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Hypothetical interventional effect of health behaviors for improving depression symptoms among patients diagnosed with cancer: a g-formula based study.

BackgroundDepressive symptoms are frequently reported among patients undergoing treatment for malignancies and among cancer survivors. However, treatment options for depression in this population remain limited due to significant side effects and suboptimal efficacy. These challenges underscore the urgent need for safe, well-tolerated, and effective strategies to alleviate depressive symptoms in individuals affected by cancer. Therefore, we aimed to evaluate the hypothetical interventional effects of seven lifestyle factors on alleviating depressive symptoms in individuals currently or previou

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… The items includes: [ 1 ] little interest or pleasure in doing things [ 2 ], feeling down, depressed, or hopeless [ 3 ], trouble falling or staying asleep, or sleeping too much [ 4 ], feeling tired or having little energy [ 5 ], Poor appetite or overeating [ 6 ], feeling bad about yourself — or that …

Диет модернизирует терапевтическое воздействие диметилфумарата, поддерживаемого иммунометаболическим нейтрофильным рецептором HCAR2.

Монометилфумарат (ММФ) и его пронаркодиметилфумарат (ДМП) в настоящее время являются наиболее широко используемыми агентами для лечения множественных склерозов (МС). Однако не все пациенты получают помощь от ДМФ. Мы предположили, что переменная реакция пациентов может быть связана с их питанием. В поддержку этой гипотезы мыши, подвергшиеся экспериментальному аутоиммунальному энцефаломиэлиту (EAE), являющемуся моделью MS, не пользовались лечением DMF при питании богатой лауричной кислотой диетой. В противоположность этому, мыши на нормальном питании чау (NC) и даже мыши на рационе с высоким сод

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… Samuel Pleasure, University of California, San Francisco, United States. Satyajit Rath, Indian Institute of Science Education and Research (IISER), India. …

Advancing Palliative Care Integration in Hematology: Building Upon Existing Evidence.

Opinion statementPatients with hematologic malignancies and their families are among the most distressed of all those with cancer. Despite high palliative care-related needs, the integration of palliative care in hematology is underdeveloped. The evidence is clear that the way forward includes standard-of-care PC integration into routine hematologic malignancy care to improve patient and caregiver outcomes. As the PC needs for patients with blood cancer vary significantly by disease, a disease-specific PC integration strategy is needed, allowing for serious illness care interventions to be ind

Assessment of Psychiatric Disorders in Consultation-Liaison Setting.

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Post-traumatic growth after cancer: a scoping review of qualitative research.

PurposeInterest is growing in post-traumatic growth (PTG) after cancer prompted, in part, by observations of positive associations with health-related quality of life. Qualitative research provides valuable insight into survivors' experiences. We conducted a scoping review of qualitative evidence on PTG in cancer, determining the number, nature, range and scope of studies, and gaps in the literature.MethodsWe systematically searched Medline, Scopus, CINAHL, Web of Science, and PsycINFO for qualitative research exploring positive changes after cancer published from 1996. From eligible studies,

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… This helped them adapt and/or rediscover, or find new, life pleasures: ‘ Being happy with myself, I accept what I am. I’ve changed my appearance. I discovered fashion, sexy underwear; sex again, my marriage, my husband, and everything. It was like being born again. I’m a success. …

A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy.

Chemotherapeutic agents cause many short and long term toxic side effects to peripheral nervous system (PNS) that drastically alter quality of life. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and enduring disorder caused by several anti-neoplastic agents. CIPN typically presents with neuropathic pain, numbness of distal extremities, and/or oversensitivity to thermal or mechanical stimuli. This adverse side effect often requires a reduction in chemotherapy dosage or even discontinuation of treatment. Currently there are no effective treatment options for CIPN. While the under

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… J., Yaron A., Pleasure S. J., Tessier-Lavigne M. (2003). Stereotyped pruning of long hippocampal axon branches triggered by retraction inducers of the semaphorin family. Cell 113, 285–299. 10.1016/S0092-8674(03)00267-8 Baldwin R. …

Сексуальный и клинический профиль испаноязычных лиц с проблемным участием в сексуальной деятельности в Интернете: сравнение между субклиническими и клиническими группами.

С учетом быстрого роста цифровых технологий и последствий этой клинической картины все большую озабоченность вызывает проблематическое участие в онлайновой сексуальной деятельности (ОСА). Однако по-прежнему отсутствует консенсус в отношении нозологических и диагностических критериев этого формирующегося состояния. Хотя в ряде исследований были изучены характеристики и прогнозы проблемной КССА, лишь немногие из них опирались на клинические пробы или всеобъемлющие диагностические инструменты, охватывающие все существующие диагностические предложения. В рамках этого исследовательского исследовани

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… This, together with the dissociation that many people with problematic engagement in OSA experience during these sexual practices, would explain why they experience great pleasure from these riskier activities. But, once they become aware of what they have done, discomfort increases. …

Глобальное состояние исследований и тенденции навязчивого сексуального поведения: всеобъемлющий библиометрический анализ.

СТРОИТЕЛЬНОЕ ПОЛОЖЕНИЕ В СВЯЗИ С СТРАТЕГИЧЕСКИМ ПОЛОЖЕНИЕМ В СВЯЗИ С СТРАТЕГИЧЕСКИМ ПОЛОЖЕНИЕМ (CSBD) - это состояние психического здоровья, которое привлекло к себе значительное внимание в ходе научных исследований, особенно после его включения в одиннадцатый пересмотренный вариант Международной классификации болезней (International Classification of Beasons) (International Classification of Bisons (CSBDD).ICD-11) Всемирной организацией здравоохранения. Несмотря на это признание, эта область по-прежнему является фрагментарной в связи с продолжающимся обсуждением вопроса о ее классификации и о

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… They also noted important clinical distinctions between HD and CSBD standards, especially regarding sexual behavior, exclusion criteria, moral incongruence, and diminished sexual pleasure. …

Телемедицина в искусстве для лечения нейроразвитых и неврологических расстройств: аналитическая оценка.

БАКГРУС: Искусственная терапия, охватывающая арттерапию, музыкальную терапию, драматическую терапию и танцевальную терапию с более широкой практикой экспрессивной терапии, продемонстрировала положительные результаты в лечении нейроразвитых и неврологических расстройств (ННД). Все более важное значение для улучшения доступа людей с нарушениями подвижности или людей, проживающих в отдаленных районах, к средствам телемедицины приобретает интеграция методов лечения искусств. Цель этого исследования состоит в том, чтобы составить карту существующей литературы, с тем чтобы дать углубленный обзор тел

AF1q inhibited T cell attachment to breast cancer cell by attenuating Intracellular Adhesion Molecule-1 expression.

China appears to consistently lag behind developed countries like the US, Japan, and the nations of Europe in the development of pharmaceuticals, putting China in an embarrassing situation. In fact, China is still dependent on foreign imports for most highly effective cures to major diseases such as cancer, diabetes, hepatitis, and neurodegenerative disease. There is no denying the fact that governmental support, and especially a signifi cant amount of fi nancial support and political assistance to include government restructuring, is needed for the establishment of new drug Research and Devel

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… Zatorre RJ Salimpoor VN From perception to pleasure: music and its neural substrates Proc Natl Acad Sci U S A 2013 110 Suppl 2 10430 10437 10.1073/pnas.1301228110 23754373 PMC3690607 49. …

The Role of Cannabinoids in Advancing Cancer Treatment: Insights from Evidence-Based Medicine.

Purpose of reviewThis document critically examines the role of cannabinoids in cancer care during an era marked by rapid advancements in oncology and changing perceptions on cannabis. It traces the historical context of cannabis in medicinal use, navigating its journey from widespread acceptance, subsequent criminalization, to its resurgence in modern therapeutic applications, particularly within the framework of Evidence-Based Medicine (EBM).Recent findingsAnchored in EBM principles, this study synthesizes current research from clinical trials, systematic reviews, and meta-analyses to evaluat

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… Cannabinoids and appetite: food craving and food pleasure. Int Rev Psychiatry. 2009;21(2):163–71. 10.1080/09540260902782810. 56. Lord S, Hardy J, Good P. Does Cannabidiol Have a Benefit as a Supportive Care Drug in Cancer? …

Supportive care interventions in hematopoietic stem cell transplantation: a systematic review and meta-analysis.

AbstractThere is no comprehensive synthesis of supportive care interventions for patients with hematologic malignancies receiving transplantation and cellular therapies (TCTs). This systematic review and meta-analysis aimed to characterize randomized controlled trials (RCTs) of TCT supportive care interventions and examine effects on patient-reported outcomes (PROs). We systematically searched MEDLINE, Embase, CINAHL, PsycInfo, Web of Science, and Cochrane Central Register of Controlled Trials. Risk of bias was assessed using Cochrane Risk of Bias 2.0. Findings were grouped by intervention and

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… El-Jawahri et al 181 (2025; United States); pilot RCT | ↓ Anxiety symptoms 8 wk after baseline | ↓ Depressive symptoms 8 wk after baseline | ↑ Overall QOL 8 wk after baseline | — | — | ↑ Satisfaction with sex, interest in sex, and orgasm pleasure 8 wk after baseline | A 5-module digital sexual health … intervention uptake. 171 Finally, a pilot trial of 8-week access to a 5-module digital sexual health intervention among HSCT survivors ≥3 months after HSCT with baseline sexual dysfunction showed feasibility and promising signals for improved sexual health (ie, satisfaction with sex, interest in sex, orgasm pleasure …

Экологическая оценка ежедневной деятельности лиц с неврологическими расстройствами: обзор.

Ежедневная деятельность определяет состояние здоровья и благополучие людей, отражая функционирование и состояние здоровья. Для людей с неврологическими расстройствами эта деятельность часто нарушается, что сказывается на автономности и качестве жизни. Традиционные оценки не учитывают тонкие колебания в режиме реального времени, в то время как экологическая временная оценка (ЕМА) охватывает деятельность < < момент-момент > > в естественном контексте, что позволяет глубже понять взаимосвязи между человеком, окружающей средой и профессиональной деятельностью. Несмотря на все более шир

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… discomfort | Not reported | Anxiety and depression | Not reported | Not reported | Self-care Broen et al [ 36 ] | Parkinson-related symptoms and somatic | Not reported | Mood | Contextual factors (location) | Contextual factors (social presence and comfort) | Event related: importance of the event, pleasure …

A geriatrician's approach to managing the complex older adult with obesity.

The prevalence of obesity in older adults is rapidly increasing due to the demographic shift occurring globally. Older adults with obesity face health care challenges due to multimorbidity, functional dependency, and disability. This population often has prior history of struggles through weight-loss attempts during the middle years of life. Therefore, weight-loss intervention needs a personalized approach, taking into consideration weight-loss attempts, relapse, and life events, including bariatric surgery, functional limitations, psychosocial status, and current residential environment. Raci

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… having little interest or pleasure in doing things? | Refer for further screening and treatment by primary care provider or psychiatry. SDOH | Housing, food insecurity, transportation | Referral to social worker. …

Psychometric Properties of the Depression Anxiety Stress Scales (DASS-42 and DASS-21) in Patients with Hematologic Malignancies.

Background/Objectives: Patients with hematologic malignancies undergo prolonged, intensive treatments involving frequent hospitalizations and experience debilitating side effects. Consequently, they are at increased risk of developing symptoms of depression, anxiety, and stress, which can undermine their quality of life. However, there is a scarcity of instruments validated for the simultaneous assessment of depression, anxiety, and stress within hematologic cancer populations. The aim of this study is to examine the construct validity, convergent and discriminant validity, and reliability of

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… For example, these changes were measured in the depression subscale with anhedonia (loss of interest or pleasure in daily activities) and inertia (feeling slowed down or lacking energy), which can also be related to anxiety and stress symptoms. …

Virtual Reality-Based Exercise Rehabilitation in Cancer-Related Dysfunctions: Scoping Review.

BackgroundVirtual reality-based exercise rehabilitation (VRER) is a promising intervention for patients with cancer-related dysfunctions (CRDs). However, studies focusing on VRER for CRDs are lacking, and the results are inconsistent.ObjectiveWe aimed to review the application of VRER in patients with CRDs.MethodsThis scoping review was conducted following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist framework. Publications were included from the time of database establishment to October 14, 2023. The databases were

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… Moreover, the virtual environment provided stimuli and pleasure, encouraging participants to be more active [ 68 - 70 ]. On the other hand, VR can directly affect exercise rehabilitation through interaction. …

Epigenome-wide association study of depression symptomatology in elderly monozygotic twins.

Depression is a severe and debilitating mental disorder diagnosed by evaluation of affective, cognitive and physical depression symptoms. Severity of these symptoms strongly impacts individual's quality of life and is influenced by a combination of genetic and environmental factors. One of the molecular mechanisms allowing for an interplay between these factors is DNA methylation, an epigenetic modification playing a pivotal role in regulation of brain functioning across lifespan. The aim of this study was to investigate if there are DNA methylation signatures associated with depression sympto

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… Introduction Depression is a multifactorial common psychiatric disorder diagnosed by evaluation of various depressive symptoms, such as low mood, loss of interest and pleasure, fatigue and loss of energy, decline in cognitive functioning, poor concentration, increase in anxiety, inappropriate guilt, …

Сексуальная дисфункция при расстройствах движения: распространенность, клинические особенности, связанные с этим факторы и управление.

Сексуальная дисфункция является распространенным, но недостаточно изученным симптомом немоторного расстройства движения. В то время как болезнь Паркинсона (PD) чаще всего исследуется, сексуальная дисфункция также отмечается в болезни Хантингтона, диспропорции и других расстройствах движения. Клинические представления являются разнородными и включают в себя сокращение желания, эректильную дисфункцию, эякуляционные и оргазмические расстройства, трудности с смазкой, диспаревинию и гиперсексуальность. В ДИ оценки распространенности заболеваний в различных исследованиях сильно различаются, главным

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… One notable outlier, a four-center Italian study using multiple validated instruments, found no significant differences in total sexual function scores between PD patients and non-Parkinsonian controls, though male patients did show significantly lower orgasm/pleasure domain scores [65] . …

An exploration of person-centred approach in end-of-life care policies in England and Japan.

BackgroundIncreasing evidence has suggested that a person-centred approach (PCA) is beneficial not only for improving care outcomes but also for mitigating the pressure on public health systems. However, policy implementation gaps have prevented the translation of this complex framework into useful practical, ethical and moral stances for end-of-life care (EOLC). This article aims to explore the meaning and implications of person-centredness in EOLC policy discourses.MethodsBy perceiving policy documents as a medium embodied with socio-political and cultural norms, we analysed how PCA in EOLC

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… It concerns various and often interrelated factors that are essential for addressing the ED needs of patients and their loved ones, including ‘life completion,’ ‘dying in a favourite place,’ ‘maintaining hope and pleasure,’ ‘not being a burden,’ ‘good relationship,’ ‘being respected as an individual, …

Creative Arts Therapy for Anxiety, Depression, and Quality of Life in Cancer Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

BackgroundCancer is a significant psychological burden for patients. Previous evidence syntheses suggest creative arts therapies (CATs) may improve psychological outcomes, but are limited by heterogeneity in intervention types, study designs, and outcomes, and the lack of a certainty of evidence assessment.AimsWe conducted a robust systematic review and meta-analysis of current randomized trial literature to explore the efficacy of CATs in improving anxiety, depression, and quality of life in cancer patients.MethodsWe searched PubMed, Embase, and PsycInfo databases for peer-reviewed randomized

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… likely due to music's ability to engage interconnected brain regions involved in emotion and reward processing, including the amygdala, hippocampus, nucleus accumbens, and prefrontal cortex; ultimately, this activation is thought to improve emotional regulation, reduce stress, and enhance feelings of pleasure …