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Сочетание низкотемпературной радиочастотной термокоагуляции и импульсной радиочастоты двустороннего ганглиона Гассериана для двусторонней тригеминной нейронгии из-за множественного склероза: отчет о деле.

Двусторонний тригеминальный нейронный вторичный склероз является крайне редким заболеванием. Когда проводится ганглионный блок Гассериана, необходимо добиться надежного долгосрочного анальгетического эффекта, избегая при этом осложнений, связанных с лечением. КИСЛОТА: 49-летний самец с множественным склерозом продемонстрировал стойкую скучную боль и пароксисмическую электрическую боль, похожую на шоковую, в своих двусторонних максимальных миллиардных молярах и челюсти. У него был диагностирован тригеминальный нейронный диагноз, вызванный множественным склерозом. Из-за серьезных побочных эффект

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… He was prescribed carbamazepine 700 mg/day, valproic acid 600 mg/day, tramadol 150 mg/day, acetaminophen 1300 mg/day, Neurotropin 4 N.U. (neurotropin units), duloxetine 20 mg/day, pregabalin 300 mg/day, and fentanyl patch 1 mg/day. … Although right facial pain remained, he was able to discontinue pregabalin and reduce the daily doses of carbamazepine, tramadol, acetaminophen, and fentanyl patch from 700 to 500 mg, 150 to 100 mg, 1300 to 1000 mg, and 1 to 0.5 mg, respectively. The doses of other medications remained unchanged. …

Early Interventional Treatments for Patients with Cancer Pain: A Narrative Review.

Between 10% and 20% of patients with cancer-related pain cannot achieve adequate control following the three-step ladder guidelines by the World Health Organization. Therefore, a "fourth step", including interventional approaches, has been suggested for those cases. Systematic reviews support the early use of interventional procedures to treat refractory cancer pain, control symptoms and prevent opioid dose escalation. There is strong evidence of the efficacy of celiac plexus or splanchnic neurolysis, vertebroplasty, kyphoplasty and intrathecal drug delivery. Those procedures have been found t

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… Patients with severe pancreatic pain (>7/10 on a numerical rating scale, NRS), poorly responding to tramadol, were randomly allocated to receiving a CPN with alcohol immediately upon initial assessment or waiting until CMM with morphine reduced their pain to an NRS<4. … In addition, the proportion of patients having adequate pain control with Tramadol increased during the first five months after an early sympathectomy. As well, the quality of life of patients receiving an early sympathectomy improved until the fifth month after the intervention. …

Adverse events associated with medium- and long-term use of opioids for chronic non-cancer pain: an overview of Cochrane Reviews.

BACKGROUND: Chronic pain is common and can be challenging to manage. Despite increased utilisation of opioids, the safety and efficacy of lo … hydromorphone, levorphanol, methadone, morphine, oxycodone, oxymorphone, tapentadol, tilidine, and tramadol). In the 14 Cochrane Reviews providing unique quantitative data, there were 61 studies with a total of 18,679 randomised participants; 12 of these studies had a cross-over design with two to four arms and a total of 796 participants. Based on the 14 …

Factors Affecting the Incidence and Severity of Oral Mucositis Following Hematopoietic Stem Cell Transplantation.

Background: Patients who receive hematopoietic stem cell transplantation (HSCT) experience several complications that oral mucositis (OM) is a frequent symptom. This study was designed to evaluate the incidence, risk factors, prophylaxis and treatment strategies for established OM. Materials and Methods: We included 173 adult patients who received autologous or allogeneic hematopoietic stem cell transplantation in this study. The World Health Organization oral toxicity scale was used to assess the severity of OM. Patients received two prophylactic regimens: regimen 1 contained nystatin, chlorh

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… Tramadol, pethidine and morphine were used by 8(5%) patients (mean number of doses: 11 doses), 8(5%) patients (mean number of doses: 8 doses) and 3(1.9%) patients (mean number of doses: 10 doses) respectively. … In our study, the most frequently prescribed medications for pain relief were tramadol and pethidine (in equal number of patients), followed by morphine on an as-needed basis. …

Pain prevalence and treatment in patients with metastatic bone disease.

The accomplishment of successful pain treatment requires evaluation, characterization and quantification. The present study characterized pain and survival in a cohort of patients with cancer with bone metastasis who were treated with intravenous bisphosphonates. A total of 84 patients self-completed the Brief Pain Inventory (BPI) and 36-Item Short Form Survey (SF-36), between November 2010 and March 2011 with a 5-year survival follow-up as a surrogate marker of cancer burden. The median age was 62 years old (34-85), 64% of patients were female and 58% of these females had breast cancer. In th

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… Analgesic treatment categorization was performed according to the WHO analgesic ladder: i) Non-opioid drugs (anti-inflammatory drugs or acetaminophen); second; ii) weak opioid drugs (tramadol and codeine), and iii) strong opioid drugs (fast or slow-acting morphine or equivalent patches) ( 47 , 48 ). … Tramadol was used to treat 22 patients, 10 patients were treated with tramadol with acetaminophen, 8 patients were treated by morphine sustained release and 5 with a transdermal patch (3 with fentanyl and 2 with buprenorphine). …

Evaluation of safety and analgesic consumption in patients with advanced cancer treated with zoledronic acid.

BackgroundThe aim of the study was evaluation of zoledronic acid with regard to safety, effect on analgesic consumption and impact on occurrence of skeletal related events in patients with bone lesions from solid tumors and multiple myeloma.MethodsWe conducted an observational, 12-month, phase IV and multi-center study. One hundred and twenty-five symptomatic (pain) bone-metastatic patients were included between 2007 and 2009: 92 prostate cancers, 28 multiple myelomas, 5 others. They were prescribed monthly infusions of zoledronic acid in accordance to each disease's treatment guidelines. Anal

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… Pain and analgesics use For analysis of analgesic requirement, prescribed analgesics were grouped into 3 groups: opioid analgesics (tramadol, hydromorphone, oxycodone, transdermal fentanyl, piritramide, morphine sulphate), non-steroidal antiinflammatory drugs (diclofenac, ketoprofen) and others (paracetamol … The most frequently prescribed analgesic was tramadol (weak opioid), followed by non-steroidal anti inflammatory drugs. …

The challenge of pharmacotherapy for musculoskeletal pain: an overview of unmet needs.

Musculoskeletal disorders are characterized by several impairments, including pain, affecting muscles, bones, joints and adjacent connective tissue, resulting in temporary or permanent functional limitations and disability. Musculoskeletal pain is particularly prevalent worldwide and greatly impacts the quality of life, social participation and economic burden. To date, several issues persist about the classification of musculoskeletal pain and its management strategies and resources. The treatment of musculoskeletal pain conditions is complex and often requires a multimodal approach, includin

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… . | PO/IV/IM/Topical | First-line drugs in mild to moderate MSK pain from OA and LBP 11 – 31 , 33 , 34 | Most frequently overused/misused medications in older patients 37 Opioids | Morphine, Codeine, Fentanyl, Meperidine, Oxycodone, Methadone, Buprenorphine, Tramadol. | PO/IV/IM/Topical | Indicated in … Mixed non-opioid–opioid Different associations of acetaminophen or NSAIDs with opioids such as tramadol, oxycodone and codeine are available in clinical practice. …

Saliva как матрица для терапевтического мониторинга наркотиков и биомаркеров заболеваний у детей и подростков.

Saliva — более доступная, менее напряженная и менее дорогостоящая биологическая матрица, чем кровь, и она может применяться в терапевтическом мониторинге лекарственных средств (ПТМ). Концентрации слюны отражают фармацевтический активный ненавязанный препарат. В этом обзоре содержится последняя информация о слюне в качестве матрицы для лечебного контроля за наркотиками и определения биомаркеров у младенцев, детей и подростков. К октябрю 2024 года по базе данных PubMed были проведены обыски литературы, 64 исследования были включены в TDM, стероиды, добавки, биомаркеры заболеваний, стоматология,

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… Significant correlations between tramadol and its metabolite concentrations in blood, saliva, and urine were found and highly potent O-desmethyl tramadol metabolite has an important role in toxicity and the likelihood of tramadol poisoning in people with extensive metabolism [ 23 ]. … Saliva has a potential to be used in toxicology screening e.g. in the case of fentanyl and diagnosing opioid exposure and risk for neonatal abstinence syndrome prior to the onset of symptoms [ 32 ] as well as in the case of tramadol, for which the correlation between plasma and saliva concentrations …

Patients with multiple myeloma referred for palliative care consultation: from retrospective analysis to future directions to improve clinical outcomes.

INTRODUCTION: New treatments have improved the overall survival of patients with multiple myeloma (MM). At diagnosis and during the course of the disease, patients often report pain and other symptoms. Given the long disease trajectory, psychological and social issues are also frequent. Recently, the potential usefulness of early palliative care (EPC) was hypothesized in the area of hematology. We conducted a retrospective analysis of patients with MM referred to our institute for a palliative care (PC) consultation between January 2017 and June 2020. Our aim was to evaluate the main reasons (

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… No. patients (%) Started paracetamol therapy alone 2 (5.1) Started an opioid therapy 5 (12.8) Opioid rotation 10 (25.7) Increased opioid dose 9 (23.1) Started adjuvant therapy alone 6 (15.4) Scrambler therapy 2 (5.1) Opioid rotation + added adjuvant therapy 2 (5.1) No modified therapy 3 (7.7) Opioid Tramadol … Started paracetamol therapy alone | 2 (5.1) Started an opioid therapy | 5 (12.8) Opioid rotation | 10 (25.7) Increased opioid dose | 9 (23.1) Started adjuvant therapy alone | 6 (15.4) Scrambler therapy | 2 (5.1) Opioid rotation + added adjuvant therapy | 2 (5.1) No modified therapy | 3 (7.7) Opioid Tramadol …

Association of KCNJ6 rs2070995 and methadone response for pain management in advanced cancer at end-of-life.

Opioids are the therapeutic agents of choice to manage moderate to severe pain in patients with advanced cancer, however the unpredictable inter-individual response to opioid therapy remains a challenge for clinicians. While studies are few, the KCNJ6 gene is a promising target for investigating genetic factors that contribute to pain and analgesia response. This is the first association study on polymorphisms in KCNJ6 and response to methadone for pain management in advanced cancer. Fifty-four adult patients with advanced cancer were recruited across two study sites in a prospective, open lab

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… palliative sedation because of refractory symptoms associated with opioid treatment in the dying phase Lotsch et al. 11 | Chronic pain | 352 chronic pain patients treated for pain of various reasons in tertiary outpatient care, Germany | Opioids (morphine, fentanyl, buprenorphine, oxycodone, tilidine, tramadol … combined AG and GG genotypes, with no significant difference in AA genotype distribution for pain diagnoses or opioid used, and no significant difference in pain score Margarit et al. 20 | Chronic pain | 222 patients with chronic lower back pain referred for opioid prescription, Spain | Opioids (fentanyl, tramadol …

Evidence-based supportive care in multiple myeloma.

Multiple myeloma (MM) is a hematological malignancy characterized by an abnormal clone of plasma cells in the bone marrow. MM and its therapy increase the risk of complications like anemia, osteolytic lesions, pain, infections, and renal abnormalities in MM patients. Supportive care for MM patients improves the quality of life. Treatment with bisphosphonates decreases skeletal-related events. Vertebroplasty and kyphoplasty are done in cases of vertebral compression fractures. Prophylactic antibiotics and antivirals can decrease infections related to morbidity. Plasmapheresis in patients with r

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… line First line First line First line Topical agents (patches) Topical lidocaine 5% (daily) 3 3 NR First line for LPNP Second line for LPNP Second line Capsaicin 8% (3 months) 1–4 1–4 NR NR NR Second line Opioids agonists Morphine 10–15 mg every 4 hr No max. dose NR Second line Third line Third line Tramadol … Topical agents (patches) Topical lidocaine 5% (daily) | 3 | 3 | NR | First line for LPNP | Second line for LPNP | Second line Capsaicin 8% (3 months) | 1–4 | 1–4 | NR | NR | NR | Second line Opioids agonists Morphine | 10–15 mg every 4 hr | No max. dose | NR | Second line | Third line | Third line Tramadol …

PB2350: SAFETY AND EFFICACY OF HYPODERMOCLYSIS IN PATIENTS WITH HEMATOLOGICAL CANCERS

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Infused drugs included isotonic fluids (5% glucose, 0.9% saline, Ringer’s solution) in 100%, tramadole in 81.25%, parenteral potassium in 78.1%, furosemide in 78.1%, dexamethasone in 18.75%, meropenem in 12.5%, methylprednisolone in 6.25%, diazepam in 6.25%, haloperidol in 6.25%, gentamicin in 6.25%, …

Bortezomib-induced painful neuropathy in patients with multiple myeloma.

Neurotoxicity towards the peripheral nervous system which appears clinically in the form of painful neuropathy is an essential dose-limiting factor during the treatment of multiple myeloma. In this review article different forms of this painful neuropathy are presented together with currently available diagnostic tools which are usually applied to confirm the diagnosis. Also, the most often used neurological scales estimating neurological deficit are presented. Special attention is paid to the management of the reversibility of bortezomib-induced neuropathic pain.

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… For pain relief, tramadol has been used extensively. It is a weak µ-opioid receptor agonist which also has the potential to inhibit reuptake of serotonin and norepinephrine. Initial dosage should be as low as 50 mg once or twice a day. … 10.1001/jama.280.21.1831 30 Rosenstock J Tuchman M LaMoreaux L Sharma U Pregabalin for treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trials Pain 2004 110 628 38 15288403 10.1016/j.pain.2004.05.001 31 Harati Y Gooch C Swenson M Double-blind randomized trial of tramadol …

Role of radiofrequency ablation and cement injection for pain control in patients with spinal metastasis.

BackgroundThe study aimed to investigate the effects and reliability of simultaneous vertebroplasty and radiofrequency ablation or radiofrequency ablation applied alone for pain control in patients with painful spine metastasis, and to investigate the effect of preventing tumor spread in long-term follow-up.MethodsPatients with painful vertebrae metastasis in the Afyonkarahisar Health Sciences University, Medical Faculty, Hospital Neurosurgery Clinic between 01.01.2015 and 01.06.2020 were recruited. They were divided into groups according to the surgical procedures applied. Group 1 included 26

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… Tenoxicam and tramadol hydrochloride were discontinued 48 h after the procedure in patients who had required them before the procedure. The need for tenoxicam significantly decreased in both groups by the end of the first week. … In our study, tramadol hydrochloride was discontinued 48 h after the procedure in groups 1 and 2, while the need for tenoxicam, another analgesic used at the end of the first week, significantly decreased. …

Real-World Pharmacological Treatment Pattern of Neuropathic Pain in China: A Retrospective, Database, Multicenter Study (ReTARdant) Protocol.

IntroductionNeuropathic pain (NP), including diabetic peripheral neuropathic pain (DPNP) and chemotherapy-induced peripheral neuropathy (CIPN) as common subtypes, imposes a significant clinical burden on patients, severely affecting their quality of life. The real-world evidence on demographic characteristics, treatment patterns, and adherence data of DPNP and CIPN is still limited.MethodsA multicenter, retrospective, observational study using electronic medical record (EMR) systems involving approximately 600 patients with DPNP and 400 with CIPN from nine hospitals was planned. The study peri

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… If ineffective, second-line treatment involves tramadol or tapentadol, with third-line treatments including serotonin-specific reuptake inhibitors, anticonvulsants, and N -methyl d -aspartate (NMDA) receptor antagonists [ 11 – 13 ]. … duloxetine 9.14%; ibuprofen 3.14%; amitriptyline 2.57% TCA 26%; anticonvulsants 41.94%; SSRI 1.21%; topical preparations 0.17%; opioids 1.39%; SNRI 2.08% Pregabalin was the first choice for patients (69.7%), followed by duloxetine and tapentadol Pregabalin 19.8%; gabapentin 14.2%; TCA 9.4%; SNRI 7.5%; tramadol …

Роль фитохимикатов в борьбе с нейропотической болью: сколько успехов мы добились?

Нетрофическая боль — это сложное и изнурительное состояние, вызванное повреждением нерва, которое характеризуется такими ощущениями, как горение, покалывание и стрельба. Она часто связана с такими условиями, как множественный склероз (MS), синдром Гильен-Барре (GBS) и диабетическая полиномропата. Лечение обычной боли часто обеспечивает ограниченное облегчение и сопровождается существенными побочными эффектами, подчеркивая необходимость изучения альтернативных вариантов лечения. Фитохимические вещества, являющиеся биоактивными соединениями, полученными от растений, привлекли внимание к их потен

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… For resistant cases, opioids and tramadol are prescribed. Tramadol offers modest pain relief but has common side effects such as dizziness and nausea, and opioids carry risks of tolerance, dependence, and other side effects [ 69 , 70 ]. … Tramadol for neuropathic pain in adults Cochrane Database Syst. Rev. 2017 2017 CD003726 10.1002/14651858.CD003726.pub4 28616956 PMC6481580 70. McNicol E.D. Midbari A. Eisenberg E. Opioids for neuropathic pain Cochrane Database Syst. …

Clinical Validation of Quality Indicators for the Pharmacological Management of Chronic Non-Cancer Pain in Older Adult Inpatients.

PurposeChronic non-cancer pain (CNCP) affects up to 88% of older adults. Pharmacological therapies are frequently prescribed long-term despite being considered second-line treatments and carrying significant risks, particularly for older adults. The present study aimed to clinically validate a set of quality indicators (QIs) that are used to improve the detection of medication-related problems during medication reviews performed by pharmacists for older adult inpatients with CNCP.Patients and methodsWe evaluated a set of medication review QIs-with previously established face and content validi

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… . | 1% | 50% | 100% | | 0% O17 | IF an older adult with CNCP requires opioids, THEN do not use tramadol. | 52% | 98% | 100% | | 0% N1 | IF an older adult with CNCP – has a history of peptic ulcer disease or gastrointestinal bleeding and/or – currently uses antithrombotics, anticoagulants, corticosteroids … QIs addressing high-risk drugs, such as tramadol (QI O17), indomethacin (N9) or ketorolac (N11), had a low potential for improvement in our population. …

Indian Society for Study of Pain, Cancer Pain Special Interest Group Guidelines on Pharmacological Management of Cancer Pain (Part III).

The Indian Society for Study of Pain (ISSP), Cancer Pain Special Interest Group, guidelines on pharmacological management of cancer pain in adults provide a structured, step-wise approach which will help to improve the management of cancer pain and to provide patients with a minimally acceptable quality of life. The guidelines have been developed based on the available literature and evidence, to suit the needs, patient population, and situations in India. A questionnaire based on the key elements of each sub draft addressing certain inconclusive areas where evidence was lacking, was made avai

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… Fentanyl is metabolized in the liver primarily to norfentanyl and other inactive and nontoxic metabolites.[ 3 ] In liver disease, the metabolism of fentanyl is affected mainly by decreased hepatic blood flow rather than severe hepatic dysfunction and is therefore relatively safe to be used.[ 4 5 ] Tramadol … Tramadol is metabolized in the liver to the active metabolite, O-desmethyltramadol (M1) which contributes to its analgesic effect. …

Chronic Pain and Bone-Related Pathologies: A Narrative Review.

PurposePain related to bone may occur as a result of trauma, bone fracture, genetic disease, arthritis, benign or malignant primary bone tumors and bone cancer metastases. We discuss the pathophysiology of chronic bone-related pain, treatment options and therapeutic perspectives.MethodsUsing predefined terms, we searched PubMed, MEDLINE, and Google Scholar for meta-analyses, evidence-based reviews, and clinical practice guidelines. This narrative article reviews pathologies linked to chronic bone pain and discusses the preventive and therapeutic strategies for better bone pain management.Resul

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… Prescription of opioids (tramadol, codeine, morphine, oxycodone, buprenorphine, hydromorphone…) is related to the intensity of pain and not to the severity of the disease, and they are used for chronic cancer and non-cancer bone pain. … A drug with a dual mode of action like tramadol, which has a centrally opioidergic mode of action and an inhibitory effect on serotonin/norepinephrine reuptake, is also used in bone pain as nociceptive and neuropathic bone pain often coexist. …

Глубокая стимуляция мозга в гипоталамической области: систематический обзор.

КОЛИЧЕСТВО: Глубокая стимуляция мозга (БРС) успешно используется для лечения циклопатии, включая движение, беспокойство и поведенческие расстройства. Гипоталамус является важнейшим интеграционным центром для многих периферийных и центральных путей, связанных с сердечно - сосудистыми, метаболическими и поведенческими функциями, и представляет собой потенциальную цель нейромодуляции в лечебных условиях. Проведение систематического обзора, изучение гипоталамических целей в ДБС, их признаков и основных клинических результатов.МЕТОДЫ: База данных PubMed, Scopus и Web of Science была подвергнута обы

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… and corticosteroids to the ipsilateral sphenopalatine ganglion (16, 100%) Postoperative CCH: verapamil (4, 25.0%), methysergide (2, 12.5%) Preoperative SUNCT: carbamazepine, gabapentin, oral and IV valproate, lamotrigine, topiramate, indomethacin, corticosteroids (methylprednisolone, prednisone), and tramadol … corticosteroids to the ipsilateral sphenopalatine ganglion (16, 100%) Postoperative CCH: verapamil (4, 25.0%), methysergide (2, 12.5%) Preoperative SUNCT: carbamazepine, gabapentin, oral and IV valproate, lamotrigine, topiramate, indomethacin, corticosteroids (methylprednisolone, prednisone), and tramadol …