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Timing of Urgent Inpatient Palliative Radiation Therapy.

PurposeUrgent indications for palliative radiation therapy (RT) include malignant spinal cord compression, symptomatic brain metastases, pain, airway obstruction, and bleeding. Data on the timing of palliative RT in the inpatient setting are limited. We report our experience with inpatient palliative RT at a tertiary academic center and evaluate the effect of a dedicated inpatient palliative RT nurse practitioner (NP) on treatment timelines.Methods and materialsWe performed a retrospective, single-institution review of 219 inpatients consulted for RT to sites of metastatic disease between May

Does McKenzie therapy improve outcomes for back pain?

CLINICAL QUESTION: What is the clinical evidence base for McKenzie therapy in management of back pain? DATA SOURCES: Studies were identifie … duration of symptoms. Studies were excluded if subjects had any of the following spinal conditions: cauda equina syndrome, cord compression, infection, fracture, neoplasm, inflammatory disease, pregnancy, any form of headache, whiplash-associated disorders, vertigo/dizziness, or vertebrobasilar insufficiency. DATA EXTRACTION: Data were independently extracted from eac …

Various neurological symptoms by neurolymphomatosis as the initial presentation of primary testicular lymphoma.

Neurological symptoms induced by the infiltration of malignant lymphoma into the nervous systems are subsumed under the term neurolymphomatosis (NL). Here, we report the case of a 30-year-old Japanese man with primary testicular lymphoma complicated, as seen in various neurological findings, by secondary NL prior to testicular swelling. Painless right scrotal enlargement was noticed more than 1 month after the appearance of neurological complications such as right upper extremity numbness, dysarthria, facial palsy, and diplopia. Proactive investigation and biopsies of extranodal sites at high

The Radiologists' Guide to Spinal Separation Surgery: What Does the Surgeon Want to Know?

Spinal tumours are an uncommon but significant cause of pain, fractures, instability, and cord compression, leading to poor quality of life and mortality. Separation surgery is a rapidly advancing technique that has seen increased utilisation in the field of spinal oncology surgery. Separation surgery can be described as a resection technique that decompresses the spinal cord whilst creating an ablative target for high-dose stereotactic radiotherapy to achieve durable local control while minimising the risk of radiation myelopathy. This has facilitated the delivery of stereotactic radiotherapy

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… The patient developed symptoms of acute cauda equina syndrome, for which we recommended an emergent surgical decompression to be performed at the referring hospital. Biopsy confirmed a conventional chordoma. …

A tertiary care centre experience with Elranatamab: A report of three cases.

IntroductionThe introduction of proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies has changed the treatment paradigm of multiple myeloma. With the advent of these new therapeutic options, life expectancy has substantially increased for myeloma patients which has led to an increased number of patients with triple-class refractory disease. Thus, there remains an unmet need for effective novel therapies with good tolerability and safety profile. Elranatamab, is the most widely used bispecific antibody currently in the Indian setting. However, it has only been used on a clin

Рециркуляция и теклистамаб в реанимированном миеломе: первый опыт у двух пациентов с обширной болезнью, прошедших курс интенсивной терапии.

Цель этой статьи состоит в том, чтобы рассказать о нашем первоначальном опыте использования двух пациентов с широко распространенной множественной миеломой, в том числе с рецидивом печени и менингелия, соответственно, с использованием двух специфической T-клеточной антерпрайзерной текклистамбы с соответствующей радиотерапией, включая рентгеновское облучение. Это ретроспективная оценка данных о пациентах в одном учреждении. Оба пациента ранее получали несколько линий системной терапии и радиотерапии по нескольким целевым показателям, в результате чего по завершении последних курсов в 2025 году

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… She was bedridden as a consequence of cauda equina syndrome due to meningeal infiltration of plasma cells, confirmed after spinal puncture ( Figure 4 ). Clinical symptoms and cranial magnetic resonance imaging (MRI) suggested intracerebral affection too. …

Эффективность идекабагена вклейкукеля у пациентов с рецидивной/отходной множественной миеломой и предыдущим проявлением центральной нервной системы: мультицентральный анализ реального мира.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Successful BCMA CAR‐T therapy for multiple myeloma with central nervous system involvement manifesting as cauda equina syndrome—a wandering road to remission . Front Oncol . 2021 ; 11 : 755584 . 34868965 10.3389/fonc.2021.755584 PMC8635736 13 Varga G , Mikala G , Gopcsa L , et al. …

Leptomeningeal Disease as an Initial Presenting Manifestation in Breast Cancer.

Leptomeningeal disease (LMD) occurs in less than 5% of breast cancer patients. Rarely, patients present with LMD at diagnosis. We report a case of a 59-year-old female who presented with lower back pain, radicular neuropathy with lower extremity weakness, and was found to have diffuse LMD. Workup was initiated to evaluate the etiology of LMD and later involved iliac bone biopsy showed metastatic adenocarcinoma consistent with breast carcinoma. Patient received radiation therapy followed by abemaciclib with letrozole and responded well with the treatment.

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… Since our patient was symptomatic from lumbar radiculopathy and cauda equina syndrome, prompt lumbosacral spine radiotherapy was administered for symptom relief. She was also started on abemaciclib with letrozole for systemic therapy. …

CAR T-cell-associated neurotoxicity in central nervous system hematologic disease: Is it still a concern?

Chimeric antigen receptor (CAR) T-cell systemic immunotherapy has revolutionized how clinicians treat several refractory and relapsed hematologic malignancies. Due to its peculiar mechanism of action, CAR T-cell-based therapy has enlarged the spectrum of neurological toxicities. CAR T-cell-associated neurotoxicity-initially defined as CAR T-cell-related encephalopathy syndrome (CRES) and currently coined within the acronym ICANS (immune effector cell-associated neurotoxicity syndrome)-is perhaps the most concerning toxicity of CAR T-cell therapy. Importantly, hematologic malignancies (especial

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… Successful BCMA CAR-T therapy for multiple myeloma with central nervous system involvement manifesting as cauda equina syndrome—a wandering road to remission. Front Oncol. (2021) 11:755584. 10.3389/fonc.2021.755584 66. Zhang Y, Zhang C, Zhou J, Zhang J, Chen X, Chen J, et al. …

Management of Primary Plasma Cell Leukemia Remains Challenging Even in the Era of Novel Agents.

Primary plasma cell leukemia (PCL) is a rare and aggressive variant of multiple myeloma (MM). PCL is characterized by peripheral blood involvement by malignant plasma cells and an aggressive clinical course leading to poor survival. There is considerable overlap between MM and PCL with respect to clinical, immunophenotypic, and cytogenetic features, but circulating plasma cell count exceeding 20% of peripheral blood leukocytes or an absolute plasma cell count of >2000/mm3 distinguishes it from MM. After initial stabilization and diagnosis confirmation, treatment of PCL in a fit patient typical

Prospective external validation of a three-predictor frailty model for 90-day survival and complications following spinal metastasis surgery.

Background contextSurgical decision-making in patients with spinal metastases remains complex due to the need to balance potential surgical benefits with limited survival and common frailty. Predictive models can assist in this process, but their clinical utility is often limited by complexity and lack of validation.PurposeTo externally validate a simple three-predictor frailty model for 90-day survival and complications, and to compare its performance with other commonly used tools.Study design/settingProspective external validation study conducted at a single tertiary cancer center.Patient s

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… Given the imminent risk of cauda equina syndrome and an acceptable surgical risk profile, the team opted for decompressive surgery with spinopelvic fixation. … Cauda equina syndrome was successfully avoided. The patient reported a substantial reduction in neuropathic pain and maintained functional motor strength until his death, which occurred 664 days after surgery. …

Spinal Epidural Abscess.

AUDIENCE: The aim of this simulation case is to educate senior medical students, resident physicians, and advanced practice providers on the … n, overflow urinary incontinence, bowel dysfunction, hyperreflexia, radicular pain, spinal shock or cauda equina syndrome.1,4Laboratory findings may include systemic leukocytosis and elevated inflammatory markers. Whereas leukocytosis is estimated to be present in two-thirds of cases,2 Davis, et al. showed that with the concurrent presence of a risk factor, an elevated …

Электронные постеры

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Доклад о серьезном миелин олигодендроците гликпротеина, связанном с антителными заболеваниями, после эктической беременности и лапароскопического медицинского аборта: значение периферического воспаления для демиелинизирующей деятельности.

Myelin oligendrocyte glycoprotein - болезнь, связанная с антителами (MOGAD) - редкое неврологическое заболевание. Одной из важных причин материнской заболеваемости и смертности во всем мире является внематочная беременность в Тубале. Регулярная беременность оказывает воздействие на MOGAD, приводя к увеличению числа рецидивов в послеродовой период. Тем не менее не существует ни сообщений о конкретных случаях, ни когортных исследований, посвященных абортам и эктуальной беременности в качестве события, способствующего изменению болезней в рамках МУГАД. Это отчет о серьезном рецидиве MOGAD после э

Spinal lesions: a comprehensive radiologic overview.

Spinal lesions encompass a diverse range of pathologies, including primary and secondary tumors, infectious processes, vascular malformations, traumatic injuries, and degenerative conditions, each with distinct imaging characteristics crucial for accurate diagnosis and management. Imaging plays vital roles in assessing lesion morphology, anatomical localization, and neurological impact, guiding clinical decision-making and therapeutic planning. This review systematically explores spinal lesions based on their anatomical compartments, highlighting key radiological features and providing a compr

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… Clinically, patients present with symptoms such as radicular pain, neurogenic claudication, or, in severe cases, cauda equina syndrome ( 103 , 104 ). Genetic factors contributing to disc herniation include variants in collagen genes (COL1A1, COL9A3, COL2A1), notably the COL9A3 rs6122316-C variant. …

Disorders of the Spinal Cord

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Neuropathic pain feature in cancer-induced bone pain: does it matter? a prospective observational study.

BackgroundCancer-induced bone pain (CIBP) is considered to have both nociceptive and neuropathic components. However, the prevalence, risk factors, and impact of the neuropathic components are yet poorly understood.MethodsWe estimate the prevalence of neuropathic pain (NP) features in patients with CIBP at a tertiary care pain clinic setting using the Douleur Neuropathique 4 questionnaire and evaluate their associated factors and their impact after 4 weeks of treatment using the Brief Pain Inventory questionnaire and the Edmonton Symptom Assessment System.ResultsA total of 133 patients were re

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… The exclusion criteria were obvious neurological involvement, such as spinal cord compression, cauda equina syndrome, or peripheral nerve compression. Patients who had preexisting neurological deficits in the same area of the CIBP or cognitive dysfunction were also excluded. 2. …

Изучение неврологических неблагоприятных реакций протеиновых ингибиторов в системе отчетности УЛХ о неблагоприятных явлениях.

ЦЕЛЬ: Бортезомиб, карфилзомиб и ixazomib являются протеозными ингибиторами (ИП), используемыми для лечения множественной миэломы (ММ). Мы провели всеобъемлющий фармакологический анализ их нейротоксичности с использованием Системы отчетности о неблагоприятных явлениях управления продуктами питания и лекарствами (FAERS), включая не только периферическую нейротоксичность, но и центральную нейротоксичность, с тем чтобы дать ориентиры для безопасного и рационального клинического использования. Мы получили отчеты о негативной реакции ПИ во время Q1 2004 с Q2 2025 из базы данных FAERS. С помощью стат

A multidisciplinary bone metastases clinic at Toronto Sunnybrook Regional Cancer Centre - A review of the experience from 1999 to 2005.

Our objective in this study was to review the experience of a one-stop multidisciplinary bone metastases clinic (BMC) that offers a coordinated multidisciplinary approach to the care of cancer patients with bone metastases in a tertiary cancer centre. Patients with symptomatic bone metastases were referred to BMC and assessed by a team of specialists in various disciplines - interventional radiology, orthopedic surgery, palliative medicine, and radiation oncology. At initial consultation, patient demographics, reasons for referral, and case disposition were recorded. From January 1999 to Febru

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… Thirty patients (46%) were classified to have a high risk of fracture at the spine because of mechanical instability (16/30), spinal cord compression (12/30), cauda equina syndrome or more than two nerve root deficits (2/30). …

Spinal brown tumors as a rare cause of spinal cord compression: Report of case series.

INTRODUCTION AND IMPORTANCE: Brown tumors (BTs) are rare benign osteolytic lesions that arise in the context of uncontrolled hyperparathyroidism. They mostly located in the large bone and rarely in the spine. Spine involvement can cause neurologic symptoms and rarely spinal cord compression. The aim of this study is to diagnose BTs of the spine in presence of spinal cord compression symptoms leading to appropriate treatment. CASE PRESENTATION: Retrospective study of 4 cases of Brown tumors revealed by spine cord compression and rapidly operated in our neurosurgery department between 2014 and