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Chlamydia trachomatis: a model for intracellular bacterial parasitism.

Chlamydia comprises a diverse group of obligate intracellular bacteria that cause infections in animals, including humans. These organisms share fascinating biology, including distinct developmental stages, non-canonical cell surface structures, and adaptations to intracellular parasitism. Chlamydia trachomatis is of particular interest due to its significant clinical importance, causing both ocular and sexually transmitted infections. The strain L2/434/Bu, responsible for lymphogranuloma venereum, is the most common strain used to study chlamydial molecular and cell biology because it grows r…

The Role of Chlamydia Trachomatis in the Pathogenesis of Cervical Cancer.

Chlamydia trachomatis (CT) is an obligate intracellular, Gram-negative bacterium that causes a variety of infections in both humans and animals. It is the causative agent of one of the most common sexually transmitted infections (STIs) with sequelae such as pelvic inflammatory disease, ectopic pregnancy, and infertility. Furthermore, Chlamydia infections have been epidemiologically linked to cervical cancer (CC) in patients with human papillomavirus (HPV) coinfection. However, a molecular mechanism linking Chlamydia to CC is yet to be established, and we still do not know if more aggressive di…

Chlamydia Trachomatis Masquerading as Scrotal Masses in Adolescents.

OBJECTIVE: To present a case series of 3 post-pubertal adolescent males with Chlamydia trachomatis presenting as scrotal masses. Scrotal masses are worrisome for malignancy, especially when imaging confirms intratesticular lesions. However, there are benign conditions which may mimic testicular cancer. Some of these conditions may not be readily considered in the pediatric population. This phenomenon is rare in the pediatric population, and this represents only the second report in the literature of this finding. METHODS: Three cases of adolescent males who presented with a scrotal mass were …

Expression and structure of the Chlamydia trachomatis DksA ortholog.

Chlamydia trachomatis is a bacterial obligate intracellular parasite and a significant cause of human disease, including sexually transmitted infections and trachoma. The bacterial RNA polymerase-binding protein DksA is a transcription factor integral to the multicomponent bacterial stress response pathway known as the stringent response. The genome of C. trachomatis encodes a DksA ortholog (DksACt) that is maximally expressed at 15-20 h post infection, a time frame correlating with the onset of transition between the replicative reticulate body (RB) and infectious elementary body (EB) forms o…

Association of Past Chlamydia trachomatis Infection With Miscarriage.

This case-control study assesses the association between past Chlamydia trachomatis infection with first-trimester miscarriage by using an enzyme-linked immunosorbent assay to detect antibodies to the protein Pgp3.

Chlamydia trachomatis Infection of the Neovagina in Transgender Women.

We report 2 cases of neovaginal Chlamydia trachomatis infection in transgender women who underwent penile-inversion vaginoplasty procedures with integrated peritoneum and urethral grafts. These tissue types may have facilitated C. trachomatis infection. Medical providers should implement neovaginal screening for bacterial sexually transmitted infections in transgender patients at risk for infection.

Урин метаболома у женщин с хламидией трахоматисом.

Цель этого исследования состояла в том, чтобы охарактеризовать метаболом мочи женщин с хламидией трахоматис (CT) врожденной инфекцией (n = 21), сравнивая ее с группой негативных признаков КТ (n = 98). С помощью протонно-ядерного магнитного резонанса (1H-NMR) спектроскопии мы обнаружили и подсчитали метаболиты мочи группы из 119 доменопаузальных женщин-белых, посещающих клинику по лечению ИППП в Италии. В случае положительного результата CT молекулярный геномотип CT производился с помощью омпа1 гена полуотраженного PCR, а затем RFLP-анализа. Нам удалось выявить несколько метаболитов, концентрац

Совпадение в аннотации оригинала
The aim of this study was to characterize the urine metabolome of women with Chlamydia trachomatis (CT) uro-genital infection (n = 21), comparing it with a group of CT-negative subjects (n = 98). By means of a proton-based nuclear magnetic resonance (1H-NMR) spectroscopy, we detected and quantified the urine metabolites of a cohort of 119 pre-menopausal Cauc…

Chlamydia trachomatis and its interaction with the cellular retromer.

Chlamydia trachomatis is an important human pathogen. This obligate intracellular bacterium grows inside the eukaryotic cell in a membrane-bound compartment, the inclusion. Recent global approaches describe the interactions of C. trachomatis with its host cell and indicate the inclusion is an intracellular trafficking hub embedded into the cellular vesicular trafficking pathways recruiting subunits of the retromer protein complex of the host cell. Here we review these recent developments in deciphering Chlamydia-host cell interactions with emphasis on the role of the retromer complex.

[The Role of Chlamydia Trachomatis in Pregnant Women with Endocervicitis.].

Infectious endocervicitis is a common disease in women of reproductive age. Itis of great clinical importance because the infection can spread over the genital tract and it can transfer both in horisontal way (sexual partner) and vertical way (foetus and new-bom). One of the most common causers for the infections endocervicitis is Chlamydia trachomatis. The aim of the study was to define the frequency of the chlamydial endocervicitis among women with desired pregnancy and examining them while pregnant and until the birth to define the possible complications.

[Will a vaccine against Chlamydia trachomatis be available soon?].

Chlamydia trachomatis is the most prevalent cause of sexually transmitted bacterial infections worldwide, with more than 100 million estimated cases annually. This obligate intracellular pathogen is known to cause pelvic inflammatory disease (PID) and chronic infections resulting in tubal factor infertility and ectopic pregnancy. However, the majority of the infections remains asymptomatic and thus untreated. For this reason, the ultimate goal for the prevention C. trachomatis infections is an effective vaccine. Here we review the major challenges and the different strategies associated with t…

Natural products for the treatment of trachoma and Chlamydia trachomatis.

The neglected tropical disease (NTD) trachoma is currently the leading cause of eye disease in the world, and the pathogenic bacteria causing this condition, Chlamydia trachomatis, is also the most common sexually transmitted pathogenic bacterium. Although the serovars of this bacterial species typically vary between ocular and genital infections there is a clear connection between genital C. trachomatis infections and the development of trachoma in infants, such that the solutions to these infections are closely related. It is the unique life cycle of the C. trachomatis bacteria which primari…

Treatment challenges for urogenital and anorectal Chlamydia trachomatis.

While true antimicrobial resistance to Chlamydia trachomatis is a rare occurrence, repeat chlamydia infections continue to be reported following treatment with a single 1 g dose of azithromycin or week long doxycycline - with considerable more concern about azithromycin treatment failure. While most repeat positive cases are likely to be reinfections, emerging evidence indicates treatment failure may play a role. Current data suggests that there may are differences in the efficacy of the drugs between rectal and non-rectal sites of infection and factors such as immune response, drug pharmacoki…

Characteristics of the Chlamydia trachomatis species - immunopathology and infections.

Chlamydiae are microorganisms exhibiting characteristics intermediate between bacteria and viruses. Chlamydia is widespread in the natural world, intracellular parasites of people and animals. They are capable of independent reproduction, because they do not synthesize ATP, in its development cycle using the host cell metabolic pathways. The life cycle of these microorganisms is original, unique among bacteria and lasts from 24 to 48 hours. Chlamydia antigens consist of 4 groups: group-specific, species-specific, type-specific and subspecies-specific. The group of species-specific antigens con

IgM Chlamydia Trachomatis Antibodies in Cases of Melasma.

BACKGROUND: Melasma is an acquired photosensitive hypermelanosis in sun-exposed areas, especially seen in females. The exact cause of this disorder is not known. Association of melasma with chronic pelvic inflammatory disease (PID) has been described earlier. Chlamydia trachomatis is an important etilogical agent in acute and chronic PID and photosensitivity has been described in almost 50% cases of chronic lymphogranuloma venereum caused by 1.1, 1.2 and 13 serovars of C. trachomatis. METHOD: Blood of 38 cases of melasma in women and 31 healthy females was tested for the presence of C. tracho…

The influence of Chlamydia trachomatis infection on spontaneous abortions.

PURPOSE: The aim of the study was to evaluate the frequency of Chlamydia trachomatis (C.t.) infection among women who experienced a miscarriage. MATERIALS AND METHODS: Patients referred to the Centre for STD Research and Diagnostics in Bialystok from the Department of Perinatology and from gynaecological outpatient clinics, after spontaneous abortion were enrolled in the study. C.t. infection diagnostics were performed among 76 women with 1 miscarriage and 44 patients with > or =2 miscarriages in anamnesis. Forty-six patients in the 2nd and the 3rd trimester of normal pregnancy served as a co…

Chlamydia trachomatis urogenital infection in women with infertility.

PURPOSE: The study objective was to evaluate the prevalence of urogenital Chlamydia trachomatis (C.tr.) infection in women with diagnosed infertility. MATERIAL AND METHODS: The study involved patients from the Department of Gynecological Endocrinology and from the Center for Reproductive Medicine "Kriobank" in Bialystok. Female patients (n=71), aged 23-41, were divided into two groups according to the main diagnosis: A--tubal infertility (23) and B--infertility of another origin (48). For direct testing, PCR method was used to detect C.tr. infection in cervical samples (Roche, Molecular Syste…