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Large nested variant of urothelial carcinoma: 23 cases mimicking von Brunn nests and inverted growth pattern of noninvasive papillary urothelial carcinoma.

We describe a rare pattern of urothelial carcinoma (UC) invasion consisting of large, irregular to regular nests, with bland cytology. We prospectively retrieved 23 cases of large nested UC from one of the author's consult files (2001 to 2010). The mean patient age was 63.7 years (39 to 89 y), and 86% were men. There were 18 cases with transurethral resection of the bladder, 2 nephroureterectomy specimens, and 3 radical cystectomy (RCs) specimens. A surface component was present in 19 of 23 cases, with 16 low-grade papillary UCs, 2 low-grade papillary UCs with <5% high-grade UC, and 1 high-gra…

Case Report: Uremia secondary to acute pyelonephritis in a patient with type 2 diabetes mellitus.

We report a 58-year-old male patient with acute kidney injury (AKI), who eventually developed anuria secondary to acute tubulointerstitial nephritis (ATIN) following acute pyelonephritis. Our patient had a 10-year history of type 2 diabetes mellitus, with an admission glycated hemoglobin (HbA1c) level of 6.3% and no prior history of renal disease. Before admission, he presented with painless gross hematuria and fever. Escherichia coli was detected in the urine culture at the local hospital, and anti-infective normalized his temperature, but urine output progressively decreased to anuria. After

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… The patient ultimately underwent extraperitoneal nephroureterectomy as definitive treatment ( 11 ). Chakit et al. proposed that the concurrent presence of urolithiasis and diabetes can aggravate pyelonephritis and trigger the formation of massive pyonephrosis. …

Simplifying Retroperitoneal Robotic Single-port Surgery: Novel Supine Anterior Retroperitoneal Access.

BACKGROUND: Multiport robotic surgery in the retroperitoneum is limited by the bulky robotic frame and clashing of instruments. Moreover, pa … ONS: Twelve patients underwent partial nephrectomy (PN) and two each underwent pyeloplasty, radical nephroureterectomy, and radical nephrectomy. In the PN group, mean age was 57 yr (interquartile range [IQR] 30-73), median body mass index was 32 kg/m2 (IQR 17-58), and 25% had stage ≥3 chronic kidney disease. The median Charlson comorbidity index was 3 (IQR 0-7) and …

Adjuvant atezolizumab versus observation in muscle-invasive urothelial carcinoma (IMvigor010): a multicentre, open-label, randomised, phase 3 trial.

BACKGROUND: Despite standard curative-intent treatment with neoadjuvant cisplatin-based chemotherapy, followed by radical surgery in eligibl … gy Group performance status of 0, 1, or 2 were enrolled within 14 weeks after radical cystectomy or nephroureterectomy with lymph node dissection. Patients had ypT2-4a or ypN+ tumours following neoadjuvant chemotherapy or pT3-4a or pN+ tumours if no neoadjuvant chemotherapy was received. Patients not treated with neoadjuvant chemotherapy must have been ineligible fo …

Tumor Type Agnostic Therapy Carrying BRAF Mutation: Case Reports and Review of Literature.

BackgroundPrecision medicine is based on molecular and genotypic patient characterization to define specific target treatment. BRAF mutation is an oncogenic driver, and the Cancer Genome Atlas has identified BRAF mutations in different cancer types. Tumor type agnostic therapy is based on targeting genomic alterations, regardless of tumor origin. In this context, novel therapeutic agents including BRAF and MEK inhibitors based on the molecular landscape in solid tumors have been investigated. Case presentation, Case 1: The first case is chemotherapy-refractory, BRAF V600E mutated intrahepaticc

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… The patient subsequently underwent laparoscopic nephroureterectomy. The final pathological report showed Bellini duct carcinoma (BDC) of the left kidney, Fuhrman Nuclear Grade IV. …

Case report: Immune-mediated meibomian gland dysfunction following pembrolizumab therapy for advanced urothelial carcinoma.

Ocular immune-related adverse events are a relatively rare complication of immune checkpoint inhibitors. Common ocular toxicities range from dry eyes to inflammatory uveitis and ocular myasthenia gravis. Here, we present the case of a 55-year-old woman with recurrent urothelial carcinoma of the ureter after initially being managed with neoadjuvant cisplatin-based chemotherapy and surgical resection. She was treated with pembrolizumab which was complicated by immune-mediated pneumonitis after the eighth cycle, which was managed with a prolonged steroid course. The patient also developed red eye

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… She eventually underwent a radical nephroureterectomy, partial cystectomy, and pelvic lymph node dissection. At the time of surgery, she was found to have microscopic foci of malignancy with negative surgical margins and negative lymph nodes in the nine total lymph nodes examined. …

Hormone replacement therapy and cancer survival: a longitudinal cohort study: protocol paper.

IntroductionHormone replacement therapy (HRT) can help women experiencing menopausal symptoms, but usage has declined due to uncertainty around risks of cancer and some cardiovascular diseases (CVD). Moreover, improved cancer survival rates mean that more women who survive cancer go on to experience menopausal symptoms. Understanding these relationships is important so that women and their clinicians can make informed decisions around the risks and benefits of HRT. This study's primary aim is to determine the association between HRT use after cancer diagnosis and the risk of cancer-specific mo

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… Urogenital—nephrectomy, nephroureterectomy, cystectomy. Liver cancers—segmental resection, lobectomy, transplantation. Brain cancers—craniectomy with resection. Other surgery (ie, not cancer related) Hysterectomy with or without oophorectomy. …

Impact of preoperative anemia on outcomes in patients undergoing curative resection for gastric cancer: a single-institution retrospective analysis of 2163 Chinese patients.

We sought to evaluate whether preoperative anemia was an important determinant of survival in gastric cancer (GC). A single institution cohort of 2163 GC patients who underwent curative resection were retrospectively analyzed. Anemia was defined as a preoperative hemoglobin level <120 g/L in males and <110 g/L in females. Overall survival (OS) was analyzed using the Kaplan-Meier method, and a multivariate Cox proportional hazards model was performed to identify the independent prognostic factor. Anemic patients had a poorer OS compared with nonanemic patients after resection for tumor-nodes-me

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… Impact of preoperative anemia on oncologic outcomes of upper tract urothelial carcinoma treated with radical nephroureterectomy. J. Urol. 191:316–322. 37. Wang, S. L. , Zhuang C. L., Huang D. D., Pang W. Y., Lou N., Chen F. F., et al. 2016. …

Keyword Index for Volume 109

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… myeloablative conditioning 2523 myeloid leukaemia 1895 nab-paclitaxel 926 nasopharyngeal carcinoma 788, 2462, 2987 National Health Insurance Research Database 2933 natural compounds 2587 neoadjuvant chemotherapy 1157, 1528, 2792, 2798, 2965 neoplasia 1192 neoplasm metastasis 387 neoplasms 60, 1318 nephroureterectomy …

Acute kidney injury: pathogenesis and therapeutic interventions.

Acute kidney injury (AKI) is a prevalent clinical condition that is associated with unacceptably high morbidity and mortality, as well as the development of chronic kidney disease (CKD). The pathogenesis of AKI is highly complex and heterogeneous, primarily attributed to metabolic disturbances arising from the disease itself and the administration of medications related to treatment. In recent years, AKI in cancer patients is highly concerned. The emergence of AKI caused injuries and dysfunction of remote organs but also enhanced the health-care costs. It's essential for early recognition of A

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… 3581 HCC cases | TACE | RIFLE AKIN KIDGO | 11.9 | Age, DM, and the number of TACE | [ 17 ] China | 2022 | 8284 HCC cases | hepatectomy | RIFLE AKIN KIDGO | 12% | male gender, age, DM, major resection of the liver, and operation-related transfusion | [ 17 ] Itay | 2022 | 576 UTUC patients | radical nephroureterectomy …

The Influence of Muscle Morphology on Oncological Outcomes: A Review.

Cancer is a common disease with significant impact on patients and society. Cancer and oncological treatment can negatively affect muscle, and muscle health impacts oncologic outcomes. This review studied the effect of different muscle parameters on oncologic outcomes. A systematic search was performed until April 2023. Parameters included were muscle thickness, cross-sectional area, skeletal muscle index, skeletal muscle mass, pennation angle, fascicle length, muscle density, echo intensity and elastography. Imaging methods included were computerized tomography, magnetic resonance imaging, ul

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… . • No effect of quantity Pan, 2021, China[ 136 ] | R | 273 urinary tract urothelial carcinoma patients treated by radical nephroureterectomy (54.2%, 68) | Not stated | L3 (RA, EO, IO, TA, PS, Ps) | MD (CT) SMI (CT) MT (CT) | • Effect on local progression: o MD: NS (multivariate: HR 0.97 * ) o SMI: NS …

34th Европейский конгресс патологии - резюме.

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40th Annual CAPO Conference-Responding to the Human Experience of Cancer and Caring for the Soul: Building on 40 Years of Global Leadership in Psychosocial Oncology.

On behalf of the Canadian Association of Psychosocial Oncology, we are pleased to present the Abstracts from the 2025 Annual Conference, titled "Responding to the Human Experience of Cancer and Caring for the Soul: Building on 40 years of global leadership in psychosocial oncology". The 40th Annual CAPO Conference was held in Toronto from 23 April 2025 to 25 April 2025. In an era marked by the rapid advancement of biologically focused precision medicine, it is imperative to redirect our attention towards the human experience of illness and the soul of medicine. Biomedicine has conceptualized i

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… She underwent left nephroureterectomy and right partial nephrectomy in December 2020. Post-surgery chemotherapy was given for 6 months. In the year 2022, recurrence was detected, received treatment with ICE protocol chemotherapy till March 2023. …

Резюме: 32 Второй Конгресс ЭСП и Международный конгресс XXXIII МПД.

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33rd Европейский конгресс патологии - резюме.

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Обязательный экзамен по патологии: лишний или необходимый?

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Резюме ЭСП 2013.

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