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Replication challenges in linking personality to resting-state functional connectomics.

An increasing number of studies are currently focusing on "personality neuroscience," a term denoting the research aimed at neuroimaging cor … e obtained using the revised "Big Five" Personality Inventory, including scores of Extraversion and Neuroticism covered in the original paper. Using a larger sample (84 subjects) with adequate statistical power (ranging from 0.75 to 0.95 across analyses), we failed to replicate any of the nine specific neuroimaging correlates of personality presented by Gao e …

Risk Factors for Neuropathic Pain in Digital Amputations.

Background/Objectives: Finger amputation is frequently followed by complications, with reported revision rates of up to 20%. One of the most … ficant correlation was found between the occurrence of neuropathic pain, cold intolerance, and the "neuroticism" personality trait. Patients with work-related injuries or psychiatric disorders also showed a higher risk of neuropathic pain and cold intolerance. Conversely, infection and delayed treatment were associated with an increased risk of revision proce …

Genomic Study of Resilience to Posttraumatic Stress Disorder in the Million Veteran Program.

BACKGROUND: Resilience following combat exposure is an important factor in understanding posttraumatic stress disorder (PTSD), associated ri … e mapping. Significant correlations were observed between DBPR scores and other variables including neuroticism (-0.61), participation in religious groups (0.29), and engaging in sports (0.39, SE = 0.05). The genetic correlation with PTSD in an external sample was moderate/high (-0.84). CONCLUSIONS: These findings extend the literature regarding DBPR as a re …

Personality-Related Traits and Psychological and Cognitive Outcomes Under High-Altitude Hypoxia: A Trait-Process-Outcome Framework.

High-altitude hypoxia is associated with sleep disruption, affective fluctuation, and changes in cognitive performance, yet prior findings r … hes candidate associations with relatively more direct evidence from mechanism-informed hypotheses. Neuroticism/emotional stability and anxiety-related traits have received comparatively more direct empirical investigation than other personality domains, but the available evidence is insufficient to regard them as established predictors of high-altitude adapt …

Genetic architecture of a Circadian Imbalance Index: genome-wide association, phenome-wide association, and Mendelian randomisation analyses.

BACKGROUND: Circadian disruption affects multiple aspects of human health, but the genetic architecture of individual susceptibility remains unclear. We examined the genetics of the Circadian Imbalance Index (CII), an additive 0-5 score combining evening chronotype, short/long sleep, high neuroticism, atypical caffeinated coffee intake, and low vitamin D. METHODS: We ran a genome-wide association study (GWAS) of CII in 312,935 European-ancestry UK Biobank participants, compared signals with component-specific and leave-one-component-out (LOCO) GWASs, and tested sex and shift work interactions…

Positive self-talk as a protective factor in the relationship between perceived stress and depressive symptoms among Myanmar migrant workers: A cross-sectional study.

Myanmar migrant workers in Thailand experience multiple migration-related stressors that may increase their vulnerability to depressive symp … symptoms (R2=0.507, adjusted R2=0.471). In the final model, perceived stress (β=0.226, p=0.001) and neuroticism (β=0.340, p<0.001) were positively associated with depressive symptoms, whereas positive self-talk frequency (β=-0.292, p<0.001) and self-talk loudness (β=-0.152, p=0.011) were negatively associated with depressive symptoms. These findings suggest t …

Motor fatigue and fatigability in early multiple sclerosis patients: an analysis of clinical, radiological and psychological underpinnings.

BACKGROUND: While fatigue is highly reported in newly diagnosed people with Multiple Sclerosis (pwMS) and motor fatigability is reported in … le (HADS) anxiety subscale (ρ=0.375,p=0.002), Beck Depression Inventory (BDI-II) (ρ=0.543;p<0.001), neuroticism (ρ=0.313;p=0.006), and all subscales of MS-Quality-Of-Life 54. We did not find predictors of fatigability, while HADS-anxiety (b=0.76; p=0.003) and BDI-II (b=0.33; p=0.009) significantly predicted fatigue. CONCLUSIONS: Our results support different …

A Genome-Wide Association Study of First-Episode Psychosis: A Genetic Exploration in an Italian Cohort.

BACKGROUND: Psychosis, particularly schizophrenia (SZ), is influenced by genetic and environmental factors. The neurodevelopmental hypothesi … well as with autism spectrum disorder, which shares some genetic overlap, and risk factors, such as neuroticism and alcohol dependence. CONCLUSIONS: The resulting genetic associations and the consequent functional analysis displayed common genetic liability between the non-affective psychosis, related traits, and risk factors. In sum, our investigation provi …

Perinatal maternal mental health and offspring internalizing and externalizing difficulties from early childhood through adolescence: Rhea mother-child cohort in Crete, Greece.

Longitudinal research assessing childhood mental health is limited, particularly in terms of tracking how early-life factors influence the d … ld outcomes between the ages of 4 and 15. Specifically, higher levels of maternal trait anxiety and neuroticism were associated with an increase in children's internalizing, externalizing, and ADHD symptoms. Both antenatal and postnatal maternal depressive symptoms were linked to a greater likelihood of internalizing and externalizing symptoms over time, but …

Preliminary behavioral differences between Spanish adults with suicidal ideation and control population.

BACKGROUND: Suicidal ideation represents a significant public health concern, serving as a crucial predictor of suicide attempts. While biol … greater depression, stress, anxiety, loneliness, and psychological inflexibility, as well as higher neuroticism and openness, and lower extraversion and agreeableness. CONCLUSIONS: Due to the preliminary nature of the study, these findings suggest the presence of distinct behavioral and psychological profiles associated with suicidal ideation. In light of th …

The relationships between stress, physical activity, mood, cognitive-emotional abilities, personality traits, and sleep.

BACKGROUND: Sleep quality and duration are shaped by a complex interplay of behavioral, psychological, and sociodemographic factors. This st … ng fatigue, anger, and vigor, also played a significant role. Additionally, personality traits like neuroticism, conscientiousness, and openness, along with body mass index, perceived health, and leisure-time physical activity, were important predictors of sleep quality. Conversely, other expected psychosocial factors-such as happiness, perceived stress, sede …

Implicit and explicit self-concepts of forgiveness in women with borderline personality disorder.

BACKGROUND: The tendency to forgive is associated with traits such as agreeableness and neuroticism, mental well-being, and interpersonal functioning. Given documented associations with interpersonal conflict and aggression in borderline personality disorder (BPD), forgiveness (or, lack thereof) may be particularly relevant for BPD symptomatology but remains understudied. This study examines forgiveness in BPD compared to a heterogeneous clinical control group without personality disorder (CC), exploring its associations with aggression and interpersonal dysfunction using both direct (self-rep…

Травматический стресс затронул людей с множественным склерозом во время пандемии SARS-COV-2.

Фон/цели: Травма представляет собой психологическое повреждение в результате тревожного или подавляющего события. Пандемия SARS-COV-2 была разрушительной и травмирующей для многих людей с множественным склерозом (pwMS). Взаимосвязь между характеристиками пациентов и травмами, полученными в ходе пандемии, еще не была тщательно изучена. Цель этого бицентрического перспективного когортного исследования состояла в том, чтобы проанализировать распространенность и развитие вероятного посттравматического стрессового расстройства (ПТСР) среди ПТСР во время пандемии SARS-COV-2 и определить параметры па

Совпадение в аннотации оригинала
Background/Objectives: Trauma is a psychological injury resulting from a distressing or overwhelming event. The SARS-CoV-2 pandemic has been … The patients with probable PTSD exhibited a distinct personality profile, with significantly higher neuroticism and harm avoidance scores and lower conscientiousness, cooperativeness, and self-directedness scores. They were also significantly more likely to report severe or very severe mental/physical/social burdens during the pandemic compared to those witho …

LSD-assisted therapy in patients with anxiety: open-label prospective 12-month follow-up.

BACKGROUND: Anxiety disorders are a major public health burden with limited treatment options. AIMS: We investigated the long-term safety a … 9), d = 1.21, P < 0.01, for the LSD-first and placebo-first groups, respectively. Personality trait neuroticism decreased (P < 0.0001) and trait extraversion increased (P < 0.01) compared with study inclusion. Individuals attributed positive long-term effects to the psychedelic experience. CONCLUSIONS: Patients reported sustained long-term effects of LSD-ass …

Social media addiction and personality dimensions among Tunisian medical students.

PURPOSE: Social media (SM) has become a common activity for today's young people. It is sometimes overused and potentially results in SM add … h an identity was significantly associated with higher SMAS-SF scores (p=0.011). We also found that neuroticism and a low level of conscientiousness were linked to high SMAS-SF scores (p=0.006, r=0.252 and p=0.050, r=-0.183, respectively). Moreover, high SMAS-SF scores were significantly related to lower global and social self-esteem scores (p=0.015, r=-0.226 …

Moderators of the relationship between callous-unemotional traits and externalizing problems in youth.

[Correction Notice: An Erratum for this article was reported online in Personality Disorders: Theory, Research, and Treatment on Oct 26 2023 … g practices, but CU traits were more strongly related to externalizing problems at higher levels of neuroticism and at lower levels of agreeableness and conscientiousness. Results contribute to a more comprehensive understanding of externalizing problems among youth high in CU traits and may inform future longitudinal and intervention research seeking to iden …

A genome-wide association study of a rage-related misophonia symptom and the genetic link with audiological traits, psychiatric disorders, and personality.

INTRODUCTION: People with misophonia experience strong negative emotional responses to sounds and associated stimuli-mostly human produced-t … etic correlations (0.21 < r G < 0.42) were observed for two clusters of personality traits: a guilt/neuroticism and an irritability/sensitivity cluster. Our results showed no genetic correlation with attention deficit and hyperactivity disorder, obsessive-compulsive disorder, and psychotic disorders. A negative correlation with autism spectrum disorder (ASD) …

The role of personality traits on self-medicated cannabis in rheumatoid arthritis patients: A multivariable analysis.

BACKGROUND: Rheumatoid arthritis (RA) patients commonly report medicinal cannabis use (MCU). Personality has been independently associated w … years. Fifty-three (29.4%) patients reported MCU. Among them, 52 (98.1%) used topical formulations. Neuroticism had the highest overall score ([Formula: see text] = 3.47 ± 0.34). Openness to experience trait was higher in MCU patients in the comparative analysis (p = 0.007). In the multivariable regression, higher openness trait (aOR: 2.81, 95%CI: 1.11-7.10) …

Resilience Phenotypes and Psychological Functioning among Individuals with Opioid Use Disorder.

BACKGROUND: Opioid use disorder (OUD) is a heterogeneous disorder. However, there is a lack of deep phenotyping investigations focusing on i … ed by higher FFM traits of: Extraversion, Openness, Agreeableness, and Conscientiousness, and lower Neuroticism versus Cluster 1. Multivariate analysis of variance revealed statistically significant differences between the two resilience clusters concerning other psychological symptoms, Λ = 0.732, F(4, 50) = 7.05, p < 0.003. CONCLUSIONS: These findings sugge …

The role of psychosocial factors in explaining sex differences in major depression and generalized anxiety during the COVID-19 pandemic.

BACKGROUND: Understanding how pandemics differentially impact on the socio-protective and psychological outcomes of males and females is imp … e Republic of Ireland are best explained by psychosocial factors of COVID-19 related anxiety, trait neuroticism, lower sleep quality, higher levels of loneliness, greater somatic problems, and, in the case of depression, increases in childcaring responsibilities and lower trait consciousnesses. Implications of these findings for public health policy and inter …