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Precision in Action: The Role of Clustered Regularly Interspaced Short Palindromic Repeats/Cas in Gene Therapies.

Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated enzyme-CAS holds great promise for treating many uncured human diseases and illnesses by precisely correcting harmful point mutations and disrupting disease-causing genes. The recent Food and Drug Association (FDA) approval of the first CRISPR-based gene therapy for sickle cell anemia marks the beginning of a new era in gene editing. However, delivering CRISPR specifically into diseased cells in vivo is a significant challenge and an area of intense research. The identification of new CRISPR/Cas variants, particularly

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… Multiplexed CRISPR/Cas9-mediated metabolic engineering of gamma-aminobutyric acid levels in Solanum lycopersicum Plant Biotechnol. J. 2018 16 415 427 10.1111/pbi.12781 28640983 PMC5787826 84. Menchaca A. Dos Santos-Neto P.C. Mulet A.P. Crispo M. …

Mechanisms, Diagnosis and Treatment of Bone Metastases.

Bone and bone marrow are among the most frequent metastatic sites of cancer. The occurrence of bone metastasis is frequently associated with a dismal disease outcome. The prevention and therapy of bone metastases is a priority in the treatment of cancer patients. However, current therapeutic options for patients with bone metastatic disease are limited in efficacy and associated with increased morbidity. Therefore, most current therapies are mainly palliative in nature. A better understanding of the underlying molecular pathways of the bone metastatic process is warranted to develop novel, wel

Natural Products as Anticancer Agents: Current Status and Future Perspectives.

Natural products have been an invaluable and useful source of anticancer agents over the years. Several compounds have been synthesized from natural products by modifying their structures or by using naturally occurring compounds as building blocks in the synthesis of these compounds for various purposes in different fields, such as biology, medicine, and engineering. Multiple modern and costly treatments have been applied to combat cancer and limit its lethality, but the results are not significantly refreshing. Natural products, which are a significant source of new therapeutic drugs, are cu

Biomimetic materials for medical applications.

AbstractRecent advances in biomedical research have facilitated the exploration of biomimetic materials and their potential for diagnosing and treating diseases. This review synthesizes reports of recent research into biomimetic materials and provides a focused analysis of their therapeutic and diagnostic efficacy across multiple physiological systems, including the locomotor, digestive, respiratory, urinary, endocrine, nervous, integumentary, hematopoietic, and circulatory systems. These findings highlight the transformative potential of these materials in the management of systemic diseases.

Obesity: pathophysiology and therapeutic interventions.

Over the past few decades, obesity has transitioned from a localized health concern to a pressing global public health crisis affecting over 650 million adults globally, as documented by WHO epidemiological surveys. As a chronic metabolic disorder characterized by pathological adipose tissue expansion, chronic inflammation, and neuroendocrine dysregulation that disrupts systemic homeostasis and impairs physiological functions, obesity is rarely an isolated condition; rather, it is frequently complicated by severe comorbidities that collectively elevate mortality risks. Despite advances in nutr

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… Diosgenin (DSG) DSG, a naturally occurring steroidal saponin found in a variety of plants, including Solanum and Dioscorea, has a variety of actions in inflammatory illnesses. DSG is also recognized to be beneficial against metabolic problems linked to obesity and IR [ 459 ]. …

Р

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Natural bioactive molecules and chemotherapeutics synergism for enhanced cancer therapy.

BACKGROUND: Chemotherapy remains a foundation of cancer care but is limited by multidrug resistance, systemic toxicities, and suboptimal selectivity, prompting interest in adjunctive strategies that improve efficacy and tolerability without adding significant burden to patients or healthcare systems. AIMS/OBJECTIVES: This review highlights evidence on natural bioactive compounds, including polyphenols, alkaloids, terpenoids, and fungal metabolites, as adjuvants to standard chemotherapeutics, with objectives to: first, delineate mechanisms by which these agents enhance cytotoxic efficacy and o

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… The traditional Chinese medicinal plant Solanum nigrum L. contains solamargine, a steroidal alkaloid with documented anti-inflammatory and anticancer properties [ 189 ]. …

Diseases of the Nervous System

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… disease of the cerebellum of the horse • Traumatic injury, e.g., by parasite larvae such as Hypoderma bovis, which have caused unilateral cerebellar ataxia in adult cattle • Tremorgenic mycotoxicoses and ryegrasses • Cerebellar degeneration in cattle in Uruguay caused by grazing the perennial shrub Solanum … identified and that are caused mainly by poisons, especially plant materials; typical examples are poisoning by the fungi Claviceps paspali, Diplodia spp., Acremonium lolii, the grass Phalaris aquatic, the ferns Zamia and Xanthorrhea spp., and herbaceous plants such as Kallstroemia, Vicia, Baccharis, Solanum …

ISEV2025 Резюме книги.

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ISEV2021 Abstract Book

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Abstracts from the World Congress of Cardiology/Brazilian Congress of Cardiology 2022

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