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The Persistence of Stigma and Other Challenges Experienced by Medical Cannabis Users: A Thematic Synthesis of Qualitative Studies.

BackgroundThe legislation, practices, and guidance shaping patient and professional access to medical cannabis (MC) for managing chronic pain and other conditions vary widely across jurisdictions. Despite promising evidence of effectiveness, challenges persist for those trying to access or prescribe MC. Little is known about how patients navigate these complex environments. We aimed to understand the evidence related to personal lived experiences associated with using MC for chronic pain and other conditions in negotiating these challenges.SummaryWe used a framework by Thomas and Harden for co

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… Future consideration: “what is the relevance of the distinction between regular use of marijuana in pursuit of pleasure and regular use for pain relief?” … They had started using cannabis recreationally for its pleasurable and euphoric effects. …

Навязчивое сексуальное поведение и проблематичное использование порнографии: всеобъемлющий, междисциплинарный и экспертный обзор описательной информации с указанием предлагаемых направлений будущей деятельности.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И МАТЕРИАЛЫ: Характер и классификация дисрегулированного сексуального поведения по-прежнему широко обсуждаются. Сексуальные расстройства, связанные с сексуальным поведением, и проблематичное использование порнографии (PUP) two Наиболее часто изученные конструкции в этой области, каждая из которых имеет значительные последствия для психического здоровья, межличностного функционирования и более широкого благосостояния. Хотя научные результаты по этим темам за последнее десятилетие быстро расширились, в последних обзорах основное внимание, как правило, уделялось конкретным п

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… and pedophiles, demonstrating its ability to discriminate between these two samples and a control group This initial version raised certain criticisms among researchers, as it included two factors that were not inherently related to CSB (i.e., violence [“Have you given others physical pain for sexual pleasure … Mechanisms Through reinforcement processes, initially pleasurable sexual behaviors may become habitual and compulsive, driven by shifts from hedonic “liking” to incentive “wanting” over time ( Berridge & Robinson, 2016 ; Brand, Snagowski, et al., 2016 ; Piazza & Deroche-Gamonet, 2013 ; Robinson & …

Azoximer Bromide: Mystery, Serendipity, and Promise.

Azoximer bromide (AZB) was identified as an immunomodulator, and was initially developed and currently successfully indicated as one of several natural polyelectrolytes, a vaccine adjuvant, and an effective agent for the treatment of infectious and inflammatory diseases of viral, bacterial, and fungal origin. AZB has the potential to increase an individual's resistance to local and general infection and is indicated for the treatment of viral infections, and has also demonstrated clinical efficacy in the treatment of a variety of secondary immunodeficiencies. However, AZB may offer long-term p

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… From the Series: The Pleasure of Science Vol. 274. . Eksmo Publishing, Moscow; (2018) p. 998–1001, ISBN: ISBN: 978-5-04-100053-0SSSR = Reports of the Academy of Sciences of the USSR. 9. Kabanov V. From Synthetic Polyelectrolytes to Polymer-Subunit Vaccines. …

Отвращение от мастурбации и гиперсексуальности

Несмотря на отсутствие данных о негативном воздействии мастурбации на здоровье, воздержание от мастурбации часто рекомендуется в качестве стратегии улучшения сексуального саморегулирования. Мы приняли рамки предполагаемых проблем с порнографией, чтобы собрать первые намеки на то, является ли воздержание от мастурбации результатом психологической и поведенческих циаддикций или противоречивых взглядов. В онлайновом опросе, проведенном с помощью нетематического " Reddit " (n = 1063), большинство участников сообщили о том, что они пытались избежать мастурбации. Как видно из корреляции ну

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… Empirical Findings Today, learning about the pleasures of masturbation at an early age is part of European sexuality education standards (“Standards for Sexuality Education in Europe,” 2010 ). …

Treatment preferences of patients with relapsed and refractory multiple myeloma: a qualitative study.

BACKGROUND: Multiple myeloma is a haematological malignancy characterized by significant morbidity and mortality. This study sought to develop an in-depth understanding of patients' lived experiences of relapsed or refractory multiple myeloma (RRMM) and its treatment, and to identify which features of treatment were most important to them. METHODS: Qualitative interviews and focus groups (FGs) were conducted with 32 people living with RRMM across Canada. In Phase 1, interviews focused on participants' accounts of their experiences with the disease and its treatment and laid the groundwork for

EVITA: a tool for the early evaluation of pharmaceutical innovations with regard to therapeutic advantage.

BackgroundNew drugs are generally claimed to represent a therapeutic innovation. However, scientific evidence of a substantial clinical advantage is often lacking. This may be the result of using inadequate control groups or surrogate outcomes only in the clinical trials. In view of this, EVITA was developed as a user-friendly transparent tool for the early evaluation of the additional therapeutic value of a new drug.MethodsEVITA does not evaluate a new compound per se but in an approved indication in comparison with existing therapeutic strategies. Placebo as a comparator is accepted only in

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… Extended-release bupropion for patients with major depressive disorder presenting with symptoms of reduced energy, pleasure, and interest: findings from a randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2006;67:865–873. doi: 10.4088/JCP.v67n0602. GlaxoSmithKline. …

Taste alterations after hematopoietic cell transplantation: a scoping review.

PurposeThis review aimed to evaluate the prevalence and characteristics of dysgeusia after hematopoietic cell transplantation (HCT).MethodsA literature search (in PubMed, Embase.com and Web of Science) for clinical studies evaluating taste before and after HCT was performed up to June 22, 2023, in collaboration with a medical information specialist. After title and abstract review (N = 807) followed by full-text review (N = 61), articles that met the inclusion criteria were summarized in a table and synthesized narratively.Results11 articles were analyzed in this review. All studies had a pros

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… Patients experiencing taste alterations may derive less pleasure from eating and drinking and might avoid certain types of food. This can negatively affect their emotional state and nutritional intake resulting in a reduced QoL, malnutrition, dehydration, weight loss, fatigue and depressed mood. …

Explanation of near-death experiences: a systematic analysis of case reports and qualitative research.

Background and objectiveSome individuals report a near-death experience (NDE) after a life-threatening crisis, which refers to a range of subjective experiences related to impending death. This experience is a phenomenon with transcendental elements, which leads to deep permanent changes in both the individual and the social lives of the NDEr's. Therefore, this study aims to review the near-death experiences of individuals with different religious and cultural views.MethodologyThis is a systematic analysis study. All the case report, case series and qualitative research studies which presented

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… Sense of pleasure 7. A sense of harmony or unity with the universe 8. Seeing the light shine 9. Feeling sharper than usual 10. Out-of-body experience 11. Seeing an unearthly realm 12. Encountering a mystical being or presence or hearing an unidentifiable voice 13. The decision to return to life 14. … Understanding pleasure 10. The experience of darkness 11. Losing the fear of death 12. Free movement of the soul 13. Hearing voices 14. Divine experiences about the Qur'an 15. …

Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl.

Trichotillomania (TTM) is defined by the Diagnostics and Statistic Manual of Mental Disorders, 4th edition (DMS-IV) as hair loss from a pati … of tension immediately prior to pulling out the hair or when attempting to resist the behavior; 3) pleasure, gratification, or relief when pulling out the hair; 4) the disturbance is not better accounted for by another mental disorder and is not due to a general medical condition (e.g., a dermatologic condition); 5) the disturbance causes clinically signi …

Уменьшившийся уровень видимости сигналов, указывающих на разрыв и дегенерацию тканей при прогрессивном многоразовом склерозе: воздействие на клинические испытания.

ИСТОРИЯ ВОПРОСА И ЦЕЛИ: Повреждения парамагнитных ободов (ПЗК) при множественном склерозе (МС) указывают на хроническое врожденное воспаление иммунной системы, способствующее прогрессированию заболеваний. Исчезновение или ослабление обода интерпретируется как реакция на лечение; однако остается неясным, действительно ли снижение степени уязвимости - похожее отражение сокращения железа в ободном отсеке - дает реальное разрешение на хроническое воспаление, старение естественного повреждения и/или дегенерацию продвинутой ткани. В поперечном разрезе PRL демонстрируют изменяющуюся видимость обода,

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… The following individuals contributed to data collection and study coordination as part of the University of California, San Francisco MS-EPIC Team: Sergio Baranzini PhD, Richard Cuneo MD, Sasha Gupta MD, Joseph Sabatino MD, Joanne Guo MD, Jill Hollenbach PHD, Sam Pleasure MD, PhD, Anna Sindalovsky, …

Mindfulness-Oriented Recovery Enhancement Restructures Reward Processing and Promotes Interoceptive Awareness in Overweight Cancer Survivors: Mechanistic Results From a Stage 1 Randomized Controlled Trial.

IntroductionThe primary aims of this Stage I pilot randomized controlled trial were to establish the feasibility of integrating exercise and nutrition counseling with Mindfulness-Oriented Recovery Enhancement (MORE), a novel intervention that unites training in mindfulness, reappraisal, and savoring skills to target mechanisms underpinning appetitive dysregulation a pathogenic process that contributes to obesity among cancer survivors; to identify potential therapeutic mechanisms of the MORE intervention; and to obtain effect sizes to power a subsequent Stage II trial.MethodsFemale overweight

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… may be explicated by the allostatic model of addiction, 11 , 12 which proposes that overstimulation of neural reward circuits with potent and addictive rewards (like highly palatable and calorie-dense foods) can increase sensitization to appetitive stimuli coupled with reduced capacity to experience pleasure …

Нейрогенная желудочно-кишечная, мочевая и сексуальная дисфункция при множественном склерозе: многодисциплинарная основа для клинической практики.

Нейрогенные желудочно-кишечные, мочевые и сексуальные симптомы широко распространены у людей с множественным склерозом и существенно ухудшают качество жизни, повседневное функционирование и психосоциальное благополучие. Несмотря на их частотность и клиническую актуальность, управление по-прежнему носит разрозненный характер по различным специальностям, тесная взаимосвязь между этими симптомами зачастую игнорируется, а у клинических работников отсутствует прагматическая основа, адаптированная к различным условиям здравоохранения. Этот обзор преобразует нынешние данные в прагматичную модель уход

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… poor sexual self-image is one of the most common contributing causes of sexual dysfunction in pwMS). 53 Sexual dysfunction is classified by the ICD-11 into: hypoactive sexual desire dysfunction (decreased libido), sexual arousal dysfunction (decreased genital/non-genital response and sexual arousal/pleasure …

Hope and Acceptance at the End of Life: Impact of Spirituality on Patients in Palliative Care.

IntroductionPalliative care aims to improve the quality of life of patients with serious illnesses. In this type of care, spirituality is placed alongside other dimensions: physical, psychological, and social. The end of life brings confrontation with dilemmas such as "none of this makes sense" or "was it worth it?" The acceptance or rejection of the journey presents spirituality as a dimension that accompanies the person in their existence. Interventions that allow for a review of life help facilitate reflection on regrets, unresolved issues, and an understanding of the legacy that generates

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… This scale consists of two questions focused on the absence of interest or pleasure and feelings of sadness in the last two weeks. The score was assigned by the patient, in each question, on a scale of zero to three, depending on the frequency with which these situations occurred. …

Определение концепций физической активности, которые имеют клиническое значение для пациентов и лиц, обеспечивающих уход: систематический обзор качественных исследований.

Физическая активность (ПА) необходима для общего здоровья. Неоптимальная ПА связана с снижением качества жизни (QOL) и преждевременной смертью. При проведении клинических исследований и разработке терапевтических методов определение тех аспектов ПО, которые имеют значение для пациентов и лиц, обеспечивающих уход, имеет важнейшее значение для разработки специальных мероприятий, выявления индивидуальных контекстуальных факторов и повышения степени удовлетворенности пациентов и их участия в обеспечении их собственного благополучия. По мере быстрого развития цифровых технологий здравоохранения (ДТ

Barriers and Facilitators of Using Sensored Medication Adherence Devices in a Diverse Sample of Patients With Multiple Myeloma: Qualitative Study.

BackgroundMany recently approved medications to manage multiple myeloma (MM) are oral, require supportive medications to prevent adverse effects, and are taken under complex schedules. Medication adherence is a concern; however, little attention has been directed toward understanding adherence in MM or associated barriers and facilitators. Advanced sensored medication devices (SMDs) offer opportunities to intervene; however, acceptability among patients with MM, particularly African American patients, is untested.ObjectiveThis study aimed to explore patients' (1) perceptions of their health be

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… The cuteness of the pouch was a source of pleasure contrasted with her feelings toward the contents of the pouch. She found it easy to locate the pouch in her bedroom and placed it in her purse when she went out. …

Effects of different art therapies on the psychological well-being and quality of life in cancer survivors: a systematic review and network meta-analysis.

ObjectiveArt therapy has gained increasing attention as an adjunctive intervention for cancer patients. This study sought to conduct the first network meta-analysis (NMA) to evaluate the effects of various art therapies on the psychological well-being and quality of life in cancer survivors, rank various interventions by efficacy, and provide evidence-based guidance for clinical practice.MethodsWeb of Science, PubMed, Embase, and the Cochrane Library, were systematically searched for studies published up to September 3, 2025. Eligible studies were selected according to predefined criteria, and

Challenges in Treating Cancer Patients With Unstable Psychiatric Disorder.

In this review, we first present a case of chronic myeloid leukemia with acute psychosis, and then we will discuss the incidence of cancer in patients with psychotic disorders, the manifestations of new-onset psychosis, and the prevalence of preexisting psychosis in cancer patients, coupled with their impact on the treatment, diagnosis, and prognosis of cancer. This was a case that presented with acute psychosis and was found to have an elevated white blood cell count upon admission to an inpatient psychiatric unit. He was diagnosed with chronic myeloid leukemia and successfully managed with i

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… We are grateful to all of those with whom we have had the pleasure to work during this and other related projects. We thank our colleagues who provided insight and expertise that greatly assisted the research, although they may not agree with all of the interpretations/conclusions of this paper. …

Насильственные сексуальные похитители, потребление порнографии и совместные нарушения среди студентов колледжей.

Проблемное использование порнографии (ППП) и другие виды сексуального поведения, связанные с навязчивым поведением, связаны с многочисленными психосоциальными последствиями, причем мужчины чаще, чем женщины. Однако меньше известно о частотности и взаимосвязи между PUP, CSB, депрессией и проблемами употребления алкоголя, особенно среди студентов колледжей, которые могут поддерживать такое поведение более высокими темпами. Цель этого исследования состояла в том, чтобы определить взаимосвязь между совместными ЦСУ, ППУ, проблемами с потреблением алкоголя и депрессией по признаку пола (77 процентов

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… relationship between alcohol use problems and PPU could be that alcohol use actually decreases symptoms of PPU (e.g., frequency, amount, distress) because (1) attention is spread across both alcohol use and pornography use, (2) the underlying motivation for the behavior (i.e., emotion regulation, coping, pleasure …

The effect of the holy Quran recitation and listening on anxiety, stress, and depression: A scoping review on outcomes.

Background and aimAnxiety, stress, and depressive disorders as common mental health problems have adverse effects in different populations. Holy Quran recitation and listening can help reduce these disorders. Therefore, the aim of this study was to investigate the effect of the Holy Quran on anxiety, stress, and depression.Materials and methodsTo retrieve eligible studies, we searched PubMed, Web of Science, and Scopus databases. The articles were screened and chosen by three researchers. The selection of studies and the data extraction from the studies were done by three researchers using the

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… Music affects a person's health through neurochemical changes and leads to an increase in the feeling of pleasure and happiness and a decrease in stress and pain in people. 86 The recitation of the Holy Qur'an, apart from its semantic load and royal mood, also has a melodious and musical word. …

A scoping review of breakthrough cancer pain: Multidimensional patient needs and influencing factors.

ObjectivesBreakthrough cancer pain (BTcP), a common complication among cancer patients, has been confirmed to have extensive impacts on patients' lives. However, existing research remains fragmented, lacking a systematic theoretical framework to integrate these findings. This scoping review aimed to systematically examine the multidimensional needs and influencing factors of BTcP patients based on Kolcaba's Comfort Theory, construct a conceptual mapping of BTcP needs and influences, and explore the theoretical foundations and practical pathways of related interventions.MethodsUsing a scoping r

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… anxiety symptoms significant 13 , 14 , 24 - Obvious psychological distress, emotional role function impaired 16 , 22 - Emotions significantly affected 18 , 27 , 29 Quality of Life and Life Enjoyment - Quality of life significantly decreased, especially in life enjoyment 9 , 18 - Severe impairment of life pleasure … symptoms significant 13 , 14 , 24 - Obvious psychological distress, emotional role function impaired 16 , 22 - Emotions significantly affected 18 , 27 , 29 Quality of Life and Life Enjoyment | - Quality of life significantly decreased, especially in life enjoyment 9 , 18 - Severe impairment of life pleasure …