Результаты поиска

Guidelines for the management of osteoporosis and fragility fractures.

The purpose of this document, a result of the harmonisation and revision of Guidelines published separately by the SIMFER, SIOMMMS/SIR, and SIOT associations, is to provide practical indications based on specific levels of evidence and various grades of recommendations, drawn from available literature, for the management of osteoporosis and for the diagnosis, prevention, and treatment of fragility fractures. These indications were discussed and formally approved by the delegates of the Italian Scientific Associations involved in the project (SIE, SIGG, SIMFER, SIMG, SIMI, SIOMMMS, SIR, and SIO

Совпадение в полном тексте источника
… Vertebroplasty or kyphoplasty can only be recommended for patients with intractable pain for weeks, with due consideration of the potential risks associated with the procedures and the uncertain benefits in the long term. … Aparisi F Vertebroplasty and kyphoplasty in vertebral osteoporotic fractures Semin Musculoskelet Radiol 2016 20 382 391 10.1055/s-0036-1592431 27842431 …

Rapid Fire

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Holistic Approach to the Diagnosis and Treatment of Patients with Tumor Metastases to the Spine.

The treatment of neoplastic spine metastases requires multi-faceted assessment and an interdisciplinary approach to patients. The metastases do not show specific symptoms but are often the first confirmation of the presence of a primary tumor in a patient. The diagnostic process includes imaging and invasive procedures, e.g., biopsy. It is essential to qualify the patient for an appropriate treatment using dedicated scales. Decompression of the spinal cord is a critical issue to save or restore neurological function in a patient with spine metastases. Surgical treatment ought to meet three cri

Совпадение в полном тексте источника
… Detailed imaging of the pedicles in CT can help with acquiring the proper trajectory during the vertebroplasty (posterolateral or through the pedicle) [ 43 ]. 3.1.4. … Pain is the main indication for vertebroplasty. The procedure should not be done on asymptomatic patients and in the case of spinal cord compression. …

Bone Pain in Cancer Patients: Mechanisms and Current Treatment.

The skeletal system is the third most common site for cancer metastases, surpassed only by the lungs and liver. Many tumors, especially those of the breast, prostate, lungs, and kidneys, have a strong predilection to metastasize to bone, which causes pain, hypercalcemia, pathological skeletal fractures, compression of the spinal cord or other nervous structures, decreased mobility, and increased mortality. Metastatic cancer-induced bone pain (CIBP) is a type of chronic pain with unique and complex pathophysiology characterized by nociceptive and neuropathic components. Its treatment should be

Совпадение в полном тексте источника
… Minimally invasive procedures, such as balloon kyphoplasty or percutaneous vertebroplasty, may be beneficial in patients who have vertebral metastases without neurological compromise but with persistent pain. … National Institute for Care and Health Excellence Percutaneous Vertebroplasty. NICE Interventional Procedure Guidance [IPG12] [(accessed on 20 November 2019)];2008 Available online: https://www.nice.org.uk/guidance/ipg12 . 53. …

Prognostic Value of Perioperative Anemia in Neurosurgical-Oncological Treatment of Spinal Metastases.

Neurosurgical resection of spinal metastases is an established treatment option for selected patients with advanced malignancies. However, high perioperative morbidity and mortality may further compromise outcomes in this vulnerable population, emphasizing the need to identify modifiable prognostic factors. Perioperative anemia is common and clinically relevant, yet its impact in this setting remains insufficiently studied. This retrospective, single-center study included 279 patients who underwent surgical treatment for spinal metastases between 2013 and 2025. Patients were stratified into th

Совпадение в полном тексте источника
… C., and Dreimann M., “Cervical Vertebroplasty for Osteolytic Metastases as a Minimally Invasive Therapeutic Option in Oncological Surgery: Outcome in 14 Cases,” Neurosurgical Focus 43 (2017): E3. 10. Georgy B. … A., “Vertebroplasty Technique in Metastatic Disease,” Neuroimaging Clinics of North America 20 (2010): 169–177. 11. Patchell R. A., Tibbs P. A., Regine W. …

Chronic Pain and Bone-Related Pathologies: A Narrative Review.

PurposePain related to bone may occur as a result of trauma, bone fracture, genetic disease, arthritis, benign or malignant primary bone tumors and bone cancer metastases. We discuss the pathophysiology of chronic bone-related pain, treatment options and therapeutic perspectives.MethodsUsing predefined terms, we searched PubMed, MEDLINE, and Google Scholar for meta-analyses, evidence-based reviews, and clinical practice guidelines. This narrative article reviews pathologies linked to chronic bone pain and discusses the preventive and therapeutic strategies for better bone pain management.Resul

Совпадение в полном тексте источника
… A recent meta analysis 71 showed kyphoplasty to be superior to vertebroplasty in terms of reducing cement leakage and of increasing postoperative vertebral body height; but this is more costly and has a longer operative time. … Vertebroplasty versus kyphoplasty in the treatment of osteoporotic vertebral compression fractures: a meta-analysis. World Neurosurg . 2023;171:65–71. PMID: 36455843. doi: 10.1016/j.wneu.2022.11.123 72. Krishnamurthy N, Grimshaw AA, Axson SA, et al. …

Соблюдение основанных на фактах рекомендаций по лечению костного здоровья, боли и мобильности пациентов с множественной миеломой: смешанный метод в палестинской системе здравоохранения.

Были разработаны рекомендации по оценке, регулированию и мониторингу состояния здоровья, боли и мобильности костных костей у пациентов с множественной миеломой, основанные на принципе " консенсус/доказательства " . Это исследование было проведено с целью оценки соответствия гематологов-онкологов принятым на основе консенсуса/доказательств рекомендациям в отношении оценки, регулирования и мониторинга состояния здоровья костей, боли и мобильности у пациентов с множественной миеломой, которые получали медицинскую помощь в палестинской системе здравоохранения. Рекомендации, основанные на

Совпадение в полном тексте источника
… In addition, 70% of the hematologists-oncologists reported inadequate adherence to ordering and evaluating calcium, vitamin D, alkaline phosphatase, electrolytes, and phosphorus levels to monitor bone health and referring patients to orthopedic surgeons for vertebroplasty, kyphoplasty, or surgical fixation … Percutaneous vertebroplasty and balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures and osteolytic tumours. J Bone Joint Surg Br. 2005;87(12):1595–604. doi: 10.1302/0301-620X.87B12.16074. 42. Knips L, Bergenthal N, Streckmann F, Monsef I, Elter T, Skoetz N. …

Quality of life and supportive care in multiple myeloma.

UnlabelledMultiple myeloma is the second most common haematological malignancy. Novel therapies have led to improvement in survival. Current myeloma management is matching the progress made in improved survival through disease control while optimising quality of life with effective supportive care. Supportive treatment is an essential part of the therapeutic management of myeloma patients because it is directed towards improving the patient's quality of life and also can improve survival. The aim of this review is to highlight the relationship among life of quality, supportive care, and improv

Совпадение в полном тексте источника
… Vertebroplasty by percutaneous injection of low-viscosity liquid bone cement into the vertebral body has been used for pain relief in patients with spine involvement [ 33 ]. … The use of vertebroplasty or kyphoplasty may be considered in patients with persistent pain. …

A new era in the management of spinal metastasis.

Despite the recent advances in cancer treatment, the incidence of patients with spinal metastases continues to grow along with the total number of cancer patients. Spinal metastases can significantly impair activities of daily living (ADL) and quality of life (QOL), compared with other types of bone metastases, as they are characterized with severe pain and paralysis caused by skeletal-related events. Reduced ADL can also lead to treatment limitations as certain anticancer agents and radiation therapy are not compatible treatments; thus, leading to a shorter life expectancy. Consequently, main

Совпадение в полном тексте источника
… Preemptive prophylactic surgeries and palliative interventions such as posterior fixation and decompression ( 41 ), separation surgery ( 42 ) and balloon kyphoplasty (BKP), including percutaneous vertebroplasty (PVP) ( 43 ), have been reported. … MISS techniques have been adopted for spinal metastases, including kyphoplasty/vertebroplasty, percutaneous fixation, tubular retractors, mini-open procedures, and thoracoscopy/endoscopy ( 100 ). …

Rare clinical experiences for surgical treatment of melanoma with osseous metastases in Taiwan.

BackgroundMalignant melanoma occurs infrequently in Taiwan. Once it has progressed into osseous metastases, the prognosis is poor. There are no reported clinical experiences of surgical management in this area.MethodsTo improve our understanding of the rare clinical experiences, we retrospectively investigated clinical characteristics, radiological findings, treatment modalities, survival outcomes and prognoses of 11 Taiwanese patients with osseous metastasis of melanoma treated surgically at two national medical centers, National Taiwan University Hospital and National Cheng Kung University H

Совпадение в полном тексте источника
… Patient age (years) | Sex | Surgical treatment | Therapy | Time (months) | | | | | | | | Diagnosis to bone metastases | Diagnosis to death | Bone metastases to death 45 | F | Wide excision | Radiotherapy | 1.77 | 7.44 | 5.67 72 | M | Posterior laminectomy for decompression, vertebroplasty with … Moreover, simultaneous instrumentation or vertebroplasty with polymethylmethacrylate (PMMA) cement can provide spinal stability to alleviate back pain in patients with pathological vertebral fractures. …

A Comprehensive Review of the Role of the Latest Minimally Invasive Neurosurgery Techniques and Outcomes for Brain and Spinal Surgeries.

Minimally invasive neurosurgical techniques offer reduced surgical trauma, lower complication rates, and faster recovery compared to traditional open procedures. Approaches such as keyhole craniotomy, endoscopic skull base surgery, endovascular neurosurgery, and percutaneous spinal techniques have advanced the management of cranial and spinal pathologies. These methods aim to minimize tissue disruption, blood loss, and hospital stay while maintaining surgical efficacy. This narrative review explores their evolution, applications, and advantages in modern neurosurgery.

Совпадение в полном тексте источника
… Percutaneous Vertebroplasty and Kyphoplasty for Osteoporotic Vertebral Fractures Vertebral fractures caused by osteoporosis are one of the most frequent and debilitating complications of osteopenia. … In recent decades, percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) have been used as minimally invasive options for the treatment of these lesions, offering promising clinical results in terms of pain reduction, restoration of function, and reduction of hospital stay. …

Percutaneous-Reinforced Osteoplasty: A Review of Emerging Treatment Strategies for Bone Interventions.

Percutaneous-reinforced osteoplasty is currently being investigated as a possible therapeutic procedure for fracture stabilization in high-risk patients, primarily in patients with bone metastases or osteoporosis. For these patients, a percutaneous approach, if structurally sound, can provide a viable method for treating bone fractures without the physiologic stress of anesthesia and open surgery. However, the low strength of fixation is a common limitation that requires further refinement in scaffold design and selection of materials, and may potentially benefit from tissue-engineering-based

Совпадение в полном тексте источника
… Bone cement has been in regular use for vertebral compression and fracture management in vertebroplasty and kyphoplasty procedures. However, the fracture strength and flexibility of cement-only repaired bone are lower than that of an intact bone. … Percutaneous osteoplasty, a procedure similar to vertebroplasty or kyphoplasty in the spine, is an effective radiological procedure used widely for the treatment of benign or malignant (extraspinal) bone lesions [ 18 ]. …

Surgical Intensity and Survival After Surgery for Extradural Spinal Metastases: Mechanical Instability, Tumor Biology, and Systemic Reserve.

Background/Objectives: Surgery for extradural spinal metastases must balance neurologic and mechanical goals against limited survival. We evaluated whether a predefined three-tier surgical-intensity classification aligned with established measures of operative burden and whether intensity was associated with 90-day mortality or overall survival. Methods: This retrospective cohort included 141 adults with extradural spinal metastases operated on between June 2020 and December 2025. Surgical intensity was classified as low, moderate, or high. SMII was calculated for all patients as a secondary c

Совпадение в полном тексте источника
… Stand-alone percutaneous vertebroplasty or kyphoplasty performed without decompression or tumor surgery was also excluded. No additional patients from the 150-patient source cohort were excluded beyond the nine intradural metastasis cases. 2.3. … Cement augmentation denoted cement use as an adjunct to decompression or tumor surgery, including cement-augmented fixation or vertebroplasty/kyphoplasty performed additionally to decompression; stand-alone augmentation-only procedures were excluded. …

Role of Decompressive Surgery in Neurologically Intact Patients with Low to Intermediate Intraspinal Metastatic Tumor Burden.

BackgroundSurgical decompression (SD) followed by radiotherapy (RT) is superior to RT alone in patients with metastatic spinal disease with epidural spinal cord compression (ESCC) and neurological deficit. For patients without neurological deficit and low- to intermediate-grade intraspinal tumor burden, data on whether SD is beneficial are scarce. This study aims to investigate the neurological outcome of patients without neurological deficit, with a low- to intermediate-ESCC, who were treated with or without SD.MethodsThis single-center, multidepartment retrospective analysis includes patient

Совпадение в полном тексте источника
… Treatment modalities included (1) decompressive surgery, (2) decompressive surgery and instrumentation, (3) instrumentation without decompression or vertebroplasty, and (4) no surgical intervention/RT only. … Cervical vertebroplasty for osteolytic metastases as a minimally invasive therapeutic option in oncological surgery: Outcome in 14 cases. Neurosurg. Focus. 2017;43:E3. doi: 10.3171/2017.5.FOCUS17175. 32. …

Is Teriparatide Superior in Treating Osteoporotic Vertebral Compression Fractures in Comparison to Bisphosphonates Treatment Alone: A 2-Year Retrospective Analysis.

STUDY DESIGN: Retrospective cohort study. PURPOSE: This study aimed to compare the efficacy of bisphosphonates and teriparatide in the management of osteoporotic vertebral compression fractures with regard to pain management, prevention of nonunion, and radiological as well as clinical outcomes. OVERVIEW OF LITERATURE: Osteoporosis refers to a skeletal disorder characterized by decreased bone strength caused by poor bone density and quality causing fragility, resulting in long periods of pain-related immobilization. METHODS: In a 24-month follow-up retrospective study, 191 patients with ost

Совпадение в полном тексте источника
… Nonunion cases become difficult to treat, requiring surgical procedures that might involve long-segment fixations along with bone grafting or vertebroplasty. Patients with nonunion have intractable pain because of a non-healing fracture [ 24 ]. … Acar N Karakasli A Karaarslan AA Ozcanhan MH Ertem F Erduran M The mechanical effect of rod contouring on rod-screw system strength in spine fixation J Korean Neurosurg Soc 2016 59 425 9 27651858 10.3340/jkns.2016.59.5.425 PMC5028600 28 Ma Y Wu X Xiao X Effects of teriparatide versus percutaneous vertebroplasty …

Current status and updated recommendations for diagnosis and treatment of plasma cell myeloma in Switzerland.

The availability of drugs such as thalidomide, bortezomib and lenalidomide changed the landscape in myeloma treatment and has extended the median survival up to 10 years with a substantial improvement in quality of life. This development prompted a Swiss expert panel to re-evaluate the current status and formulate updated clinical recommendations for the diagnosis and treatment of plasma cell myeloma. These recommendations should help clinicians in their decision making to achieve the best outcome based on currently available data.

Совпадение в полном тексте источника
… The choice between vertebroplasty and kyphoplasty depends on the expertise of the orthopaedic surgeon or interventional radiologist. In up to 40% of patients, lytic lesions will require radio- therapy for pain control. … Percutaneous vertebroplasty and kyphoplasty for painful vertebral body fractures in cancer patients. Journal of neurosurgery. 2003;98(1 Suppl):21–30. PubMed PMID: 12546384. 92 Lane JM, Hong R, Koob J, Kiechle T, Niesvizky R, Pearse R, et al. …

Vertebral Primary Bone Lesions: Review of Management Options.

The assessment and treatment of vertebral primary bone lesions continue to pose a unique yet significant challenge. Indeed, there exists little in the literature in the way of compiling and overviewing the various types of vertebral lesions, which can often have complicated intervention strategies. Given the severe consequences of mismanaged vertebral bone tumors-including the extreme loss of motor function-it is clear that such an overview of spinal lesion care is needed. Thus, in the following paper, we aim to address the assessment of various vertebral primary bone lesions, outlining the re

Совпадение в полном тексте источника
… Small or slow-developing lesions may only require corticoid injections or percutaneous vertebroplasty to eradicate the tumor. … For more posterior, uncomplicated vertebral damage, balloon kyphoplasty and vertebroplasty are used to reinforce the remaining bone with cement [ 89 , 90 ]. Figure 6 Schematic of laminectomy protocol. …

Myeloma therapy: pursuing the plasma cell

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… The issues discussed include bone disease and its treatment with kyphoplasy and vertebroplasty, anaemia, functional imaging and renal impairment. The final section addresses ‘Other Plasma Cell Disorders’. …

Mexican Multicenter Experience of Metastatic Spinal Disease.

Background Spinal metastatic disease is a silent progressive cancer complication with an increasing prevalence worldwide. The spine is the third most common site where solid tumors metastasize. Complications involved in spinal metastasis include root or spinal cord compression, progressing to a declining quality of life as patient autonomy reduces and pain increases. The main objective of this study is to report the incidence of patients and typology of spinal metastases in three reference centers in Mexico. Methodology Retrospective cohorts of patients diagnosed with spinal metastases from Ja

Совпадение в полном тексте источника
… Thoracic percutaneous vertebroplasty for the treatment of vertebral hemangioma in a patient with Forestier’s disease: a case report. Nurmukhametov R, Enelis B, Bernard E, et al. Cureus. 2022;14:0. doi: 10.7759/cureus.32466. 24. … Percutaneous pedicle screw fixation combined with percutaneous vertebroplasty for the treatment of thoracic and lumbar metastatic tumors. Ma X, Zhao Y, Zhao J, Wu H, Feng H. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10075092/ J Clin Transl Res. 2023;9:93–100. 43. …

Guillain-Barré syndrome in patients with multiple myeloma: three cases report and literature review.

BackgroundMultiple myeloma (MM) with Guillain-Barré syndrome (GBS) is relatively rare, and the specific mechanism is still unclear. The previous infection, surgery, and medication use may have contributed to the occurrence of GBS. The use of bortezomib in patients with MM can easily lead to peripheral neuropathy, which is similar to the symptoms of GBS, making it challenging to diagnose GBS.Cases presentationThree patients with IgA type MM experienced lower limb weakness during treatment. Combined with lumbar puncture, nerve conduction studies, and other tests, the diagnosis was confirmed as G

Совпадение в полном тексте источника
… Percutaneous vertebroplasty (PVP) of second lumbar vertebrae was performed in July 2021, and postoperative pathological reported plasma cell tumor. … Mortality | Cases report [ 36 ] | 3-7% [ 37 ] Abbreviations Multiple myeloma Guillain-Barré syndrome Cerebrospinal fluid Nerve conduction studies Medical research council Intravenous immunoglobulins Peripheral neuropathy Magnetic resonance imaging Hemoglobin β2-microglobulin Percutaneous vertebroplasty …