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Hormone replacement therapy in women with cancer and risk of cancer-specific mortality and cardiovascular disease: a protocol for a cohort study from Scotland and Wales.

BackgroundHormone replacement therapy (HRT) is widely used and has proven benefits for women with menopausal symptoms. An increasing number of women with cancer experience menopausal symptoms but the safety of HRT use in women with cancer is unclear. There are particular concerns that HRT could accelerate cancer progression in women with cancer, and also that HRT could increase the risk of cardiovascular disease in such women. Therefore, our primary aim is to determine whether HRT use alters the risk of cancer-specific mortality in women with a range of common cancers. Our secondary objectives

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… American Association of Clinical Endocrinologists. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of menopause. Endocr Pract. 2011;17(Suppl 6):1–25. doi: 10.4158/EP.17.S6.1. 4. Manson JE, Kaunitz AM. … American Association of Clinical Endocrinologists and American College of endocrinology position statement on menopause–2017 update. Endocr Pract. 2017;23(7):869–880. doi: 10.4158/EP171828.PS. 7. Joint Formulary Committee . British National Formulary. 75. …

Клиническое лечение заболеваний щитовидной железы, вызванных аутоиммунной алемтузумабской болезнью: обзор повествования.

Alemtuzumab — это мощное лекарство против CD52, которое является общепринятым средством лечения у пациентов с множественным склерозом в силу его доказанной эффективности. Вместе с тем около 50% пациентов пользуются алемтузумабами в результате развития вторичных аутоиммунных заболеваний щитовидной железы, представляющих собой целый ряд заболеваний щитовидной железы, вызванных аутоиммунной алемтузумой. Болезнь грейвеса (GD) является наиболее распространенным заболеванием AIATD с частотой заболевания около 60% и отличается от традиционной формы. Действительно, GD с изменяющимися курсами гораздо б

The Rise of Oncoendocrinology: How Modern Cancer Therapies Are Reshaping Endocrine Practice.

The emergence of immune checkpoint inhibitors, targeted therapies, CAR T-cell therapy, and antibody-drug conjugates has transformed modern oncology, significantly improving survival across a wide range of malignancies. However, these advances have also introduced a growing spectrum of endocrine and metabolic complications, redefining the scope of endocrine practice. Therapy-induced endocrinopathies, including thyroid dysfunction, hypophysitis, adrenal insufficiency, diabetes, pancreatitis, dyslipidemia, gonadal dysfunction, and metabolic syndrome, are recognized as clinically significant and o

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… These growing clinical demands have spurred the creation of dedicated oncoendocrinology teams within cancer centers, underscoring the need for close collaboration between oncologists and endocrinologists. … Ultimately, the expanding role of the endocrinologist will be central to ensuring that patients not only survive cancer but also maintain long-term endocrine health and quality of life. …

The Continuum of Thyroid Disorders Related to Immune Checkpoint Inhibitors: Still Many Pending Queries.

BackgroundUntil more data are available to shed light on the thyroid disorders related to immune checkpoint inhibitors (ICPi) implemented for the treatment of hematological malignancies, the decision-making is guided by pertinent data derived mostly from solid tumors.MethodsThe present review provides a comprehensive and updated overview of the thyroid disorders related to ICPi, namely to inhibitors of cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed cell death (PD) 1 (PD-1), and the ligand of the latter (PD-L1).ResultsWith the increasing recognition of ir thyroid disorders, many outstand

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… In the case of clinical suspicion of ir thyroid disorders, ICPi-treated patients with hematological malignancies should be promptly referred to endocrinologists. … To promptly detect a recovery of ir hypothyroidism, the tapering of thyroid hormone replacement under an endocrinologist’s consultation and retesting of the thyroid function is recommended [ 80 ]. …

Pathological Fractures in Rare Bone Diseases: Clinical Cases.

Rare bone diseases, though uncommon, present significant diagnostic and therapeutic challenges due to their clinical variability and overlapping symptoms with more prevalent conditions. This article describes a clinical case series of three patients with bone fragility fractures caused by rare bone diseases - primary hyperparathyroidism with brown tumor, Gorham-Stout disease, and alkaptonuria - treated at the Department of Orthopedic and Traumatology of Pisa University Hospital between 2018 and 2023. Each case highlights the diagnostic complexities, including inconclusive biopsies, nonspecific

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… She has been periodically evaluated by the endocrinologists as a normal follow-up procedure. Case 2 A 42-year-old man, with no history of oncological diseases, reported blunt trauma to his left shoulder in December 2020 resulting in pain and limitation of shoulder mobility. … Collaboration between orthopedic surgeons, endocrinologists and geneticists is essential for correct evaluation and management. …

Hyponatraemia and the syndrome of inappropriate antidiuresis (SIAD) in cancer.

Hyponatraemia is a common electrolyte abnormality seen in a wide range of oncological and haematological malignancies and confers poor performance status, prolonged hospital admission and reduced overall survival, in patients with cancer. Syndrome of inappropriate antidiuresis (SIAD) is the commonest cause of hyponatraemia in malignancy and is characterised by clinical euvolaemia, low plasma osmolality and concentrated urine, with normal renal, adrenal and thyroid function. Causes of SIAD include ectopic production of vasopressin (AVP) from an underlying tumour, cancer treatments, nausea and p

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… It remains a challenge for endocrinologists to build partnerships with local oncology and haematology services, to ensure that patients with malignancy are properly assessed for causation of hyponatraemia and that management of SIAD is appropriate. … Scientific Reports 919419. ( 10.1038/s41598-019-56026-5) Garrahy A, Thompson CJ.2017Syndrome of inappropriate antidiuresis should it be managed by specialised endocrinologists? …

Metformin-induced vitamin B12 deficiency: An underdiagnosed cause of diabetic neuropathy.

Metformin-induced vitamin B12 deficiency is a prevalent condition among patients with type 2 diabetes mellitus. In recent years, a growing body of evidence has demonstrated the association between vitamin B12 deficiency and the onset, progression, and worsening of diabetic neuropathy (DNP) as well as its improvement with supplementation in cases of deficiency. Major clinical guidelines for diabetes and DNP remain vague in their recommendations for B12 measurement and supplementation, and some guidelines do not address it at all. Given that vitamin B12 therapy is an economical, safe, and widely

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… recommend routine screening, but suggests evaluation if clinical suspicion exists; highlights the importance of ruling out pernicious anemia | Not specified | If due to metformin: Oral cobalamin 50 μg/day for 1 month; prophylactic supplementation not recommended | [ 46 ] American Association of Clinical Endocrinologists … American association of clinical endocrinologists and American college of endocrinology - clinical practice guidelines for developing a diabetes mellitus comprehensive care plan - 2015. Endocr Pract. 2015;21 Suppl 1:1–87. doi: 10.4158/EP15672.GL. 41. Tesfaye S, Kempler P. …

Effects of Osteoporosis Medication Use on Reprocedure Rates Following Vertebral Augmentation: A Nationwide Cohort Study.

BACKGROUD: In this study, we aimed to investigate the effects of osteoporosis medication use and prescription duration on the rates of reprocedures for re-fractures in patients who underwent vertebral augmentation (VA). METHODS: This retrospective cohort study was conducted using data collected from the National Health Insurance Service database of South Korea. Patients aged 50 years or older who underwent VA in 2012 were included in this study. A reprocedure was defined as an additional VA performed for re-fractures during a follow-up period of up to 5 years. Patients were categorized based

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… American Association of Clinical Endocrinologists/American College of Endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis-2020 update executive summary. Endocr Pract. 2020;26(5):564–570. doi: 10.4158/GL-2020-0524. 19. … American Association of Clinical Endocrinologists/American College of Endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis-2020 update. Endocr Pract. 2020;26(Suppl 1):1–46. doi: 10.4158/GL-2020-0524SUPPL. 20. …

Is insulin the preferred treatment for HbA1c >9%?

The algorithms and guidelines of the American Association of Clinical Endocrinologists and the American Diabetes Association recommend that insulin administration be strongly considered for people with type 2 diabetes (T2D) with HbA1c levels exceeding 9.0% and 10%, respectively. Although the caveat is given in both sets of recommendations that this is particularly appropriate when patients are "symptomatic," referring to urinary frequency with increased thirst and appetite, weight loss, and ketosis, the clinical definition of such presentations may be ill-defined, and it is noteworthy that bot…

Diffuse and Prolonged Bone Pain Revealing Tumor-Induced Osteomalacia: A Case Report.

Tumor-induced osteomalacia should be considered in patients with unexplained bone pain and fractures. Advanced imaging, such as Ga68-DOTATATE PET/CT, enables precise tumor localization, and surgical excision can rapidly normalize phosphate metabolism and resolve symptoms, underscoring the importance of early diagnosis and intervention.

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… We believe that long‐term management of TIO requires a multidisciplinary approach, involving endocrinologists, radiologists, surgeons, and even other specialists. … L., “Phosphaturic Mesenchymal Tumors: What an Endocrinologist Should Know,” Journal of Endocrinological Investigation 41, no. 10 (2018): 1173–1184, 10.1007/s40618-018-0849-5. 15. …

Long-term follow-up of boys who have undergone a testicular biopsy for fertility preservation.

STUDY QUESTION: What is the long-term reproductive health outcome of patients who have undergone testicular sampling for fertility preservation (FP) before and during the pubertal transition period? SUMMARY ANSWER: In long-term follow-up after testicular sampling for FP, hormonal data showed that 33% of patients had primary seminiferous tubule insufficiency (high FSH) while semen analyses showed 52% of patients having a severe reduction in total sperm counts or complete absence of ejaculated sperm. WHAT IS KNOWN ALREADY: During childhood and adolescence, both treatments for cancer and benign

Severe Headache and Deterioration of Vision in Left Eye in a Chronic Hemodialysis Patient Revealing a Brown Tumor of Sphenoid Sinus.

BACKGROUND/OBJECTIVES: Brown tumors are rare bone lesions associated with hyperparathyroidism, particularly secondary hyperparathyroidism (SHPT), in chronic renal failure. While brown tumors commonly affect bones rich in marrow, the involvement of the sphenoid sinus is extremely rare and can present with neurological symptoms. This study reports a case of a sphenoid sinus brown tumor in a patient on hemodialysis, highlighting its clinical presentation and diagnostic challenges. METHODS: A 31-year-old woman undergoing chronic hemodialysis presented with a severe headache, diplopia, and progres

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… Finally, our case highlights the need for a multidisciplinary approach involving endocrinologists, radiologists, and surgeons to optimize patient outcomes. While our case provides valuable insights, it has certain limitations. … Overall, a multidisciplinary approach involving endocrinologists, radiologists, and surgeons is vital to optimize patient outcomes and minimize complications. …

Hormone replacement therapy and cancer survival: a longitudinal cohort study: protocol paper.

IntroductionHormone replacement therapy (HRT) can help women experiencing menopausal symptoms, but usage has declined due to uncertainty around risks of cancer and some cardiovascular diseases (CVD). Moreover, improved cancer survival rates mean that more women who survive cancer go on to experience menopausal symptoms. Understanding these relationships is important so that women and their clinicians can make informed decisions around the risks and benefits of HRT. This study's primary aim is to determine the association between HRT use after cancer diagnosis and the risk of cancer-specific mo

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… American association of clinical endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of menopause: Executive summary of recommendations . Endocr Pract 2011 ; 17 : 949 – 54 . 10.4158/EP.17.6.949 22193145 3 Menon U , Burnell M , Sharma A , et al . … American association of clinical endocrinologists and American College of endocrinology position statement on MENOPAUSE-2017 update . Endocr Pract 2017 ; 23 : 869 – 81 . 10.4158/EP171828.PS 28703650 43 National Institute for Health and Care Excellence . …

Calcitriol Unleashed: A Rare Culprit in Hypercalcemia Associated With Rare Primary Pancreatic Lymphoma - A Case Report.

Hypercalcemia of Malignancy is a complicated condition often linked to parathyroid hormone, parathyroid hormone-related peptide, or bone metastasis. This report presents a unique case of calcitriol-mediated hypercalcemia in an 89-year-old female with primary pancreatic lymphoma, highlighting the rarity and complexity of this presentation. Initially, the patient's condition was thought to be related to sarcoidosis, but the recurrence of hypercalcemia led to the discovery of pancreatic B-cell lymphoma as the underlying cause. It also emphasizes the need to explore new treatment options. Interest

European Cancer Organisation Essential Requirements for Quality Cancer Care: Hematological malignancies.

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… Endocrinology Endocrinologists in hematological malignancy primarily address treatment side effects like glucocorticoid‐induced diabetes and adrenal insufficiency. They also oversee fertility preservation efforts, which should be available for all patients undergoing treatment 51 (Table 9 ). … Table 9 Essential requirements for endocrinologists. Have expertise in glucocorticoid‐induced diabetes and adrenal insufficiency. Have expertise in drug‐induced endocrine side effects and optimal treatments. Have expertise in assisted medical procreation. …

Полиаутоимунитет и множественные аутоиммунные синдромы: забытая клиническая проблема.

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… demonstrated in patients with Hashimoto’s thyroiditis and polyautoimmunity, suggesting a link between gut barrier dysfunction and systemic autoimmune activation.[ 1 , 4 ] Management Challenges and Clinical Insight The management of MAS requires a multidisciplinary approach involving rheumatologists, endocrinologists …

Adrenocortical Carcinoma: A Challenging Diagnosis.

Adrenocortical carcinoma (ACC) is a rare malignancy with aggressive behaviour and a poor prognosis. Patients can present with adrenal hormonal excess or with nonspecific symptoms driven by the presence of an abdominal mass or metastatic disease. Many are completely asymptomatic and diagnosed incidentally. ACC can cause considerable morbidity and mortality, mostly due to its ability to invade surrounding tissues, produce hormones, and spread to distant organs. The authors describe a case of a 62-year-old woman who presented with subacute dorso-lumbar pain. A computed tomography (CT) scan reveal

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… This multidisciplinary team may include endocrinologists, surgeons, oncologists, pathologists and geneticists, as well as nursing and palliative care for patients and their families. …

Interventions to improve adherence to anti-osteoporosis medications: an updated systematic review.

An earlier systematic review on interventions to improve adherence and persistence was updated. Fifteen studies investigating the effectiveness of patient education, drug regimen, monitoring and supervision, and interdisciplinary collaboration as a single or multi-component intervention were appraised. Multicomponent interventions with active patient involvement were more effective.IntroductionThis study was conducted to update a systematic literature review on interventions to improve adherence to anti-osteoporosis medications.MethodsA systematic literature review was carried out in Medline (

Analyzing the factors associated with efficacy among teriparatide treatment in postmenopausal women with osteoporosis.

BACKGROUND: Teriparatide (TPTD) is a widely used anabolic agent for the treatment of osteoporosis. Several factors have been identified to be related to bone mineral density (BMD) increase in anti-osteoporosis treatment with other agents; however, there has been no systematic analysis to summarize the associated determinants of BMD reaction to daily teriparatide treatment. METHODS: In this retrospective study, we performed a comprehensive investigation involving not only clinical data but also several relevant lifestyle factors to be examined for their potential contribution to BMD response.

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… Therefore, according to the 2016 AACE (American Association of Clinical Endocrinologists) and ACE (American College of Endocrinology) Clinical Practice Guidelines, teriparatide can be considered an alternative first-line option in patients with the highest fracture risk, for instance, long-term administration … AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY CLINICAL PRACTICE GUIDELINES FOR THE DIAGNOSIS AND TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS − 2016–EXECUTIVE SUMMARY. Endocrine Pract. 2016;22(9):1111–1118. doi: 10.4158/EP161435.ESGL. 51. …

A Rebalancing of Financial Valuations and Expectations Moving Forward in the Telehealth Sector as the United States Moves Toward a Post-COVID-19 Reality.

The telehealth sector of health care delivery experienced significant growth at the start of the pandemic as web-based care quickly became essential for the ongoing safety of patients and health care providers, such as clinicians and other health care professionals. After vaccines were introduced, however, telehealth companies lost value as the need for web-based care appeared to lessen. Presently, both existing telehealth companies and new entrants to the space are seeking ways to innovate, gain investor and customer buy-in, and overcome competitors. New companies are hoping to be seen not as

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… Intern Med J 2021 12 51 12 2021 2026 10.1111/imj.15441 34227718 34227718 PMC8447012 32 Endocrinologists convert to telemedicine virtually overnight during COVID-19 pandemic Consult QD 2020 2021-11-04 https://consultqd.clevelandclinic.org/endocrinologists-convert-to-telemedicine-virtually-overnight-during-covid …