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Study of Liposomes Containing Extract from the Leaves of Protium heptaphyllum (Aubl.) March in Animals Submitted to a Mutagenic Model Induced by Cyclophosphamide.

Cyclophosphamide (CPA) is an alkylating agent used as a chemotherapy agent in the treatment of cancer, but it has immunosuppressive effects. Protium heptaphyllum (P. heptaphyllum) is a plant rich in triterpenes and flavonoids, with some bioactive and therapeutic properties presented in the literature. Thus, the present study aimed to investigate the chemoprotective potential of P. heptaphyllum extract inserted into liposomes against oxidative damage chemically induced by CPA. Male Swiss mice received 1.5 mg/kg of P. heptaphyllum liposomes as a pre-treatment for 14 consecutive days (via gavage)

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… Contrary to our findings, studies with Solanum scabrum and Cola verticillata extracts, plants rich in flavonoids, demonstrated a decrease in renal GPx activity in rats exposed to CPA (100 mg/kg) [ 66 ]. … Protective effect of hydroethanolic extracts of Solanum scabrum and Cola verticillata against cyclophosphamide induced toxicity in female rats. J. Food Res. 2014;3:18–30. doi: 10.5539/jfr.v3n3p18. 67. Akomolafe S.F., Olasehinde T.A., Oyeleye S.I., Aluko T.B., Adewale O.O., Ijomone O.M. …

Role of phytoconstituents in the management of COVID-19.

BackgroundCOVID-19, a severe global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged as one of the most threatening transmissible disease. As a great threat to global public health, the development of treatment options has become vital, and a rush to find a cure has mobilized researchers globally from all areas.Scope and approachThis review focuses on deciphering the potential of different secondary metabolites from medicinal plants as therapeutic options either as inhibitors of therapeutic targets of SARS-CoV-2 or as blockers of viral particles entry

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… hACE-2 [ 55 ] Iso-gemichalcone Image 128 binds with TMPRSS2 [ 174 ] Lactones Limonin Image 129 Nigella sativa binds with NSP16 [ 35 ] Durumolide K Image 130 binds with TMPRSS2 [ 174 ] Fatty acids Dihomo-gamma-linolenic acid Image 131 Chinese medicinal plant 3CLpro [ 11 ] Phthalates Solvanol Image 132 Solanum … 128 | | binds with TMPRSS2 | [ 174 ] Lactones Limonin | Image 129 | Nigella sativa | binds with NSP16 | [ 35 ] Durumolide K | Image 130 | | binds with TMPRSS2 | [ 174 ] Fatty acids Dihomo-gamma-linolenic acid | Image 131 | Chinese medicinal plant | 3CLpro | [ 11 ] Phthalates Solvanol | Image 132 | Solanum …

The Most Competent Plant-Derived Natural Products for Targeting Apoptosis in Cancer Therapy.

Cancer is a challenging problem for the global health community, and its increasing burden necessitates seeking novel and alternative therapies. Most cancers share six basic characteristics known as "cancer hallmarks", including uncontrolled proliferation, refractoriness to proliferation blockers, escaping apoptosis, unlimited proliferation, enhanced angiogenesis, and metastatic spread. Apoptosis, as one of the best-known programmed cell death processes, is generally promoted through two signaling pathways, including the intrinsic and extrinsic cascades. These pathways comprise several compone

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… Chloroform extract prepared from the whole plant of Solanum lyratum (known as nightshades) has been shown to stimulate both extrinsic and intrinsic pathways of apoptosis in three human oral cancer cell lines (HSC-3, SAS, and CAL-27 cells). … Chloroform Extract of Solanum lyratum Induced G0/G1 Arrest via p21/p16 and Induced Apoptosis via Reactive Oxygen Species, Caspases and Mitochondrial Pathways in Human Oral Cancer Cell Lines. Am. J. Chin. Med. 2015;43:1453–1469. doi: 10.1142/S0192415X15500822. 66. …

The Mediterranean Diet, a Rich Source of Angiopreventive Compounds in Cancer.

Diet-based chemoprevention of cancer has emerged as an interesting approach to evade the disease or even target its early phases, reducing its incidence or slowing down tumor progression. In its basis in the essential role of angiogenesis for tumor growth and metastasis, angioprevention proposes the use of inhibitors of angiogenesis in cancer prevention. The anti-angiogenic potential exhibited by many natural compounds contained in many Mediterranean diet constituents makes this dietary pattern especially interesting as a source of chemopreventive agents, defined within the angioprevention str

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… Tomatoes As a consequence of Christopher Columbus’s voyages, novel foods from the New World were incorporated into the MD, including tomatoes ( Solanum lycopersicum ). … Tomato (Solanum lycopersicum) Carotenoids and Lycopenes Chemistry; Metabolism, Absorption, Nutrition, and Allied Health Claims—A Comprehensive Review. Crit. Rev. Food Sci. Nutr. 2015;55:919–929. doi: 10.1080/10408398.2012.657809. 141. Hwang E.S., Bowen P.E. …

Adjuvant Properties of Caffeic Acid in Cancer Treatment.

Caffeic acid (CA) is a polyphenol belonging to the phenylpropanoid family, commonly found in plants and vegetables. It was first identified by Hlasiwetz in 1867 as a breakdown product of caffetannic acid. CA is biosynthesized from the amino acids tyrosine or phenylalanine through specific enzyme-catalyzed reactions. Extensive research since its discovery has revealed various health benefits associated with CA, including its antioxidant, anti-inflammatory, and anticancer properties. These effects are attributed to its ability to modulate several pathways, such as inhibiting NFkB, STAT3, and ERK

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… angulata (Poppers) | 120 | [ 35 ] | Perilla frutescens (Purple mint) | 1890 870 | [ 35 ] [ 40 ] Physalis peruviana (Goldenberry) | 860 | [ 35 ] | Melissa officinalis (Lemon balm) | 26.8 1740 | [ 35 ] [ 28 ] Satureja hortensis (Summer savory) | 248 | [ 41 ] | Mentha arvensis (Pudina) | 1080 | [ 35 ] Solanum … Phenolic acid contents in fruits of aubergine (Solanum melongena L.) Pol. J. Food Nutr. Sci. 2005;14:37–41. 43. Meinhart A.D., Damin F.M., Caldeirão L., de Jesus Filho M., da Silva L.C., da Silva Constant L., Filho J.T., Wagner R., Godoy H.T. …

Venetoclax Induces Cardiotoxicity through Modulation of Oxidative-Stress-Mediated Cardiac Inflammation and Apoptosis via NF-κB and BCL-2 Pathway.

Cardiovascular damage induced by anticancer therapy has become the main health problem after tumor elimination. Venetoclax (VTX) is a promising novel agent that has been proven to have a high efficacy in multiple hematological diseases, especially acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL). Considering its mechanism of action, the possibility that VTX may cause cardiotoxicity cannot be ruled out. Therefore, this study was designed to investigate the toxic effect of VTX on the heart. Male Sprague-Dawley rats were randomly divided into three groups: control, low-dose VTX

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… Protective effect of Solanum torvum on doxorubicin-induced nephrotoxicity in rats Food Chem. Toxicol. 2010 48 436 440 10.1016/j.fct.2009.10.042 19883716 43. Debrincat M. Pleines I. Lebois M. Lane R.M. Holmes M.L. Corbin J. Vandenberg C.J. Alexander W.S. Ng A.P. Strasser A. …

Polyphyllin I Inhibits the Metastasis of Cervical Cancer Through the Regulation of the β-Catenin Signaling Pathway.

Cervical cancer ranks as the fourth most prevalent cancer and cause of cancer-related mortality among women globally. It exhibits a recurrence/metastasis rate of approximately 30% and a dismal 5-year survival of only 17% in metastatic cases. Despite significant advancements in surgical techniques, chemoradiotherapy, and targeted therapies, effective treatment options for metastatic cervical cancer remain limited. This study explored Polyphyllin I (PPI), which is a monomeric compound derived from the Rhizoma of Paris Polyphyllin, as a potential inhibitor of cervical cancer metastasis. Mechanist

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… Traditional Chinese medicines (TCMs) like Rhizoma Paridis, toad venom, Prunella vulgaris, and Solanum nigrum are increasingly utilized in anticancer therapy [ 18 ]. …

Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination.

Vitamin C (L-ascorbic acid) has been known as an antioxidant for most people. However, its physiological role is much larger and encompasses very different processes ranging from facilitation of iron absorption through involvement in hormones and carnitine synthesis for important roles in epigenetic processes. Contrarily, high doses act as a pro-oxidant than an anti-oxidant. This may also be the reason why plasma levels are meticulously regulated on the level of absorption and excretion in the kidney. Interestingly, most cells contain vitamin C in millimolar concentrations, which is much highe

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… . | Solanaceae | Pepper | 107–154 a | [ 27 ] Solanum tuberosum L. | Solanaceae | Potato | 8–30 a | [ 11 , 29 ] Solanum lycopersicum L. | Solanaceae | Tomato | 9–17 a | [ 47 , 48 ] Fermented vegetable | | | | Brassica oleracea var. capitata (L.)Alef. | Brassicaceae | Sauerkraut | 103–277 b | [ 28 …

Устранение неврологических расстройств путем борьбы с нейродегенеративными ассоциированными ферментами: естественные и синтетические молекулы.

Неврологические расстройства, включая нейродегенеративные и нейро-воспалительные заболевания, создают значительные проблемы в области здравоохранения и клинических проблем. Недавние исследования показали, что различные ферменты играют ключевую роль в наступлении и развитии этих расстройств. В этом обзоре изучается терапевтический потенциал адресации этих ферментов естественными и синтетическими молекулами. К таким заболеваниям, как болезнь Альцгеймера, болезнь Паркинсона и множественный склероз, причастны основные ферменты, включая ацетилхолинестеразу, оксидазу моноамина, бета-секретазу, тау к

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… Intranasal administration of Solanum tuberosum lectin-coupled polyethylene glycol (PEG-PLGA) nanoparticles has the potential to effectively boost the direct transport of bFGF into the rat brain, while simultaneously reducing the number of peripheral adverse effects [ 231 ]. …

A Narrative Review on the Antitumoral Effects of Selected Mediterranean Plant Products from Southern Italy.

Natural products are a valuable source of bioactive compounds with established roles in oncology. Their structural diversity and ability to target multiple cancer-related pathways make them promising candidates for anticancer drug development. Increasing preclinical and clinical data highlight their potential not only to exert direct antitumor effects but also to enhance patient tolerance to conventional therapies by reducing side effects and improving treatment adherence. The Mediterranean region, known for its biodiversity and traditional dietary habits, provides a rich array of natural comp

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… Interestingly, core plant-based foods integral to the MD, including Olea europaea (olive), Allium sativum (garlic), Allium cepa (onion), Vitis vinifera (grapes), Citrus (oranges, bergamot, lemon), Solanum lycopersicum (tomato), Capsicum annuum (pepper), and herbs such as Origanum vulgare (oregano) and …

Exploration of the Use of Natural Compounds in Combination with Chemotherapy Drugs for Tumor Treatment.

Currently, chemotherapy is the main treatment for tumors, but there are still problems such as unsatisfactory chemotherapy results, susceptibility to drug resistance, and serious adverse effects. Natural compounds have numerous pharmacological activities which are important sources of drug discovery for tumor treatment. The combination of chemotherapeutic drugs and natural compounds is gradually becoming an important strategy and development direction for tumor treatment. In this paper, we described the role of natural compounds in combination with chemotherapeutic drugs in synergizing, reduci

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… Solamargine is a steroidal alkaloid from the traditional Chinese herb Solanum nigrum L., with anti-inflammatory and antitumor biological activities [ 27 ]. …

Plant Antimicrobial Peptides as Potential Tool for Topic Treatment of Hidradenitis Suppurativa.

Among chronic skin autoinflammatory diseases, Hidradenitis Suppurativa (HS) stands out for its chronicity, highly variable condition, and profound impact on the patients' quality of life. HS is characterized by suppurative skin lesions in diverse body areas, including deep-seated painful nodules, abscesses, draining sinus, and bridged scars, among others, with typical topography. To date, HS is considered a refractory disease and medical treatments aim to reduce the incidence, the infection, and the pain of the lesions. For this purpose, different classes of drugs, including anti-inflammatory

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… . | 6C = C1–C9, C2–C7, C3–C4, C5–C11, C6–C12, C8–C10 | Q948Z4 | Snakin-1 | Solanum tuberosum | 9,664 | 88 | 29–88 | α -helix | Cyclotide | Antimicrobial and protease inhibitor activities Probably target: plasma membrane and trypsin. | 3C = C1–C4, C2–C5, C3–C6 | P84522 | Leaf cyclotide 1 | Viola hederacea …

Всеобъемлющая оценка взаимодействия капсикум генотипа-окружающей среды с использованием моделей Biplot AMMI и GПЭ в различных поэтапных средах трансплантации.

Генотип х взаимодействие с окружающей средой (ГЭИ) создает серьезную проблему для выявления стабильных, высокоурожайных капсикум генотипов при неоднородных агроклиматических условиях. В настоящем исследовании дается оценка 96 Генотипы различных капсикум (Capsicum annuum L.) four поэтапная трансплантация среды в течение 2022 и 2023 в северо-западных Гималаях для разборки ГЭИ в целях получения фруктовой урожайности и ее составных характеристик. Совокупный анализ разницы показал, что она весьма значительна (p) ≤ 0.01) воздействие генотипа, окружающей среды и ГЭИ на все признаки, что свидетельству

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… Study on genetic variability and heritability in cherry tomato ( Solanum lycopersicum var. cerasiforme ) for yield and quality traits. Agric. Res. J. 59 (6). 10.5958/2395-146X.2022.00144.2 (2022). 48. …

Natural products targeting ferroptosis in cancer: molecular mechanisms and applications.

Ferroptosis is a novel class of programmed cell death that is mainly dependent on intracellular iron accumulation and lipid peroxidation. Ferroptosis is closely related to a variety of human diseases, especially different kinds of cancer. Several small molecule inducers have been developed to induce ferroptosis in tumor cells, some of which have been used in clinical studies. However, these chemical small molecules have toxic effects that limit its wide application. Natural products, however, have a natural advantage in cancer therapy due to their low toxicity and side effects. Some natural pr

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… Alkaloids induce ferroptosis in tumor cells Solasonine, a steroidal alkaloid derived from the natural herb Solanum melongena, exhibits potent anticancer activity. …

The metabolites from traditional Chinese medicine targeting ferroptosis for cancer therapy.

Cancer is a major disease with ever-increasing morbidity and mortality. The metabolites derived from traditional Chinese medicine (TCM) have played a significant role in combating cancers with curative efficacy and unique advantages. Ferroptosis, an iron-dependent programmed death characterized by the accumulation of lipid peroxide, stands out from the conventional forms of cell death, such as apoptosis, pyroptosis, necrosis, and autophagy. Recent evidence has demonstrated the potential of TCM metabolites targeting ferroptosis for cancer therapy. We collected and screened related articles publ

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… In addition, lipoxygenase (LOX) could oxygenate PUFA-PE to produce fatty acid hydroperoxides, thus driving cell ferroptosis ( Kagan et al., 2017 ). 3 The metabolites of TCM drugs targeting ferroptosis for cancer therapy 3.1 Alkaloids Solasonine, a steroidal glycoalkaloid derived from Solanum nigrum …

Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment.

Chemotherapeutic drugs are indispensable in cancer treatment, but their effectiveness is often lessened because of non-selective toxicity to healthy tissues, which triggers inflammatory pathways that are harmful to vital organs. In addition, tumors' resistance to drugs causes failures in treatment. Chlorogenic acid (5-caffeoylquinic acid, CGA), found in plants and vegetables, is promising in anticancer mechanisms. In vitro and animal studies have indicated that CGA can overcome resistance to conventional chemotherapeutics and alleviate chemotherapy-induced toxicity by scavenging free radicals

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… Chlorogenic Acid Biosynthesis Appears Linked with Suberin Production in Potato Tuber (Solanum tuberosum) J. Agric. Food Chem. 2015;63:4902–4913. doi: 10.1021/jf505777p. 64. Petersen M., Abdullah Y., Benner J., Eberle D., Gehlen K., Hücherig S., Janiak V., Kim K.H., Sander M., Weitzel C., et al. …

Therapeutic Uses and Pharmacological Properties of Shallot (Allium ascalonicum): A Systematic Review.

BackgroundShallot (Allium ascalonicum L.) is a traditional plant species used throughout the world both for culinary purposes and as a folk remedy. To date (i.e., April 2022), there is no report on the main pharmacological activities exerted by shallot preparations and/or extracts.Scope and approachThe aim of this study was to comprehensively review the pharmacological activities exerted by shallot, with rigorous inclusion and exclusion criteria based on the scientific rigor of studies. Prisma guidelines were followed to perform the literature search.Key findings and conclusionsThe literature

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… . # Coriandrum sativum; Zingiber offcinale; Alpinia galanga; Cymbopogon citratus; Citrus hystrix; Citrus aurantiifolia; Capsicum frutescens; Curcuma longa; Ocimum basilicum; Ocimum sanctum; Momordica charantia; Solanum torvum; Morinda citrifolia . ## Mentha longifolia; Cuminum cyminum; Zataria multiflora …

Proceedings of International Conference on Cell Death in Cancer and Toxicology. February 20-22, 2018. Guest Editors: Kausar M. Ansari, CSIR-IITR, India and Dhyan Chandra, Roswell Park, USA.

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C

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… Found in plants including Solanum glaucophyllum (S. malacoxylon ), S. linneanum (S. hermannii, S. sodomaeum) , S. erianthum, S. torvum, Cestrum diurnum, Stenotaphrum secundatum, Trisetum flavescens, Nierembergia veitchii . … Usually a plant poisoning caused by the following calcinogenic plants: Solanum glaucophyllum (S. malacoxylon), S. linneanum (S. hermannii, S. sodomaeum), S. erianthum, S. torvum, Cestrum diurnum, Stenotaphrum secundatum, Trisetum flavescens, Nierembergia veitchii . …

Nanotechnology in Prostate Cancer: PSMA-Targeted Nanoplatforms, TME-Responsive Therapy, Immunomodulation, and Clinical Translation Challenges.

The field of nanotechnology has demonstrated considerable potential in the diagnosis and treatment of prostate cancer, particularly through the use of prostate-specific membrane antigen (PSMA)-targeted platforms and tumor microenvironment (TME)-responsive systems. In the context of diagnosis, nanoparticle-based molecular imaging probes have been shown to enhance detection sensitivity and specificity. These probes include superparamagnetic iron oxide, which is utilized in magnetic resonance imaging, and near-infrared fluorescent nanomicelles. Additionally, nanostructured liquid biopsy systems h