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Special Issue "Anticancer Drugs".

The focus of this Special Issue of Pharmaceuticals is on the design, synthesis, and molecular mechanism of action of novel antitumor, drugs with a special emphasis on the relationship between the chemical structure and the biological activity of the molecules. This Special Issue also provides an understanding of the biologic and genotypic context in which targets are selected for oncology drug discovery, thus providing a rationalization for the biological activity of these drugs and guiding the design of more effective agents. In this Special Issue of Pharmaceuticals dedicated to anticancer dr

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… We have great pleasure in accepting the invitation to be guest editors for this Special Issue of “Pharmaceuticals”. …

Алкоголь и каннабис используют строгость в связи с навязчивым сексуальным поведением и проблематичным использованием порнографии в неклинической выборке: перекрестное исследование.

ВВЕДЕНИЕ: Насильственные сексуальные расстройства и проблематичное использование порнографии (ППП) часто связаны с расстройствами, связанными с потреблением веществ, однако их связи с конкретными веществами в неклинических группах по-прежнему плохо известны. В настоящем исследовании рассматриваются связи между остротой потребления алкоголя и каннабиса и симптомами CSBD и ППУ в неклинической выборке взрослого населения. МЕТОДЫ: В мае-октябре имеющим на то право взрослым было предложено провести анонимное онлайновое обследование 2025. Показатели распространенности потребления алкоголя и каннабис

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… According to ICD-11, CSBD is defined as a persistent pattern of failure to control intense, repetitive sexual impulses or urges, manifested in repetitive sexual behaviors, unsuccessful attempts to reduce these behaviors, and their continuation despite negative consequences and little subjective reward or pleasure …

Оценка женской сексуальной дисфункции у пациентов с повторным множественным склерозом.

Множественный склероз (MS) затрагивает главным образом молодых людей репродуктивного возраста с существенными последствиями на протяжении всей жизни, среди которых сексуальная дисфункция (SD) является одним из наиболее забытых в ходе обычного клинического лечения. ЦЕЛЬ: Оценка УР у женщин, у которых диагностированы повторные выбросы MS (RRMS). МЕТОДЫ: Это межсекторальное аналитическое исследование было проведено в больнице " Санта Каса де Сан-Паулу " , Факультет медицины, Сан-Паулу, Бразилия, в период с ноября 2020 года по март 2022 года. В выборку входили 80 женщин-больных с диагноз

Навязчивое сексуальное поведение и изменения в одиночных сексуальных поступках во время пандемии COVID-19

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… Scores range from 2 to 8, with higher scores indicating greater endorsement of depression symptoms (i.e., depressed mood and lack of interest or pleasure). Cronbach’s alpha for this sample was α  = 0.90. …

Воздействие транскутановой стимуляции нервы на сексуальную функцию женщин у пациентов с множественным склерозом: обзор скрипта.

Среди женщин с множественным склерозом (СМС) широко распространена сексуальная дисфункция (СФД), что приводит к значительным нарушениям качества жизни. Несмотря на различные имеющиеся методы лечения, в нынешних подходах зачастую не учитывается сложный, многофакторный характер ЛСД в этой группе населения. Транскутановая стимуляция берцового нерва (TTNS) недавно привлекла внимание как неинвазивная нейромодуляционная терапия, которая продемонстрировала потенциальные выгоды от нейрогенной дисфункции мочевого пузыря, при этом предварительные данные свидетельствуют о частичном улучшении сексуальной

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… At the neurobiological level, sexual desire and pleasure are regulated by a complex interaction of the opioid-endocannabinoid system and the dopaminergic network, both integral to the brain's reward pathways. …

Seroepidemiology of Toxoplasma gondii infection in psychiatric inpatients in a northern Mexican city.

BACKGROUND: Patients with psychiatric disorders were found to show a high seroprevalence of Toxoplasma gondii infection. There is scarce information about the epidemiology of T. gondii infection in psychiatric patients in Mexico. Therefore, we sought to determine the prevalence of T. gondii infection and associated socio-demographic, clinical and behavioural characteristics in a population of psychiatric patients in Durango City, Mexico. Seroprevalence in patients was compared with that obtained in a control population. METHODS: One hundred and thirty seven inpatients of a public psychiatric

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… In this study, we considered a senior center as a place where the elderly attend courses such as handicraft, dancing, primary school, high school, singing, etc., and organize local and national travels for pleasure. …

Acceptance in Patients With Cancer: A Scoping Review.

BackgroundCancer is generally perceived as a major stressor. Occasionally, patients are able to accept their diagnosis and prognosis, and it is not uncommon for patients who initially experience great distress to eventually learn to accept their disease. A deeper understanding of acceptance can enable clinicians to better support patients in achieving a more peaceful state of mind. The purpose of this literature review was to provide a comprehensive overview of existing research on acceptance in patients with cancer.Recent findingsStudy selection resulted in the inclusion of 54 studies. All st

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… Hinton | 1999 | Acceptance was described in terms of death's inevitability, faith and spiritual values, life's diminishing rewards (lack of pleasure), completing life, final benefits, humour, sharing, final activities etc. Individuals often used more than one concept. … Hinton | Acceptance was described in terms of death's inevitability, faith and spiritual values, life's diminishing rewards (lack of pleasure), completing life, final benefits, humour, sharing, final activities etc. Individuals often used more than one concept. …

Анализ МРТ на основе АИ показывает атрофию мозга в доброкачественном релапсирующем многократном склерозе.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Существование и определение доброкачественного множественного склероза (МС) остаются противоречивыми, особенно с учетом расхождений между клиническим представлением и основополагающими изменениями в изображениях. В этом исследовании мы стремились изучить атрофию мозга, связанную с доброкачественными релапсирующими MS (BRRMS), особенно в том, что касается местоположения и масштабов. Мы проанализировали объемы глобальных и региональных серых веществ (GM) и белого вещества (WM), нагрузку на WM, индекс каллосум корпус (CCI) и площадь каллосум корпусов (CCA) в четко определен

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… The limbic system plays a crucial role in behavior, emotions, the reward-pleasure system, and higher cognitive functions ( 35 ). Injury to the limbic system has been associated with cognitive dysfunction in MS ( 36 ). …

Сексуальные отношения с лицами, страдающими расстройством бдительности: обзор.

Целью этого обзора повествования является проведение синтетического обзора современных знаний о взаимосвязи между расстройством гиперактивности (АДХД) и сексуальным функционированием взрослых с уделением особого внимания нейробиологическим механизмам, коморбидным расстройствам и воздействию фармакотерапии. Шесть независимых исследователей провели всеобъемлющий обзор литературы с использованием баз данных PubMed, Scopus и Google Scientist, охватывающих публикации, имеющиеся по состоянию на май 2024 года. Были включены первоначальные исследовательские документы, обзоры и метаанализы на английско

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… A sexual disorder entails a clinically significant disruption of sexual responsiveness or the experience of sexual pleasure (DSM-5) [ 1 ]. …

Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series.

Palmitoylethanolamide (PEA), an endogenous fatty acid amide, has been demonstrated to bind to a receptor in the cell nucleus - the peroxisome proliferator-activated receptor - and performs a great variety of biological functions related to chronic and neuropathic pain and inflammation, as has been demonstrated in clinical trials. These include peripheral neuropathies such as diabetic neuropathy, chemotherapy-induced peripheral neuropathy, carpal tunnel syndrome, sciatic pain, osteoarthritis, low-back pain, failed back surgery syndrome, dental pains, neuropathic pain in stroke and multiple scle

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… He was able to resume full activities as an industrial designer and was working with much pleasure on a new machine. Patient 5 This was a 66-year-old Caucasian male suffering from chronic idiopathic axonal polyneuropathy, showing a mean pain score of 8 on the NRS. …

Internet-Delivered Cognitive Behavioural Therapy for Major Depression and Anxiety Disorders: A Health Technology Assessment.

BACKGROUND: Major depression is defined as a period of depression lasting at least 2 weeks characterized by depressed mood, most of the day, nearly every day, and/or markedly diminished interest or pleasure in all, or almost all, activities. Anxiety disorders encompass a broad range of disorders in which people experience feelings of fear and excessive worry that interfere with normal day-to-day functioning.Cognitive behavioural therapy (CBT) is a form of evidence-based psychotherapy used to treat major depression and anxiety disorders. Internet-delivered CBT (iCBT) is structured, goal-oriente…

Cognitive deficits in bipolar disorders: Implications for emotion.

Prominent cognitive deficits have been documented in bipolar disorder, and multiple studies suggest that these deficits can be observed among non-affected first-degree relatives of those with bipolar disorder. Although there is variability in the degree of cognitive deficits, these deficits are robustly relevant for functional outcomes. A separate literature documents clear difficulties in emotionality, emotion regulation, and emotion-relevant impulsivity within bipolar disorder, and demonstrates that these emotion-relevant variables are also central to outcome. Although cognitive and emotion

The Multifaceted Nature of GLP-1: Molecular Mechanisms and Signaling Pathways in Metabolic and Neurodegenerative Diseases.

The aim of this article is to present the current state of knowledge regarding the use of GLP-1 agonists in the treatment of type 2 diabetes, obesity, and other potential clinical indications, including neurodegenerative conditions. The article describes the characteristics of the diseases discussed, with particular emphasis on the pathophysiological mechanisms and the impact of metabolic disorders on the course of the diseases. In addition, the specific role of GLP-1 receptor agonists and their mechanisms of action leading to improved clinical outcomes were discussed, including their impact o

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… Activation of GLP-1 receptors in the area postrema affects the dopaminergic system, weakening motivational stimuli associated with eating foods with high pleasure value, which leads to reduced appetite [ 21 ]. … Its role is to regulate motivation, pleasure, and reward processes, e.g., in the process of eating. Activation of GLP-1 receptors within the VTA reduces the consumption of tasty, high-fat foods mainly by limiting meal size. …

Alternative management of proximal aortic dissection: concept and application.

Dear Editor, The chapter on mental, behavioural and neurodevelopmental disorders of the 11th revision of the International Classification of … ty At least five out of ten symptoms, one of which must be depressed mood or diminished interest or pleasure At least five out of nine symptoms, one of which must be depressed mood or diminished interest or pleasure The threshold for the diagnosis of depression is higher if the person is bereaved Not made explicit Yes No Antidepressant-related mania qualif …

Исследование, посвященное детской травме и сексуальному нарциссизму у лиц с навязчивым сексуальным поведением, принимающих советы

Навязчивое сексуальное поведение (CSB) ассоциируется с травмами и безнадзорностью в детстве. Имеются свидетельства того, что ЦСБ имеет отношение к физическому и сексуальному насилию в отношении детей. Сексуальный нарциссизм был связан с агрессией, сексом в молодом возрасте и многими партнерами по сексу. В этом исследовании были рассмотрены связи между жестоким обращением с детьми и безнадзорностью, сексуальным нарциссизмом и гиперсексуальным поведением между участниками группы поддержки сексуальной зависимости и группой участников контроля. В нем приняли участие 118 взрослых, в том числе 72 му

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… Finally, individuals with narcissistic personality disorder may concentrate on their own pleasure and may not pay attention to their partner's needs, and they can be very controlling and manipulative in their sexual relationships expecting submission from their partners. …

Характеристики использования веществ среди лиц с проблематичным использованием порнографии: обзор сферы охвата.

Потребление порнографии является весьма распространенным явлением в развитых странах, при этом исследования показывают, что 70% мужчин и женщин 40% За последний год порнография рассматривалась женщинами. Использование психоактивных веществ у лиц с проблематичным использованием порнографии (ППУ) является областью, заслуживающей дальнейшего изучения в связи с возможностью его совокупного негативного воздействия, включая риск наркомании и потенциальное негативное воздействие на психическое и эмоциональное здоровье. В настоящем аналитическом обзоре рассматриваются модели потребления веществ и связ

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… PPU has been reported to alter the brain’s award system and can result in decreased sensitivity to pleasure and dopamine [ 17 ]. PPU can negatively impact relationships by reducing intimacy and its overuse has been associated with sexual dysfunction [ 3 ]. …

Low-quality of patient-reported outcome reporting in randomized clinical trials of major depressive disorder-a meta-epidemiological review.

ObjectiveOur goal was to review current peer-reviewed articles in which the BDI (Beck Depression Inventory), PHQ-9 (Patient Health Questionnaire), or QIDS-SR16 (16-Item Quick Inventory of Depressive Symptomatology) was used as the primary or secondary outcome measure and to evaluate the quality of PRO (Patient-Reported Outcome) reporting in RCTs (Randomized Controlled Trials) according to the 2013 PRO-specific CONSORT (Consolidated Standards of Reporting Trials) extension.MethodsWe systematically searched in electronic databases. A study would be included if it included patients diagnosed with

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… It is a debilitating disease characterized by depressed mood, diminished interests or pleasure, impaired cognitive function, disturbed sleep or appetite and suicidal ideation ( 17 ). MDD is primarily a subjective experience, and the degree of impairment was directly related to symptom severity. …

Sexual Function in Women Survivors of Hematologic Malignancy after Autologous Hematopoietic Stem Cell Transplantation.

A multicenter, cross-sectional study was conducted to assess the sexual function of women survivors of hematologic malignancy after autologous hematopoietic stem cell transplantation (AHSCT), and to compare it with that of healthy women controls. Fifty-six sexually active women survivors of hematologic malignancy who underwent AHSCT were recruited through convenience sampling, as well as 60 healthy women. Demographic and clinical data questionnaires and the Female Sexual Function Index (FSFI) were completed. Survivors had a median age of 44 years and a median time since transplant of 3 years,

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… Their sample had a good level of sexual functioning, with the domain of sexual activity most negatively affected and the domain of pain and pleasure least affected. Tierney et al., (2015) studied 63 premenopausal women one year after HSCT [ 25 ]. …

The Unmet Needs of Pancreatic Cancer Carers Are Associated with Anxiety and Depression in Patients and Carers.

Pancreatic cancer has one of the lowest survival rates, and patients experience debilitating symptoms. Family carers provide essential daily care. This study determined the prevalence of and risk factors for unmet supportive care needs among carers for pancreatic cancer patients and examined which carer needs were associated with anxiety and depression in carers and patients. Eighty-four pancreatic cancer patients and their carers were recruited. The carers completed a needs survey (SCNS-P&C). Both carers and patients completed the Hospital Anxiety and Depression Scale. Log binomial regression

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… The HADS-D assesses symptoms of depression, including low mood, loss of interest or pleasure and a sense of hopelessness. It explores emotional and cognitive aspects of depression, like feeling sad and experiencing a lack of enjoyment in daily activities. …

Fit & strong! Promotes physical activity and well-being in older cancer survivors.

IntroductionPhysical activity reduces fatigue and depression while improving quality of life in cancer survivors. Exercise is generally considered safe and is recommended to survivors of all ages. Despite the high prevalence of cancer in the elderly, few studies address physical activity interventions targeting this older population. Fit & Strong! is an evidence-based physical activity program shown to improve level of physical activity, exercise-self-efficacy, and mood in older adults with osteoarthritis. This study tests the feasibility and short-term impact of the Fit & Strong! exercise pro

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… Some enjoyed meeting others with similar experiences and took pleasure in sharing information. All respondents stated that they would recommend the course to another cancer survivor. One of the survivors thought the survivorship discussions were too emotional. …