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A case report of semaglutide induced sarcopenia: causes of fatigue in older adults.

Semaglutide, a medication used for type 2 diabetes and weight loss, may have unexpected side effects such as sarcopenia and age-related loss of muscle mass and strength. A 74-year-old male patient with type 2 diabetes and dyslipidemia presented with progressive fatigue over 2 years. He experienced a significant decline in walking endurance and speed despite the absence of joint pain or other obvious causes. He had a history of ocular myasthenia gravis and localized prostate cancer, both of which were well-managed. Further investigation revealed a weight loss of 8 kg after starting semaglutide …

Correlation of C-Reactive Protein With Severe Fatigue in Patients With Myasthenia Gravis.

BACKGROUND AND OBJECTIVES: Most patients with myasthenia gravis (MG) suffer from fatigue, which can be defined as a subjective lack of energy and difficulty in initiating or sustaining voluntary activities. This is conceptually different from muscle weakness or muscle fatigability. Fatigue is one of the most reported symptoms in MG and has been hypothesized to be an innate mechanism to minimize muscle activity in order to protect muscles from (further) damage. The exact pathophysiology of fatigue remains unclear, and it is very likely a multifactorial phenomenon. The aim of this study was to p…

Development of machine learning models for chronic fatigue prediction in granulomatosis with polyangiitis.

BACKGROUND: Chronic fatigue severely compromises the quality of life in patients with granulomatosis with polyangiitis (GPA). Traditional diagnostic methods are often time-consuming, relying on clinical expertise and detailed questionnaires. This study aimed to develop a machine learning model capable of predicting chronic fatigue in GPA patients based on clinical data, with a particular focus on improving diagnostic capacity in regions with limited access to specialists. METHODS: This cross-sectional study collected data on fatigue (measured by the Modified Fatigue Impact Scale, MFIS), funct…

The Impact of Fatigue on Health, Function, and Survival Between Ages 70 and 100.

OBJECTIVE: Although fatigue is common with aging, its association with health outcomes throughout the entire aging life span have been poorly described. This longitudinal study aimed to examine the trajectory of fatigue between ages 70 and 100, and its long-term impact on health, function, and survival. DESIGN: The Jerusalem Longitudinal Study is a prospective longitudinal cohort study, spanning 1990 to 2022. SETTING AND PARTICIPANTS: A representative sample of community-dwelling Jerusalem residents, born 1920-1921, examined at ages 70, 78, 85, 90, 95, and 100 (n = 604, 1024, 1222, 729, 508,…

A Signal for Voice and Speech Abnormalities in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Background/Objectives: Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may report abnormalities in voice and speech; however, no formal research has been conducted in this area. Methods: An online mixed-methods survey was completed by 685 people with ME/CFS. A total of 302 respondents completed the qualitative component (44.09%). Questions assessed disease experience with ME/CFS and post-exertional malaise without prompting on specific symptoms. Within the qualitative results, a search of the terms "speech, voice," "words," and "speak" was conducted. Results: Excludin…

Bibliometric and visual analysis of overlooked fatigue in kidney transplantation: a narrative review.

BackgroundFatigue significantly influences and predicts quality of life, social function, and graft survival after kidney transplantation. Accurate assessment and management of fatigue in kidney transplant recipients are vital, especially when planning treatment strategies and potential rehabilitation programs. However, there is no bibliometric report in this area.MethodsThe Web of Science Core Collection for all original articles and reviews published in English on this topic was searched up from 1 January 1978 to 31 December 2023. A total of 719 articles meeting inclusion criteria were analy…

Burnout and fatigue and the employment of nurses in several workplaces: a cross-sectional study.

OBJECTIVES: The purpose of this study is to assess the relationship between burnout and fatigue and the employment of nurses in several workplaces. MATERIAL AND METHODS: The study group consisted of 234 professionally active female and male nurses employed in medical facilities in various regions of Poland. The study was conducted using an online survey consisting of 2 parts: the Maslach Burnout Inventory (MBI) questionnaire and an original questionnaire including questions about demographic, professional and fatigue data. RESULTS: More than half of the nurses (54.70%) worked in an additiona…

Fatigue as main symptom in an elderly multiple myeloma patient: a Case Report.

INTRODUCTION: The high prevalence of fatigue as an atypical clinical manifestation in general practice creates notable diagnostic challenges, particularly in geriatric patients. METHODS: We describe a case of an 80-year-old female presenting with fatigue, initially attributed to poorly controlled diabetes mellitus or upper respiratory infection, who was ultimately diagnosed with multiple myeloma after admitted to the Department of General Medicine at a general hospital. Initial diagnostic workup including physical examination revealed the presence of anterior thoracic mass with undetermined e…

Fatigue as a modifier of diet quality in adults with Charcot Marie Tooth disease.

Charcot Marie Tooth disease (CMT) is a neurological condition characterised by fatigue alongside motor and sensory impairments. CMT also has a high prevalence of lifestyle dependent co-morbidities, despite which there are limited dietary guidelines for those with CMT. The present study aimed to determine whether diet quality and nutrient intake differed between CMT and control, and whether this may be associated with fatigue and mobility. Age matched participants [n = 25 CMT aged 53.6(15.3) years, n = 27 controls aged 51.5(12.0) years] completed 3-day food diaries, and online surveys. Food dia…

Association of obesogenic environment and hedonic appetite with chronic fatigue in Turkish adults.

BACKGROUND: Chronic fatigue is a persistent state of physical, emotional, and cognitive exhaustion that does not resolve with rest. Behavioral and environmental factors may contribute to the onset and course of chronic fatigue. In this context, we aimed to examine the predictive roles of obesogenic environment and hedonic appetite in chronic fatigue. METHOD: We conducted the study on 505 Turkish adults aged 18-65. Participants completed a questionnaire form containing questions about demographic characteristics, dietary habits, the Chalder Fatigue Scale (CFS), the Power of Food Scale (PFS), a…

The influence of milling protocols on the fatigue behavior of different CAD-CAM materials.

OBJECTIVES: To assess the fatigue behavior of a glass-ceramic and a resin composite milled with two different protocols in a 4-axis milling machine. METHODS: Lithium disilicate and resin composite crowns were milled using fine or extra fine mode in a 4-axis machine (n= 15). A full crown molar fiber-reinforced resin epoxy die was scanned and used as substrate. Respective surface treatments were applied, and the restorations were bonded with dual resin cement. Cyclic fatigue test was carried out (20 Hz, initial load 400 N, step size 50 N up to 1500 N, then increased to 100 N with 10,000 cycles …

Experimental Study on the Fatigue Degradation of Prestressed Concrete Slabs for Composite Bridges.

Concrete slabs in composite bridges are inevitably subjected to heavy vehicular loads during their service life. To evaluate the fatigue performance of the prestressed concrete slabs in composite bridges, two full-scaled models of prestressed concrete slabs were first designed and tested, with the load amplitude was selected as the variable. To simulate the damage caused by the initial passage of heavy vehicles, this was simplified into the form of a static cyclic load. The mechanical deformation state and crack distribution of the slab were analyzed. Further, a finite-element model was establ…

Impact of treatments on fatigue in axial spondyloarthritis: a systematic review and meta-analysis.

OBJECTIVES: Fatigue is frequent in axial SpA (axSpA) and is difficult to improve. This systematic review aimed to assess the effects of axSpA treatment on fatigue. METHODS: A systematic review following the PRISMA recommendations was performed on PubMed, Cochrane and Embase databases. We included controlled interventional studies, cohort studies conducted in patients with axSpA meeting the ASAS 2009 criteria and measuring fatigue between 12 and 156 weeks of treatment. We excluded studies not written in English, case reports, abstracts, systematic reviews, meta-analysis and studies with missin…

Sleep Deficiency and Fatigue in Adults with Inflammatory Bowel Disease: A Systematic Review.

PURPOSE: Fatigue is one of the most common and disabling symptoms experienced by people with inflammatory bowel disease; however, interventions to treat fatigue are limited. The purpose of this systematic review is to examine the relationship between sleep deficiency and fatigue in adults with inflammatory bowel disease and to describe the demographic and clinical factors associated with fatigue to inform future intervention work. METHODS: We conducted a systematic review and reported the results using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The sear…

Fatigue in Post-COVID-Condition is accompanied by hypoperfusion of right-occipital areas.

BACKGROUND AND PURPOSE: A proportion of individuals recovering from COVID-19 continue to experience persistent symptoms, including fatigue and cognitive difficulties - a syndrome commonly referred to as Post-COVID condition (PCC), which affects an estimated 2-10% of cases. In this study, we evaluated cerebral blood flow (CBF) to better understand the pathophysiological mechanisms underlying PCC. MATERIALS AND METHODS: In this prospective, monocentric study, we analyzed clinical and cerebral blood flow (CBF) data from a cohort of 55 patients who met the WHO diagnostic criteria for Post-COVID c…

Применение телемедицины в лечении усталости пациентов с множественным склерозом: обзор аналитического исследования.

Усталость является распространенным симптомом у людей с множественным склерозом, однако доказательства эффективности телемедицины в лечении этого симптома остаются неполными. Несмотря на положительные результаты клинических испытаний, его учет в практической деятельности и систематическая оценка являются ограниченными. ЦЕЛЬ: Цель этого исследовательского проекта заключается в тщательной оценке того, насколько хорошо телемедицина помогает пациентам, страдающим от усталости. МЕТОДЫ: Этот аналитический обзор проводился в соответствии с методологической основой Института Джоанны Бриггс и с учетом

Совпадение в аннотации оригинала
BACKGROUND: Fatigue is a prevalent symptom in people with Multiple Sclerosis, but evidence for the effectiveness of telemedicine in treating this symptom remains incomplete. Despite favorable clinical trial results, its integration into practice and systematic evaluation is limited. OBJECTIVE: The purpose of this research project is to carefully assess how …

Fatigue Syndrome in Patients with Bone and Soft Tissue Sarcomas: An Observational Study.

OBJECTIVES: The aim of the present study is to describe the course of fatigue syndrome in patients with musculoskeletal tumors starting from chemotherapy and to compare it with that of other cancer populations. The second objective is to identify the risk factors for a higher level of fatigue. METHODS: A prospective prognostic observational cohort study was carried out. All patients diagnosed with musculoskeletal tumors who started chemotherapy treatment over 12 years of age were identified and enrolled consecutively from July 2019 to April 2021 in the osteo-oncology department. Patients' fat…

Development of a prediction model for clinically-relevant fatigue: a multi-cancer approach.

PURPOSE: Fatigue is the most prevalent symptom across cancer types. To support clinicians in providing fatigue-related supportive care, this study aims to develop and compare models predicting clinically relevant fatigue (CRF) occurring between two and three years after diagnosis, and to assess the validity of the best-performing model across diverse cancer populations. METHODS: Patients with non-metastatic bladder, colorectal, endometrial, ovarian, or prostate cancer who completed a questionnaire within three months after diagnosis and a subsequent questionnaire between two and three years t…