эпизодического и невидимого характера симптомов, что приводит к стигматизации, дилеммам с раскрытием информации и неадекватным условиям проживания. Традиционные подходы к интеграции инвалидов зачастую не учитывают реальные реалии работников с НР, что требует более глубокого изучения того, как отдельные лица и организации строят смысл вокруг инвалидности и инклюзивности. ЦЕЛИ: В настоящем исследовании рассматривается

Совпадение в аннотации оригинала
BACKGROUND: Workplace inclusion for employees with chronic conditions such as multiple sclerosis (MS) remains a challenge because of the episodic and invisible nature of symptoms, leading to stigma, disclosure dilemmas and inadequate accommodations. Traditional approaches to disability inclusion often fail to address the lived realities of employees with MS,…

Genetically reduced MTHFR activity confers protection against multiple sclerosis.

OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) generates the active form of folate required for homocysteine metabolism. The C677T variant in MTHFR reduces enzymatic activity, increases homocysteine levels, and is associated with risk of several neurological diseases. However, its link to multiple sclerosis (MS) risk remains uncertain. We therefore investigated the association of this variant with risk and severity of MS. METHODS: We obtained genetic associations of C677T with homocysteine levels (n = 1210), MS risk (meta-analysis of three datasets: 43,069 cases), and MS severity (12…

[Symptoms and Signs of Multiple Sclerosis: Beyond Charcot's Triad].

In 1868, Jean-Martin Charcot systematically described the clinical and pathological findings of multiple sclerosis (MS), establishing it as a distinct disease entity. Additionally, he noted the importance of the triad of tremors (intentional tremors), nystagmus, and dysarthria (scanning speech). While he did not propose them as diagnostic criteria, he recognized their value in differentiating MS from other disorders affecting the central nervous system.

Normal appearing white matter and disability in multiple sclerosis.

BACKGROUND AND OBJECTIVES: Multiple sclerosis (MS) is characterized by lesions and atrophy on conventional MRI, yet these often fail to explain disability. Diffusion MRI (dMRI) detects microstructural injury with diffusion tensor (DTI) and kurtosis imaging (DKI) offering sensitivity, and Standard Model Imaging (SMI) providing biologically interpretable parameters. We evaluated whether these clinically feasible dMRI metrics are associated with disability beyond volumetric and lesion measures, and whether effects arise from normal-appearing white matter (NAWM). METHODS: This cross-sectional stu…

Материнство и задержка диагностики у женщин с множественным склерозом.

Множественный склероз (МС) чаще всего диагностируется у женщин в возрасте от 20 до 40 лет, что часто совпадает с периодом воспитания детей. В ходе этого анализа диагностических задержек с MS, стратифицированных статусом родителей, женщины, имеющие детей, имели больше времени на диагностику MS, чем женщины, не имеющие детей (β = 1,28, p = 0,001), контроль за возрастом при наступлении симптомов, подтипа прогрессивных заболеваний, курения и социальных факторов здоровья. Аналогичная разница между мужчинами, имеющими и не имеющими детей, не наблюдается. Связь между материнством и более длительным с

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is most frequently diagnosed in women between the ages of 20-40, often coinciding with child-rearing years. In this analysis of MS diagnostic delay stratified by parenthood status, women with children had longer time to MS diagnosis than those without children (β = 1.28, p = 0.001), controlling for age at symptom onset, progressive di…