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[Parosteal osteosarcoma: a clinical study of 48 cases].

OBJECTIVE: To investigate the way of diagnosis and therapy of parosteal osteosarcoma. METHODS: A retrospective review was conducted of 48 patients treated at our department between June 1964 and December 2001. The average age of patients in this study was 29.2 years (13 - 47 years). Thirty-two of the patients were female; sixteen were male. The single most common site is the posterior aspect of the distal femur (in 36 patients), followed by the femur shaft (in 6 patients), the proximal tibia (in 2 patients), etc. Nine patients had been operated on before referral to our department. RESULTS:

The Curious Case of the Black Buboes.

Anthracosis is an environmental lung disease caused by carbon deposition and pigmentation in the airways. However, in rare instances, it can also have systemic involvement. We present a patient with B-symptoms and diffuse lymphadenopathy who was diagnosed with the infrequently described nodal anthracosis. A 64-year-old Vietnamese gentleman with a 50-pack-year smoking history who was recently diagnosed with prostate cancer post-radical prostatectomy and awaiting radiation therapy presented with generalized weakness, low-grade fever, night sweats, and unquantifiable weight loss for a month. He w

Diagnostic Utility of Thoracoscopy in Recurrent Exudative Pleural Effusion: A Single-Arm Interventional Study.

Background and objectives Recurrent pleural effusion has always posed a challenge for definitive etiological diagnosis because it relies on nonspecific investigative methods like pleural fluid analysis.The basic nature of fluid, like transudate or exudate, can be differentiated by Light's criteria. The common causes of exudative effusion are tuberculosis, malignancy, and pneumonia. The non-specific method of diagnosis mainly depends upon pleural fluid biochemical and cytological tests in order to decide an empirical treatment. The blind method of pleural biopsy by introducing a specialized ple

Breathlessness with pulmonary metastases: a multimodal approach.

Case Study  Sarah is a 58-year-old breast cancer survivor, social worker, and health-care administrator at a long-term care facility. She li … ed to feel "air hungry." She rated her breathlessness at 4/10 on the Borg scale. SECOND RECURRENCE: MULTIPLE PULMONARY NODULES  Sarah's chest x-rays remained clear for 6 months, but she developed a chronic cough shortly before the 9-month exam. An x-ray revealed several bilateral lung lesions and growth in the area of the previously resected lung nodule. Systemic therapy wa …

Multiple cystic lung disease.

Multiple cystic lung disease represents a diverse group of uncommon disorders that can present a diagnostic challenge due to the increasing number of diseases associated with this presentation. High-resolution computed tomography of the chest helps to define the morphological aspects and distribution of lung cysts, as well as associated findings. The combination of appearance upon imaging and clinical features, together with extrapulmonary manifestations, when present, permits confident and accurate diagnosis of the majority of these diseases without recourse to open-lung biopsy. The main dise

Seasonal clustering of sinopulmonary mucormycosis in patients with hematologic malignancies at a large comprehensive cancer center.

BackgroundInvasive Mucorales infections (IMI) lead to significant morbidity and mortality in immunocompromised hosts. The role of season and climatic conditions in case clustering of IMI remain poorly understood.MethodsFollowing detection of a cluster of sinopulmonary IMIs in patients with hematologic malignancies, we reviewed center-based medical records of all patients with IMIs and other invasive fungal infections (IFIs) between January of 2012 and August of 2015 to assess for case clustering in relation to seasonality.ResultsA cluster of 7 patients were identified with sinopulmonary IMIs (

Легкомерный амилоидоз диагностируется Branbronchial Lung Biopsy: Three-Case Series with Divide Radiodial Provisions.

Легкий амилоидоз является редким заболеванием с различными радиологическими проявлениями, которое может имитировать злокачественную или диффузную межстициальную болезнь легких. Хотя традиционные щипцы трансбронхиальной биопсии легких (ТБЛБ) являются установленным менее инвазивным диагностическим методом, его клиническая роль может различаться в зависимости от вида заболевания. Мы сообщали о трех пациентах с легочным амилоидозом, диагностированным обычными щипцами ТББ. Двое из них были поражены носовыми повреждениями, имитирующими злокачественность; ТББ установил диагноз, и системная оценка пок

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… Case Series Case 1 A 73‐year‐old man with a history of smoking (45 pack‐years) and occupational welding exposure was referred to our hospital after multiple pulmonary nodules were incidentally detected on chest computed tomography (CT) performed for exertional dyspnea. … Case 2 A 79‐year‐old man with a history of smoking (43 pack‐years) and occupational welding exposure was referred to our hospital after multiple pulmonary nodules were detected on chest CT performed for cough and sputum production. …

Pulmonary amyloidosis: clinicopathologic spectrum and diagnostic pitfalls in a 12-patient case series.

BACKGROUND: Pulmonary amyloidosis is a rare, underrecognized manifestation of amyloid disease that may present as nodular, tracheobronchial, or diffuse alveolar-septal involvement and can mimic common pulmonary conditions. This study aimed to characterize the clinicopathologic features, diagnostic patterns, and management approaches of patients with pulmonary amyloidosis in a real-world setting. METHODS: We performed a retrospective review of patients with pathology-confirmed pulmonary amyloidosis diagnosed between January 2020 and December 2024 at a tertiary academic medical center in Detroi

Chest and Mediastinum

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Adoption value of support vector machine algorithm-based computed tomography imaging in the diagnosis of secondary pulmonary fungal infections in patients with malignant hematological disorders.

This study aimed to assess the feasibility of diagnosing secondary pulmonary fungal infections (PFIs) in patients with hematological malignancies (HM) using computerized tomography (CT) imaging and a support vector machine (SVM) algorithm. A total of 100 patients with HM complicated by secondary PFI underwent CT scans, and they were included in the training group. Concurrently, 80 patients with the same underlying disease who were treated at our institution were included in the test group. The types of pathogens among different PFI patients and the CT imaging features were compared. Radiomic f

Diagnosis and treatment of cystic lung disease.

Cystic lung disease (CLD) is a group of lung disorders characterized by the presence of multiple cysts, defined as air-filled lucencies or low-attenuating areas, bordered by a thin wall (usually < 2 mm). The recognition of CLDs has increased with the widespread use of computed tomography. This article addresses the mechanisms of cyst formation and the diagnostic approaches to CLDs. A number of assessment methods that can be used to confirm CLDs are discussed, including high-resolution computed tomography, pathologic approaches, and genetic/ serologic markers, together with treatment modalities

Mapping the research trends and hotspots on solid pulmonary nodules from 2000-2024: insights from bibliometric analysis.

BackgroundDue to extensive low-dose computed tomography (CT) screening, the detection rate of solid pulmonary nodules (PNs) is constantly rising. However, existing studies lack a comprehensive understanding of its emerging research trends and interdisciplinary progress, especially in terms of artificial intelligence (AI) integration and molecular characteristics. In this study, we conduct a comprehensive bibliometric analysis to clarify the current research trends and predict future research hotspots in this field, in order to improve diagnostic accuracy, reduce overtreatment, and promote inno

Treatment effects of human amnion-derived mesenchymal stem cells for skin lesions and metastatic pulmonary calcification in calciphylaxis patients - case series and literature review.

BACKGROUND: Calciphylaxis, also termed calcific uremic arteriolopathy (CUA) in patients with end-stage kidney disease (ESKD), is a rare and fatal condition characterized by cutaneous ischemic necrosis. METHODS: Three patients with calciphylaxis and metastatic pulmonary calcification (MPC) were treated with human amnion-derived mesenchymal stem cells (hAMSCs). Effects were evaluated using the Visual Analogue Scale (VAS), modified Bates-Jensen Wound Assessment Tool for CUA (BWAT-CUA), wound quality of life questionnaire (Wound-QoL), and histological analysis. MPC was assessed by high-resolution

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… Chest CT in March 2020 revealed multiple pulmonary nodules with calcification in the lungs, which presented earlier than CUA ( Figure 5(B) ). At this time, he had no typical respiratory symptoms. …

The Story of Localized Amyloidosis: Something Old and Something New - A Case Series.

Localized amyloidosis is a rare benign disease characterized by extracellular deposition of misfolded proteins in a specific organ without systemic involvement, which might lead to organ dysfunction. Patients with localized amyloidosis do not develop systemic diseases such as cardiac, renal, hepatic, or nerve involvement. Typically, the localized disease is managed by surgical resection, while the systemic disease is treated with a combination chemotherapy and immunotherapy. However, some patients can have challenging clinical presentations, delaying diagnosis and organ dysfunction, and they m

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… However, there exists a handful of patients presented in case series, such as Khoor et al, particularly that of a 62-year-old male with multiple pulmonary nodules in the setting of lymphoplasmacytic lymphoma treated with systemic chemotherapy. …

SUBJECT INDEX Volume 125 (JANUARY–JUNE, 2004)

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The Proceedings of the 19th International Cancer Imaging Society Meeting and Annual Teaching Course : Verona, Italy. 7 - 9 October 2019.

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Chemotherapy-induced pulmonary complications in cancer: Significance of clinicoradiological correlation.

Chemotherapy while revolutionizing cancer management by improving survival and quality of life; is also associated with several adverse effects. Lung is the most common organ affected in chemotherapy-related complications, due to either drug toxicity or more commonly due to infections caused by immunosuppression and less commonly due to immune-mediated injury. Radiology, when used in combination with clinical and lab data, can help reach the specific diagnosis or narrow down the differentials. The common radiological patterns of drug toxicity include pulmonary interstitial and airway infiltrat

Proceedings of the International Cancer Imaging Society (ICIS) 17th Annual Teaching Course : Berlin, Germany. 02 - 04 October 2017

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Coexistence of Autoantibodies against the Golgi Complex and Ro52 Antigen in a Patient with Nonspecific Interstitial Pneumonia.

Nonspecific interstitial pneumonia (NSIP) is often associated with connective tissue diseases (CTD). The diagnosis of NSIP was confirmed in a 63-year-old man by high-resolution computed tomography and an open lung biopsy. Anti-Golgi complex autoantibodies (AGA) and anti-Ro52 antibodies were simultaneously detected at high concentrations. Autoantibodies to aminoacyl-tRNA synthetases (ARS) were negative. The patient was treated with corticosteroids for six months. During the seven-year follow-up, NSIP had a slow progression and patient had not developed the clinical features of CTD. The present

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… Fig. 7.7.56 Posteroanterior chest radiograph of a patient with adult pulmonary Langerhans’ cell histiocytosis (PLCH) shows multiple pulmonary nodules with different sizes located at the right upper lung zone ( arrowheads ) Fig. 7.7.57 Axial HRCT illustration of a patient with PLCH shows diffusely bronchiectatic … , cystic changes of the lung parenchyma in a bilateral pattern with right pneumothorax Fig. 7.7.56 Posteroanterior chest radiograph of a patient with adult pulmonary Langerhans’ cell histiocytosis (PLCH) shows multiple pulmonary nodules with different sizes located at the right upper lung zone ( arrowheads …

Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (rhu GM-CSF) as Adjuvant Therapy for Invasive Fungal Diseases.

BackgroundSargramostim (yeast-derived, glycosylated recombinant human granulocyte-macrophage colony-stimulating factor [rhu GM-CSF]) augments innate and adaptive immune responses and accelerates hematopoietic recovery of chemotherapy-induced neutropenia. However, considerably less is known about its efficacy as adjunctive immunotherapy against invasive fungal diseases (IFDs).MethodsThe clinical courses of 15 patients with pediatric malignancies and IFDs treated adjunctively with sargramostim at a single institution were analyzed in a retrospective cohort review. Further, a systematic review of