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Weight gain, body composition, and metabolic parameters of dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: an ancillary analysis of the ODYSSEY trial.

BACKGROUND: ODYSSEY trial showed superior efficacy of dolutegravir-based antiretroviral therapy (ART) versus then-current, non-dolutegravir … ODYSSEY-B) were enrolled in 29 centres in Germany, Portugal, South Africa, Spain, Thailand, Uganda, Zimbabwe, and the UK in two cohorts (children weighing ≥14 kg and children weighing <14 kg). Treatment effects (dolutegravir vs standard of care) were estimated on randomised allocation, accounting for treatment switches (substantial in standard of care arm …

Use of Herbal Medicine Is Associated With Late-Stage Presentation in Tanzanian Patients With Cancer: A Survey to Assess the Utilization of and Reasons for the Use of Herbal Medicine.

PurposeIn Tanzania, patients with cancer present late with advanced stages. Among other reasons, the use of herbal medicine (HM) might contribute to delay in diagnosis and treatment. This study aims to understand the utilization of HM and the reasons for its' use.MethodsA semistructured 30-item questionnaire with closed- and open-ended questions was applied to a cohort of patients with cancer at Kilimanjaro Christian Medical Centre. Content analysis was performed for answers to open-ended questions.ResultsThree hundred two patients were interviewed, 50.9% males and 49.1% females. The mean age

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… Traditional medical practitioners use media on a large scale to advertise their products and do this in a manner that lacks both medical and business ethics, according to a study analyzed the situation in South Africa, Mozambique, and Zimbabwe. 15 This, however, remains an assumption, and further research …

Global burden and regional inequalities of cancer in older adults from 1990 to 2021 and its projection until 2050.

BackgroundGlobal ageing will further exacerbate the cancer burden, and the intersection of cancer and ageing represents an emerging and significant global public health challenge.MethodsBased on the Global Burden of Disease 2021 (GBD 2021) data, we utilized the estimated annual percentage change and Joinpoint regression model to examine the temporal trends in the global cancer burden among elderly population from 1990 to 2021. Pearson's rank correlation analysis was conducted to assess the relationship between disease burden and the socio-demographic index (SDI). Furthermore, an autoregressive

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… As illustrated in Supplementary Fig. 1, in 2021, Greenland in North America, Mongolia in Asia, Bolivia in South America, Zimbabwe in Africa, and several European countries presented significantly elevated mortality rates. … Conversely, mortality rates have continued to rise in Zimbabwe, Mongolia, and several European nations. Furthermore, while cancer mortality among the elderly population in India remains relatively low, it has demonstrated a significant upward trend. …

Оперативная полная ремиссия после one Цикл четырехкратного режима на основе изатуксимаба 1q21-positive первичная плазменная лейкемия: отчет о деле.

Первичная плазменная лейкемия (PPCL) представляет собой редкое и агрессивное нарушение плазменных клеток. Пациенты часто имеют большое число циркуляционных плазменных клеток и на ранней стадии заболевания, что часто сопровождается серьезными инфекциями и дисфункцией органов, что приводит к плохому общему прогнозу. Текущие стратегии лечения ПХХЛ в значительной степени экстраполируются из интенсивных индукционных режимов, используемых для лечения множественной миэломы; однако терапевтические результаты остаются ограниченными, особенно у пациентов с повышенным риском цитогенетических аномалий и н

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… Footnotes Edited by: Nicola Sgherza , AOU Policlinico Consorziale di Bari, Italy Reviewed by: Jingjing Deng , Capital Medical University, China Emmanuel Obeagu , Africa University, Zimbabwe Data availability statement The original contributions presented in the study are included in the article/ …

Calcium supplementation commencing before or early in pregnancy, for preventing hypertensive disorders of pregnancy.

BACKGROUND: The hypertensive disorders of pregnancy include pre-eclampsia, gestational hypertension, chronic hypertension, and undefined hyp … study (1355 women), which took place across multiple hospital sites in Argentina, South Africa, and Zimbabwe. Most analyses were conducted only on 633 women from this group who were known to have conceived, or on 579 who reached 20 weeks' gestation; the trial was at moderate risk of bias due to high attrition rates pre-conception. Non-pregnant women with p …

Virological outcomes and genotypic resistance on dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial.

BACKGROUND: ODYSSEY showed superior efficacy for dolutegravir-based antiretroviral therapy (ART) versus standard of care (SOC) in children living with HIV starting first-line or second-line ART aged 4 weeks or older. Here, we aim to compare virological outcomes and resistance in the dolutegravir group versus SOC for first-line and second-line ART up to 96 weeks. METHODS: ODYSSEY was an open-label, multicentre, randomised, non-inferiority trial done in 29 centres in seven countries (Germany, Spain, South Africa, Thailand, the UK, Uganda, and Zimbabwe). ODYSSEY recruited children living with HI…

Mosaic HIV-1 vaccine regimen in southern African women (Imbokodo/HVTN 705/HPX2008): a randomised, double-blind, placebo-controlled, phase 2b trial.

BACKGROUND: HIV type 1 (HIV-1) remains a global health concern, with the greatest burden in sub-Saharan Africa. Despite 40 years of research … V-2 aged 18-35 years at 23 clinical research sites in Malawi, Mozambique, South Africa, Zambia, and Zimbabwe. Participants were centrally randomly assigned (1:1) to receive intramuscular injections of vaccine or saline placebo in stratified permuted blocks via an interactive web response system. Study participants, study site personnel (except those with p …

Interventions for improving coverage of childhood immunisation in low- and middle-income countries.

BACKGROUND: Immunisation plays a major role in reducing childhood morbidity and mortality. Getting children immunised against potentially fa … ries (Côte d'Ivoire, Ghana, Honduras, India, Indonesia, Kenya, Nigeria, Nepal, Nicaragua, Pakistan, Zimbabwe), and three lower-income countries (Afghanistan, Mali, Rwanda). The interventions evaluated in the studies were health education (seven studies), patient reminders (13 studies), digital register (two studies), household incentives (three studies), r …

Circumcision devices versus standard surgical techniques in adolescent and adult male circumcisions.

BACKGROUND: Medical circumcisions are among the most common surgical procedures performed in males. The usual indications are phimosis (inab … ria. Trials were conducted in China, South Africa, Kenya and Zambia, Mozambique, Rwanda, Uganda and Zimbabwe. Primary outcomes Serious adverse events: there were no serious adverse events in either treatment arm (11 trials, 3472 participants). Moderate adverse events: there may be a slight increase in moderate adverse events when devices are used compared …

Efficacy and safety of dolutegravir with emtricitabine and tenofovir alafenamide fumarate or tenofovir disoproxil fumarate, and efavirenz, emtricitabine, and tenofovir disoproxil fumarate HIV antiretroviral therapy regimens started in pregnancy (IMPAACT 2010/VESTED): a multicentre, open-label, randomised, controlled, phase 3 trial.

BACKGROUND: Antiretroviral therapy (ART) during pregnancy is important for both maternal health and prevention of perinatal HIV-1 transmissi … in nine countries (Botswana, Brazil, India, South Africa, Tanzania, Thailand, Uganda, the USA, and Zimbabwe). Pregnant women (aged ≥18 years) with confirmed HIV-1 infection and at 14-28 weeks' gestation were eligible. Women who had previously taken antiretrovirals in the past were excluded (up to 14 days of ART during the current pregnancy was permitted), …

A single-center 7-year experience with end-stage renal disease care in Nigeria-a surrogate for the poor state of ESRD care in Nigeria and other sub-saharan african countries: advocacy for a global fund for ESRD care program in sub-saharan african countries.

Background. A single-center ESRD care experience in a Nigerian teaching hospital is presented as a surrogate case to demonstrate the prevailing ESRD care situation in Nigeria and most SSA countries. Methods. The data of 320 consecutive ESRD patients undergoing maintenance haemodialysis treatment during a seven-year period were retrospectively analyzed. Results. Over 80% of the subjects funded dialysis treatments from direct out of pocket payment. The mean duration on dialysis before dropout was 5.2 ± 7.6 weeks, with majority 314 (98.1%) of the patients unable to sustain dialysis above 12 weeks

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… Others are Zimbabwe (59), Kenya (100), and Sudan (200). South Africa is the only SSA country with a more reliable ESRD data and much higher access to organized ESRD care. …

Multiple myeloma in Niger Delta, Nigeria: complications and the outcome of palliative interventions.

BACKGROUND: Multiple myeloma (MM) is one of the hematological malignancies that require palliative care. This is because of the life-threatening nature and the suffering associated with the illness. The aim of this study is to bring to the fore the complications experienced by people living with MM in the Niger-Delta region of Nigeria and the outcome of various palliative interventions. METHODS: This was a 10-year multi-center retrospective study of 26 patients diagnosed and managed in three major centers in the Niger-Delta region of Nigeria from January 2003 to December 2012. Information on

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… Zimbabwe, an African country, has an incidence rate of ~3.5/100,000/year. 6 Although the incidence rate is not known in Nigeria, MM representŝ8.2% of all hematological malignancies. 7 The cause of MM has not yet been identified. …

Global epidemiological trend of cancer incidence and death in adults aged 60 years and older: a systematic analysis of data from GLOBOCAN 2022 and GBD2021.

BACKGROUND: Updated and comprehensive global assessments of cancer statistics specifically targeting adults aged ≥ 60 years have remained limited. To address this gap, we conducted a systematic epidemiological analysis of cancer burden in this rapidly growing demographic worldwide. METHODS: Population-based data from the Global Cancer Observatory (GLOBOCAN) 2022 and the Global Burden of Diseases (GBD) 2021 were used and analyzed in this study. The main outcomes of this study were age-standardised incidence (ASIR) or mortality rate (ASMR), and average annual percent change (AAPC). A Bayesian ag

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… Monaco, Bermuda, and the United States of America had the highest ASIR (Table S3), and the highest ASMR was observed in Monaco, Mongolia, Greenland, Zimbabwe, and Uruguay (Table S3). …

Outcomes and microbiological patterns of bacteremia in chemotherapy-related febrile neutropenia at a tertiary facility in Kenya.

IntroductionFebrile neutropenia (FN) is a major cause of mortality and morbidity in patients with malignancy post-chmotherapy. Current guidelines for managing FN recommend starting empiric antibiotic therapy (EAT) promptly. The choice of antibiotic is based on the patient's condition, local data on common microorganisms isolated, and their resistance patterns. Of note, there is a growing trend of isolating multi-drug-resistant gram-negative bacteria in these patients. In sub-Saharan Africa, there are insufficient data on the mortality rates of FN. There is also a lack of local epidemiologic da

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… There are a few studies that have looked at children with cancer, such as the multi-center prospective supportive care for children with cancer in Africa (SUCCOUR) study conducted in five sub-Saharan African countries (Zimbabwe, Cameroon, Kenya, Ghana, and Malawi) from September 2019 to March 2020. …

Поддержка со стороны сверстников в хронических условиях с точки зрения сверстников: систематический обзор.

Цель: Поддержка со стороны сверстников может стать ценным дополнением к обычному уходу за пациентами с хроническими заболеваниями. Хотя выгоды, связанные с поддержкой со стороны сверстников, хорошо задокументированы, в большинстве исследований основное внимание уделяется интересам получателей помощи. Учитывая центральную роль, которую играют сторонники из числа сверстников, их опыт следует рассматривать как не менее важный. В рамках этого систематического обзора обобщается имеющаяся литература, посвященная опыту сочувствующих друг другу лиц с хроническими заболеваниями. Метод: Мы проводили сис

Towards a unified approach for multiple myeloma care in Kenya - proceedings of the Inaugural Multiple Myeloma Congress.

The rising burden of multiple myeloma in Kenya has not been met by a commensurate effort for control. Patients and practitioners struggle with unavailability and unaffordability of diagnostics, drugs and stem cell transplant leading to presentation at advanced stages and under-treatment with increased morbidities and mortality. A concerted effort among stakeholders is urgently needed to develop strategies for myeloma control. The scarcity of providers also carries grave consequences for Kenyan patients. The Academic Model Providing Access To Healthcare (AMPATH) multiple myeloma program organiz

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… Kenya | | | Medipoint EA LTD | | Philips Pharmaceuticals Academia | Kenya | | | Moi University | | University of Nairobi | | Aga Khan University | | Maseno University | | Kenyatta University | | University of Kabianga | International | | | Indiana University | | University of Zimbabwe …

Глобальное, региональное и национальное бремя множественной миеломы 1990 в адрес 2021 и прогнозы в отношении 2040:: систематический анализ глобального бремени болезней; 2021 Учёба.

Множественная миелома (ММ) представляет собой злокачественное гематологическое расстройство, характеризующееся аномальным распространением клональных клеток плазмы костного мозга и чрезмерным производством иммуноглобулинов, часто приводящим к серьезным повреждениям органов. В связи с высоким уровнем заболеваемости, рецидивов и смертности ММ ложится тяжелым бременем на отдельных лиц и глобальные системы здравоохранения. В этом исследовании используются последние данные, полученные в рамках исследования глобального бремени болезней 2021 (ГБМ) 2021) проанализировать эпидемиологические тенденции в

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… The countries with the highest DALY burden in 2021 were the Bahamas (117.5 years per 100,000; 95% UI: 94.3–145.1), Monaco (93.3 years per 100,000; 95% UI: 47.4–150.1), and Zimbabwe (88.7 years per 100,000; 95% UI: 48.8–126.7). …

The level of knowledge about palliative care in Iranian patients with cancer.

BackgroundPatient awareness plays an important role in integrating palliative care into the patient care process. Lack of awareness can create a negative attitude towards palliative care and affect patients' decisions during the treatment process. The present study was conducted to determine the level of knowledge about palliative care in Iranian patients with cancer.MethodsThe descriptive study was conducted with a convenience sample of 103 cancer patients admitted to an oncology center in Yazd, Iran, A three-part questionnaire including demographic information, sources of palliative care inf

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… Tapera O Nyakabau A Limited knowledge and access to palliative care among women with cervical cancer: an opportunity for integrating oncology and palliative care in Zimbabwe BMC Palliat Care 2020 19 1 1 9 32054480 10.1186/s12904-020-0523-5 PMC7020584 50. …

Multiple myelomas in cats.

Multiple myelomas are uncommon neoplasms of the bone marrow of cats [Weber NA, Tebeau CS (1998) An unusual presentation of multiple myeloma in two cats. Journal of the American Animal Hospital Association34 (6), 477-483]. Nine cats diagnosed with multiple myelomas were retrospectively identified over a 16-year period (1986-2002). Cats with multiple myelomas were older than 7 years (mean age 11.7 years); six males and three females were affected (2.1), but no breed predisposition was evident. Treatment of multiple myelomas consisted of supportive management in the nine cats and anti-neoplastic

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… Multiple myeloma associated with paraproteinuria and hyperviscosity syndrome: a case report , Zimbabwe Veterinary Journal 26 ( 3–4 ), 1995 , 102 , 20 ref Dunn T.B. …

Всемирный конгресс по болезням остеопороза, остеоартрита и мускулоскелета 2025).

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… Ferrand 4 1 Musculoskeletal Research Unit, University of Bristol, Bristol, United Kingdom, 2 The Health Research Unit Zimbabwe, The Biomedical Research and Training Institute, Harare, Zimbabwe, 3 Department of Obstetrics and Gynaecology, University Teaching Hospital, Lusaka, Zambia, 4 Clinical Research … Department, London School of Hygiene and Tropical Medicine, London, United Kingdom, 5 Department of Paediatrics, University of Zimbabwe, Harare, Zimbabwe, 6 Research Centre Borstel, Leibniz Lung Centre, Borstel, Germany, 7 Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom …