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The dyschromatopsia of optic neuritis is determined in part by the foveal/perifoveal distribution of visual field damage.

Most hypotheses of acquired dyschromatopsia invoke the mechanism of selective damage to specific components of the afferent visual system to explain the predominance of red-green and blue-yellow hue-discrimination defects found in neural and retinal disorders, respectively. However, this pattern of hue-discrimination disturbance in ocular disease may vary. There are frequent exceptions which are inadequately explained by existing hypotheses. In an effort to explain the pattern and pathogenesis of acquired dyschromatopsias better, the authors examined patients with nonproliferative diabetic ret

Lymphocytes subclasses and function in patients with optic neuritis in childhood with special reference to multiple sclerosis.

Ten patients with childhood optic neuritis (5 with a single attack of ON and 5 with later MS) were studied at various stages of the disease. Lymphocyte count and function were analysed in the peripheral blood of all patients, 3 repeatedly, and in one they were also analysed in the CSF. T-lymphocytes counts were normal in all but 2 MS cases who had high counts. In acute stages the T4/T8 ratio were high in 1/3 determinations, in recovery low in 2/2 determinations, and in stable stages normal in 6/8 determinations. Lymphocyte function, measured by PHA, ConA and PWM stimulation, was normal in all …

[Partial closure of the central artery and vein of the retina in retrobulbar optic neuritis (author's transl)].

The changes in the fundus of a 57-year-old patient (perimacular turbid retinal oedema, cloudy peripapillary exsudates and peripheral retinal hemorrhages) could not be interpreted satisfactorly on a clinical basis. Histologic examination revealed a retrobulbar optic neuritis associated with round cell infiltrates around the central retinal blood vessels impeding their blood flow.

Trans-synaptic degeneration in the optic pathway. A study in clinically isolated syndrome and early relapsing-remitting multiple sclerosis with or without optic neuritis.

OBJECTIVE: Increasing evidence suggest that neuronal damage is an early and diffuse feature of Multiple Sclerosis (MS) pathology. Analysis o … ration of 4.0±3.5 months, 28 MRI healthy controls (HC) and 31 OCT-HC were studied. Ten patients had optic neuritis at presentation (MSON+), 40 presented with other symptoms (MSON-). MRI examination included 3D-T1, 3D-FLAIR and 3D-DIR sequences. Global cortical thickness (gCTh), pericalcarin CTh (pCTh) and white matter volume (WMV) were analysed by means of Frees …

Detection of optic nerve atrophy following a single episode of unilateral optic neuritis by MRI using a fat-saturated short-echo fast FLAIR sequence.

We describe an MRI technique for quantifying optic nerve atrophy resulting from a single episode of unilateral optic neuritis. We imaged 17 patients, with a median time since onset of optic neuritis of 21 months (range 3-81 months), using a coronal-oblique fat-saturated short-echo fast fluid-attenuated inversion-recovery (sTE fFLAIR) sequence. The mean cross-sectional area of the intraorbital portion of the optic nerves was calculated by a blinded observer from five consecutive 3 mm slices from the orbital apex forwards using a semiautomated contouring technique and compared with data from 16 …

Diagnostic challenges in suspected optic neuritis: a 5-year retrospective application of the 2022 international criteria.

BACKGROUND: Optic neuritis (ON) is a frequent cause of subacute visual loss, and distinguishing it from other causes of acute visual impairment remains challenging, particularly in non-specialized settings. OBJECTIVE: To retrospectively apply the 2022 International Diagnostic Criteria to patients presenting with suspected optic neuritis, classify patients according to the diagnostic criteria, identify the most frequent alternative diagnoses, and assess access to paraclinical investigations. METHODS: This retrospective observational study included patients presenting to the emergency departme…

Ring-enhancing demyelinating lesions in the brain and optic neuritis: atypical presentation of paediatric neuropsychiatric SLE.

Paediatric-onset systemic lupus erythematosus (SLE) is a rare but clinically significant condition, often presenting with central nervous system (CNS) involvement. The most common CNS manifestations include headaches, seizures and psychosis. We present two cases of neuropsychiatric SLE with unusual clinical and imaging features.The first case involves an adolescent girl who presented with unilateral vision loss and elevated intracranial pressure. MRI revealed large well-defined ring-enhancing lesions in the bilateral subcortical white matter. She underwent extensive evaluation for infectious,

Дискриминативная ассимиляция магического и ретинального нерва, толщина слоя в множестве склероза и оптического нерита.

ЦЕЛЬ: Определение дискриминативных способностей макулярного и сетчатого слоя нервно-паралитического волокна (RNFL) в множестве склероза (MS) по сравнению с нормальным и выявление оптического неврита (ON) у пациентов, страдающих НР. МЕТОДЫ: Это межсекторальное исследование по вопросам контроля за конкретными случаями включало в себя 133 Возрастной состав участников 30-45 годы: 66 Определённые пациенты MS18 ) и 67 :: контроль за состоянием здоровья в зависимости от возраста и пола. Был установлен диагноз MS ≥5 За годы до поступления в школу. К числу критериев исключения относятся другие невролог

Совпадение в аннотации оригинала
PURPOSE: To determine the discriminative abilities of macular and retinal nerve fiber layer (RNFL) thicknesses in multiple sclerosis (MS) from normal and to identify optic neuritis (ON) in MS patients. METHODS: This cross-sectional case-control study included 133 participants aged 30-45 years: 66 definite MS patients (18 with ON) and 67 age- and sex-matched…

Effects of coronavirus disease 2019 in patients with optic neuritis: a single-centre retrospective cohort study.

BACKGROUND: The relationship between coronavirus disease 2019 (COVID-19) and optic neuritis (ON) remains unclear, with limited evidence on its clinical features and outcomes. This study aimed to investigate the impact of COVID-19 on ON subtypes and prognosis. METHODS: We conducted a single-centre retrospective cohort study, comparing acute ON patients with and without recent COVID-19 infection during the omicron wave (December 2022 to January 2023). A historical control group from the pre-COVID-19 era was included for comparison. RESULTS: A total of 55 ON patients were included, of whom 12 h…

Structural and functional biomarkers of visual dysfunction in MOG antibody-positive optic neuritis: a scoping review.

INTRODUCTION: Myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) commonly manifests as optic neuritis (ON) in association with serum MOG immunoglobulin G (MOG-IgG). This review will evaluate the literature on visual dysfunction in MOG-IgG ON, with a focus on ophthalmic structural biomarkers and ancillary outcome measures. METHODS: PubMed was systematically searched using the terms "optic neuritis", "visual outcomes" and "myelin-oligodendrocyte glycoprotein" between 2007 to January 2025. High-contrast visual acuity (HCVA), low-contrast visual acuity (LCVA), contrast sensit…

Significance of brain lesions associated with optic neuritis in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease.

BACKGROUND: Optic neuritis (ON) is a common presenting core clinical attack type in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and can be associated with brain lesions at presentation. The significance of these brain lesions and their contribution to disease course, however, are poorly understood. METHODS: Multi-center retrospective chart review of clinical, laboratory, and radiologic data of pediatric MOGAD patients who presented with an ON phenotype. RESULTS: 35 episodes of ON, including 29 new onset MOGAD attacks and 6 ON relapses, were analyzed among 32 total…

Criteria for the use of plasmapheresesis in optic neuritis: A practice review from French expert centers.

INTRODUCTION: Some patients remain severely disabled after an episode of optic neuritis. Several studies have shown that plasmapheresis (PE) can improve visual prognosis in the absence of satisfactory recovery after corticosteroids. However, there is no clear ophthalmological criterion for doing PE, and practices vary widely. The objective of the present study was to better define the rationales for use of PE. MATERIAL AND METHODS: We investigated the real-life indications for PE in French expert centers. Based on the responses to a questionnaire and the current literature, we further provide…

Комплексный подход к дифференцированию системного лейкоцита от других аутоиммунных заболеваний, вызываемых оптическим невритом.

Системная волчанка (SLE) представляет собой сложное аутоиммунное заболевание со значительной заболеваемостью и смертностью. Ранняя диагностика имеет решающее значение для эффективного управления. В качестве потенциальных первых признаков SLE появились окулярные проявления, в частности оптический нейрит (ON). В этом систематическом обзоре литературы анализируются 23 исследования, включая восемь ретроспективных исследований, пять межсекторальных исследований, два групповых исследования, четыре тематических доклада, один обзор описательной части и три систематического обзора литературы, в целях и

Совпадение в аннотации оригинала
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with significant morbidity and mortality. Early diagnosis is crucial for effective management. Ocular manifestations, particularly optic neuritis (ON), have emerged as potential early signs of SLE. This systematic literature review analyzes 23 studies, including eight retrospective studies, f…

Analysis Based on Clinical Data and Imaging - Factors Affecting the Prognosis of Patients with Optic Neuritis.

OBJECTIVE: To analyze the risk factors that affect the prognosis of patients with optic neuritis through imaging examinations and clinical data analysis. METHODS: 130 patients with optic neuritis admitted to our hospital from February 2018 to February 2022 were selected as the study subjects. They were divided into a poor prognosis group (n = 52) and a good prognosis group (n = 78) based on their prognosis. Imaging examination and clinical data analysis, along with the assessment of the predictive value of statistically significant continuous variables using ROC experiments and risk factors u…

The clinical profile of new-onset optic neuritis in arabs, a tertiary center experience in Kuwait.

BACKGROUND: Optic neuritis is an inflammatory disorder of the optic nerve and is often the initial manifestation of systemic demyelinating diseases such as multiple sclerosis (MS), neuromyelitis optic spectrum disorder (NMOSD), and myelin-oligodendrocyte glycoprotein (MOG) antibody-mediated disease. There are ethnic variations in the etiology of optic neuritis across the world. While multiple sclerosis is common in the West, NMOSD and MOG are more common causes in Asian patients. There is a paucity of reports on the clinical profile of optic neuritis in the Middle East. OBJECTIVES: To study t…