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[Effect of acupuncture on expression of transfer growth factor-β1 in lacrimal gland of rabbits with dry eye].

OBJECTIVE: To observe the effect of acupuncture on expression of transforming growth factor-β1(TGF-β1) in lacrimal gland of rabbits with dry … ye drops in their eyes 3 times a day, one drop each time. Rabbits of the acupuncture group reveived electroacupuncture(4 Hz/20 Hz, 1 mA) at "Cuanzhu"(BL2) and "Tongziliao"(GB1) for 15 min, and received acupuncture at "Jingming"(BL1), "Taiyang" (EX-HN5) and "Sizhukong"(TE23) for 15 min, once a day. Rabbits of the sham acupuncture group received blunt acupuncture at t …

[Clinical research and the effect mechanism on premature ovarian failure treated with acupuncture in recent 20 years].

OBJECTIVE: To review and collect the study achievements and the effect mechanism of acupuncture in the treatment of premature ovarian failur … and the lower limbs. Many therapeutic methods were used, such as acupuncture with filiform needle, electroacupuncture, moxibustion and the acupoint thread-embedding therapy. The effect mechanisms possibly referred to the recovery of the sexual level through regulating the hypothalamus-pituitary gland-ovarian axle (HPOA) function, the improvement of the histological …

Controlled trials of therapy in fibromyalgia syndrome.

Many different interventions have been studied in the therapy of fibromyalgia syndrome (Tables 1 and 2). While most have been effective, in … tandardized measure of the efficacy of a given therapy) of several non-medication therapies such as electroacupuncture exceeded that of traditional medication therapies. Unfortunately, lack of uniformity in the use of outcome measures across included trials and the small numbers of comparable non-medication trials makes definitive conclusions regarding relative effi …

Effects of preconditioning of electro-acupuncture on postoperative cognitive dysfunction in elderly: A prospective, randomized, controlled trial.

Electro-acupuncture is a burgeoning treatment using the needle inserting into the body acupoints and the low-frequency pulse current being electrified by an electric acupuncture machine. This study was designed to evaluate the effects of preconditioning of electro-acupuncture on postoperative cognitive dysfunction in elderly.Ninety patients scheduled spine surgery were randomly assigned into 2 groups using a random number table: control group (group C) and electro-acupuncture group (group EA). In group EA, electro-acupuncture was applied on Baihui, Dazhui, and Zusanli acupoints 30 minutes befo

Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice.

Acupuncture is reported to be effective in treating obesity related illnesses, but its mechanism is still unclear. To investigate this mechanism we applied electro-acupuncture (EA) in a mouse model of obesity and used RNA-seq to identify molecular consequences. Deletion of the transcription factor STAT5 from neurons (Stat5NKO) led to obesity. Acupuncture, in turn, reduced body weight and the ratio of epididymal white adipose tissue (Epi-WAT) to body weight, and it also decreased plasma concentrations of glucose, triglyceride, and cholesterol. In addition, EA increased cold endurance of Stat5NK

Electro-acupuncture preconditioning abrogates the elevation of c-Fos and c-Jun expression in neonatal hypoxic-ischemic rat brains induced by glibenclamide, an ATP-sensitive potassium channel blocker.

This study aimed to clarify the neuroprotective mechanism of electro-acupuncture (EA) preconditioning on hypoxic-ischemic brain injury (HIBI). Using Western blot, the expression of c-fos protein (c-Fos) and c-jun protein (c-Jun) induced by glibenclamide, an ATP-sensitive potassium (K(ATP)) channel blocker was examined from cerebral cortical and hippocampal samples in neonatal hypoxic-ischemic rats, with or without EA preconditioning. EA was performed on Hegu (LI4), a well-known acupoint commonly used in Oriental medicine for the treatment of neuronal injury resulting from hypoxia-ischemia (HI)

A clinical pilot study comparing traditional acupuncture to combined acupuncture for treating headache, trigeminal neuralgia and retro-auricular pain in facial palsy.

Traditional acupuncture (TA) and ear acupuncture (EA) are used for treatment of headache, trigeminal neuralgia, and retro-auricular pain. The purpose of this study is to develop effective treatment using combined acupuncture (CA) which consists of TA and EA and to set clinical protocols for future trials. Participants were divided into TA (n = 15) control and CA (n = 34) experimental groups. Obligatory points among Korean Five Element Acupuncture and optional individual points along with symptom points were used in the TA group. The CA group was exposed to ear points of Fossion and TA. Acupunc

Research trends of acupuncture therapy for painful peripheral nervous system diseases from 2004 to 2023: a bibliometric and meta-analysis.

BackgroundPeripheral nervous system diseases (PNSD) have represented a major global health burden, leading to significant economic impacts and diminished productivity. This bibliometric analysis was performed to summarize the current research trends and hotspots over the past two decades, aiming to provide a comprehensive perspective for future research.MethodsAll data were sourced from the Web of Science Core Collection (WoSCC) on March 1, 2024, for publications between January 1, 2004, and December 31, 2023. Data visualization and analyses, including descriptive statistics, co-occurrence map

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… Subgroup analysis Chronic low back pain One RCT reported that electroacupuncture, compared with sham electroacupuncture, showed no significant difference in pain score changes ( 27 ). [MD = −1.43, 95% CI (−4.18, 1.32), one RCT, 106 participants, p = 0.31]. … Effectiveness of acupuncture and Electroacupuncture for chronic neck pain: a systematic review and Meta-analysis . Am J Chin Med . ( 2017 ) 45 : 1573 – 95 . doi: 10.1142/S0192415X17500859 , PMID: 29121797 36. Ulett GA Han SP Han JS . Electroacupuncture: mechanisms and clinical application . …

Acupuncture in the treatment of chemotherapy-induced peripheral neuropathy: a meta-analysis and data mining.

BackgroundThe efficacy and acupoint selection of acupuncture in treating chemotherapy-induced peripheral neuropathy (CIPN) remain controversial. This study aims to explore the specific efficacy and acupoint selection of acupuncture in treating CIPN through a meta-analysis and data mining.MethodsSearching for clinical trials on acupuncture treatment for CIPN in 8 databases, evaluating its efficacy and safety through a meta-analysis, and exploring its acupoint selection through data mining.ResultsThe meta-analysis included 21 studies and 2,121 patients, showing that compared with the control gro

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… Inclusion criteria (1) The study type was a randomized controlled clinical trial. (2) Participants were cancer patients with or without CPNI, regardless of cancer type or stage. (3) The intervention group was acupuncture/electroacupuncture or acupuncture/electroacupuncture combined with conventional … Ren conducted electroacupuncture intervention on the PC6, SJ5S, SP6, and ST36 points in neuropathic rats, and the results showed that the expression level of Na + channels in the brain of successfully modeled rats increased, and electroacupuncture intervention could significantly reduce the level of …

Comparative effectiveness of acupuncture combined with rehabilitation for post-stroke hemiplegia: a systematic review and network meta-analysis.

BACKGROUND: Hemiplegia, as a common sequela of stroke, can severely affect patients' quality of life. Although rehabilitation therapy can im … ted the highest efficacy (MD = 16.4, 95%CI: 2.88 to 29.9; SUCRA = 87.87%), followed by MOX + RT and electroacupuncture combined with rehabilitation (EA + RT). Finally, for Modified Ashworth Scale (MAS) scores, SA + RT was ranked first (MD = -1.10, 95%CI: -2.05 to -0.15; SUCRA = 78.38%), with MOX + RT ranking second. CONCLUSION: Current evidence indicates that combi …

Comparative efficacy of acupuncture-related interventions for perimenopausal depression and anxiety: A systematic review and frequentist meta-analysis.

BACKGROUND: This study aimed to compare the efficacy and safety of different acupuncture-related interventions for perimenopausal depression … ns were manual acupuncture (MA) + Chinese herbal medicine (CHM) (RR = 1.52, 95 % CI: 1.12-2.08) and electroacupuncture (EA) + CHM (RR = 1.49, 95 % CI: 1.05-2.12). Regarding depressive symptoms measured by the Hamilton Depression Scale (HAMD), EA + Western medicine (WM) (MD = -5.04, 95 % CI: -6.97 to -3.12) and MA + CHM (MD = -5.69, 95 % CI: -10.47 to -0.92) achieved …

Comparative efficacy of acupuncture-related therapies for Parkinson's disease: A systematic review and network meta-analysis.

BACKGROUND: Parkinson's disease (PD) is a prevalent neurodegenerative disorder marked by progressive motor and non-motor symptoms. Although … ty-seven RCTs (n = 4262; 2002-2024) were included. Interventions comprised manual acupuncture (MA), electroacupuncture (EA), warm acupuncture (WA), fire acupuncture (FA), and moxibustion (MOX), used alone or in combination with conventional medication (CM) or Chinese herbal medicine (CHM). For total effective rate (41 RCTs; n = 3086), the most pronounced benefit was …

Current state of research on acupuncture for the treatment of post-stroke dysphagia: a scoping review.

OBJECTIVE: Post-stroke dysphagia (PSD) is a common complication of stroke. Acupuncture as one of the traditional therapies in traditional Ch … systematic reviews, and 10 guidelines. Acupuncture interventions included manual acupuncture (MA), electroacupuncture (EA), and MA/EA combined with acupuncture-related methods (such as scalp acupuncture, auricular acupuncture, warm acupuncture, etc.). The most frequently used acupoint was RN23. Acupuncture is often applied in combination with other treatments, such …

[Fu's subcutaneous needling combined with scalp acupuncture for shoulder-hand syndrome phaseⅠafter cerebral infarction: a randomized controlled trial].

OBJECTIVE: To compare the therapeutic effect of Fu's subcutaneous needling combined with scalp acupuncture and simple scalp acupuncture for … oup, acupuncture was applied at parietal area and anterior parietal area of Yu's scalp acupuncture, electroacupuncture was connected for 30 min, with disperse-dense wave, in frequency of 2 Hz/100 Hz and in electric current of 1 mA, and the needles were retained for 6 h, once a day for continuous 14 days. On the basis of the treatment in the scalp acupuncture group, …

[Effects of different acupuncture and moxibustion methods on articular cartilage morphology and NF-κB p65/NLRP3 pathway in rats with knee osteoarthritis].

OBJECTIVE: To compare the effects of filiform needling, electroacupuncture (EA) and moxibustion on articular cartilage morphology and nuclear transcription factor-κB (NF-κB) p65/ Nod-like receptor protein 3 (NLRP3) pathway in rats with knee osteoarthritis (KOA). METHODS: Wistar rats were randomly divided into blank control， model, filiform needling, EA and moxibustion groups, with 8 rats in each group. The KOA model was established by injecting sodium iodoacetate into the right knee cavity. Filiform needling, EA and moxibustion groups were treated with the right side of "Dubi" (ST35) and "Nei…

[Effect of dexmedetomidine and midazolam on respiration and circulation functions in patients undergoing open heart surgery under acupuncture-assisted general anesthesia].

OBJECTIVE: To evaluate the effect of Dexmedetomidine and Midazolam on respiratory and circulation in patients experiencing open heart surgery under acupuncture-assisted general anesthesia. METHODS: Sixty patients undergoing open heart surgery (cardiac valve replacement surgery and aortic valve replacement surgery) were randomly and equally divided into Dexmedetomidine (D) and Midazolam (M) groups. Electroacupuncture (EA) was applied to bilateral Yunmen (LU 2), Zhongfu (LU1), Lieque (LU7) and Neiguan (PC6). For patients of group D, Dexmedetomidine (i.v., loading dose: 1 microg/kg, and succeden…

Electro-acupuncture attenuates inflammatory responses and intraabdominal pressure in septic patients: A randomized controlled trial.

BACKGROUND: A pathological increase in intraabdominal pressure (IAP) and inflammatory responses have negative effects on splanchnic, respiratory, cardiovascular, renal, and neurological function in septic patients with intestinal dysfunction. Electro-acupuncture (EA) has been evidenced to have a bidirectional neuron-endocrine-immune system regulating effect in patients with intestinal dysfunction. The purpose of current study was to evaluate the effects of EA at "Zusanli" (ST36) and "Shangjuxu" (ST37) on inflammatory responses and IAP in septic patients with intestinal dysfunction manifested s

Acupuncture effects on non-motor symptoms of Parkinson's disease (sleep, mood, and fatigue): a systematic review and meta-analysis.

BACKGROUND: Parkinson's disease (PD) causes multiple non-motor symptoms (NMSs), such as insomnia, anxiety, and fatigue, that worsen the quality of life. Pharmacological options offer limited relief, prompting interest in acupuncture as an adjunctive therapy. METHODS: Following PRISMA 2020 guidelines (PROSPERO CRD420251172700), PubMed, Embase, Web of Science, and Cochrane Library were searched from 1 Jan 2015 to 28 Oct 2025 for randomized and controlled observational studies comparing manual or electroacupuncture with sham or usual care in idiopathic PD. Outcomes were sleep quality (PDSS and P…

Integrated Western and Traditional Chinese Medicine Approaches for Herpes Zoster and Post-Herpetic Neuralgia: A Narrative Review.

BACKGROUND: Herpes zoster (HZ) and postherpetic neuralgia (PHN) impose a substantial global burden, particularly in older and immunocompromi … mechanistic research evaluating Western therapies, TCM interventions (herbal medicine, acupuncture/electroacupuncture, and other external modalities), or integrated regimens used alongside standard Western care. Study quality and risk of bias were appraised qualitatively with attention to sample size, blinding, outcome measures, and reporting of adverse events. RE …