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The effect of ixekizumab treatment on MRI sacroiliac joint structural lesions in patients with radiographic axial spondyloarthritis: post-hoc analysis of a 52-week, randomised, placebo-controlled trial with an active reference arm.

BACKGROUND: The effect of biological disease-modifying antirheumatic drugs (DMARDs) on sacroiliac joint lesions over 52 weeks in biological … ive to biological DMARDs with active radiographic axial spondyloarthritis, radiographic evidence of sacroiliitis, and an inadequate response or intolerance to non-steroidal anti-inflammatory drugs. Patients were randomly assigned (1:1:1:1) to 80 mg ixekizumab every 2 weeks (Q2W) or every 4 weeks (Q4W), 40 mg adalimumab Q2W, or placebo. At week 16, patients rec …

Up-regulation of fatty acid oxidation in the ligament as a contributing factor of ankylosing spondylitis: A comparative proteomic study.

OBJECTIVES: The present study first utilized a standardized shotgun proteomic analysis method to determine differences in protein expression … tory rheumatic disease with a predilection for the axial skeleton. Clinical hallmarks of AS include sacroiliitis, uveitis, enthesitis and persistent spinal inflammation. The pathogenic mechanism of disease causation and perpetuation remains poorly understood. In this study, we primarily cultured fibroblast cells from ligament biopsies, knowing that fibroblast …

The Use of Imaging in Management of Patients with Low Back Pain.

Lower back pain (LBP) is one of the most common chief complaints encountered in primary care. Advanced imaging studies, including computerized tomography (CT) and magnetic resonance imaging (MRI), are frequently ordered in the setting of LBP. Structural abnormalities are commonly identified by CT and MRI in patients complaining of low back pain, however, these findings are also found in asymptomatic patients. In the past decade, multiple guidelines have been published to help providers identify patients in whom the use of advanced imaging is appropriate. In this article, we review common condi

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… Sacroiliitis can also be seen on MRI and CT and can be an isolated cause of LBP. … diagnostic utility of spinal magnetic resonance imaging in axial spondylarthritis Arthritis Rheum 2009 60 1331 41 19404934 10.1002/art.24493 59 Battafarano DF West SG Rak KM Fortenbery EJ Chantelois AE Comparison of bone scan, computed tomography, and magnetic resonance imaging in the diagnosis of active sacroiliitis …

Minimally Invasive Sacroiliac Joint Fusion: A Lateral Approach Using Triangular Titanium Implants and Navigation.

UNLABELLED: Minimally invasive sacroiliac (SI) joint fusion is indicated for low back pain from the SI joint that is due to degenerative sacroiliitis and/or sacroiliac joint disruption. This technique is safe and effective in relieving pain uncontrolled by nonoperative management1-4. There is some controversy, but there continues to be increasing evidence of effectiveness. DESCRIPTION: This procedure is performed, with the patient under general anesthesia and in the prone position, using fluoroscopy or 3-dimensional (3D) navigation such as cone-beam computed tomographic (CT) imaging. After na…

Integrating imaging and biomarker assessment to better define psoriatic arthritis and predict response to biologic therapy.

The treatment options for PsA have substantially expanded over the last decade. Approximately 40% of patients will not respond to first-line anti-TNF-α therapies. There is limited data to help clinicians select the most appropriate biologic therapy for PsA patients, including guidance for decisions on biologic therapy switching. In this review we will examine the current understanding of predictors of response to treatment. Imaging technology has evolved to allow us to better study psoriatic disease and define disease activity, including synovitis and enthesitis. Enthesitis is implicated in th

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… Early detection of sacroiliitis on magnetic resonance imaging and subsequent development of sacroiliitis on plain radiography. A prospective, longitudinal study. J Rheumatol 1999;26:1953–8. 54. Anandarajah AP, Ory P, Salonen D. et al. … Colour Doppler ultrasonography can be used to detect the changes of sacroiliitis and peripheral enthesitis in patients with ankylosing spondylitis during adalimumab treatment. Clin Exp Rheumatol 2015;33:844–50. 87. Mouterde G, Aegerter P, Correas J-M, Breban M, D’Agostino M-A.. …

Therapeutic potential of single-nucleotide polymorphism-mediated IL6R inhibitors in ankylosing spondylitis treatment.

OBJECTIVE: Interleukin-6 (IL-6) is a multiple-effect cell factor implicated in the etiopathogenesis of several rheumatologic disorders. The blockade of the IL-6 pathway via IL6R inhibitors effectively treats these disorders. However, the clinical significance of the IL6R blockade for ankylosing spondylitis (AS) therapy remains controversial. With advances in genomics, increasing evidence has revealed the role of heritability in the etiology of disease, and Mendelian randomization (MR) analyses are being used more broadly to infer causation. Therefore, this MR study aims to evaluate the potenti

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… In addition, Du et al. confirmed that AS patients with sacroiliitis and other arthritis conditions (e.g., knee and neck) have higher serum IL-6 levels and that IL-6 levels are significantly related to CT image classifications of sacroiliitis through case–control studies, suggesting that IL-6 has a significant …

Pure red cell aplasia in a patient with rheumatoid arthritis after JAK inhibitor exposure-diagnostic challenges.

We describe a patient with long-standing rheumatoid arthritis (RA) who developed severe refractory transfusion-dependent anaemia lasting several months following treatment with a JAK1 inhibitor (Filgotinib). The patient proceeded with extensive investigations, including bone marrow assessment, and was initially diagnosed with Filgotinib-associated anaemia. However, despite stopping this agent, the anaemia persisted with fluctuating reticulocyte count resulting in multiple hospital admissions. Although the anaemia was initially attributed to Filgotinib, its persistence alongside delayed reticul

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… Medical history included seropositive RA, solitary sacroiliitis, interstitial lung disease, osteoporosis with previous spinal fractures and fibromyalgia. She previously had several disease modifying agents for her RA including Methotrexate, Sulfasalazine, Adalimumab, Etanercept and Abatacept. …

От костной боли до тяжелых реналовых симптомов: Путешествие пациента с множественной миеломой и Брюселлозом (деловой отчет).

В эндемических районах заметный рост серологовых титер Брюселлы с динамичным спадом после лечения поддерживает настоящую инфекцию даже в присутствии моноклональной гаммопатии. Для того чтобы избежать диагностических задержек и оптимизировать управление пациентами, следует рассматривать сопутствующие инфекционные и злокачественные процессы у пациентов с острой почечной недостаточностью и переплетающимися системными симптомами.

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… Osteoarticular involvement is one of the most frequent complications and may manifest as spondylitis, sacroiliitis, or peripheral arthritis [ 2 ]. …

Ход работы сессии 31st Европейский педиатрический конгресс по педиатрии: часть 1.

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… Of the 125 patients with arthritis, 77% had peripheral arthritis, 14.4% axial involvement, defined as radiographic sacroiliitis, and 9% combined axial and peripheral arthritis. …

Воспаление и воспаление болезней, маркеры и посредники: роль КПИ в некоторых воспламенительных заболеваниях

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… For the diagnosis of ankylosing spondylitis, the presence of radiographic sacroiliitis is quite essential according to the newly modified New York criteria. The diagnosis of spondyloarthritis is often delayed as the occurrence of radiographic sacroiliitis takes nearly 8–11 years. … Elevated levels of CRP at baseline have been used as biomarkers in predicting radiographic sacroiliitis progression. Thus CRP was helpful in definite diagnosis of ankylosing spondylitis (Tant et al. 2014 ). …

Omalizumab for the Treatment of Chronic Spontaneous Urticaria in Adults and Adolescents: An Eight-Year Real-Life Experience.

Background: Omalizumab, an anti-IgE monoclonal antibody, is an effective treatment for patients with chronic spontaneous urticaria (CSU) resistant to antihistamines, but about 10% are unresponsive. Our aim was to assess the effectiveness, safety, and drug survival (DS) of omalizumab by considering clinical and laboratory characteristics. Methods: We conducted a retrospective study on 296 patients with severe CSU treated with omalizumab. Disease activity, comorbidities, and serum levels of total IgE and anti-thyroid autoantibodies were evaluated over a period of up to 8 years. DS was analyzed u

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… disease | 1 (0.3) - Diverticulosis | 1 (0.3) - Cardiovascular disease | 1 (0.3) - Psychiatric disease | 3 (0.9) - Familiar Mediterranean Fever | 1 (0.3) - Autoimmune atrophic gastritis | 1 (0.3) - HBV | 1 (0.3) - HCV | 1 (0.3) - Hypertension | 1 (0.3) - Lupus | 3 (0.9) - Multiple myeloma | 1 (0.3) - Sacroiliitis …

The Pathophysiology and Treatment of Pyoderma Gangrenosum-Current Options and New Perspectives.

Pyoderma gangrenosum (PG) is an uncommon inflammatory dermatological disorder characterized by painful ulcers that quickly spread peripherally. The pathophysiology of PG is not fully understood; however, it is most commonly considered a disease in the spectrum of neutrophilic dermatoses. The treatment of PG remains challenging due to the lack of generally accepted therapeutic guidelines. Existing therapeutic methods focus on limiting inflammation through the use of immunosuppressive and immunomodulatory therapies. Recently, several reports have indicated the successful use of biologic drugs an

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… Interestingly, Sadik et al. [ 156 ] reported induction of PG, palmoplantar pustulosis, and sacroiliitis after switching from secukinumab to brodalumab in plaque psoriasis patients. Kao et al. [ 150 , 157 ] documented effective treatment of PG lesions in four patients after ixekizumab therapy. … First emergence of pyoderma gangraenosum, palmoplantar pustulosis and sacroiliitis in a psoriasis patient associated with switching from secukinumab to brodalumab J. Eur. Acad. Dermatol. Venereol. 2019 33 e406 e407 10.1111/jdv.15714 31131924 157. Kao A.S. King A.D. Daveluy S. …

A Continuous Registry of Medical Record, Patient Input, and Epidemiological Data of Patients With Ulcerative Colitis: a Multicentre, Prospective, Observational Clinical Registry Study in Japan.

BackgroundThis registry aims to allow for a prospective non-interventional observational study of ulcerative colitis. This will facilitate monitoring of the current state of ulcerative colitis in Japan and improving the long-term disease course and adverse events associated with current treatment options.MethodsInclusion of patients from five centres in Japan is planned. The study is expected to take place from July 15, 2020, to November 30, 2024. Background, demographics, and medical history/information will be collected from electronic medical records at enrolment. Medical information includ

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… tacrolimus, infliximab, adalimumab, golimumab, tofacitinib, ciclosporin, vedolizumab, ustekinumab, azathioprine, mercaptopurine, leukocyte apheresis (including granulocyte and monocyte adsorption apheresis). c Includes peripheral joint involvement, spondyloarthritis (including ankylosing spondylitis and sacroiliitis …

Дилопия и экстремальная гиперамиласемия>100,000 U/L) Провозглашение агрессивного поведения ИгГ каппы миэломы: доклад о деле и обзор литературы.

RATALE: Хотя производство амилазы эпителиальными опухолями было хорошо задокументировано, его связь с множественной миеломой (ММ) является крайне редкой, о чем сообщалось лишь ограниченное число случаев. Кроме того, насколько нам известно, информация о бинокльной диплопии в качестве известной и первичной клинической функции у пациентов с MM и одновременно гиперамиласемией не получила широкого распространения. ОЗАБОЧЕННОСТЬ: В настоящем докладе содержится описание 75-year-old человек с иммуноглобулином G kappa MM, поражающим диплопию и экстремальную гиперамиласемию ()>100,000 U/L) с нормальным

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… Bilateral sacroiliitis was noted, with heterogeneous reduction in bone density of the sacral and coccygeal vertebrae and bilateral sacral bones, etiology undetermined; eighth, cranial base CT with 3D reconstruction showed abnormal density in the sphenoid sinus with absorption and destruction of the clivus …

Ход работы сессии 28th Европейский конгресс педиатрической ремуматологии (ПСР) 2022) Прага, Чешская Республика. 20-23 сентябрь 2022.

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Identification of Common Differentially Expressed Genes and Potential Therapeutic Targets in Ulcerative Colitis and Rheumatoid Arthritis.

Ulcerative colitis (UC) and rheumatoid arthritis (RA) are immune-mediated inflammatory diseases (IMIDs) with similar symptoms and common genomics. However, the relationship between UC and RA has not been investigated thoroughly. Therefore, this study aimed to establish the differentially expressed genes (DEGs) and potential therapeutic targets in UC and RA. Three microarray datasets (GSE38713, GSE1919, and GSE12251) were selected from the Gene Expression Omnibus (GEO) database for analysis. We used R software to identify the DEGs and performed enrichment analyses. Search Tool for the Retrieval

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… Ulcerative colitis complicating seronegative HLA-A2-B27 rheumatoid arthritis with sacroiliitis. Ann. Rheum. Dis. 51 1009–1011. 10.1136/ard.51.8.1009 Korpetinou A., Skandalis S. S., Labropoulou V. T., Smirlaki G., Noulas A., Karamanos N. K., et al. (2014). …

Bone marrow biopsy in geriatric patients above the age of 85 years: invaluable or unnecessary? A retrospective analysis.

Bone marrow biopsy (BMB) is a well-established diagnostic tool for various hematological, oncological, and other medical conditions. However, treatment options for geriatric patients (pts) facing these diseases are often constrained. In this single-center, retrospective analysis we assessed the diagnostic value of BMB in geriatric pts aged ≥ 85 years and examined its impact on therapeutic decisions. We examined 156 BMB procedures in 129 pts, extracting data from the electronic patient records and applying descriptive statistical methods. Nearly half of the primary diagnostic procedures (26; 44

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… Morotti A, Barozzino MC, Guerrasio A. rare bone marrow biopsy complication: A challenging case of Sacroiliitis and Staphilococcus Aureus Sepsis. Clin Pract. 2016;6(1):823. doi: 10.4081/cp.2016.823. 22. Houtman D, Barten DG, Laurent-de Gast AN. A woman with inguinal pain after a bone marrow biopsy. …

Резюме ESPR 2013Европейское общество педиатрической радиологии 50th Ежегодное совещание и 36th Курсы для аспирантов. Июнь 3–7 2013. Будапешт, Венгрия.

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Immune mechanism of low bone mineral density caused by ankylosing spondylitis based on bioinformatics and machine learning.

Background and Objective: This study aims to find the key immune genes and mechanisms of low bone mineral density (LBMD) in ankylosing spondylitis (AS) patients. Methods: AS and LBMD datasets were downloaded from the GEO database, and differential expression gene analysis was performed to obtain DEGs. Immune-related genes (IRGs) were obtained from ImmPort. Overlapping DEGs and IRGs got I-DEGs. Pearson coefficients were used to calculate DEGs and IRGs correlations in the AS and LBMD datasets. Louvain community discovery was used to cluster the co-expression network to get gene modules. The modu

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… Severity of sacroiliitis and erythrocyte sedimentation rate are associated with a low trabecular bone score in young male patients with ankylosing spondylitis . J. Rheumatol. 45 , 349 – 356 . 10.3899/jrheum.170079 29335346 Kim H-R. Lee S-H. Kim H-Y. Kim H-Y. ( 2006 ). …

Ход работы сессии 25th Европейский конгресс педиатрической ремуматологии (ПСР) 2018) Лиссабон, Португалия. 5-8 сентябрь 2018

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