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Interactions between kidney disease and diabetes: dangerous liaisons.

BackgroundType 2 diabetes mellitus (DM) globally affects 18-20 % of adults over the age of 65 years. Diabetic kidney disease (DKD) is one of the most frequent and dangerous complications of DM2, affecting about one-third of the patients with DM2. In addition to the pancreas, adipocytes, liver, and intestines, the kidneys also play an important role in glycemic control, particularly due to renal contribution to gluconeogenesis and tubular reabsorption of glucose.MethodsIn this review article, based on a report of discussions from an interdisciplinary group of experts in the areas of endocrinolo

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… In addition, there should be participation of a multidisciplinary team consisting of nephrologists, endocrinologists, nutritionists, and nurses. … Funding Our workgroup formed by nephrologists, endocrinologists and diabetologists worked between 2014 and 2015 discussing issues related to diabetes and the kidney were sponsored by Novartis in a complete independent educational program. References 1. …

Applications of Structural Expert Elicitations for Economic Evaluations: A Systematic Review Update.

BackgroundStructured expert elicitation (SEE) has become increasingly important in health technology assessment and economic evaluations. Complementing previous work, we aimed to synthesize recent developments in published SEE applications within health economics over the past 8 years.MethodsA systematic literature search was conducted in Medline and Embase databases from April 2017 to February 2026, supplemented with snowball sampling, to identify applications of SEE as part of economic evaluations. Data extraction and synthesis focused on expert selection, elicitation methods, and analytical

Bone health in cancer: perspective on the use of osteoanabolic agents.

Cancer negatively impacts bone health through various mechanisms, including treatment-induced bone loss and malignant bone lesions, often leading to increased fracture risk and higher morbidity and mortality. Antiresorptive agents (bisphosphonates and denosumab) are the current standard of care to reduce the risk of skeletal-related events and prevent treatment-related fragility fractures in patients with cancer. While there is strong evidence to support their benefits in cancer, there is potential room for further reduction in the risk of pathologic and fragility fractures. This narrative rev

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… American Association of Clinical Endocrinologists/American College of Endocrinology Clinical Practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis-2020 update . …

Subjective Cognitive Dysfunction in Chronic Illness: A Systematic Review and Meta-Synthesis.

BackgroundQualitative studies have examined the experiences of subjective cognitive dysfunction in specific populations or specific disease stages, but there has not yet been a systematic synthesis and evaluation of findings related to perceptions of subjective cognitive dysfunction in nondementia-related chronic illnesses.ObjectiveThe aim of this study was 2-fold: (1) to undertake a systematic review of experiences of subjective cognitive dysfunction in people with nondementia-related chronic disease and (2) to develop an explanatory framework to describe the experiences of living with subjec

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… Health care providers may face challenges in working with these patients, whether because cognitive dysfunction may not be their area of expertise (eg, endocrinologists working with people with diabetes) or because they are unfamiliar with current therapies or guidelines for screening for cognitive dysfunction …

Comprehensive Diagnosis and Management of POEMS Syndrome.

Polyneuropathy Organomegaly, Endocrinopathy, Monoclonal protein and Skin changes syndrome is a rare multisystem condition with a range of manifestations which are often overlooked as trivial comorbidities, until their whole triggers the possibility of the diagnosis. The diagnosis is typically delayed by 12-16 months, by which time patients can be severely disabled. There are no established consensus guidelines. We provide clinicians a comprehensive blueprint for managing POEMS from diagnostic suspicion through the work-up, selection of therapy, follow-up, and treatment of relapse based on publ

Challenges in the management of bone metastases: focus on differentiated thyroid cancer and neuroendocrine tumors.

Bone metastases represent an uncommon but clinically significant complication in endocrine malignancies including differentiated thyroid cancer and neuroendocrine tumors. Although these malignancies typically follow an indolent course, the development of bone metastases is associated with a worse prognosis and increased risk of skeletal-related events. The optimal strategies for the prevention and management of bone metastases in these patients remain unclear and are largely extrapolated from studies in other solid tumors. This presents a unique clinical challenge as treatment decisions need t

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… While current guidelines advocate for the aggressive treatment of bone metastases [ 4 ], endocrinologists often treat malignancies with a favorable prognoses and excellent long-term survival. …

Mining the FAERS database reveals new safety signals for 120 mg denosumab in oncology practice.

OBJECTIVE: To detect and quantify adverse drug event (ADE) signals linked to 120 mg denosumab in the real world. METHODS: We queried the US Food and Drug Administration Adverse Event Reporting System (FAERS) for reports on 120 mg denosumab, standardized, and categorized these events with Preferred Terms (PT) and System Organ Classes (SOC) from MedDRA version 27.1. Disproportionality analysis was performed using the reporting odds ratio (ROR) and Bayesian confidence propagation neural network (BCPNN). RESULTS: We identified 10,963 ADE reports for 120 mg of denosumab. Among 10 963 reports, 41.

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… American Association Of Clinical Endocrinologists/american College Of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis- 2020 Update Executive Summary. Endocr Pract. 2020;26(5):564–70. doi: 10.4158/GL-2020-0524 6. …

Clinical Characteristics and Serum Vitamin D Levels in Patients with MRONJ Associated with Antiresorptive Therapy: A Retrospective Study.

Background and Objectives: Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication associated with antiresorptive therapy. Although several local and systemic risk factors have been documented, the role of metabolic biomarkers and their relationship with clinical characteristics remains insufficiently investigated. The aim of the present study was to evaluate the relationships between antiresorptive therapy, serum vitamin D levels, demographic characteristics, and lesion location in patients diagnosed with MRONJ. Materials and Methods: This retrospective study included 72

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… Overall, these results support the importance of an interdisciplinary approach involving oral and maxillofacial surgeons, oncologists, and endocrinologists in the prevention and management of patients at increased risk of developing MRONJ. …

Individualized survival prediction and risk stratification using machine learning for patients with malignant struma ovarii: a population-based study with external validation.

BACKGROUND: Malignant struma ovarii (MSO) is a rare thyroid-type cancer originating in ovarian teratoma. Prognosis of MSO is less studied without unanimous staging or stratification system. This study aimed to developed and validated a machine learning (ML)-based model to predict overall survival (OS) for patients with MSO and to risk-stratify them. METHODS: Patients with histologically confirmed MSO diagnosed in 1975-2021 from the Surveillance, Epidemiology, and End Results (SEER) program were identified as the training cohort. Patients in a systematic literature review were collected as the

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… The complexity of the disease requires multidisciplinary team (MDT) discussion including gynecologists, surgeons, endocrinologists, radiologists and pathologists. Prognosis of MSO remains controversial with most patients having favorable outcomes but some having lethal disease ( 7 - 9 ). …

Долгосрочное воздействие COVID-19 на репродуктивное здоровье женщин и его связь с аутоиммунными заболеваниями, включая множественный склероз.

Озабоченность по поводу долгосрочного влияния COVID-19 на репродуктивное здоровье женщин растет, и появляющиеся исследования указывают на потенциальные связи с яичниковой дисфункцией, менструальными нарушениями, проблемами фертильности и неблагоприятными последствиями беременности. Регулирование послевирусной иммунной дисдукции связано как с развитием, так и с обострением аутоиммунных заболеваний, включая множественный склероз (МС). Длинный процесс COVID связан с иммунологической дисфункцией, гормональными дисфункциями и хроническим воспалением, что может усугублять аутоиммунные расстройства и

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… Long COVID’s involvement of multiple organ systems often compels patients to seek care from several specialists, including neurologists, rheumatologists, cardiologists, endocrinologists, and gynecologists, which may contribute to fragmented and uncoordinated management. …

Real-practice management and treatment of idiopathic multicentric Castleman disease with siltuximab: a collection of clinical experiences.

Castleman disease (CD) is a group of lymphoproliferative disorders that share common histopathological features yet have widely different aetiologies, clinical features and grades of severity as well as treatments and outcomes. Siltuximab is currently the only therapy approved by the FDA and EMA for idiopathic multicentric CD and is recommended as first-line therapy in treatment guidelines. Despite the extensive characterization of siltuximab treatment in clinical trials, available evidence from real-world practice is still scant. This collection of clinical experiences focuses on patients tre

Risk of fractures in half a million survivors of 20 cancers: a population-based matched cohort study using linked English electronic health records.

BACKGROUND: A history of multiple myeloma, prostate cancer, and breast cancer has been associated with adverse bone health, but associations across a broader range of cancers are unclear. We aimed to compare the risk of any bone fracture and major osteoporotic fractures in survivors of a wide range of cancers versus cancer-free individuals. METHODS: In this population-based matched cohort study, we used electronic health records from the UK Clinical Practice Research Datalink linked to hospital data. We included adults (aged ≥18 years) eligible for linkage, and we restricted the study start t

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… This holistic approach demands collaboration among oncologists, primary care physicians, endocrinologists, nutritionists, physiatrists, physiotherapists, and other relevant specialists. 34 , 35 From a research perspective, further work needs to be done to investigate the drivers of the increased fracture …

Bone health in patients with cancer: a SEOM-SEIOMM consensus review of risk factors, assessment strategies, and management approaches.

Anticancer therapies frequently compromise skeletal health and increase fracture risk. This narrative review synthesizes information and provides guidance on assessment, prevention, and management of therapy-related bone loss in adults with cancer. Major contributors to bone loss in this population include aromatase inhibitors, androgen deprivation therapy, systemic glucocorticoids, chemotherapy, and selected targeted or immune agents. Recommended assessments include clinical evaluation, laboratory tests (calcium, vitamin D, and renal function), and bone mineral density by dual-energy X-ray ab

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… Camacho PM Petak SM Binkley N Diab DL Eldeiry LS Farooki A American Association Of Clinical Endocrinologists/American College Of Endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis - 2020 update Endocr Pract 2020 26 1 46 10.4158/gl-2020-0524suppl … American Association Of Clinical Endocrinologists/American College Of Endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis - 2020 update. Endocr Pract. 2020;26:1–46. 10.4158/gl-2020-0524suppl. 32427503 10.4158/GL-2020-0524SUPPL 47. …

Clinical Posters From JADPRO Live 2022

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Effectiveness of bilingual health education on obesity and dietary behaviors in Mongolian adolescents: a six-month intervention study.

BackgroundObesity among adolescents has become a global public health concern. Previous studies have shown that multidimensional interventions, such as school-based programs, health education, and guidance on diet and physical activity, effectively improve obesity in adolescents. However, there is a lack of research on bilingual health education interventions in minority language environments in rural and pastoral areas of China. Based on a 2023 field survey of students from three Mongolian middle schools in Ar Horqin Banner, Chifeng City, Inner Mongolia, this study evaluated the effect of a 6

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… Intervention team composition A specialized multidisciplinary team was formed, comprising three endocrinologists (responsible for delivering medical theory), two nutritionists (responsible for dietary guidance), and three endocrinology nurses (responsible for on-site coordination and follow-up management …

Trichloroethylene: An Invisible Cause of Parkinson's Disease?

The etiologies of Parkinson's disease (PD) remain unclear. Some, such as certain genetic mutations and head trauma, are widely known or easily identified. However, these causes or risk factors do not account for the majority of cases. Other, less visible factors must be at play. Among these is a widely used industrial solvent and common environmental contaminant little recognized for its likely role in PD: trichloroethylene (TCE). TCE is a simple, six-atom molecule that can decaffeinate coffee, degrease metal parts, and dry clean clothes. The colorless chemical was first linked to parkinsonism

A systematic review of ongoing clinical trials in optic pathway gliomas.

INTRODUCTION: Optic pathway gliomas (OPGs), also known as Visual Pathway Gliomas, are insidious, debilitating tumours. They are most commonly WHO grade 1 pilocytic astrocytomas and frequently occur in patients with neurofibromatosis type 1. The location of OPGs within the optic pathway typically precludes complete resection or optimal radiation dosing, hence outcomes remain poor compared to many other low-grade gliomas. The aim of this systematic review was to formulate a comprehensive list of all current ongoing clinical trials that are specifically looking at clinical care of OPGs in order t

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… OPGs require multidisciplinary care by neurosurgeons, neuro-oncologists, radiation oncologists, endocrinologists, ophthalmologists, pathology, neuropsychology, paediatricians, geneticists and a host of allied health professionals. This multifaceted care underlies the complexity of the disease. …

Diabetic and Nondiabetic Endocrine Emergencies: Clinical Spectrum and Outcomes From a Tertiary Care Center in North India.

ObjectiveEndocrine emergencies, although uncommon, are potentially life-threatening and require prompt diagnosis and timely intervention. Although diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are well described, data on nondiabetic endocrine emergencies remain limited, particularly from low-resource settings. This study aimed to evaluate spectrum, clinical characteristics, and outcomes of endocrine emergencies presenting to a tertiary care hospital in North India.MethodsA prospective observational study was conducted over 18 months at a tertiary care academic hospital

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… The involvement of a multidisciplinary team including endocrinologists, emergency physicians, and intensivists ensures a thorough evaluation of each case. …

Morphofunctional parameters as predictors of autologous hematopoietic stem cell transplantation outcomes.

IntroductionThere is a lack of predictive factors for specific complications in patients who undergo autologous hematopoietic stem cell transplantation. A complete morphofunctional assessment is not usually performed before the procedure. Malnutrition is related to lower survival in cancer patients. Our aim is to identify both risk and protective factors for such complications to refine management and improve outcomes.MethodsWe have implemented the program 'RHeNutrir', which involves a systematic malnutrition and sarcopenia screening, as well as a complete nutritional and functional assessment

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… Therefore, in addition to performing pre-transplant tests, it would be desirable to optimize the management of these diseases before auto-HSCT by involving the specialists such as pulmonologists, endocrinologists, etc. …

Взгляды пациентов и группы по уходу за почками на лечащую нагрузку и способность пожилых людей с хроническими заболеваниями почек: качественное исследование.

ЦЕЛЬ: Хроническая болезнь почек (КХД) часто является множественным заболеванием, а прогрессирование к более серьезным заболеваниям, как правило, связано с увеличением потребностей в управлении, включая изменение образа жизни, увеличение количества медикаментов и расширение участия клинических работников. В ходе этого исследования были изучены взгляды группы по уходу за пациентами и почками на характер и масштабы этой рабочей нагрузки (нагрузка на лечение), а также факторы, способствующие укреплению способности (способности управлять здоровьем) пожилых людей, имеющих ККД. DESIGN: Качественное п

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… A limitation was the lack of input from primary care clinicians, as well as other specialties (eg, endocrinologists, cardiologists) with a key role in CKD care, which may have resulted in additional themes. …