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Почему навязчивое сексуальное поведение не является формой зависимости, как наркомания

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… Some researchers argue that the science is not quite there 3 or that the other substantial differences need to be considered, such as the role of pleasure. 4 Consider the difference in reasons for seeking treatment. …

Music therapy for depression.

BACKGROUND: Depression is a highly prevalent mood disorder that is characterised by persistent low mood, diminished interest, and loss of pleasure. Music therapy may be helpful in modulating moods and emotions. An update of the 2008 Cochrane review was needed to improve knowledge on effects of music therapy for depression. OBJECTIVES: 1. To assess effects of music therapy for depression in people of any age compared with treatment as usual (TAU) and psychological, pharmacological, and/or other therapies.2. To compare effects of different forms of music therapy for people of any age with a dia…

Taste and smell disturbances in patients with chronic oral graft vs. host disease: An observational study.

BackgroundA common complication of allogeneic hematopoietic stem cell transplantation (alloHSCT) is chronic oral graft vs. host disease (cGvHD). Oral cGvHD may present as mucosal lesions, salivary gland dysfunction, and trismus. Moreover, taste and smell ability may be affected, but the prevalence, nature and severity of altered taste and smell function, and their impact on quality of life (QoL) are understudied.AimTo identify the prevalence, nature, and severity of taste and smell disturbances, their impact on QoL and to assess whether altered taste/smell ability is associated with oral mucos

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… Taste buds can distinguish five basic tastes: sweet and umami serve intake of high calorie food and pleasure of eating, bitter warns for unbecoming ingredients, and salt and sour are integrated in the homeostasis of the ionic and osmotic regulation [ 8 ]. … Genetics of taste and smell: poisons and pleasures . Prog Mol Biol Transl Sci . ( 2010 ) 94 : 213 – 40 . 10.1016/B978-0-12-375003-7.00008-X 21036327 PMC3342754 33. Abasaeed R Coldwell SE Lloid ME Soliman SH Macris PC Schubert MM . …

По сравнению с BCMA-Targeted Biotices и High-Dose Melphalan.

Дисгейя является побочным эффектом anti-GPRC5DxCD3 Как известно, другие виды лечения миэломы, такие, как высокодозырный мелфалан (MEL) с аутологической трансплантацией стволовых клеток (ASCT), также изменяют вкусовое восприятие пациентов с множественной миеломой (MM). В ходе этого исследования изучаются спектр, распространенность и острота дисгейских заболеваний у пациентов, получающих TAL и MEL, и сопоставляются полученные результаты с биоритами антиBCMA в качестве средства контроля за лечением клеток Т. МЕТОДЫ: АНАЛИЗ И ОФИЦИАЛЬНЫЕ ДЕЙСТВИЯ 87 Пациенты MM разделились на three группы обработк

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… Additionally, 46.2% of patients reported reduced pleasure in consuming specific foods, such as fibrous meat dishes or roasts, which were challenging to swallow due to dry mouth. They conveyed that, prior to TAL therapy, food had been an important source of self‐reward and joy. … The onset of taste disturbances resulted in a profound loss of this source of pleasure for 61.5% of patients, leading to frustration when familiar taste perceptions during meals remained unfulfilled. …

Impact of Social Needs and Identity Experiences on the Burden of Illness in Patients with Multiple Myeloma: A Mixed-Methods Study.

Multiple myeloma (MM) is a common hematologic malignancy, but due to its incurable nature, patients experience many relapses in their lifetime and hence face unique challenges. This mixed-methods study consisting of an online survey and subsequent focus groups aimed to understand how social and identity experiences affected the diagnostic, treatment, and care journey for patients with MM. Twenty-three adult patients with MM participated in this study. The survey participants identified common determinants negatively impacting their health, including mental health concerns (experienced by 90.5%

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… Felt at least somewhat stressed due to family dynamic/wellbeing | 8 (38.1) Felt at least somewhat stressed due to financial strain | 8 (38.1) Felt at least somewhat stressed due to food insecurity | 6 (28.6) Felt at least somewhat stressed due to transportation problems | 4 (19.0) Little interest or pleasure … Some respondents reported more severe mental health concerns such as feeling little pleasure or interest in doing things (14.3%), or feeling down, depressed, or hopeless at least half the days (14.3%). …

Real-World Data on Therapies for Relapsed or Refractory Multiple Myeloma: Key Data from ASH 2023-A Podcast.

Immunotherapies have significantly improved outcomes in patients with multiple myeloma yet maintaining a durable response in heavily pretreated patients remains challenging. Therapies that target B cell maturation antigen (BCMA) provide additional treatment options in patients whose disease becomes refractory to several drug classes in early lines of therapy. Clinical trial data from selected patient populations and controlled settings are complemented by real-world data (RWD) from actual clinical practice. In this podcast, the authors reviewed and discussed seven abstracts presented at the 65

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… Of course, I have the pleasure to share the virtual stage with Dr Rodriguez-Otero. I think, Paula, this meeting was quite intriguing in many ways. … It has been a pleasure for me to be here with you discussing these abstracts and—until the next time. Acknowledgments Medical Writing. Medical writing support was provided by William Clafshenkel, PharmD, PhD, of Nucleus Global and was funded by Pfizer. …

The habenula as a novel link between the homeostatic and hedonic pathways in cancer-associated weight loss: a pilot study.

BACKGROUND: Little is known about the brain mechanisms underlying cancer-associated weight loss (C-WL) in humans despite this condition negatively affecting their quality of life and survival. We tested the hypothesis that patients with C-WL have abnormal connectivity in homeostatic and hedonic brain pathways together with altered brain activity during food reward. METHODS: In 12 patients with cancer and 12 healthy controls, resting-state functional connectivity (RSFC, resting brain activity observed through changes in blood flow in the brain which creates a blood oxygen level-dependent signa

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… C‐WL. 7 Factors such as depression, pain, gastrointestinal obstruction, constipation, and altered taste may also play a role in the development of C‐WL. 8 Central nervous system regulation of appetite involves a homeostatic metabolic need (hunger) and a hedonic, reward‐based consumption component (pleasure … We hypothesized that functional connectivity between the homeostatic pathway mediating hunger (in which the hypothalamus is a key component) and hedonic or pleasure pathway (which includes the nucleus accumbens) would be impaired in patients with cancer with weight loss. …

Assessment of depression symptoms among cancer patients: a cross-sectional study from a developing country.

Cancer patients experience psychological symptoms such as depression during the cancer treatment period, which increases the burden of symptoms. Depression severity can be assessed using the beck depression inventory (BDI II). The purpose of the study was to use BDI-II scores to measure depression symptoms in cancer patients at a large tertiary hospital in Palestine. A convenience sample of 271 cancer patients was used for a cross-sectional survey. There are descriptions of demographic, clinical, and lifestyle aspects. In addition, the BDI-II is a tool for determining the severity of depressio

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… Many of the symptoms needed to diagnose depression are often caused by cancer treatments (e.g. chemotherapy, biological therapy), such as fatigue, weight loss, anhedonia (the inability to feel pleasure in typically enjoyable activities) and psychomotor retardation. … These questions address various aspects, such as feelings of sadness, pessimism, past failures, loss of pleasure, guilt, self-criticism, suicidal thoughts, agitation, changes in sleeping and eating patterns, concentration difficulties, fatigue, and diminished interest in activities once enjoyed. …

Контекстуальная модель поведения в химсексе: структурное уравнение моделирования психологических предикторов гиперсексуальности и использования веществ

Фон и цель. Chemsex, определенный как намеренное использование психоактивных веществ в сексуальных контекстах, становится все более распространенным среди геев и бисексуалов и связан с широким спектром психических, физических и социальных последствий. Целью этого исследования было проверить контекстуальную модель поведения, изучающую, как психическая негибкость, одиночество, трудности в интимных отношениях и внутреннее гомофобное чувство вносят вклад в гиперсексуальность и сексуальное использование веществ. Методы. Проведено поперечное исследование с участием 252 испытуемых, говорящих на испан

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… The most frequently cited reasons were enhancing pleasure and sensations (71%, n  = 179), increasing desire and arousal (66.6%, n  = 168), and feeling more uninhibited (56%, n  = 141). … Importantly, the most frequently reported motivations for chemsex practice—such as enhancing pleasure, increasing arousal, and alleviating emotional distress—underscore the reinforcing nature of these behaviors and suggest their potential role as mechanisms of emotional regulation. …

Integrative oncology in Cancer Care Continuum

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… This was a great learning period for us and indeed a pleasure to come up with this issue. …

Аспекты достоинства в семьях, обеспечивающих уход за лицами, страдающими множественным склерозом.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Основное внимание в этом исследовании уделяется сохранению достоинства и посягательству на достоинство членов семьи, обеспечивающих уход за лицами, страдающими множественным склерозом. АИМ: Цель исследования заключалась в углублении понимания того, как семьи, ухаживающие за лицами, страдающими множественным склерозом, воспринимают сохранение или лишение их достоинства. Применялся герменевый подход. МЕТОДЫ ИССЛЕДОВАНИЙ: Авторы провели научные опросы в форме бесед с восемью лицами, обеспечивающими уход за членами семьи. АНАЛИЗ И МЕТОДЫ ТОЛКОВАНИЯ: Нашим компасом и руководс

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… It is a true and rewarding pleasure to help others. The experiences of the family caregivers taught them to take care of themselves, to overcome and preserve their own dignity. As learned from the above, they do this in different ways. … Implications for practice Family caregivers felt it was a natural pleasure to help their loved ones and bear the burdens these carried. During this time, they became realistic and reconciled with the situation and life. …

Нейропсихологические аспекты расстройств контроля импульсов в болезни Паркинсона.

Синдромы импульсного контроля (ИДД), такие, как чрезмерные азартные игры, навязчивое сексуальное поведение, поедание бингов, навязчивые покупки, а также синдром регулирования дофамина, могут возникать как изнурительное нервно-психическое осложнение болезни Паркинсона (PD). Хотя патофизиология не в полной мере понятна, она, вероятно, включает мезолимбичную допаминергическую чрезмерную оптимизацию в сочетании с факторами уязвимости, связанными с заболеваниями, в плане поощрения, мотивации и ингибиционных сетей контроля. В настоящем описательном обзоре резюмируются данные о нейропсихологических,

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… They are typically preceded by mounting tension and followed by feelings of pleasure, gratification, or relief ( Evans et al., 2019 ; World Health Organization, 2022 ). … Punding is not primarily motivated by rewards, pleasure, or obsessive-compulsive tendencies. Contrastingly, it is often perceived as unrewarding and disruptive. However, interruptions during the activity cause impatience, anxiety, or annoyance ( Rajalingam and Fasano, 2023 ). …

Longitudinal symptom network patterns in cancer patients during the end of life.

Patients with cancer at the end of life experience a wide range of distressing physical and psychological symptoms, which often interact and intensify each other. Understanding how these symptoms are connected is essential for improving quality of life and providing effective palliative care. This study analyzed data from 26,318 medical visits of 8,026 patients receiving palliative care, focusing on symptom interactions during the final months of life. Symptom networks were estimated using the Ising Model across six time periods prior to death, with centrality measures used to identify key sym

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… Their network analysis revealed that anhedonia (loss of pleasure) was the most central symptom. Sleep disturbances, fatigue, suicidal thoughts, feelings of worthlessness, and depressed mood were among the symptoms closely related to each other and to anhedonia. … Their findings revealed that cancer patients want more support for fatigue, feelings of weakness, lack of pleasure, and sleep disturbances. Bickel et al.‘s study highlighted some of the needs of cancer patients and the relationships between their symptoms. …

Пищевая зависимость от поведенческих пристрастий: сетевой подход.

СПРАВОЧНАЯ ИНФОРМАЦИЯ/AIMS: Сопоставимость психических расстройств является хорошо задокументированным явлением. Вместе с тем не было проведено никакого расследования по вопросу о соучастии и механизмах, лежащих в основе пищевой зависимости и поведенческих пристрастий. Таким образом, цели этого исследования заключались в следующем: a) проведение сетевого анализа для изучения взаимосвязей между клиническим профилем пациентов, нуждающихся в лечении от игорного расстройства, навязчивым расстройством, связанным с покупкой и покупкой (CBSD), навязанным расстройством сексуального поведения, и сопутс

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… registered lower mean levels of self-directedness than FA− patients, and this result suggests that these patients may exhibit greater difficulty in decision-making tasks and may be less successful in achieving long-term goals; therefore, their behavior would be more oriented toward achieving short-term pleasurable … The model also suggests that in the early stages of BAs (characterized by problematic and risky behaviors), positive feelings, reward, or pleasure are the main driving motivations. …

Pruritus: an overview. What drives people to scratch an itch?

Pruritus is a common complaint associated with many conditions. It negatively impacts sleep, quality of life, and mortality. Itch is transmitted along both histaminergic and non-histaminergic pathways with a complex interplay between keratinocytes, immune cells and cutaneous neurons. Individuals who present with pruritus should undergo a thorough assessment, especially those over 65 years old, to exclude underlying malignancy. Treatment no longer consists of antihistamines alone. Physicians now have an array of therapies in their armamentarium, to help alleviate this distressing symptom.

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… memory, visual-spatial awareness and consciousness, is activated after acute itch stimulation. 11 In contrast, no activation of the precuneus was identified, after application of an acute painful stimulus. 12 Once scratching begins, imaging shows activation of the reward system due to the feeling of pleasure … As noted above, there is a complex interaction between pain and itch – e.g. when patients scratch an itch it initially incites a pleasurable sensation. Medications, such as morphine, a μ -opioid receptor agonist, are known to cause pruritus. …

Biomarkers of Tumor Metastasis and Invasiveness.

The identification of proteins as new cancer diagnostic and prognostic biomarkers continues to attract considerable attention in the oncology literature, especially in the context of invasion and metastasis activation process [...].

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… In this Special Issue, 169 authors representing 98 affiliations from 18 countries over 4 continents have made 17 contributions, and it is a great honor and pleasure for the Editors to introduce this collective work which summarizes important insights in this field of research. …

Trazodone in the Management of Major Depression Among Elderly Patients with Dementia: A Narrative Review and Clinical Insights.

ObjectiveMajor depressive disorder (MDD) often co-occurs with dementia and other neurological disorders, and treatment with antidepressants can improve symptoms, quality of life, and survival in these patients. This narrative review provides an expert opinion about the role and effectiveness of trazodone in the treatment of older adults with MDD and cognitive impairment due to physical illnesses, such as dementia.ResultsBecause of its mechanism of action, trazodone can treat several depression symptoms often seen in people with dementia, including insomnia, agitation, anxiety, cognitive impair

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… individual must experience at least five of the common symptoms of depression according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) ( Box 1 ) for a period of at least two weeks, and at least one of the symptoms must be either depressed mood, or loss of interest or pleasure … Box 1 Common Symptoms of Depression in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition Depressed mood Loss of interest or pleasure in nearly all activities Significant weight loss or gain, or changes in appetite Insomnia or hypersomnia Psychomotor agitation or retardation Fatigue …

Ограничение способности любить и гиперсексуальное поведение в их отношениях с психотиком и паранойей.

Предпосылки к способности к любви (КТЛ) и проблематичной сексуальности можно было бы рассматривать в качестве показателей психопатологических страданий. 521 Темы390 женщин и женщин 131 мужского пола; возрастный период: 18-50) Завербованные субъекты заполнили психометрический протокол, включающий в себя следующие инструменты измерения:1) реестр возможностей любить;2) Гиперсексуальная инвентаризация поведения,3) Краткий список симптомов. Выражения указывают на значительную обратную корреляцию между CTL и как параноидальной идеей, так и психотиком, при этом гиперсексуальность положительно соотнос

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… According to Kernberg, CTL encompasses the ability to form deep object relations, experience sexual pleasure, and share personal values with a significant other. …

Сексуальное здоровье после неврологических расстройств: всеобъемлющий обзор данных о лечении.

Предыстория/задачи: Сексуальная дисфункция (СД) и более широкие проблемы сексуального здоровья являются распространенными после неврологических расстройств, однако улики вмешательства разрознены по различным условиям и результатам. В ходе этого зонтичного обзора были собраны и оценены на систематической основе данные о мерах, направленных на УР и сексуальное здоровье неврологических групп населения, а также квалифицированные выводы с использованием достоверной информации. Методы: с момента создания были проведены обыски PubMed, Web of Science, Cochrane Bibrary, Embase, PsycINFO, EBCOCOhost и S

Impulsivity and sexual compulsivity - a comparison of untreated individuals with CSBD, individuals undergoing long-term treatment for CSBD, and a healthy control group.

BACKGROUND: Compulsive Sexual Behavior Disorder (CSBD) has been classified in the eleventh revision of the International Classification of Diseases (ICD-11) as an impulse control disorder. Impulsivity, risk-taking, and compulsivity play an important role in CSBD. AIMS: The present study aims to examine impulsivity and sexual compulsivity by comparing three groups: untreated individuals with CSBD, individuals undergoing long-term treatment for CSBD, and a healthy control group. The study aims to use questionnaires and computerized tasks measuring risk-taking and delay discounting in order to i

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… Goodman ( 3 ) claimed that ‘sexual addiction’ meets the description of addiction as a condition where a certain behavior can be a source of pleasure in an adaptive way, but under certain circumstances it becomes maladaptive to avoid emotional distress. … A shift in the reinforcement mechanism, from seeking pleasure (positive reinforcement) to alleviating distress (negative reinforcement), may be at the core of the pathological transition to dependence ( 28 ). …