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Effect of carbamazepine on the pharmacokinetics of paliperidone extended-release tablets at steady-state.

Given the potential concomitant use of carbamazepine and paliperidone extended-release (ER) in the treatment of schizophrenia or schizoaffective disorder, this open-label, two-treatment sequential study investigated the effect of repeated administration of carbamazepine on the steady-state pharmacokinetics of paliperidone. Sixty-four patients with a diagnosis of schizophrenia or bipolar-I disorder received the following treatments in a fixed sequential order, without washout between treatments: (i) paliperidone ER 6 mg tablet once daily for 7 days, and (ii) paliperidone ER 6 mg once daily conc

Insulin resistance in patients with type 1 diabetes: relationship with metabolic and inflammatory parameters.

Although insulin resistance is usually associated with the development of type 2 diabetes, it can also be a feature of patients with type 1 diabetes. Insulin resistance has been documented in type 1 diabetes and may contribute to the high risk of cardiovascular disease in this population. To investigate the relationship of insulin resistance with metabolic and inflammatory parameters we divided 304 patients according to median estimated glucose disposal rate (eGDR = 9.72 mgkg(-1)min(-1)) into lower (n = 153) and higher (n = 151) insulin sensitivity groups. Patients with lower insulin sensitivi

Declining interest in tattoos in the Balkans: a Google Trends analysis.

Dear Editor, Tattooing is a popular decorative procedure worldwide1,2. Its prevalence in adults ranges from 20 to 30%1,3. However, Google Tr … Greece, North Macedonia, and the nations of the former Yugoslavia: Bosnia and Herzegovina, Serbia, Croatia, Montenegro, and Kosovo) from January 1, 2004, to December 27, 2025. Results are displayed as a set of time series. The values are not the actual search counts but percentages relative to the total searches across the specified geography and time. T …

Impact of health policy and practice on finding the best fit for patients with type 2 diabetes after metformin failure: Croatian pilot study.

AIM: We assessed the impact of clinical practice and health policy on the choice and efficacy of different second-line therapies for the treatment of type 2 diabetes (T2DM) after failure of metformin. METHODS: This retrospective database analysis included 200 patients with a follow-up period of 6 months. The primary end-point was achievement of HbA1c <7% and fasting (FBG) and postprandial glucose levels (PPG) <7.2mmol/L and <10mmol/L, respectively after three and six months of different add-on treatments. Secondary end-points were weight change during treatment and incidence of hypoglycemia.

[Hepatitis caused by tick-borne meningoencephalitis virus (TBEV)--a rare clinical manifestation outside the central nervous system involvement].

OBJECTIVE: North part of Croatia, especially the Koprivnica-Krizevci County has been a well-known endemic area of tick-borne encephalitis (TBE) for more than 50 years. To date, this disease caused by tick-borne encephalitis virus (TBEV) has retained the leading position among inflammatory diseases of the central nervous system (CNS), with an average morbidity of 19 patients per year. In 88% of patients the infection manifested with signs of meningitis or meningoencephalitis with a biphasic course. TBE may take a more severe course with different neurologic dysfunction or even lethal outcome. T…

The effect of eradicating Helicobacter pylori infection on the course of adenomatous and hyperplastic gastric polyps.

OBJECTIVE: Histopathological and clinical data strongly suggest that Helicobacter pylori is the cause of chronic gastritis and peptic ulcera … 997, 6700 patients who had undergone upper gastrointestinal endoscopy at the two centres in Zagreb, Croatia, were candidates for participation in the study. Hyperplastic and adenomatous polyps were diagnosed on a basis of at least three histological samples taken from the polyp. In seven patients endoscopy had to be repeated because forceps biopsy samplin …

[Is permanent renal function damage possible after hemorrhagic fever with renal syndrome?].

AIM: To investigate the possibility of permanent renal function impairment and other organ lesions following hemorrhagic fever with renal sy … ge to the liver parenchyma in some patients. The results obtained showed that the HFRS infection in Croatia may have entailed chronic sequels. To confirm this hypothesis, additional studies including a control group of hantavirus negative persons are needed.

[Changes in autonomic control of heart rate after ischemic cerebral stroke].

BACKGROUND AND PURPOSE: Heart rate variability (HRV) is a physiological phenomenon which reflects the influence of the autonomic nervous sys … one of the neurologic departments of the Hospital for Medical Rehabilitation in Krapinske Toplice, Croatia, where rehabilitation was carried out (mean duration 20 +/- 9 days) in the 1999-2002 period. Inclusion criteria were: age under 70 years, first ischemic stroke verified by CT scan within 2-12 weeks of the acute phase of the disease, Barthel index 30 …

The association study of polymorphisms in DAT, DRD2, and COMT genes and acute extrapyramidal adverse effects in male schizophrenic patients treated with haloperidol.

Extrapyramidal symptoms (EPSs) are common adverse effects of antipsychotics. The development of acute EPSs could depend on the activity of dopaminergic system and its gene variants. The aim of this study was to determine the association between dopaminergic type 2 receptor (DRD2) dopamine transporter (SLC6A3) and catechol-O-methyltransferase (COMT) gene polymorphisms and acute EPSs in 240 male schizophrenic patients treated with haloperidol (15-mg/d) over a period of 2 weeks. Acute EPSs were assessed with Simpson-Angus Scale. Three dopaminergic gene polymorphisms, the DRD2 Taq1A, the SLC6A3 VN

Burnei's "double X" internal fixation technique for supracondylar humerus fractures in children: indications, technique, advantages and alternative interventions : Study and Research Group in Pediatric Orthopaedics-2012.

BACKGROUND: The Study and Research Group in Pediatric Orthopedics-2012 initated this retrospective study due to the fact that in Romania and … s been presented at the 29th Annual Meeting of the European Pediatric Orthopedic Society in Zagreb, Croatia, April 7-10, 2010, being titled "Distal humeral Z-osteotomy for posttraumatic cubitus varus or valgus", having as authors Gh. Burnei, Ileana Georgescu, Ştefan Gavriliu, Costel Vlad and Daniela Dan. As members of this group, based on the performed st …

Health-related quality of life in Croatian general population and multiple myeloma patients assessed by the EORTC QLQ-C30 and EORTC QLQ-MY20 questionnaires.

Background The impact of disease and treatment on the patient's overall well-being and functioning is a topic of growing interest in clinical research and practice. The aim of this study is to obtain reference data on quality of life of Croatian general population. Further, we aim to assess the impact of the disease and its primary systemic treatment on their health related quality of life (HrQoL) in multiple myeloma (MM) patients. Patients and methods Participants for the first part of the study were randomly selected from adult Croatian population. In the clinical part of the study MM patien…

Rezpegaldesleukin treatment of moderate-to-severe atopic dermatitis (REZOLVE-AD): final results from the 16-week induction period of an international, double-blind, placebo-controlled, randomised phase 2b study.

BACKGROUND: Rezpegaldesleukin is an interleukin-2 receptor agonist that selectively expands and enhances the function of regulatory T cells … ucted in 107 community research centres or hospitals in ten countries (Australia, Bulgaria, Canada, Croatia, Czechia, Germany, Hungary, Poland, Spain, and the USA). Eligible patients were adults (aged 18 years or older) with confirmed atopic dermatitis (American Academy of Dermatology Consensus Criteria) diagnosed at least 12 months before enrolment, with …

Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid.

Endemic (Balkan) nephropathy is a chronic tubulointerstitial disease frequently accompanied by urothelial cell carcinomas of the upper urinary tract. This disorder has recently been linked to exposure to aristolochic acid, a powerful nephrotoxin and human carcinogen. Following metabolic activation, aristolochic acid reacts with genomic DNA to form aristolactam-DNA adducts that generate a unique TP53 mutational spectrum in the urothelium. The aristolactam-DNA adducts are concentrated in the renal cortex, thus serving as biomarkers of internal exposure to aristolochic acid. Here, we present mole

Skin Changes in Suspected Lyme Disease.

Dear Editor, Ticks carry many diseases, bacteria, and viruses and represent a very important healthcare issue both in Croatia and globally. Although most ticks are not infected with pathogens dangerous to humans, some ticks can transmit infectious diseases with significant morbidity and mortality. This is caused by the increasing incidence of many tick-borne diseases over a growing geographical area. Many factors influence which species of ticks are present in a given geographical area, as well as the density of their population and the risk of human exposure to infected ticks. The average mor…

Different Therapeutic Paths (Colchicine vs. Anakinra) in Two Patients With Schnitzler's Syndrome.

Schnitzler's syndrome is a rare autoinflammatory syndrome with unidentified mechanism of disease and etiology with unknown definitive treatment algorithm. The two obligatory criteria for the diagnosis of Schnitzler's syndrome include chronic urticarial rash and monoclonal gammopathy (immunoglobulin M or immunoglobulin G). In this article, we describe two patients with different courses of disease with different average lengths of time between initial symptoms and the final diagnosis (6 months to 8 years). Exclusion of more common conditions is needed to ensure the correct diagnosis. Treatment

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… Division of Clinical Immunology and Rheumatology, Dubrava University Hospital, Zagreb, Croatia Received: April 20, 2016 Accepted: April 25, 2016 Published online: July 11, 2016 Correspondence: Marko Barešić, MD. … Department of Internal Medicine, Division of Clinical Immunology and Rheumatology, University Hospital Center Zagreb, 10000 Zagreb, Croatia. Tel: +385 12 388 330 e-mail: markobaresic@gmail.com ©2016 Turkish League Against Rheumatism. All rights reserved. …

Препятствия и факторы, способствующие реформированию системы здравоохранения.

ВВЕДЕНИЕ: Системы здравоохранения во всем мире сталкиваются с растущим давлением, обусловленным растущим бременем неинфекционных заболеваний и старением населения, а также хронической нехваткой рабочей силы, инфраструктурными ограничениями и структурными дисгармониями между моделями ухода, предназначенными для лечения острых заболеваний, и долгосрочными потребностями сложных пациентов. Многие страны предпринимают комплексные усилия по преобразованию, включая перенос ухода ближе к дому, улучшение раннего выявления заболеваний и решение проблем, связанных с рабочей силой. Цель этого исследования

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… | Croatia | 2020 (Implemented) | S | Lung cancer | Croatia introduced a national lung cancer screening programme in October 2020, becoming the first country in the European Union (EU) to do so. … In Croatia, lung cancer screening places substantial responsibility on individual primary care physicians for eligibility assessment and appointment booking, creating potential bottlenecks under conditions of workforce strain ( 53 ). …

Therapeutic ultrasound for chronic low back pain.

BACKGROUND: This is an update of a Cochrane Review published in 2014. Chronic non-specific low back pain (LBP) has become one of the main ca … BP. The included studies were carried out in secondary care settings in Turkey, Iran, Saudi Arabia, Croatia, the UK, and the USA, and most applied therapeutic ultrasound in addition to another treatment, for six to 18 treatment sessions. The risk of bias was unclear in most studies. Eight studies (80%) had unclear or high risk of selection bias; no studie …

Глобальное, региональное и национальное экономическое бремя гематологовых магнестов1990-2021) с прогнозами 2050.

Гематологические колебания (ГМ) обусловливают значительные затраты на здравоохранение и производительность труда во всем мире. Однако различия в экономическом воздействии между регионами и странами по-прежнему недостаточно изучены. Цель этого исследования заключалась в оценке глобального, регионального и национального экономического бремени ТМ и его подтипов (лейкемии, лимфомы без ходжкина, множественной миэломы и Ходжкинской лимфомы) 1990 в адрес 2021, с прогнозами 2050. Методические данные о глобальном бремени болезней 2021 Исследование использовалось для оценки экономического бремени ТМ с и

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… Notably, several smaller economies experienced disproportionately high economic burdens from HM, with the highest GDP shares observed in Tajikistan (23.8%), Puerto Rico (17.1%), and Croatia (5.8%) in 2021 ( Figure 3 ). … When assessed as a proportion of GDP in 2021, the highest NHL-related economic burdens were observed in Tajikistan (7.97%, 95% UI: 6.02%−10.34%), Puerto Rico (6.41%, 95% UI: 5.35%−7.60%), and Croatia (1.99%, 95% UI: 1.70%−2.30%), highlighting the disproportionate impact on smaller economies. …

Compulsive sexual behavior, religiosity, and spirituality: A systematic review.

Abstract Background and aims In recent years, increasing attention has been given to the relationship between compulsive sexual behavior (CSB), religiosity, and spirituality. This review summarizes research examining the relationship CSB has with religiosity and spirituality, clarifying how these constructs inform the assessment and treatment of this syndrome. Methods The present paper reviews research published through August 1, 2021, using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Only studies providing quantitative analyses were included. Re

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… Studies took place in several countries, though a majority were conducted in the United States ( n = 34, 61%), while seven were conducted in Israel (13%), five in Croatia (9%), and four in Poland (7%). … Croatia Not reported - all Croatian Not reported; all were high school sophomores at time of recruitment Not reported Note. …

Hematopoietic stem cell transplantation in Zagreb: the first 40 years.

Hematopoietic stem cell transplantation is the most effective treatment for acute leukemia, severe aplastic anemia, and some hereditary hematological disorders. The principal source of stem cells in this procedure are bone marrow and peripheral blood cells. In recent years, the transplantation outcome has significantly improved. The availability of the donor no longer poses a problem, as transplantation has been performed routinely from related, unrelated, and haploidentical donors. A high success rate has been reported in elderly patients transplanted with reduced-intensity conditioning. Impr

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… Figure 1 The timeline of important developments related to hematopoietic stem cell transplantation (HCST) in Croatia. Transplantation is the treatment of choice for some hereditary hematologic disorders and for young patients with severe aplastic anemia. … Eur J Clin Microbiol Infect Dis 1995 14 768 74 10.1007/BF01690991 8536724 88 Grubic Z Stingl K Cecuk-Jelicic E Zunec R Serventi Seiwerth R Labar B Evaluation of mixed chimerism in bone marrow transplantation program in Croatia. …