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Construction and validation of a risk prediction model for perianal infection in patients with haematological malignancies during chemotherapy: a prospective study in a tertiary hospital in China.

ObjectivesPerianal infection is a serious complication in patients undergoing chemotherapy for haematological malignancies. Therefore, we aimed to develop a predictive model to help medical staff promptly screen patients at a high risk of perianal infection during chemotherapy.DesignThis was a single-centre prospective observational study.SettingThis study was conducted in a tertiary teaching hospital in Chengdu, China.ParticipantsThe study sample comprised 850 patients with haematological malignancies who underwent chemotherapy at the department of haematology or our hospital between January

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… In the morning and evening, sitz baths can also be performed with povidone-iodine diluent, metronidazole plus saline and traditional Chinese medicine preparations 24–26 to prevent the recurrence of the infection during the myelosuppression period. …

Oral Surgical Management of Bone and Soft Tissues in MRONJ Treatment: A Decisional Tree.

BACKGROUND: The aim of the present work was to analyze a 10-year retrospective series of surgically treated medication-related osteonecrosis of the jaws (MRONJ) cases, reporting the clinical outcome and success rate for each adopted procedure in order to draw a treatment algorithm that is able to standardize clinical decision making and maximize the success of oral surgical treatment of MRONJ. METHODS: Different surgical approaches were categorized taking into consideration two variables a) hard tissue management (defined as debridement, saucerization or marginal resective surgery of maxillar

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… As previously reported [ 10 ], according to our center’s clinical routine, after MRONJ diagnosis the patients are included in a 8–10-week outpatient-based medical treatment program which includes local antiseptic administration (chlorhexidine and povidone iodide) and targeted antibiotic therapy. …

A Standardized Method for Vertical Sleeve Gastrectomy Bariatric Surgery Investigations in Cancer.

Obesity is a global epidemic that has affected the lives of over 14% of adults worldwide and over a third of Americans. Obesity is associated with the increased risk of thirteen obesity-associated cancers and poor cancer outcomes. Bariatric surgery is the most effective method of sustained weight loss and has been steadily increasing in clinical use over the past 4 decades. Importantly, bariatric surgery is established to decrease cancer risk. Vertical sleeve gastrectomy (VSG) is currently the most common bariatric surgery procedure. To evaluate underlying mechanisms of bariatric associated ca

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… Consumables | Catalog Number | Notes Puritan 6” Sterile Standard Cotton Swab | 25-806-10pPC | *10 Pack ideal USP Type VII Gauze Sponges 2x2in | 2252 | Autoclaved Dermacea Non-Woven Sponge, 2 x 2 Inch Square | 441403 | Betadine solution (povidone-iodine solution USP, 10%) | NDC 67618-150-01 | Puralube … We recommend preparation with cotton tip applicators soaked in betadine antiseptic solution (Povidone-Iodine solution USP, 10%, (NDC67618-150-01, Purdue Products L.P., Stamford, CT) which sits for a minimum of 15 seconds prior to being wiped with an alcohol prep pad and repeating this process three times …

Dermatologic conditions in women receiving systemic cancer therapy.

As advances in cancer therapies have improved cancer-related survival, novel therapeutics have also introduced a variety of dermatologic toxicities, and an increased number of patients are living with these sequalae. Women with cancer in particular experience a spectrum of dermatologic conditions that affect their skin, hair, nail, and mucosal surfaces. Studies have shown that these toxic effects can significantly affect quality of life and alter a woman's self-image, cultural identity, femininity, sexuality, and mental health. In severe instances, dermatologic toxicities may even disrupt canc

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… Recently, an RCT showed a 2% povidone-iodine solution to be an effective treatment for chemotherapy-associated paronychia ( Capriotti et al., 2019 ). …

Topical antibiotics for treating bacterial keratitis: a network meta-analysis.

BACKGROUND: Infectious keratitis, commonly known as corneal infection, is a major cause of blindness, affecting approximately six million pe … alosporin monotherapy, penicillin monotherapy, dual therapy, triple therapy, and other monotherapy (povidone-iodine, honey, placebo), yielding 10 pair-wise comparisons. We judged 12 studies (54.5%) to be at high risk of bias and 10 studies (45.5%) to raise some concerns for bias. Based on the critical outcome (mean days to healing) analyzed by surface unde …

Malignant Pleural Effusion: Palliative Managements and Indication for Pleurodesis Based on Survival Scores.

Neoplastic pleural effusion is one in which malignant neoplastic cells are detected in the pleural fluid or in the parietal pleura. When secondary, it confirms disseminated neoplastic disease and suggests a reduced life expectancy and low quality of life. This review was described by a group of physician members of the Brazilian Society of Oncological Surgery regarding the treatment of neoplastic pleural effusion, developed to guide surgeons, palliative care physicians and clinical oncologists in their clinical practice to assess patients indicated for pleurodesis based on survival scores.

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… In the absence of talc, our alternative sclerosing agent is povidone–iodine (PVPI). Observational studies and small randomized trials report that PVPI achieved successful pleurodesis in 86%–96% of patients, with no significant difference in efficacy compared to talc [ 58 ]. …

Cementless, Cruciate-Retaining Primary Total Knee Arthroplasty Using Conventional Instrumentation: Technical Pearls and Intraoperative Considerations.

BACKGROUND: Total knee arthroplasty (TKA) is commonly indicated for patients with severe tibiofemoral osteoarthritis in whom nonoperative tr … , and the knee is extended. The joint space is then bathed in approximately 500 mL of sterile 0.35% povidone-iodine solution, followed by pulsatile lavage with 1 L of sterile isotonic sodium chloride solution without antibiotics. Stability is then tested again, testing the (7) checkpoints previously discussed. At this point, the only modification that can …

Связанный с лекарствами остеонекроз челюсти у нескольких пациентов миэломы: серия случаев.

Остеонекроз челюсти (MRONJ), связанный с лекарственными препаратами, является осложнением антирепрессивной и антиангиогенной терапии, используемой при лечении злокачественных заболеваний, и может вызывать значительную функциональную и эстетичную заболеваемость у пациентов. Множественная миелома (ММ) — гематологическая порча плазмы и клеток, часто связанная с остеолитической болезнью костей. Антирезорптивная терапия (АРТ) уменьшает связанные со скелетом явления в MM и других магнатах с участием скелета, но связана с повышенным риском заболевания MRONJ. В настоящем документе представлены клиниче

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… During the debridement, irrigation was performed with 0.2% chlorhexidine, povidone-iodine (1:10 saline dilution) and saline. Primary closure was achieved with 3-0 Vicryl-Rapide sutures and a Whitehead's varnish pack was secured with 3-0 silk. …

Nephrology in Veterinary Medicine.

Veterinary nephrology is a specialized field of veterinary medicine providing a high level of care for animals with all types of kidney disease. Veterinarians complete extensive training to become board-certified in veterinary nephrology-urology. Companion animal nephrology is the most advanced field; however, all species are afflicted by a variety of renal disorders. Most naturally occurring animal kidney diseases have similar disorders found in people; where veterinary research is lacking, clinical management is often modified from standard of care in people. Veterinarians have become adept

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… Povidone iodine sclerotherapy for treatment of idiopathic renal hematuria in two dogs. J Am Vet Med Assoc. 2017;250(2):205–210. doi: 10.2460/javma.250.2.205 91. Block G, Adams LG, Widmer WR, Lingeman JE. …

Study of a novel Ca/P/S-based cement implanted in the osteoporotic goat spine and its clinical application in preventing adjacent vertebral fractures.

Osteoporotic vertebral compression fracture (OVCF) has been increasing over the last decades. In addition to primary OVCF, the adjacent vertebral fracture (AVF) is a frequent serious complication in OVCF patients receiving percutaneous vertebroplasty or kyphoplasty, resulting in poor long-term outcome and recurrent symptoms. The aim of the present study is to investigate the bone regeneration behavior of a novel Ca/P/S-based resorbable cement (Ezechbone® Cement CBC-400) implanted into surgically created vertebral defects of ovariectomized (OVX) goats. Furthermore, the present study provides a

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… After shaving and cleaning with 70% v/v ethanol and Betadine® (povidone iodine 10% w/v), a longitudinal, midline incision was made in the dorsal skin over the lumbar vertebra between L1 and L3. The left paraspinal muscles were elevated and retracted using a Taylor retractor. …

Vascular Access Devices for Stem Cell Transplantation: A Review of Catheter Types-A Crucial Step Towards the Enhancement of Patient Care.

Central venous access devices (CVADs) play a pivotal role in managing stem cell recipients, providing reliable access for the administration of chemotherapy, blood products, progenitor infusion, parenteral nutrition, and other crucial treatments. This review critically evaluates the various types of CVADs commonly employed in transplant settings, examining their indications, complications, and best practices to enhance patient outcomes. Moreover, it emphasizes the significance of broadening the selection algorithm for vascular devices and incorporating patient expectations and comfort into rou

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… IJV/SCV (matched analysis) | CRBSI | 5.7 vs. 14.2/1000 cath-days; no significant difference short-term | Indirect (oncology) | Hentrich et al. 2023 [ 35 ] Antimicrobial strategies | CHG-alcohol vs. povidone-iodine; antimicrobial/silver-coated CVCs | CLABSI/CRBSI | RR 0.51 (95% CI 0.27–0.97) for CHG vs …

Parenteral Ozone Therapy Combined with Topical Antimicrobials Enhances Tissue Repair in Mandibular Osteonecrosis of Elderly Female Rats.

Medication-related osteonecrosis of the jaws (MRONJ) remains a challenging complication associated with antiresorptive therapy, highlighting the need for effective adjunctive preventive strategies. This study evaluated the effects of systemic ozone therapy, alone or combined with topical 10% metronidazole paste or 2% chlorhexidine gel, on alveolar repair in a zoledronate-induced rat model of MRONJ. Forty-two ovariectomized female Wistar rats were allocated into seven experimental groups. Following mandibular first molar extraction, animals received systemic ozone therapy and/or topical antimic

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… After oral antisepsis with 10% povidone–iodine, syndesmotomy and tooth extraction were performed using instruments adapted for rats. All animals underwent the same procedure ( Figure 1 ). Figure 1 Schematic representation of the experimental design. 2.3.1. …

Abstracts for NAPCON 2025

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A Novel Intravesical Dextrose Injection Improves Lower Urinary Tract Symptoms on Interstitial Cystitis/Bladder Pain Syndrome.

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a painful recurrent condition characterized by the discomfort of the bladder, and current treatment options have limited effectiveness. Prolotherapy is a well-known treatment that involves the injection of non-biologic solutions to reduce pain and/or promote proliferation of soft tissue, and dextrose is the most common injectate. This study investigated the effects of dextrose prolotherapy in a rat model of IC/BPS and patients with IC/BPS. We used cyclophosphamide to induce IC/BPS in rats, and intravesical instillation of 10% dextrose sol

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… The urethral opening area was then disinfected with 10% povidone-iodine. Further, a polyethylene catheter (Polyethylene Tubing 50, PE50, BD, USA) was subsequently clamped with sterile instruments for urethral intubation. …

Tips and Tricks and Clinical Outcome of Cryopreserved Human Amniotic Membrane Application for the Management of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Pilot Study.

Medication-related osteonecrosis of the jaw (MRONJ) is a complication of certain pharmacological treatments such as bisphosphonates, denosumab, and angiogenesis inhibitors. There are currently no guidelines on its management, particularly in advanced stages. The human amniotic membrane (hAM) has low immunogenicity and exerts anti-inflammatory, antifibrotic, antimicrobial, antiviral, and analgesic effects. It is a source of stem cells and growth factors promoting tissue regeneration. hAM acts as an anatomical barrier with suitable mechanical properties (permeability, stability, elasticity, flex

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… After intra- and extraoral disinfection with Povidone-iodine, local injections without vasoconstrictors were made around the MRONJ sites. …

Navigating Stomatologic Complications Secondary to Antineoplastic Agents-A Comprehensive Review.

This review systematically examines the oral complications associated with conventional and novel anti-cancer therapies. It highlights that while molecularly targeted agents including monoclonal antibodies targeting the vascular endothelial growth factor and its receptor, the epidermal growth factor receptor, tyrosine kinase inhibitors, and immune checkpoint inhibitors tend to exhibit a lower overall toxicity profile compared to traditional cytotoxic chemotherapeutics, they are nonetheless linked to significant oral adverse events. These complications encompass inflammatory mucosal reactions k

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… Evidence suggests that rinsing with sterile water or physiologic saline is more effective than chlorhexidine, and povidone-iodine rinses have been shown to reduce OM severity [ 105 ]. Anti-inflammatory agents, such as benzydamine, are employed for both prevention and treatment. …

The 20th Anniversary of Pegaptanib (MacugenTM), the First Approved Aptamer Medicine: History, Recent Advances and Future Prospects of Aptamers in Therapy.

In addition to classic small-molecule drugs and modern protein-based biologics, an intriguing class of medicines is the therapeutic oligonucleotides. Most approved drugs in this category are antisense oligomers or those acting via RNA interference, both of which use base hybridization. Aptamers, also known as chemical antibodies form a smaller, yet equally interesting group of oligonucleotides that can recognize a wide range of molecular targets. Despite their high potential, only two aptamers have been approved to date, pegaptanib (MacugenTM) and avacincaptad pegol (IzervayTM), both for the t

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… In a study where povidone-iodine irrigation was used pre- and post-injection among 15,144 administered injections (548 of which were pegaptanib), no cases of endophthalmitis were detected [ 168 ]. …

Research progress on the anti-cancer mechanisms of edible salty-flavored Chinese materia medica.

Edible salty-flavored Chinese materia medica (ESCM) refers to a category of traditional Chinese medicine (TCM) that also serve as food, characterized by their salty flavor. According to the TCM theory, ESCM can soften and disperse knots, thus potentially offering benefits for cancer prevention and treatment. With cancer remaining a major global health challenge, its primary prevention strategies, especially through dietary modification, are crucial. ESCM have recently garnered substantial attention, due to their remarkable clinical efficacy and low side-effect profile. Researches on ESCM demon

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… Quinquefolii Radix extract, Dextrin, Stevia sugar | G20230352 Xinzhu Nutritional Brand Di Huang Xuan Shen Tablets | Rehmanniae Radix, Scrophulariae Radix, Fritillariae Thunbergii Bulbus, Moutan Cortex, Menthae Haplocalycis Herba, Ophiopogonis Radix, Glycyrrhizae Radix Et Rhizoma, White granulated sugar, Povidone …

Porokeratoses-A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants.

Porokeratosis is a heterogeneous group of keratinising disorders characterised by the presence of particular microscopic structural changes, namely the presence of the cornoid lamella. This structure develops as a consequence of a defective isoprenoid pathway, critical for cholesterol synthesis. Commonly recognised variants include disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis of Mibelli, palmoplantar porokeratosis (including porokeratosis palmaris et plantaris disseminata and punctate porokeratosis), linear porokeratosis, verrucous porok

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… Small papules of DSAP slowly progress into keratotic plaques characterised by a keratotic rim, which might be enhanced using exogenous pigmenting agents, such as povidone–iodine [ 20 ], fake tan lotion [ 21 ], gentian violet [ 22 , 23 ] but also permanent marker or ink. …

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