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Bone metastasis and pain research through the dual lens of bibliometrics and bioinformatics: knowledge structure, frontiers, and core pathway analysis (2015-2024).

BackgroundCancer-induced bone pain (CIBP) represents a formidable clinical challenge with complex mechanisms, and existing treatments remain unable to effectively control pain in many patients. This study combined bibliometric and bioinformatic approaches to delineate key research trends, principal themes and future directions in the field of bone metastasis and pain research over the past decade (2015-2024).MethodsWe selected 1,822 relevant documents from the Web of Science Core Collection for bibliometric analysis to identify major research characteristics, collaboration networks and emergin

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… #9 percutaneous osteoplasty: Concerned the application of percutaneous osteoplasty (vertebroplasty/kyphoplasty) in treating spinal metastases and relieving pain. … 2019 | 2020 | 5.4008 | 2015 | Bone 2020 | 2022 | 6.384 | 2015 | Spinal metastasis 2021 | 2022 | 12.7326 | 2015 | Case report 2021 | 2024 | 8.6152 | 2015 | Microwave ablation 2021 | 2024 | 7.2359 | 2015 | Thermal ablation 2021 | 2024 | 6.3333 | 2015 | Update 2021 | 2022 | 5.8583 | 2015 | Percutaneous vertebroplasty …

Ablation-First Balloon-Assisted Acetabuloplasty for Painful Acetabular Metastases: Clinical Outcomes and Mechanical Rationale.

PURPOSE: To evaluate the safety, technical feasibility, and clinical outcomes of a strict two-step protocol-CT/fluoroscopic-guided thermal ablation followed by Balloon-Assisted Acetabuloplasty (BAA)-for the treatment of painful acetabular metastases, utilized as an immediate mechanical stabilization bridge prior to radiotherapy. MATERIALS AND METHODS: A retrospective study was conducted on 16 consecutive patients treated for severe mechanical pain (VAS ≥ 6) and impaired mobility due to osteolytic acetabular metastases. The physiological rationale mandated a strict procedural sequence: (1) pre

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… Vertebroplasty and kyphoplasty: A comprehensive review. Neurosurg. Focus. 2005;18:e1. doi: 10.3171/foc.2005.18.3.2. 4. Beall D.P., Chambers M.R., Thomas S., Amburgy J., Webb J.R., Jr., Goodman B.S., Datta D.K., Easton R.W., Linville D., II, Talati S., et al. …

Fatty Infiltration of Multifidus Muscles: An Easily Overlooked Risk Factor for the Severity of Osteoporotic Vertebral Fractures.

ObjectivesOsteoporotic vertebral fractures (OVFs) are a critical public health concern requiring urgent attention, and severe OVFs impose substantial health and economic burdens on patients and society. Analysis of the risk factors for severe OVF is imperative to actively prevent the occurrence of this degenerative disorder. This study aimed to investigate the risk factors associated with the severity of OVF, with a specific focus on changes in the paraspinal muscles.MethodsA total of 281 patients with a first-time single-level acute OVF between January 2016 and January 2023 were enrolled in t

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… The exclusion criteria were as follows: (i) patients with a history of spinal surgery, including vertebroplasty, discectomy, spinal decompression, or fusion surgery ( n = 65); (ii) patients with pathological fractures due to multiple myeloma, spinal metastasis, or infection ( n = 43); (iii) patients …

Impact of Spinal Instrumentation on Neurological Outcome in Patients with Intermediate Spinal Instability Neoplastic Score (SINS).

Background: Adequate assessment of spinal instability using the spinal instability neoplastic score (SINS) frequently guides surgical therapy in spinal epidural osseous metastases and subsequently influences neurological outcome. However, how to surgically manage ‘impending instability’ at SINS 7−12 most appropriately remains uncertain. This study aimed to evaluate the necessity of spinal instrumentation in patients with SINS 7−12 with regards to neurological outcome. Methods: We screened 683 patients with spinal epidural metastases treated at our interdisciplinary spine center. The preoperati

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… All patients were primarily treated by (a) decompressive surgery, (b) decompressive surgery and instrumentation, (c) instrumentation without decompression, (d) vertebroplasty or (e) local radiotherapy. …

Prognostic role of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with bone metastases.

BackgroundSkeletal metastases are a common problem in patients with cancer, and surgical decision making depends on multiple factors including life expectancy. Identification of new prognostic factors can improve survival estimation and guide healthcare providers in surgical decision making. In this study, we aim to determine the prognostic value of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in patients with bone metastasis.MethodsOne thousand and twelve patients from two tertiary referral centers between 2002 and 2014 met the inclusion criteria. Bivariate and multiv

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… revision procedures, (2) patients with metastatic involvement of the acetabulum or pelvis requiring reconstruction, (3) operative treatments other than endoprosthetic reconstruction, plate-screw fixation, intra-medullary nailing, and dynamic hip screw for long bone fractures, and (4) kyphoplasty and vertebroplasty …

Multiple Myeloma: Cast Nephropathy, VTE, and Neurologic Complications.

Multiple myeloma accounts for approximately 1% of neoplastic diseases and 13% of hematologic cancers. Complications often associated with MM include neurologic and hematologic issues, infections, renal insufficiency, and bone involvement. It is crucial for advanced practice professionals caring for myeloma patients to assess patients accurately, be keenly aware of possible associated complications, and be familiar with appropriate interventions to prevent further injury. This article will provide an overview of MM-related renal insufficiency, with a focus on cast nephropathy, venous thromboemb

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… Central venous catheters and surgeries such as vertebroplasty and kyphoplasty lead to vascular wall injury and damage (Rome et al., 2008). …

Development of a Multimodal Machine Learning Model for Predicting Second Osteoporotic Vertebral Compression Fractures.

PURPOSE: Osteoporosis increases the probability of osteoporotic vertebral compression fractures (OVCF), and the resultant pain severely limits physical activity and increases mortality and morbidity. This study aimed to develop a high-precision multimodal prediction model to forecast the risk of a second OVCF. MATERIALS AND METHODS: This retrospective study included 178 patients from a single institution with a first OVCF between January 1, 2000, and December 31, 2019. The study dataset included 18 preoperative clinical variables, including demographics, medications, comorbidities, bone miner

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… Patients who underwent vertebral augmentation (vertebroplasty or kyphoplasty) at the index level remained eligible for inclusion; however, imaging or morphological changes confined to the treated vertebra were not considered second OVCF. …

Fracture severity dependence of bone and muscle performance in patients following single or multiple vertebral fractures.

BACKGROUND: Few studies focus on the clinical, laboratory, radiological, and biological characteristics of bone and muscle of multiple vertebral fractures, which are associated with a more poor prognosis compared with single fracture. PURPOSE: To compare the BMD, bone turnover, muscularity, fatty infiltration of muscle, and prevalence of co-morbidities in patients with single and multiple vertebral fractures. METHODS: We recruited 100 patients with single fracture (age 66.96 ± 8.24 years) and 100 with multiple fractures (age 69.90 ± 7.80 years); performed dual-energy X-ray absorptiometry of

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… For patients who had undergone percutaneous vertebroplasty and pedicle screw fixation, we avoid the areas with bone cement and fixation during X-ray examination to accurately reflect the patients’ bone density. …

The core symptom in multiple myeloma patients undergoing chemotherapy: a network analysis.

BACKGROUND: During chemotherapy for multiple myeloma, symptoms include those related to the disease, as well as adverse effects of the treatment. Few studies have explored the relationships between these symptoms. Network analysis could identify the core symptom in the symptom network. OBJECTIVE: The aim of this study was to explore the core symptom in multiple myeloma patients undergoing chemotherapy. METHODS: This was a cross-sectional study in which sequential sampling was used to recruit 177 participants from Hunan, China. Demographic and clinical characteristics were surveyed using a se

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… The analgesic ladder, vertebroplasty, and complementary and alternative medicine were also effective in controlling pain [ 35 ]. However, the study showed that the polypharmacy increased mortality, falls, adverse drug reaction, and hospitalization and readmissions [ 38 ]. …

Could kinesiology taping help mitigate pain, breathlessness and abdominal-related symptoms in cancer?

We present the case of a woman who was an amateur athlete diagnosed with primary breast cancer, and 10 years later with terminal metastatic cancer. This case report was prepared posthumously in co-operation with her next of kin (husband). The patient first presented to a sports physiotherapist (AR) for her pain-management and to help maintain physical fitness so that she could continue with sports and an active lifestyle. The patient continued with physiotherapy for several months to enable her to be active. However, when her health deteriorated significantly due to advancing cancer, the treat

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… The patient was scheduled for further sessions of chemotherapy and vertebroplasty to treat vertebral compression fractures the lower cervical and midthoracic spinal region that had resulted from the metastases. …

Samarium-153-ethylene diamine tetramethylene phosphonate, a beta-emitting bone-targeted radiopharmaceutical, useful for patients with osteoblastic bone metastases.

Bone metastases are prevalent among cancer patients and frequently cause significant morbidity. Oncology providers must mitigate complications associated with bone metastases while limiting therapy-related adverse effects and their impact on quality of life. Multiple treatment modalities, including chemotherapy, surgery, external beam radiation therapy, and radioisotopes, among others, have been recommended and utilized for palliative treatment of bone metastases. Radioisotopes such as samarium-153 are commonly used in the setting of multifocal bone metastases due to their systemic distributio

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… There are many different modalities physicians employ to treat bony metastases, including analgesic pain medication, surgical intervention, vertebroplasty, chemotherapy, hormone therapy, bisphosphonates, external beam radiation therapy (EBRT), and radiopharmaceuticals. …

Myeloma Bone Disease: A Comprehensive Review.

Multiple myeloma (MM) is a neoplastic clonal proliferation of plasma cells in the bone marrow microenvironment, characterized by overproduction of heavy- and light-chain monoclonal proteins (M-protein). These proteins are mainly found in the serum and/or urine. Reduction in normal gammaglobulins (immunoparesis) leads to an increased risk of infection. The primary site of origin is the bone marrow for nearly all patients affected by MM with disseminated marrow involvement in most cases. MM is known to involve bones and result in myeloma bone disease. Osteolytic lesions are seen in 80% of patien

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… Vertebroplasty or Kyphoplasty These are minimal invasive procedures that include percutaneous injection of bone cement into fractured vertebral body for stabilization. … Percutaneous vertebroplasty to treat painful myelomatous vertebral deposits—long-term efficacy outcomes Ann. Hematol. 2010 90 95 100 10.1007/s00277-010-1021-2 20607538 113. Dudeney S. Lieberman I. Reinhardt M.-K. Hussein M. …

LncRNA CASC15 serves as a diagnostic biomarker for postmenopausal osteoporotic fractures and its knockdown enhances HBMSC osteogenic differentiation via miR-152-3p.

OBJECTIVE: Long non-coding RNA CASC15 plays a role in the development of various human diseases. However, the diagnostic role and molecular mechanisms of CASC15 in postmenopausal osteoporosis (PMOP) remain unclear. METHODS: This study enrolled 137 healthy postmenopausal women and 141 PMOP patients. CASC15 and miR-152-3p levels in serum and HBMSCs were measured via RT-qPCR. Western blotting and RT-qPCR were employed to analyze the protein and mRNA expression levels of osteogenic markers (RUNX2, ALP, OCN, Col I). CASC15's diagnostic value was assessed by the ROC curve. Proliferation (CCK-8) and

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… Vertebroplasty for painful osteoporotic vertebral compression fractures: a protocol for a single-center doubled-blind randomized sham-controlled clinical trial. VOPE2. J Orthop Surg Res. 2024;19(1):813. 26. Shen L, Yang H, Zhou F, Jiang T, Jiang Z. …

Управление болью у пациентов с множественными миеломами: обзор литературы.

Устранение боли у больных раком с множественной миеломой (ММ) представляет собой серьезную проблему. В ходе этого обзора тщательно изучаются нынешние стратегии борьбы с обезболиванием, трудности и будущие направления деятельности на местах. В обзоре стратегии лечения обезболивающих делятся на фармацевтические и нефармакологические. Заглядывая в будущее, следует отметить многообещающие области для будущих исследований и разработок, такие, как включение точной медицины в обезболивающие методы и изучение новаторских методов лечения. Несмотря на существующие ограничения, прогресс в борьбе с обезбо

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… Procedures such as PVA and vertebroplasty have shown results in alleviating pain associated with vertebral metastasis. However, their applicability and effectiveness across all MM patients need further exploration [ 46 ]. …

Evaluation of different scoring systems for spinal metastases based on a Chinese cohort.

IntroductionsThe spine is one of the most common sites of metastasis for malignancies. This study aimed to compare the predictive performance of seven commonly used prognostic scoring systems for surgically treated spine metastases. It is expected to assist surgeons in selecting appropriate scoring systems to support clinical decision-making and better inform patients.MethodsWe performed a retrospective study involving 268 surgically treated patients with spine metastases between 2017 and 2020 at a single regional oncology center in China. The revised Tokuhashi, Tomita, modified Bauer, revised

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… The exclusion criteria were as follows: (1) loss to follow‐up within 1 year after surgery without the capacity to definitively determine survival at the 1‐year time point and (2) percutaneous vertebroplasty as the exclusive surgical procedure. …

Multiple myeloma: an overview of management.

Multiple myeloma represents 2% of all new cancer diagnoses in the United Kingdom and accounts for 2% of all cancer deaths. In the past few decades, there have been huge improvements in life expectancy which have been driven by novel therapeutic agents, autologous stem cell transplants and intensified supportive care. This review will discuss the pathogenesis of multiple myeloma, current management approaches and the direction of future treatments. In addition, this review will highlight the high burden of symptoms that patients experience and therefore the great benefits that can be gained fro

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… All patients with significant spinal disease should be referred to a specialist spinal surgery team for assessment as they may benefit from bracing, vertebroplasty or kyphoplasty. 5 Patients with MM have a weakened immune system and infection is a common cause of presentation and of death, especially …

Бремя лечения, секвенирования и использования ресурсов здравоохранения в множестве миеломы в Латинской Америке: обзор целевой литературы.

Утверждение основных классов лекарственных препаратов позволило улучшить выживание пациентов с множественной миеломой (ММ). В то же время большинство пациентов сталкиваются с рецидивом или становятся противниками этих методов лечения, причем повторное лечение имеет ограниченную эффективность. Доступ к этим основным методам лечения в разных странах Латинской Америки (ЛАТАМ), что может привести к неоптимальным клиническим результатам. Цель этого целевого обзора литературы заключалась в том, чтобы понять эпидемиологию, бремя лечения, последовательность лечения и наличие MM в Аргентине, Бразилии,

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… When using the Oswestry scale for evaluating patient disability, 45.8% of patients were reported to have poor functionality (score 31–50); patients with spinal fractures who were treated with vertebroplasty were three times more likely to have good functionality on the Oswestry scale (odds ratio [OR] … Quality of life in patients with multiple myeloma treated with percutaneous vertebroplasty. Coluna/Columna. 2014;13(1):53–6. 10.1590/S1808-185120141301RC105. 72. Pepe C, Asano E, Senna T, Asano E, Rosim RP. Impacto econômico do mieloma múltiplo no sistema privado de saúde do Brasil. …

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Анализ боли в скелете, общих симптомов и показателей результатов, сообщаемых пациентами, а также их значения для выявления симптоматического развития - междисциплинарное перспективное исследование у пациентов с множественной миеломой.

Задержка с диагностированием множественной миеломы (ММ) и прогрессирующего заболевания (ПД) может как увеличить риск осложнений в скелете, так и повлиять на качество жизни пациентов (QoL). В этом перспективном исследовании мы проанализировали боль в скелете, общие симптомы и описанные пациентом итоговые показатели (ПРОМ) у пациентов с MM и их значение для выявления симптоматического развития. Мы провели оценку 502 пациенты, 47 с первоначальным диагнозом (ID) MM и 455 Пациенты-последовательницы. В ID, 74% Сообщили о боли в костях, главным образом в позвоночнике. Общие симптомы, особенно усталос

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… The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: a consensus statement from the International Myeloma Working Group (IMWG) Blood Cancer J. 9 2019 27 10.1038/s41408-019-0187-7 30808868 PMC6391474 …

Opportunistic CT for Prediction of Adverse Postoperative Events in Patients with Spinal Metastases.

The purpose of this study was to assess the value of body composition measures obtained from opportunistic abdominal computed tomography (CT) in order to predict hospital length of stay (LOS), 30-day postoperative complications, and reoperations in patients undergoing surgery for spinal metastases. 196 patients underwent CT of the abdomen within three months of surgery for spinal metastases. Automated body composition segmentation and quantifications of the cross-sectional areas (CSA) of abdominal visceral and subcutaneous adipose tissue and abdominal skeletal muscle was performed. From this,

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… Exclusion criteria comprised (1) revision procedures, (2) vertebroplasty or kyphoplasty, (3) absence of L4 level coverage on the CT scan, and (4) metal artifacts on CT scans hindering analysis. …