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2021 ACMT Annual Scientific Meeting Abstracts-Virtual.

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Chemotherapy-induced peripheral neuropathy in adults: a comprehensive update of the literature.

Commonly used chemotherapeutic agents in oncology/hematology practice, causing toxic peripheral neuropathy, include taxanes, platinum compounds, vinca alkaloids, proteasome inhibitors, and antiangiogenic/immunomodulatory agents. This review paper intends to put together and discuss the spectrum of chemotherapy-induced peripheral neuropathy (CIPN) characteristics so as to highlight areas of future research to pursue on the topic. Current knowledge shows that the pathogenesis of CIPN still remains elusive, mostly because there are several sites of involvement in the peripheral nervous system. In

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… 23 , 33 Options for treatment or prevention Previous evidence in relation to the symptomatic management of painful TIPN shows that amitriptyline, glutamine, low-dose of oral prednisone, and gabapentin may alleviate the patients’ pain. 4 Newer drugs, such as duloxetine alone or in combination with pregabalin … Successful treatment by adding duloxetine to pregabalin for peripheral neuropathy induced by paclitaxel. Am J Hosp Palliat Care. 2013;30(7):734–736. doi: 10.1177/1049909112463416. 39. Moore DH, Donnelly J, McGuire WP, et al. …

Chronic pruritus: a narrative review.

Chronic pruritus encompasses a manifestation of several cutaneous, allergic, infectious, neurological, psychological, and systemic conditions, whose etiological investigation and therapeutic strategy can be challenging. This comprehensive review aims to enhance the understanding of pruritus by highlighting important elements in its pathogenesis, including keratinocytes, Merkel cells and mast cells, nerve fibers, histaminergic and nonhistaminergic pathways, and the interaction of itch signals with the central nervous system. Diagnostic evaluation of chronic pruritus may require a meticulous app

Management of Chemotherapy-Induced Peripheral Neuropathy (CIPN) in Oncologic Patients-A New Promise? Preliminary Results.

BackgroundChemotherapy-induced peripheral neuropathy (CIPN) is a common, often debilitating side effect of several chemotherapeutic agents, particularly taxanes and platinum compounds. Current management strategies remain limited, with few agents demonstrating consistent efficacy. Our aim was to evaluate the efficacy and safety of a novel topical cream containing 1% amitriptyline and 0.5% ketamine in alleviating CIPN symptoms in oncology patients.MethodsA prospective observational study was conducted at Barzilai Medical Center following the approval of the local ethics committee. Thirty-seven

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… Over the years, several studies regarding novel pharmacologic agents, including pregabalin, gabapentin, tricyclic antidepressants, and venlafaxine, were conducted, but due to weak or inconsistent evidence supporting their use, they are not formally recommended by ASCO guidelines [ 21 , 22 , 23 ]. …

Упорное использование опиоидов связано с более коротким выживанием миэломы.

Цель " Превышение " содержания опиоидов связана со значительным кризисом в области общественного здравоохранения, однако по-прежнему имеет решающее значение в качестве адъюнкт-процесса лечения во многих миеломах (ММ). Остаются вопросы о балансе между выгодами от продолжающегося использования опиоидов, особенно когда миэлома пациента находится в ремиссии. Этот ретроспективный обзор посвящен ассоциации хронического опиоида (COU) среди пациентов, преимущественно цветных. 174 В одном из городских медицинских центров были изучены пациенты, получившие аутологическую трансплантацию стволовы

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… We additionally documented adjuvant analgesic (i.e., gabapentin, pregabalin, tricyclic antidepressants, or serotonin-norepinephrine reuptake inhibitors). For analysis of survival outcomes, patients were divided into two groups: chronic opioid use and non-chronic opioid use. …

Initial management and disposition of metastatic spinal cord compression in the emergency department: a review of the literature.

BACKGROUND: Metastatic spinal cord compression (MSCC) is a serious medical emergency that can complicate the course of various malignancies, including prostate, breast, and lung cancers. Appropriate evaluation and effective management of MSCC early in the emergency department are necessary to minimize neurologic deterioration and optimize the trajectory of patient recovery. METHODS: This literature review examines and summarizes current evidence surrounding the emergency department approach for timely recognition, initial evaluation, and management of MSCC. RESULTS: A comprehensive clinical

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… For instance, gabapentin or pregabalin can be considered for neuropathic pain, steroids for inflammatory pain, and bisphosphonates for bone-related pain [ 44 ]. …

Adult hypophosphatasia treated with reduced frequency of teriparatide dosing.

We report a 41-year-old man diagnosed with the adult form of hypophosphatasia (HPP) and treated for 4 years with less frequent than conventional daily doses of teriparatide (TPTD). He presented with a history of three low-energy fractures and low bone mineral density (BMD) ineffectively treated with bisphosphonate. We identified within ALPL, the gene that encodes the homodimeric "tissue-nonspecific" isoenzyme of alkaline phosphatase (ALP) and underlies HPP, a heterozygous missense mutation (c.455 G>A→R135H). Characteristic painful periarticular calcification removed at a shoulder did not recur

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… He had flatfeet, chronic headache, and mild musculoskeletal pain (since 2010), for which he received pregabalin (75 mg po twice daily). Arterial hypertension and dyslipidemia (with high lipoprotein(a) 149 mg/dl; normal <30) was treated with metoprolol (75 mg po/d) and rosuvastatin (10 mg po/d). …

Prurigo Nodularis: Pathogenesis and the Horizon of Potential Therapeutics.

Chronic pruritus that lasts for over 6 weeks can present in various forms, like papules, nodules, and plaque types, with prurigo nodularis (PN) being the most prevalent. The pathogenesis of PN involves the dysregulation of immune cell-neural circuits and is associated with peripheral neuropathies, possibly due to chronic scratching. PN is a persistent and challenging condition, involving complex interactions among the skin, immune system, and nervous system. Lesional skin in PN exhibits the infiltration of diverse immune cells like T cells, eosinophils, macrophages, and mast cells, leading to

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… Gabapentinoids, such as gabapentin and pregabalin, are commonly prescribed to reduce itching by inhibiting calcium signaling [ 202 ]. Elderly patients are typically initiated at low doses (e.g., 100 mg nightly) and gradually titrated upwards due to the risk of significant sedation. … Pregabalin, with a similar mechanism of action, is gradually titrated upwards with doses ranging from 75 to 600 mg daily. …

ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts

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… community pharmacists in Scotland PEPI-120 Application of evidence-based medicine criteria to paediatric off-label drug utilization PEPI-181 Role of community pharmacists in health promotion in Khartoum state, Sudan PT-247 Cotrimoxazole induced agranulocytosis in an AIDS patient: a case report DI-31 Pregabalin …

A Single Center Study Investigating Clinical Outcomes of Testing for Multiple Myeloma and Immune Deficiency at Low Globulin Levels

Background Both primary (e.g. common variable immune deficiency, CVID) and secondary immune deficiency as well as multiple myeloma (MM) require medical intervention and treatment delay can exacerbate morbidity. This study investigated the potential importance of low levels of calculated globulin to detect immune deficiency and MM associated with immunoparesis (light chain, non-secretory MM). Methods One hundred and thirty-nine patient serum samples from community physicians and outpatient clinics for liver function tests with low calculated globulin (Results Approximately 47% of patients in th

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… Antiepileptic drugs associated with a reduction in immunoglobulin levels were carbamazepine, phenytoin, gabapentin, lamotrigine, levetiracetam and pregabalin. Four patients were on combined treatment with both antiepileptic drugs and immunosuppressants. …

A prospective, multicenter, open-label study of the clinical efficacy of tapentadol extended-release in the treatment of cancer-related pain and improvement in the quality of life of opioid-naïve or opioid-resistant patients.

PurposeThis study aimed to investigate the clinical efficacy of tapentadol extended-release (ER) on pain control and the quality of life (QoL) of patients with moderate to severe chronic cancer pain in clinical practice in Korea.MethodsIn this prospective, open-label, multicenter trial, patients with sustained cancer pain as well as chronic pain, who were or were not using other analgesics were enrolled. Thirteen centers recorded a total of 752 patients during the 6-month observation period, based on the tapentadol ER dose and tolerability, prior and concomitant analgesic treatment, pain inten

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… However, according to a recent report, many experts recommend using strong opioid analgesics as soon as possible for moderate to severe pain, together with anti-neuropathic pain drugs, such as pregabalin [ 14 ]. …

Intravenous Ketamine for Cancer Pain Management, Including Flares During the COVID-19 Pandemic: A Retrospective Study.

OBJECTIVES: Cancer-related neuropathic pain (CNP) affects an increasing proportion of cancer patients, given improved survival, but it remains difficult to treat. There are no studies on an extended intravenous ketamine protocol and its synergies with common neuropathy treatments to treat CNP. This study aims to 1) evaluate the safety and effectiveness of an intravenous ketamine protocol to treat refractory CNP and 2) uncover synergies between ketamine and common neuropathy treatments. METHODS: This is a single-center, retrospective review of 57 patients and 192 infusions, with prospective fo

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… Traditional treatment modalities are limited to medications such as opioids, tricyclic antidepressants (TCAs), serotonin-norepinephrine reuptake inhibitors (SNRIs), gabapentinoids (gabapentin, pregabalin), other anticonvulsants, and topical analgesics, as well as desensitization techniques, offering …

Gabapentin and Duloxetine Prevent Oxaliplatin- and Paclitaxel-Induced Peripheral Neuropathy by Inhibiting Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Phosphorylation in Spinal Cords of Mice.

Chemotherapy-induced peripheral neuropathy is a common factor in limiting therapy which can result in therapy cessation or dose reduction. Gabapentin, a calcium channel inhibitor, and duloxetine, a serotonin noradrenaline reuptake inhibitor, are used to treat a variety of pain conditions such as chronic low back pain, postherpetic neuralgia, and diabetic neuropathy. It has been reported that administration of gabapentin suppressed oxaliplatin- and paclitaxel-induced mechanical hyperalgesia in rats. Moreover, duloxetine has been shown to suppress oxaliplatin-induced cold allodynia in rats. Howe

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… The mechanisms of action of gabapentin and pregabalin Curr. Opin. Pharmacol. 2006 6 108 113 10.1016/j.coph.2005.11.003 16376147 18. Chappell A.S. Ossanna M.J. Liu-Seifert H. Iyengar S. Skljarevski V. Li L.C. Bennett R.M. Collins H. …

Сочетание невропатической боли с мочевым пузырем и дисфункцией кишечника, функциональной инвалидностью и качеством жизни пациентов с множественным склерозом.

ЦЕЛИ: Изучение связи между нейропатической болью (НБ) и дисфункцией мочевого пузыря/булочка при множественном склерозе (МС) и оценка связи NP с функциональной инвалидностью, качеством жизни, тревогой, депрессией и качеством сна. ПАТИЕНТЫ И МЕТОДЫ: 2017 Пересмотренные критерии McDonald 18 и 65 В наше исследование были включены возрастные группы. Мы проанализировали данные 175 (больные)56 мужчина, 119 (женщины). Пациенты оценивались с точки зрения демографических и клинических характеристик, NP, мочевого пузыря/беспозвоночной дисфункции, инвалидности, состояния здоровья и качества жизни, тревоги

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… Regular pain-management drugs used in the past 3 months—analgesics (including paracetamol, nonsteroidal anti-inflammatory drugs, opioids), antiepileptics (including pregabalin, gabapentin and carbamazepine), and antidepressants—were recorded. …

Множественные склерозы и припадки: клинические, диагностические и терапевтические корреляции.

ВВЕДЕНИЕ: Изъятия происходят чаще среди лиц с множественным склерозом (ПМС), чем среди населения в целом. В настоящее время не проводится никаких исследований, в которых соотносятся клинические, диагностические и терапевтические результаты ПМС и изъятия. Определяем распространенность припадков (припадков) у людей с синдромом MS/Clinical Insidential (CIS) и характеризуем популяцию PCMS/CIS и припадки (припадки). Мы использовали регистр MS в Южном Уэльсе для идентификации всех людей, имеющих MS/CIS и всю историю припадков, проживающих в Кардиффе и Вале. Из электронных записей были получены ретро

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… Incidental use of gabapentin/pregabalin (e.g., neuropathic pain, spasticity) was also noted in 28 patients but was only counted as ASM in one case where it was explicitly prescribed for seizure control. …

Increasing use of sodium nitrite in suicides-an emerging trend.

Sodium nitrite (NaNO2) is a compound with broad practical applications in food preservation, automotive maintenance, and animal control. Sodium nitrite is also potentially fatal when ingested, as it interferes with the ability of red blood cells to transport oxygen. While incidents of accidental consumption have been reported in the literature, case reports of sodium nitrite being used as a pharmacological suicide agent are becoming more frequent. Therefore, a study was undertaken to evaluate trends in sodium nitrite deaths in South Australia between 2000 and 2019. All cases of fatal sodium ni

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… “sodium nitrite – food grade” from ‘back 2 basics artisan supplies’ | • Blue-gray hypostasis • Pulmonary edema • Urine dipstick positive for nitrite • No evidence of ketosis or pathologically significant alteration of renal function | • Lorazepam (0.022) • Fentanyl (2ug/L) • Metoclopramide (0.14) • Pregabalin …

Evaluation of safety and analgesic consumption in patients with advanced cancer treated with zoledronic acid.

BackgroundThe aim of the study was evaluation of zoledronic acid with regard to safety, effect on analgesic consumption and impact on occurrence of skeletal related events in patients with bone lesions from solid tumors and multiple myeloma.MethodsWe conducted an observational, 12-month, phase IV and multi-center study. One hundred and twenty-five symptomatic (pain) bone-metastatic patients were included between 2007 and 2009: 92 prostate cancers, 28 multiple myelomas, 5 others. They were prescribed monthly infusions of zoledronic acid in accordance to each disease's treatment guidelines. Anal

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… For analysis of analgesic requirement, prescribed analgesics were grouped into 3 groups: opioid analgesics (tramadol, hydromorphone, oxycodone, transdermal fentanyl, piritramide, morphine sulphate), non-steroidal antiinflammatory drugs (diclofenac, ketoprofen) and others (paracetamol, metamizole, pregabalin …

Decoding chemotherapy-induced peripheral neuropathy: ion channels, disease models, and future directions.

Chemotherapy-induced peripheral neuropathy (CIPN) is a significant side effect of cancer treatments like paclitaxel and oxaliplatin, impacting patient quality of life (QoL). Despite much research, its underlying mechanisms remain unclear and effective therapies are lacking. This review evaluates whether current experimental models accurately reflect CIPN, emphasizing recent molecular and cellular findings, especially the role of sensory ion channels. We outline limitations of existing models and propose more translational preclinical approaches to better capture disease complexity and patient

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… Other medications for neuropathic pain such as gabapentin, pregabalin, and tricyclic antidepressants - often used in diabetes or post-herpetic neuralgia - have shown inconsistent or negative results in CIPN studies ( Loprinzi et al., 2020 ). … Pregabalin silences oxaliplatin-activated sensory neurons to relieve cold allodynia. eNeuro 10, ENEURO.0395–22.2022. 10.1523/ENEURO.0395-22.2022 Jolivalt C. G., Frizzi K. E., Guernsey L., Marquez A., Ochoa J., Rodriguez M., et al. (2016). Peripheral neuropathy in mouse models of diabetes. Curr. …

Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial.

(1) Background: Chemotherapy-induced peripheral neuropathy (CIPN) decreases the quality of life of patients and can lead to a dose reduction and/or the interruption of chemotherapy treatment, limiting its effectiveness. Potential pathophysiological mechanisms involved in the pathogenesis of CIPN include chronic oxidative stress and subsequent increase in free radicals and proinflammatory cytokines. Approaches for the treatment of CIPN are highly limited in their number and efficacy, although several antioxidant-based therapies have been tried. On the other hand, ozone therapy can induce an ada

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… The recent ASCO guideline on the prevention and management of CIPN [ 8 ] does not recommend for the prevention of CIPN oxcarbazepine or venlafaxine (despite the promising initial reports) among several other agents, such as carbamazepine, gabapentin, pregabalin, and the antioxidants previously mentioned … Outside the context of clinical trials, there is no recommendation for the use of other drugs/interventions for the treatment of stablished CIPN, including gabapentin, pregabalin, tricyclic antidepressants, oral cannabinoids, or topical gel treatment containing baclofen, amitriptyline HCL, plus/minus …

Роль габапентина в управлении нейрогенными сверхактивными пузырями: систематический обзор.

ВВЕДЕНИЕ: Нееврогенная дисфункция нижних мочевых трактов, как правило, регулируется на основе поэтапного подхода, начиная с антихолинергических препаратов, переходя к ботулиническим токсиновым инъекциям и хирургическим вмешательствам. Габапентин предлагает менее инвазивный вариант, либо как придаток к антихолинергике, либо как самостоятельная терапия. Для определения воздействия габапентина на снижение давления мочевого пузыря, увеличение мощности мочевого пузыря и снижение симптомов недержание у пациентов с NOAB.МАТЕРИАЛЫ И МЕТОДЫ: В целях выявления исследований по габапентину для НУАБ на Пуб

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… Gabapentin and pregabalin, which is the S-enantiomer of 3-isobutyl GABA, are known as gabapentinoids. The excitation of afferent C fiber activity might be a possible cause of lower urinary tract symptoms in neurogenic bladder dysfunction. …