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Association between exercise habits including exercise partner and allergic rhinitis in a Japanese population.

BACKGROUND: Evidence on the association between physical activity (PA) and allergic rhinitis (AR) remains inconsistent. While the prevalence of AR was high in Japan, no epidemiological study regarding this issue has been conducted. OBJECTIVE: This study examined the association between exercise habits including exercise partner and self-reported AR among Japanese young adults. METHODS: This cross-sectional study included 12,497 university students who underwent annual health checkups. Exercise habits were evaluated using a self-administered questionnaire on frequency (none, 1-2/month, 1-3/we…

Olopatadine plus mometasone for seasonal allergic rhinitis treatment: A pooled analysis of clinical trials.

OBJECTIVE: This study was conducted to analyze the efficacy and safety of a fixed-dose combination of olopatadine HCl (antihistamine) and mometasone furoate (corticosteroid) (Olo/Mom, GSP301) for the treatment of Seasonal Allergic Rhinitis (SAR). METHODS: Efficacy data from one phase II (NCT02318303 [GSP301-201]) and two pivotal phase III double-blind, randomized, active, placebo-controlled (NCT02631551 [GSP301-301] and NCT02870205 [GSP301-304]) clinical trials were collated and analyzed. These studies investigated Olo/Mom (administered twice daily/BID) compared with placebo and its monothera…

EpCAM aptamer modified carbon@manganese dioxide nanoflower for synergistic drug-nanozyme allergic rhinitis treatment.

Allergic rhinitis (AR) is a prevalent upper respiratory allergic disorder that significantly impacts patients' quality of life.In this research, we developed a multifunctional nanozyme-drug synergistic therapy nanosystem for the treatment of allergic rhinitis (AR). The nanosystem, called EpCAM aptamer modified carbon@manganese dioxide nanoflower (Apt-C@MnO2 NFs), combines porous carbon nanospheres and MnO2 nanozymes to achieve synergistic reactive oxygen species (ROS) scavenging. EpCAM aptamer (Apt) is an epithelial cell adhesion molecule. The designed material was modified with EpCAM aptamers…

Schisandrin A alleviates allergic rhinitis by restoring Th1/Th2 and Treg/Th17 immune balance.

Allergic rhinitis (AR) is a common chronic inflammatory disorder characterized by nasal mucosal inflammation, sneezing, and rhinorrhea. Schisandrin A (Schis-A) has demonstrated significant anti-inflammatory effects in models of allergic asthma. This study aimed to evaluate the therapeutic efficacy of Schis-A in AR and to elucidate its underlying molecular mechanisms. An AR mouse model was established by sensitization and challenge with ovalbumin (OVA), followed by oral administration of Schis-A at doses of 40 and 80 mg/kg/day. Nasal symptoms were monitored and quantified. OVA-specific immunogl…

Stellate ganglion block causing reproducible improvement of allergic rhinitis and asthma: a case report.

INTRODUCTION: Stellate ganglion block (SGB) is hypothesized to influence immunologic and physiologic processes through autonomic modulation. Though similar effects of SGB on atopic disease have been intermittently observed over the past century, methodological concerns limit the internal and external validity of these prior efforts. OBJECTIVES: To describe a case of simultaneous and reproducible improvement in allergic rhinitis and asthma after SGB, and to contextualize this observation within the existing literature. METHODS: A 35-year-old woman with Complex Regional Pain Syndrome (CRPS) fo…

Symptomatic Interventions for Allergic Rhinitis Without Comorbid Asthma: A Dose-Stratified Network Meta-analysis.

BACKGROUND: Allergic rhinitis (AR) is a prevalent chronic condition with a substantial global burden. Although numerous therapeutic interventions exist, their comparative efficacy and safety remain unclear. The objective was to evaluate symptomatic interventions for seasonal and perennial AR without comorbid asthma via a systematic review and dose-stratified network meta-analysis (NMA). METHODS: We systematically searched Web of Science, Cochrane Library, Scopus, PubMed, and Embase for randomized controlled trials. Studies evaluating immunotherapy, alternative medicine, or primarily enrolling…

Epithelial AhR-NKX3-1-Senescence Axis Drives Barrier Function and Inflammation in Allergic Rhinitis.

BACKGROUND: Allergic rhinitis (AR) is a common airway disease characterized by epithelial barrier dysfunction and Type 2 inflammation. Although the aryl hydrocarbon receptor (AhR) regulates mucosal immunity and epithelial homeostasis, its role in epithelial pathology in AR remains poorly defined. We sought to determine the contribution of AhR signaling to AR pathogenesis and to identify downstream mechanisms linking barrier dysfunction to Type 2 inflammation. METHODS: AhR expression and transcriptomic profiles were analyzed in nasal tissues from AR patients and controls. AhR-deficient (AhR-/-…

Asthma, Atopic Dermatitis, and Allergic Rhinitis in Pediatric Celiac Disease: A Case-control Study.

Celiac disease is a gluten-induced immune-mediated enteropathy. Recent studies suggest an increasing association between celiac disease and atopic conditions such as asthma, atopic dermatitis, and allergic rhinitis, although the underlying mechanisms are not fully understood. In this matched case-control study, the prevalence of asthma, atopic dermatitis, and allergic rhinitis was evaluated among 173 children with celiac disease and 173 age- and sex-matched healthy controls in Zahedan, Iran, in 2023. The diagnosis of celiac disease was based on European Society for Paediatric Gastroenterology,…

Comparative safety analysis of coseasonal versus preseasonal Artemisia annua sublingual immunotherapy for allergic rhinitis.

PURPOSE: Patients with seasonal allergic rhinitis (SAR) usually seek treatment when symptoms become unbearable during the pollen season. It remains unclear whether initiating sublingual immunotherapy (SLIT) during the pollen season affects patients' safety. This study aims to compare the tolerability of initiating Artemisia annua SLIT during the pollen season versus before the season. METHODS: Ninety patients with Artemisia-induced SAR were recruited and equally randomized into the coseasonal initiation treatment (COS-SLIT) group and the preseasonal initiation treatment (PRE-SLIT) group. The …

Seasonal Proteomic Variations and Biomarkers in Seasonal Allergic Rhinitis: Insights from Olink Inflammation Profiling.

PURPOSE: Seasonal allergic rhinitis (SAR) is a prevalent inflammatory condition, yet its molecular mechanisms and reliable biomarkers remain incompletely understood. This study aimed to identify key inflammation-related proteins and pathways associated with SAR by investigating seasonal proteomic profile variations and their correlations with SAR symptoms. PATIENTS AND METHODS: Serum samples were collected from nineteen SAR patients during both allergy (in-season, IS) and non-allergy (out-of-season, OS) periods. Differentially expressed proteins (DEPs) were identified using the Olink Target 9…

Radiofrequency Ablation of Inferior Turbinates With Posterior Nasal Nerve Neurolysis for Refractory Rhinitis Medicamentosa.

OBJECTIVE: To explore the effectiveness of surgical intervention in treating refractory rhinitis medicamentosa (RM) and determine whether laser posterior nasal neurolysis improves outcomes. METHOD: This is a retrospective cohort study from February 2023 to June 2025, which enrolled patients with RM refractory to medical treatment who received either radiofrequency ablation turbinate reduction (RF) alone or combined RF ablation with laser posterior nasal nerve neurolysis (RPN3). RESULTS: The study included 37 patients with refractory RM (RF group = 9, RPN3 group = 28). During the 12-month fol…

The natural history of childhood-onset nonallergic rhinitis; a long-term follow-up study.

BACKGROUND: Non-allergic rhinitis (NAR) is characterized by symptoms of nasal inflammation without allergic sensitization. The long-term outcome of NAR in children is poorly defined. OBJECTIVE: To determine the natural history of childhood-onset NAR and the development of allergic rhinitis (AR) in these children. METHODS: NAR patients who were followed for more than 10 years were evaluated at 3-5 years (E2) and 9-12 years (E3) after the first evaluation (E1). Nasal symptoms, disease severity, comorbidities, medication used, and aeroallergen sensitization were assessed. RESULTS: Eighty-two N…

Predictive Value of Ipratropium Responsiveness on Posterior Nasal Nerve Neurectomy Outcomes in Chronic Rhinitis.

OBJECTIVE: Procedures targeting the posterior nasal nerve (PNN) are effective in treating chronic rhinitis after failed medical therapy. We evaluate how ipratropium response predicts PNN intervention outcomes. STUDY DESIGN: Retrospective review from January 2013 to June 2025. STUDY SETTING: Tertiary academic center. METHODS: We reviewed patients with chronic rhinitis who trialed ipratropium nasal spray and received PNN surgical neurectomy or in-office ablation (cryotherapy or radiofrequency ablation). Ipratropium responsiveness was self-reported. Outcomes were assessed with the SNOT-22 ques…

Updates on Artificial Intelligence-Assisted Allergic Rhinitis and its Impact on Asthma Care Pathways.

The use of artificial intelligence (AI) in medicine has been growing steadily over the past decade, but it has not been until the past few years that it has been employed officially in many different medical environments, from AI-assisted diagnosis to therapeutic decisions and even AI-assisted interventions. The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines have always been at the avant-garde in embracing new techniques in guideline development since its conception. We present a narrative review of ARIA's developmental stages, particularly focusing on the final one: the integrat…

Montelukast treatment response according to eosinophil-derived neurotoxin level in children with allergic rhinitis.

BACKGROUND: Eosinophil-derived neurotoxin (EDN) is an important biomarker of eosinophilic inflammation. METHODS: This study evaluated Montelukast treatment response according to EDN concentration in children with perennial allergic rhinitis (PAR). Fifty-two children with PAR were recruited and took a combination of Montelukast (5mg) and Levocetirizine (5mg) "Mont/Levo Group" or only Montelukast (5mg) "Mont Group" for 4 weeks. All caregivers were instructed to record rhinitis symptoms for 4 weeks. EDN was measured before and after treatment. RESULTS: Daytime nasal symptom scores (DNSS) signif…

Jingfang Granules alleviates OVA-induced allergic rhinitis through regulating endoplasmic reticulum stress signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Jingfang Granules (JF) is a modified herbal compound preparation that is empirically used in clinical practice for the treatment of allergic diseases. Nevertheless, the role of JF in allergic rhinitis (AR) has yet to be demonstrated, and its potential mechanisms of action remain to be fully evaluated. AIM OF STUDY: The objective of this research is to examine the underlying mechanisms by which JF can be used to treat AR. This will be achieved through the use of an ovalbumin (OVA)/aluminum hydroxide AR model in mice. MATERIALS AND METHODS: ICR mice were adminis…

Продвижение исследований по аллергическому риниту с помощью исследований феномерных ассоциаций: < < Понимание из известных генетических лоси > > .

КОЛИЧЕСТВО: Аллергический ринит (АР) является распространенным хроническим респираторным заболеванием, которое может привести к развитию различных других заболеваний. Несмотря на сообщения о генетических рисках, связанных с АР, связь между этими loci и AR коморбидиумами или другими заболеваниями остается неясной. МЕТОДЫ: В рамках этого исследования было проведено исследование по вопросу о феномерной ассоциации (ФеВАС), в котором использовались известные данные о рисках, связанных с АР, для изучения воздействия известных вариантов риска АР на широкий спектр фенотипов. Впоследствии для дальнейше

Совпадение в аннотации оригинала
BACKGROUND: Allergic rhinitis (AR) is a common chronic respiratory disease that can lead to the development of various other conditions. Although genetic risk loci associated with AR have been reported, the connections between these loci and AR comorbidities or other diseases remain unclear. METHODS: This study conducted a phenome-wide association study (Ph…

Association between allergic rhinitis and hypertension risk: A bidirectional 2-sample mendelian randomization study.

Previous studies have suggested a potential association between allergic rhinitis (AR) and hypertension, but the genetic basis remains unclear. In this study, we aimed to explore the genetic correlation and potential causal association between AR and hypertension. Using a large-scale genome-wide association study (GWAS) public database, we conducted meticulous screening to acquire the most up-to-date GWAS data on single nucleotide polymorphisms (SNPs) relevant to AR and hypertension, with a significance threshold of P < 5 × 10-8. Then, we investigated the causal association between AR and hype…

Association Between Immune-Related Disease and Allergic Rhinitis: A Two-Sample Mendelian Randomization Study.

BACKGROUND: Immune-related diseases can interact with each other, and growing evidence suggests that these diseases are associated with allergic rhinitis (AR). However, it is unclear whether previously observed associations reflect causal relationships. OBJECTIVE: This study estimated the genetic association between various immune-related diseases and AR using two-sample Mendelian randomization (MR). METHODS: Eight immune-related diseases were selected as exposure factors, and AR was selected as the outcome. The 8 immune-related disease categories included atopic dermatitis (AD), Graves' dis…

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay.

Allergic rhinitis (AR) is a chronic, non-infectious inflammatory disease of the nasal mucosa, primarily mediated by specific immunoglobulin E (IgE), affecting approximately 10%-20% of the world's population. While immunofluorescence (IF) staining has long been a standard technique for detecting disease-specific protein expression, conventional IF techniques are limited in their ability to detect the expression levels of three or more proteins in the same sample. Consequently, multicolor IF techniques have been developed in recent years, which allow the simultaneous labeling of multiple targets…