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Systemic amyloidosis causing intestinal hemorrhage and pseudo-obstruction.

There are two major forms of amyloidosis, primary amyloidosis (AL) and secondary amyloidosis. AL amyloidosis results from deposition of immunoglobulin light chains or their fragments. One such example is AL amyloidosis associated with multiple myeloma, in which overproduced immunoglobulin light chains get deposited onto tissues, leading to tissue dysfunction. Amyloidosis in the intestines can present as a wide spectrum of non-specific gastrointestinal (GI) complaints including abdominal pain, changes in bowel habits, overt gastrointestinal bleeding and complaints related to altered motility in

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… Previous colonoscopies were significant for internal hemorrhoids. A surgical consult was called on hospital day #1 when the patient was noted to have a small bowel obstruction on CT. A nasogastric tube was placed. …

[Analysis on the technical characteristics and clinical efficacy of robotic-assisted intersphincteric resection for patients with low rectal cancer].

Objective: To explore the technical characteristics and short-term clinical efficacy of robotic-assisted intersphincteric resection (ISR) fo … ne case of anastomotic leakage, one case of anastomotic stenosis, one case of inflammatory external hemorrhoids and one case of urinary retention occurred after surgery,and all of them were cured by conservative treatment. The mean diameter of tumors was (2.9±1.2) cm, and the number of harvested lymph node was 12.8 ± 3.3. In the whole group, the circumcision …

Anorectal Complications During Neutropenic Period in Patients with Hematologic Diseases.

BackgroundNeutropenic patients are susceptible to any anorectal disease, and symptomatic anorectal disease afflicts 2-32% of oncology patients. Perianal infections are the most feared complication, considering the lack of natural defense against infectious microorganisms. When septic complications develop, the anorectal disease is potentially fatal, especially in neutropenic patients in whom mortality rates range between 11-57%. Although anorectal diseases are a frequent complication with potentially fatal outcomes among patients with hematologic diseases, sufficient data are not available in

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… complication including Fournier’s gangrene that requires rapid diagnosis and intervention as recurrence and mortality rates may be expressive. 3 , 8 In a series of 92 patients with acute or chronic leukemia, most common manifestations were a perirectal abscess (27%) followed by anal fissures (23%), external hemorrhoids …

Origin, Clinical Characteristics and 30-Day Outcomes of Severe Hematochezia in Cirrhotics and Non-cirrhotics.

BACKGROUND: The sites of origin, causes and outcomes of severe hematochezia have not been compared between cirrhotics and non-cirrhotics. In cirrhotics versus non-cirrhotics presenting with severe hematochezia, we aimed at (1) identifying the site and etiology of gastro-intestinal bleeding and independent predictors of bleeding from the upper gastrointestinal tract versus small bowel or the colon, (2) comparing 30-day clinical outcomes, and (3) proposing an algorithm for management of severe hematochezia. METHODS: In this cohort study from two university-based medical centers, 860 consecutive

On the etiology of anal squamous carcinoma.

The thesis is based on 13 publications in English and a review of the literature. The underlying work was done with the overall aim to descr … the Danish-Swedish case-control study challenge the long held belief that benign anal lesions (e.g. hemorrhoids) and anal inflammation (e.g. in association with Crohn's disease) are linked to an increased risk of anal SC. The work documents strong links between a variety of sexual behavior measures and the risk of anal SC. The previously observed excess of an …

The 2024 Saudi Pharmacotherapy Didactic Curriculum Toolkit: A Modified Delphi Study.

BACKGROUND: Several pharmacy schools in Saudi Arabia (S.A.) refer to the American College of Clinical Pharmacy (ACCP) pharmacotherapy toolkit in developing their pharmacotherapy curriculum. However, the ACCP toolkit does not specifically address the healthcare needs of the Saudi population. A tailored pharmacotherapy curriculum that offers graduates the essential competencies to better serve the nation's needs is warranted. This study aims to develop a population-centered didactic pharmacotherapy toolkit for the Saudi population to assist pharmacy schools in designing pharmacotherapy course co

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… portal hypertension, ascites, varices, hepatic encephalopathy, hepatorenal syndrome) 1 Inflammatory bowel disease (Crohn’s disease, ulcerative colitis) 1 Irritable bowel syndrome 1 Peptic ulcer disease (including stress-related mucosal injury, and gastrointestinal bleeding) 2 Anorectal disorders (e.g., hemorrhoids … hypertension, ascites, varices, hepatic encephalopathy, hepatorenal syndrome) 1 | Inflammatory bowel disease (Crohn’s disease, ulcerative colitis) 1 | Irritable bowel syndrome 1 | Peptic ulcer disease (including stress-related mucosal injury, and gastrointestinal bleeding) 2 | Anorectal disorders (e.g., hemorrhoids …

Evaluating the Impact of Insurer-Sponsored Health Coaching on Hospitalization and Costs in India: A Retrospective Cohort Study.

Health coaching programs are emerging as a promising intervention to improve disease management and reduce healthcare costs, particularly in the context of insurer-sponsored wellness initiatives. While such programs have shown positive outcomes in Western healthcare settings, their effectiveness in India remains underexplored. This study examines the impact of a health coaching program implemented by a prominent Indian health insurer (Aditya Birla Health Insurance), focusing on hospitalization rates and claims paid among high-risk policyholders. To assess the intervention's effectiveness, a re

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… of anal and rectal regions | Non-preventable K602 - Anal fissure, unspecified | Preventable K603 - Anal fistula | Non-preventable K61 - Abscess of anal and rectal regions | Non-preventable K62 - Other diseases of anus and rectum | Preventable K63 - Other diseases of intestine | Non-preventable K64 - Hemorrhoids … and perianal venous thrombosis | Preventable K649 - Unspecified hemorrhoids | Preventable K70-K77 - Diseases of liver | Non-preventable K74 - Fibrosis and cirrhosis of liver | Preventable K75 - Other inflammatory liver diseases | Non-preventable K76 - Other diseases of liver | Preventable K80 - Cholelithiasis …

61st Annual Conference of Indian Society of Gastroenterology, Virtual Diamond Jubilee ISGCON 2020, 19-20th December 2020.

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… Twenty-two (91.6%) patients had evidence of cirrhosis- 21 presented with UGI bleeding while one had bleeding from hemorrhoids. Two patients without cirrhosis were presumed to have non-variceal bleeding. …

Study on chronic toxicity, metabolic profiles and potential mechanisms of Aristolochiae Fructus in rats.

ETHNOPHARMACOLOGICAL RELEVANCE: Aristolochiae Fructus (AF) is a "notable" Traditional Chinese Medicines (TCM), renowned for its efficacy in clearing lung heat, descending qi, relieving cough and asthma, as well as its well-documented toxicity. Traditionally used for conditions such as lung heat with cough and dyspnea, and hemorrhoidal swelling and pain, modern pharmacological research has uncovered additional potential clinical applications. However, in-depth studies have revealed that its constituent aristolochic acid I (AA-I) possesses potent nephrotoxicity and carcinogenicity, which poses a

Clinical and hematological evaluation of geriatric anemia.

BACKGROUND: Anemia in the elderly is a cause of concern. It is not merely physiological due to aging and requires appropriate evaluation. Anemia has a significant negative impact on cardiac function, cognition, sleep, frequent hospitalization, mobility, morbidity, and mortality. Anemia in the elderly is attributable to many causes: nutrient deficiencies, chronic inflammatory diseases, thyroid disorders, diabetes mellitus, gastrointestinal (GI) tumors and bleeding, chemotherapy-induced anemia, and drug-induced hemolysis. OBJECTIVES: We aimed to evaluate the clinical and hematological profile o

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… In colonoscopy, five patients had hemorrhoids, two of them had a rectal polyp, one patient had a colonic polyp, and one patient was diagnosed to have carcinoma of colon. Figure 4 Bar diagram showing the upper GI scopy findings The etiology pattern is shown in Table 1 . …

Dose-escalation studies of mesenchymal stromal cell therapy for decompensated liver cirrhosis: phase Ia/Ib results and immune modulation insights.

Decompensated liver cirrhosis (DLC) is characterized by severe liver dysfunction and immune dysregulation, posing significant treatment challenges. Mesenchymal stromal cell (MSC) therapy has shown promise in DLC treatment, but the optimal dosing strategies and dose-dependent therapeutic mechanisms in humans remain unclear, limiting its clinical application. We conducted sequential Phase Ia/Ib trials using a single-arm, dose-escalation design to evaluate the safety and tolerability of MSC therapy in DLC patients while also exploring its immunomodulatory effects and gathering preliminary therape

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… Six AEs occurred in Phase Ib: one case of diarrhea (level 2, unlikely to be related), one case of bleeding gums (level 2, unlikely to be related), one upper respiratory tract infection (level 3, possibly related) in Cohort A, and two cases of fever (level 1, possibly related) and one case of hemorrhoids … | 0 | 0 | 0 | 0 | 0 | 0 | 0 Categories Rash | 0 | 1 | 1 | 0 | 0 | 0 | 2 Fever | 0 | 0 | 0 | 0 | 0 | 2 | 2 Upper respiratory tract infection | 0 | 0 | 0 | 0 | 1 | 0 | 1 Influenza-like symptoms | 0 | 0 | 0 | 1 | 0 | 0 | 1 Kidney calculi | 0 | 0 | 1 | 0 | 0 | 0 | 1 Diarrhea | 0 | 0 | 0 | 0 | 1 | 0 | 1 Hemorrhoids …

Анализ траекторий заболеваний, ведущих к множественным склерозам: общенациональное когортное исследование.

ОКРУЖАЮЩАЯ СРЕДА: Продромальная фаза множественного склероза (MS) получает все большее признание, однако в большинстве исследований основное внимание уделяется изолированным симптомам или статичной коморбиде, в результате чего меняющаяся структура преднамеренного бремени болезней недооценивается. ЦЕЛЬ: Охарактеризовать динамические траектории заболеваний, предшествующие НР, путем моделирования продольной сети. МЕТОДЫ: ЗДРАВООХРАНЕНИЯ 10,273 Психиатрические заболевания и 47,167 Были проанализированы соответствующие меры контроля в Швеции. Были построены сети совместного лечения заболеваний thre

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… of ICDs Shannon index MS 1 R—Symptoms/signs Dizziness/giddiness; Headache; Chest/throat pain; Dyspnea; Palpitations 142 2.76 2 S—Injury/poisoning Fracture of lower leg; Fracture of forearm; Fracture of foot; Joint sprain; Shoulder/upper arm fracture 106 2.41 3 K—Digestive Cholelithiasis; GERD; IBS; Hemorrhoids …

Low molecular weight heparin for the prevention of hepatic veno-occlusive disease (VOD) after hematopoietic stem cell transplantation: a prospective phase II study.

We evaluated 40 patients undergoing high-dose chemo/radiotherapy (HDCT) and hematopoietic stem cell transplantation (HSCT) (allogeneic (22), autologous (18)) to determine the safety and feasibility of administering low molecular weight heparin (LMWH) as hepatic veno-occlusive disease (VOD) prophylaxis. Patients received a once daily subcutaneous injection of dalteparin 2500 anti-Xa i.u. commencing the day prior to starting HDCT, and continuing until day +30 post HSCT or hospital discharge, whichever came first. Dosage adjustments were made for patients developing renal failure. All bleeding ep

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… UPN 442 developed bleeding per rectum secondary to hemorrhoids on day +4 following a sibling allogeneic HSCT for myelodysplastic syndrome. CBC at this time revealed a Hgb of 72 g/l and platelet count of 42 × 10 9 /l. She was transfused with 2 U of PRBCs and the bleeding resolved. …

Ранние коморбиды и диагностические проблемы у людей с множественным склерозом, которые могут оказать воздействие на лечение заболеваний.

КОЛИЧЕСТВО: Сопоставимость людей с множественным склерозом (PwMS) может влиять на состояние здоровья и качество жизни. ЦЕЛИ: РАССЛЕДОВАНИЕ СВЯЗАННЫХ five через несколько лет после диагностики, времени возникновения коморбидности, возраста и полового воздействия, а также различий между множественным склерозом (МС) и другими хроническими аутоиммунными заболеваниями (АИД). МЕТОДЫ: В этом ретроспективном когортном исследовании мы систематически оценивали различия в частотах диагностики в недавно диагностированном PwMS (n = 9,880) по сравнению с соответствующими контрольными устройствами (noAID, n

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… Three ICD-10 codes for acute tonsillitis, hemorrhoids, and perianal venous thrombosis, and enthesopathies were recorded less frequently for PwMS. The more conservative approach requiring at least two recordings of an ICD-10 code yielded very similar results ( Figure S1C, D ). Table 2. …

Opioid Consumption Patterns After Anorectal Operations: Development of an Institutional Prescribing Guideline.

BACKGROUND: Closer scrutiny of prescription patterns following surgery could contribute to the national effort to combat the opioid epidemic. OBJECTIVE: This study aimed to define opioid consumption patterns following anorectal operations for development of an institutional prescribing guideline. DESIGN: This was a retrospective cohort study. SETTING: The study was conducted at a single tertiary care center. PATIENTS: Patients undergoing outpatient anorectal surgery between July 2018 and January 2019 were included. MAIN OUTCOME MEASURES: The study measured prescription and consumption qua

Disability Weights Measurement for 228 Causes of Disease in the Korean Burden of Disease Study 2012.

Disability weight for each disease plays a key role in combining years lived with disability and years of life lost in disability adjusted life year. For the Korean Burden of Disease 2012 study, we have conducted a re-estimation of disability weights for causes of disease by adapting the methodology of a recent Global Burden of Disease study. Our study was conducted through a self-administered web-based survey using a paired comparison (PC) as the main valuation method. A total of 496 physicians and medical college students who were attending in third or fourth grade of a regular course conduc

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… 0.864 | 0.796-0.917 Hypertensive heart disease | 0.575 | 0.472-0.675 Cardiomyopathy and myocarditis | 0.753 | 0.667-0.828 Atrial fibrillation and flutter | 0.551 | 0.451-0.650 Aortic aneurysm | 0.727 | 0.644-0.803 Peripheral vascular disease | 0.530 | 0.432-0.627 Endocarditis | 0.668 | 0.576-0.752 Hemorrhoids …

Percutaneous coronary intervention and 30-day unplanned readmission with chest pain in the United States (Nationwide Readmissions Database).

Percutaneous coronary intervention (PCI) improves anginal chest pain in most, but not all, treated patients. PCI is associated with unplanned readmission for angina and non-specific chest pain within 30-days of index PCI. Patients with an index hospitalization for PCI between January-November in each of the years 2010-2014 were included from the United States Nationwide Readmissions Database. Of 2 723 455 included patients, the 30-day unplanned readmission rate was 7.2% (n = 196 581, 42.3% female). This included 9.8% (n = 19 183) with angina and 11.1% (n = 21 714) with non-specific chest pain.

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… 243 | Poisoning by nonmedical substances Syncope | 245 | Syncope Other non‐cardiac | 10 | Immunization and screening for infectious disease 45 | Maintenance chemotherapy, radiotherapy 52 | Nutritional deficiencies 55 | Fluid and electrolyte disorders 56 | Cystic fibrosis 57 | Immunity disorder 120 | Hemorrhoids …

The erectile and ejaculatory implications of the surgical management of rectal cancer.

Colorectal cancer is a significant cause of cancer-related deaths worldwide. Although advances in surgical technology and technique have decreased mortality rates, surviving patients often experience sexual dysfunction as a common complication. The development of the lower anterior resection has greatly decreased the use of the radical abdominoperineal resection surgery, but even the less radical surgery can result in sexual dysfunction, including erectile and ejaculatory dysfunction. Improving the knowledge of the underlying causes of sexual dysfunction in this context and developing effectiv

A Qualitative Investigation on Patient Empowerment in Prostate Cancer.

Purpose: Men with prostate cancer often describe low levels of empowerment. eHealth interventions may represent useful tools to deliver care and education and to meet patients' needs within an empowerment framework. In order to design a platform for cancer patients' empowerment within the H2020 iManageCancer project, the perspective of the target population for the platform was assessed. The present study aims to assess the qualitative experience of prostate cancer patients during treatment in order to provide insights for clinical practice with a particular focus on the design of a web platfo

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… . | Residence | Marital status | Education | Comorbidities | Prostatectomy 1 | Lombardy | Married | University | Ischemic cardiopathy (PTCA), Hemorrhoids | Yes 2 | Milan Area | Widowed | High School | Pulmonary arterial hypertension | Yes 3 | Other region | Married | University | Ascending aortic ectasia …