Результаты поиска

New directions in the treatment of autism spectrum disorders from animal model research.

INTRODUCTION: Currently, there is not an effective pharmacotherapy for the core symptoms of the autism spectrum disorders (ASD), which include aberrant social behavior, delayed communication and repetitive behavior and/or restricted interests. There are several drugs that treat the symptoms associated with autism including irritability, aggressiveness and hyperactivity. Current drug research is based on the ongoing genetic, animal model and neuropathologic research. Two areas in particular, the glutamate and oxytocin systems, provide exciting new avenues for drug discovery. AREAS COVERED: Thi

Agitated Psychiatric Patient.

AUDIENCE: This scenario was developed to educate emergency medicine residents about the diagnosis and management of the agitated psychiatric … haloperidol and droperidol), second-generation antipsychotics (olanzapine, quetiapine, risperidone, aripiprazole, and ziprasidone), benzodiazipenes (eg, lorazepam and midazolam), and N-methyl-D-aspartic acid (NMDA) receptor antagonists (eg, ketamine).7,8 It is important to exclude other medical causes of agitation, consider the differential diagnoses, and then …

Issues Related to the Frequency of Exploratory Analyses by Evidence Review Groups in the NICE Single Technology Appraisal Process.

BackgroundEvidence Review Groups (ERGs) critically appraise company submissions as part of the National Institute for Health and Care Excellence (NICE) Single Technology Appraisal (STA) process. As part of their critique of the evidence submitted by companies, the ERGs undertake exploratory analyses to explore uncertainties in the company's model. The aim of this study was to explore pre-defined factors that might influence or predict the extent of ERG exploratory analyses.ObjectiveThe aim of this study was to explore predefined factors that might influence or predict the extent of ERG explora

Совпадение в полном тексте источника
… Dapagliflozin in combination therapy for treating type 2 diabetes TA289 Ruxolitinib for disease-related splenomegaly or symptoms in adults with myelofibrosis TA290 Mirabegron for treating symptoms of overactive bladder TA291 Pegloticase for treating severe debilitating chronic tophaceous gout TA292 Aripiprazole … for the treatment of HER2-positive metastatic gastric cancer TA211 | Prucalopride for the treatment of chronic constipation in women TA212 | Bevacizumab in combination with oxaliplatin and either fluorouracil plus folinic acid or capecitabine for the treatment of metastatic colorectal cancer TA213 | Aripiprazole …

Validation of the interleukin-10 knockout mouse model of colitis: antitumour necrosis factor-antibodies suppress the progression of colitis.

Bipolar II disorder (BP-II) is defined, by DSM-IV, as recurrent episodes of depression and hypomania. Hypomania, according to DSM-IV, requir … e, and the second-generation antipsychotics (i.e. olanzapine, quetiapine, risperidone, ziprasidone, aripiprazole). Hypomania should be treated even if associated with overfunctioning, because a depression often soon follows hypomania (the hypomania-depression cycle). For the treatment of acute BP-II depression, two controlled studies of quetiapine have not fou …

Drug Repurposing for the Management of Depression: Where Do We Stand Currently?

A slow rate of new drug discovery and higher costs of new drug development attracted the attention of scientists and physicians for the repurposing and repositioning of old medications. Experimental studies and off-label use of drugs have helped drive data for further studies of approving these medications. A deeper understanding of the pathogenesis of depression encourages novel discoveries through drug repurposing and drug repositioning to treat depression. In addition to reducing neurotransmitters like epinephrine and serotonin, other mechanisms such as inflammation, insufficient blood supp

Совпадение в полном тексте источника
… Aripiprazole (Short-Acting Oral and Injectable and Long-Acting Injectable [Abilify Maintena]): Drug Information. [(accessed on 4 June 2021)]; Available online: https://uptodatefree.ir/topic.htm? … path=aripiprazole-short-acting-oral-and-injectable-and-long-acting-injectable-abilify-maintena-drug-information . 59. US Food and Drug Administration Brexanolone. [(accessed on 5 June 2021)]; Available online: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211371lbl.pdf . 60. …

Contribution of Real-World Evidence in European Medicines Agency's Regulatory Decision Making.

Real-world data/evidence (RWD/RWE) may provide insightful information on medicines' clinical effects to guide regulatory decisions. While its contribution has been recognized for safety monitoring and disease epidemiology across medicines' life cycles, using RWD/RWE to demonstrate efficacy requires further evaluation. This study aimed to (i) characterize RWD/RWE presented by applicants to support claims on medicines' efficacy within initial marketing authorization applications (MAAs) and extension of indication applications (EoIs), and (ii) analyze the contribution of RWD/RWE to regulatory dec

Совпадение в полном тексте источника
… Of the eight MAAs (8/16) where RWD was presented as supportive evidence only ( aripiprazole , product X , hydroxycarbamide , product Y , emapalumab , edavarone , ravulizumab , and oral live cholera vaccine ), three were authorized, one was refused, and four were withdrawn. … | Treatment of adults with schizophrenia, moderate to severe manic episodes in bipolar I disorder and for the prevention of a new manic episode in adults who experienced predominantly manic episodes and whose manic episodes responded to aripiprazole treatment | Withdrawn | Efficacy/effectiveness data …

Paradoxes of evidence in Russian addiction medicine.

BACKGROUND: For many years, clinical protocols for treatment of drug abuse patients and treatment standards in Russian Federation were not g … a double blind placebo-controlled design involving 1593 patients assessing effects of amisulpride, aripiprazole, flupentixolum dekonoat, olanzapine, quetiapine, tiapride showed that antipsychotics do not result in abstinence, do not reduce abuse and do not stop craving in alcoholic patients: "Antipsychotics should not be used in patients with a primary diagno …

Clinical innovations and future directions of nanoparticles in the treatment of psychiatric and neurological disorders.

Nanoparticles (NPs) provide a versatile toolkit for psychiatry and neurology by leveraging tunable size, surface chemistry, and payload control to overcome long-standing barriers in central nervous system (CNS) therapy. Lipid, polymeric, inorganic, and hybrid NPs can be engineered to traverse the blood-brain barrier (BBB) via receptor/transporter pathways, target specific cell types, and deliver sustained or stimuli-responsive release. Beyond drug delivery, NPs improve imaging, enable gene/RNA therapeutics, and support anti-inflammatory and neuroprotective strategies, advancing precision medic

Совпадение в полном тексте источника
… Similarly, Sawant et al. [ 121 ] designed aripiprazole-loaded poly(caprolactone) NPs for intranasal delivery, providing a noninvasive, brain-targeted approach. … Aripiprazole loaded poly(caprolactone) nanoparticles: Optimization and in vivo pharmacokinetics. Mater Sci Eng C Mater Biol Appl. 2016;66:230–43. 10.1016/j.msec.2016.04.089 122. Siskind D, McCartney L, Goldschlager R, Kisely S. …

Prescription and use of psychoactive medications among cancer patients and associated factors in lower and upper middle-income countries: systematic review.

PURPOSE: To describe the prescription and use of psychoactive medications among cancer patients in low- and middle-income countries (LMICs) and explore the factors influencing their prescription and use. METHODS: This systematic review was conducted following the PRISMA guidelines. Six electronic databases were searched. We included observational studies that investigated the prescription and use of psychoactive medications among adult cancer patients in low- and middle-income countries (LMICs) according to the 2024 World Bank's classification. Eligible studies specifically focused on the use

Совпадение в полном тексте источника
… Antipsychotics, such as haloperidol (first-generation), and second-generation antipsychotics including quetiapine, olanzapine, risperidone, and aripiprazole, were used for managing psychotic symptoms and acute agitation. Across studies, psychotropic medication use showed marked variability. … Conventional and Atypical antipsychotics (4.0%) *Fluoxetine, Escitalopram, Citalopram, Sertraline, Duloxetine, Venlafaxine, Amitriptyline, Imipramine, Nortriptyline, Mirtazapine, Trazodone, Vortioxetine *Clonazepam *Alprazolam, Lorazepam, Bromazepam *Zolpidem * Haloperidol, Chlorpromazine, and Quetiapine, Aripiprazole …

Сексуальная дисфункция при расстройствах движения: распространенность, клинические особенности, связанные с этим факторы и управление.

Сексуальная дисфункция является распространенным, но недостаточно изученным симптомом немоторного расстройства движения. В то время как болезнь Паркинсона (PD) чаще всего исследуется, сексуальная дисфункция также отмечается в болезни Хантингтона, диспропорции и других расстройствах движения. Клинические представления являются разнородными и включают в себя сокращение желания, эректильную дисфункцию, эякуляционные и оргазмические расстройства, трудности с смазкой, диспаревинию и гиперсексуальность. В ДИ оценки распространенности заболеваний в различных исследованиях сильно различаются, главным

Совпадение в полном тексте источника
… Aripiprazole has the lowest SD rates among antipsychotics (16–20%). Benzodiazepines [176] Changes in libido, ED, decreased orgasm. Sedation and cognitive effects may indirectly impair sexual function. Reduce dose or discontinue if possible. Use lowest effective dose. … Aripiprazole has the lowest SD rates among antipsychotics (16–20%). Benzodiazepines [176] Changes in libido, ED, decreased orgasm. Sedation and cognitive effects may indirectly impair sexual function. Reduce dose or discontinue if possible. Use lowest effective dose. …

Challenges in Treating Cancer Patients With Unstable Psychiatric Disorder.

In this review, we first present a case of chronic myeloid leukemia with acute psychosis, and then we will discuss the incidence of cancer in patients with psychotic disorders, the manifestations of new-onset psychosis, and the prevalence of preexisting psychosis in cancer patients, coupled with their impact on the treatment, diagnosis, and prognosis of cancer. This was a case that presented with acute psychosis and was found to have an elevated white blood cell count upon admission to an inpatient psychiatric unit. He was diagnosed with chronic myeloid leukemia and successfully managed with i

Совпадение в полном тексте источника
… After his treatment ended and his psychosis resolved, it was concluded that his psychosis was likely due to androgen deprivation therapy used in the treatment of cancer, and he remained stable on aripiprazole 2 mg at the 2-year follow-up [ 28 ]. … Antipsychotics drug aripiprazole as a lead against breast cancer cell line (MCF-7) in vitro. PLoS One. 2020;15(8):e0235676. doi: 10.1371/journal.pone.0235676. 49. Shaw V, Srivastava S, Srivastava SK. Repurposing antipsychotics of the diphenylbutylpiperidine class for cancer therapy. …

Глубокая стимуляция мозга в гипоталамической области: систематический обзор.

КОЛИЧЕСТВО: Глубокая стимуляция мозга (БРС) успешно используется для лечения циклопатии, включая движение, беспокойство и поведенческие расстройства. Гипоталамус является важнейшим интеграционным центром для многих периферийных и центральных путей, связанных с сердечно - сосудистыми, метаболическими и поведенческими функциями, и представляет собой потенциальную цель нейромодуляции в лечебных условиях. Проведение систематического обзора, изучение гипоталамических целей в ДБС, их признаков и основных клинических результатов.МЕТОДЫ: База данных PubMed, Scopus и Web of Science была подвергнута обы

Совпадение в полном тексте источника
… 1, 16.7%), lorazepam (1, 16.7%), lithium (1, 16.7%), levopromazine (1, 16.7%), levomepromazine (2, 33.3%), gabapentin (2, 33.3%), flunitrazepam (1, 16.7%), diazepam (1, 16.7%), cyproterone (1, 16.7%), clonazepam (1, 16.7%), citalopram (1, 16.7%), chlorpromazine (1, 16.7%), carbamazepine (1, 16.7%), aripiprazole … 1, 16.7%), lorazepam (1, 16.7%), lithium (1, 16.7%), levopromazine (1, 16.7%), levomepromazine (2, 33.3%), gabapentin (2, 33.3%), flunitrazepam (1, 16.7%), diazepam (1, 16.7%), cyproterone (1, 16.7%), clonazepam (1, 16.7%), citalopram (1, 16.7%), chlorpromazine (1, 16.7%), carbamazepine (1, 16.7%), aripiprazole …

[Immigration from countries with a strong migratory pressure and participation in cervical cancer screening program in the Local Health Unit 2, Umbria Region. Impact on the probability of high-grade lesions and cervical cancer].

Dear Editor, The costs of antipsychotic drugs (APDs) used in the treatment of mental disorders with psychosis are mentioned in treatment gui … 15 1/30* 38.72 14,132 - Trevicta 175, 263, 350, 525 LAI 350/1 3426.95 9.788 1/90* 38.08 13,899 - 17 Aripiprazole Abilify 5, 10, 15, 20 tb; 1 sol 20/28 113.25 0.404 20 8.08 2,949 - Abilify Main. 400 LAI 400/1 971.17 2.420 1/30* 32.37 11,815 - BV: Baseline value (in mg of the form and the number in the box), Price#: Box price of the base value in TRY, TRY/mg: Va …

2021 ACMT Annual Scientific Meeting Abstracts-Virtual.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Clozapine versus other atypical antipsychotics for schizophrenia.

BACKGROUND: Clozapine is an atypical antipsychotic demonstrated to be superior in the treatment of refractory schizophrenia which causes fewer movement disorders. Clozapine, however, entails a significant risk of serious blood disorders such as agranulocytosis which could be potentially fatal. Currently there are a number of newer antipsychotics which have been developed with the purpose to find both a better tolerability profile and a superior effectiveness. OBJECTIVES: To compare the clinical effects of clozapine with other atypical antipsychotics (such as amisulpride, aripiprazole, olanzap…

[Atypical antipsychotics and sexual dysfunction: five case-reports associated with risperidone].

LITERATURE FINDINGS: Sexual and reproductive function side effects of atypical antipsychotics are frequent, often underestimated and badly t … f the dose of the antipsychotic, or switching to a prolactin-sparing agent (olanzapine, quetiapine, aripiprazole and clozapine) is recommended. Before this, women with amenorrhea secondary to antipsychotic-induced hyperprolactinemia should be advised that menses may resume. Especially after long-standing amenorrhea they may assume being menopaused, hence may b …

Thiostrepton Suppresses the Progression of Rhabdomyosarcoma by Inhibiting the PI3K-AKT Signaling Pathway.

Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma with 5-year survival below 30% in high-risk/metastatic cases, was investigated through integrated bioinformatics analysis (identifying 269 conserved differentially expressed genes in GEO datasets GSE28511/GSE141690) and experimentally validated thiostrepton (TST), a ribosomal-targeting antibiotic, as a potent therapeutic candidate via Connectivity Map analysis (p p AKT, JAK, CDKs). This was confirmed by PI3K activator 740 Y-P rescue experiments, which partially reversed the effects of TST (p < 0.05). These findings establish

Совпадение в полном тексте источника
… | Dasatinib | −0.52 | KIT inhibitor|Bcr‐Abl inhibitor|Ephrin inhibitor|PDGFR inhibitor|Src inhibitor|Tyrosine kinase inhibitor 4 | Sorafenib | −0.52 | RAF inhibitor|FLT3 inhibitor|KIT inhibitor|PDGFR inhibitor|RET inhibitor|VEGFR inhibitor 5 | Thiostrepton | −0.52 | Protein synthesis inhibitor 6 | Aripiprazole …

Trazodone in the Management of Major Depression Among Elderly Patients with Dementia: A Narrative Review and Clinical Insights.

ObjectiveMajor depressive disorder (MDD) often co-occurs with dementia and other neurological disorders, and treatment with antidepressants can improve symptoms, quality of life, and survival in these patients. This narrative review provides an expert opinion about the role and effectiveness of trazodone in the treatment of older adults with MDD and cognitive impairment due to physical illnesses, such as dementia.ResultsBecause of its mechanism of action, trazodone can treat several depression symptoms often seen in people with dementia, including insomnia, agitation, anxiety, cognitive impair

Совпадение в полном тексте источника
… In emergent situations necessitating intramuscular (IM) administration, the primary recommendation is olanzapine, given that IM aripiprazole, previously favored, is no longer available. Haloperidol injection is the secondary choice, with potential consideration of an IM benzodiazepine thereafter. … In urgent scenarios, the initial approach includes oral second-generation antipsychotics such as aripiprazole and risperidone. …

The Future of Oncology in Psychiatric Medications.

Recent years have provided numerous reports on the mechanisms of action of psychiatric medications (antidepressants, antipsychotics, mood stabilizers, and antidementia drugs) that directly inhibit the growth of cancer cells, as well as on their indirect effects on the psyche and immune system, and their supportive effects on chemotherapeutic agents. The mechanisms of the anticancer activity of psychiatric drugs include inhibition of dopamine and N-methyl-D-aspartate receptors that work via signaling pathways (PI3K/AKT/mTOR/NF-κB, ERK, Wnt/ß-catenin, and bcl2), metabolic pathways (ornithine dec

Совпадение в полном тексте источника
… Antipsychotic Drug | Psychiatric Disorder Treated | Cancer Treated | Anticancer Mechanism of Psychiatric Drugs aripiprazole | - schizophrenia - schizoaffective disorder - delusional disorder - bipolar disorder - delirium - delusional disorder - psychotic depression - substance-related psychosis | - breast …

Abstracts from the 11th International Conference for Healthcare and Medical Students (ICHAMS) : Virtual. 10-12 February 2022.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Responders continued escitalopram, while non-responders received adjunctive aripiprazole for a further 8 weeks. Insomnia and suicidal ideation were evaluated at weeks 0, 8, and 16, while suicidal risk was evaluated at baseline. … In the aripiprazole group, those who remitted at week 16 demonstrated significantly lower suicidal ideation scores at week 8 than non-remitters (p=0.015), indicating level of suicidal ideation prior to initiating aripiprazole treatment is correlated to remission. …