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Autologous stem cell transplantation improves quality of life in economically challenged, Brazilian multiple myeloma patients.

OBJECTIVES: 1) To characterize the impact of multiple myeloma on the quality of life of patients treated in two public institutions in São Paulo State, Brazil, using a generic Short Form 36 Health Survey and a questionnaire specific for oncologic patients (QLQ-C30) upon diagnosis, after the clinical treatment, and at day +100 after autologous stem cell transplantation; 2) to evaluate whether autologous stem cell transplantation can improve the quality of life of our economically challenged population aside from providing a clinical benefit and disease control. METHODS: We evaluated 49 patient

Treatment Outcomes of Multiple Myeloma in Developing Countries: A Systematic Review and Meta-Analysis.

Multiple myeloma (MM) treatment outcomes in developing countries may be impacted by resource constraints. This systematic review and meta-analysis evaluated efficacy outcomes of MM treatments across developing regions. Comprehensive searches in five major databases identified 37 eligible studies from Asia, Africa, Latin America, and Eastern Europe. The Newcastle-Ottawa Scale was used to assess risk of bias. Newer novel agents including daratumumab, carfilzomib, and pomalidomide showed limited use across studies. For patients receiving autologous stem cell transplantation (ASCT), the pooled ove

Submarines, spacecraft and exhaled breath.

Foreword The International Association of Breath Research (IABR) meetings are an eclectic gathering of researchers in the medical, environme … ed environment of a submarine or the ISS can build up contaminants from consumer products, cooking, refrigeration, accidental fires, propulsion and atmosphere maintenance. However, the most immediate concern is sustaining human metabolism: removing exhaled CO(2) and replacing metabolized O(2). Another important concern is a suite of products from chemical react …

Листерия моноцитогены и ауреат ауреуса Staphylococus у пациента с множественной миеломой: отчет по делу.

ВВЕДЕНИЕ: Listeria monocitogenes представляет собой грозный патоген, который представляет собой значительную угрозу для иммунокомпромизации и может вызвать редкие нетипичные формы заболевания, особенно осложненные при кондиционировании Staphylococcus aureus. КАСЕ: Мы представляем случай пациента с моноцитогенесом менингоэнцефалитом, эндокардитом, сепсисом и С. ауреусом остеомиелитом, высветив сложность лечения распространяемой полимикробной инфекции. A 64-year-old Женщина с множественной миеломой лечится химиотерапией с температурой, изменившимся психическим состоянием, тошнотой и диареей в от

Developing high-concentration monoclonal antibody formulations for subcutaneous administration to improve patient treatment.

The transition of immunotherapy administration from intravenous infusion to subcutaneous (SC) administration of monoclonal antibody formulations for oncology patients has garnered significant interest. SC administration offers multiple benefits, including potential for at-home administration, enhanced patient compliance, reduced hospital congestion, lowered health care costs, and improved sustainability by reducing drug wastage and minimizing environmental impact. However, for many biologics, the shift to SC administration requires the development of high-concentration monoclonal antibody prod

Структура и состав микробных сообществ в водной толще Южного залива Мексики и обнаружение предполагаемых микроорганизмов, деградирующих углеводороды.

В ходе этого исследования была проведена оценка сообщества бактериопланктонов и его связи с экологическими переменными, включая общую концентрацию нефтяных углеводородов (ТПГ), в районе шельфа Юкатан в Южном заливе Мексики. Анализ разнообразия бета на основе последовательности 16S rRNA показал различия в структуре общины бактериопланктона между участками отбора проб. ПЕРМАНОВА указала, что эти изменения могут быть связаны главным образом с глубокими изменениями (см.5 в адрес 180 m), концентрация растворенного кислорода (2.06 в адрес 5.93 мг L-1), и концентрация хлорофилла (0.184 в адрес 7.65 м

"Detection of sedative and antipsychotic in exhumed institutionalized patients: a forensic toxicological case series".

Post-mortem toxicological analysis in exhumed bodies presents considerable methodological and interpretative difficulties. These limitations become particularly relevant in judicial contexts involving elderly individuals in long-term care, where pharmacological regimens may be deliberately omitted from medical records. This study investigates a series of 15 exhumed cases in which the detection of sedative and antipsychotic drugs, particularly Midazolam and Promazine, raised concerns of potentially unauthorized or inappropriate administration. All cases underwent full forensic autopsy, includin

Summary of the National Advisory Committee on Immunization (NACI) Statement: Updated recommendations on herpes zoster vaccination for adults who are immunocompromised.

BACKGROUND: Herpes zoster (HZ), or shingles, results from the reactivation of latent varicella-zoster virus and poses a significant health burden and immunocompromised adults are at higher risk of HZ and its complications. In 2018, the recombinant zoster vaccine (RZV, Shingrix®) was strongly recommended by the National Advisory Committee on Immunization (NACI) for immunocompetent adults aged 50 years and older. Since then, evidence has accumulated on the use of RZV in immunocompromised adults and in 2021, Health Canada expanded the authorization of RZV to adults 18 years of age and older who a

Reflections on the applicability of palliative thoracentesis in Primary Care.

Under normal conditions, there is a small volume of fluid in the pleural space as a result of the balance between its inflow from the pleural capillaries and its drainage through the lymphatics. Pleural effusion (PE) will occur when this balance is disturbed. The initial step in its study is to determine whether PE it is a transudate or an exudate. The first is caused by an alteration in the hydrostatic or oncotic pressure of both the pleural capillaries and the pleural space, without any structural damage to the pleura and with a simple differential diagnosis. In the second, there will be an

Retrospective Analysis of Clinicopathological Characteristics of Lacrimal Gland Pleomorphic Adenoma and Mechanism of Tumorigenesis by the Imbalance Between Apoptosis and Proliferation.

BACKGROUND Lacrimal gland pleomorphic adenoma (LGPA) is the most common clinically benign epithelial tumor of the lacrimal gland and is predominantly comprised of epithelial cells and interstitial components. At present, the exact pathogenesis of LGPA remains unclear. Previous research has indicated that the occurrence of LGPA may be related to excessive cell proliferation. MATERIAL AND METHODS This study observed the clinicopathological characteristics of LGPA and investigated the tumorigenesis mechanism of cell over-proliferation caused by the imbalance between apoptosis and proliferation. A

Целая Боди Криотерапия воздействует на уровень D витамина крови у людей с множественным склерозом.

Цель этого исследования заключалась в изучении и оценке воздействия серии из 20 методов криотерапии на уровень витамина D в крови женщин с множественным склерозом и здоровыми женщинами. Методы: Это исследование проводилось с участием трех групп участников. Экспериментальная группа состояла из 15 женщин в возрасте от 34 до 55 лет, у которых был диагностирован множественный склероз (МС), которые прошли криотерапию всего тела. Первая контрольная группа состояла из 20 женщин с РС, которые не проходили криотерапию. Вторая контрольная группа состояла из 15 женщин в возрасте от 30 до 49 лет, которые

Randomized double-blind clinical trial of a new human epoetin versus a commercially available formula for anemia control in patients on hemodialysis.

ObjectivesAnemia is a common complication among chronic kidney disease patients on hemodialysis, occurring mostly due to erythropoietin deficiency. This randomized noninferiority trial sought to compare the efficacy and safety of a new epoetin formulation developed by Bio-Manguinhos, a biologics manufacturer affiliated with the Brazilian government, with those of a commercially available product currently used in Brazil (a biosimilar epoetin formulation).MethodsThe sample size needed to enable demonstration of noninferiority with a statistical power of 85% for a between-group difference in hem

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… During the shift immediately preceding scheduled epoetin administration, the study pharmacists labeled and preloaded syringes with the appropriate epoetin dose for each patient, which were then stored in an appropriate container under refrigeration. …

Metabolic Insights From Composition-Based Analysis of Kidney Stones: A Retrospective Study of 506 Patients.

BACKGROUND: Kidney stone disease is a highly prevalent condition with increasing global incidence and recurrence. The stone composition reflects underlying metabolic and biochemical alterations, and its evaluation may provide clinically relevant information for effective management. AIM: To evaluate the distribution of stone composition in a large surgical cohort and explore its association with routinely assessed metabolic parameters and recurrence patterns. METHODS: This retrospective single-center study included 506 adult patients who underwent surgical stone removal between 2018 and 2024

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… Urine was collected and stored under refrigeration at 4°C and promptly transported to the central laboratory. Spot urine pH was measured upon arrival, and the mean pH was recorded. …

Analysis of the Mortality Trends of 23 Major Cancers in the Indian Population Between 2000 and 2019: A Joinpoint Regression Analysis.

PurposeCancer mortality trends have not been documented across the population of India. We, therefore, analyzed the overall and individual cancer mortality trends for 23 major cancers between 2000 and 2019 on the basis of Global Health Observatory (GHO) database.Materials and methodsThis study examined cancer mortality trends for 23 major cancer sites on the basis of 12.85 million cancer deaths obtained from the GHO of the WHO between 2000 and 2019. A joinpoint regression model was used to analyze the long-term trends of cancer mortality. Annual percentage change (APC) and average APC were est

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… This may be due to lifestyle changes, increase in the consumption of fruits, reduced use of salt-preserved foods, increased use of refrigeration, and reduced tobacco consumption. 9 , 13 , 14 Furthermore, we observed that cancers of the breast, thyroid, and gallbladder had a higher mortality rate in …

Effects of CAR-T Cell Therapy on Immune Cells and Related Toxic Side Effect Analysis in Patients with Refractory Acute Lymphoblastic Leukemia.

OBJECTIVE: To observe the effects of chimeric antigen receptor T (CAR-T) cell immunotherapy on immune cells and related toxic side effects in patients with refractory acute lymphoblastic leukemia (ALL). METHODS: A retrospective study was conducted in 35 patients with refractory ALL. The patients were treated with CAR-T cell therapy in our hospital from January 2020 to January 2021. The efficacy was evaluated at one and three months post treatments. The venous blood of the patients was collected before treatment, 1 month after treatment, and 3 months after treatment. The percentage of regulato

Developing a pan-cancer research autopsy programme.

AimsRapid procurement of a wide variety of metastatic and primary cancers and normal tissues after death through rapid autopsy opens largely unexplored avenues in cancer research. We describe a high-volume rapid research autopsy programme at a large academic medical centre.MethodsAdvanced-stage cancer patients, most commonly inpatients in palliative care facilities, were approached to participate in a cancer research autopsy programme with the goal of acquiring multidimensionally annotated tissue for cancer research. On death of an enrolled patient, a predetermined notification plan was enacte

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… While the time between death and refrigeration of the body was not captured routinely in our current study, inclusion of this parameter would be a valuable future addition. Figure 5 (A) Bar chart showing the ordered time intervals (in hours) between death and start of the research autopsy (n=105). …

History and Development of Autologous Stem Cell Transplantation for Acute Myeloid Leukemia.

This review describes the development of cryopreservation, the birth of autologous stem cell transplantation (ASCT) and its past and present use to consolidate adult patients with acute myelogenous leukemia (AML). It summarizes the first autografts in patients in relapse, the experience of autografting in complete remission (CR), using bone marrow unpurged or purged in vitro with cyclophosphamide-derivatives, and the important shift to peripheral blood stem cells. The review also discusses the results of recent studies in favor of the use of ASCT to consolidate good- and intermediate-risk pati

Факторы риска и результаты новой инфекции моноцитогенов листерии в Пакистане: понимание из больницы третичной медицинской помощи.

Listeria monocitogenes — грэм-положительный стержень, ответственный за листериоз. Она стала одним из основных патогенов, передающихся через пищевые продукты, и была причастна к многочисленным вспышкам во всем мире, часто встречающимся с бактерией, и может привести к серьезным проявлениям, таким, как менингоэнцефалит, особенно у лиц с иммунокомпромиссом и у пожилых людей. Инфекция материнства связана с худшими последствиями беременности. Цель этого исследования заключается в оценке факторов риска, клинических особенностей и результатов лечения пациентов, инфицированных моноцитогенами Листерии,

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… Monocytogenes is capable of persisting under adverse conditions, including low moisture, refrigeration temperatures, and high-salt environments, which pose significant challenges for its control in food systems.[ 3 ] Due to its prolonged incubation period, prompt diagnosis is difficult. …

Cryoglobulinemia Associated With Multiple Myeloma in a Dog Presenting With Epistaxis and Skin Lesions.

A 10-year-old female neutered Labrador Retriever presented with epistaxis, discoloration and crusting of the nose and a necrotic lesion on the lip. Bloodwork revealed pancytopenia, azotemia, hypoalbuminemia and hyperglobulinemia. Aggregates of amorphous basophilic material were seen in a room-temperature blood smear which were not present in the sample after warming to 37°C, and grossly a cryoprecipitate was noted in the patient's serum at 4°C. This was interpreted as cryoglobulin. Computed tomography showed multiple heterogeneous lesions in the spleen. Cytology of the splenic lesions revealed

IGF-1 defends against chronic-stress induced depression in rat models of chronic unpredictable mild stress through the PI3K/Akt/FoxO3a pathway.

This study aims to investigate the role of IGF-1 in chronic-stress induced depression through the PI3K/Akt/FoxO3a pathway. A rat model of chronic unpredictable mild stress (CUMS) was established. In total, 48 rats were randomized into control (normal rats), CUMS (CUMS modeled rats) and CUMS + IGF-1 (injection of IGF-1 before CUMS modeling) groups. Body weight, horizontal (number of horizontal crossing) and vertical activity (rearing times), and sucrose consumption were identified one day before and after the open-field test. The mRNA and protein expression of PI3K, Akt, FoxO3a and Bim in the h