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[Sex, erectile dysfunction, and the heart: a growing problem].

BACKGROUND: Erectile dysfunction (ED) is defined as the inability to attain and/or maintain penile erection sufficient for satisfactory sexu … otent inhibitors of the P450 3A4 pathway may increase the plasma concentrations of sildenafil, like cimetidine, erythromycin, digitoxin, and CSE inhibitors (simvastatin, atorvastatin, etc.). A creatinine clearance < 30 ml/min also increases plasma levels of sildenafil. SAFETY PROFILE OF SILDENAFIL: Sildenafil is safe in healthy subjects. In a postmarketing …

Drug dosage adjustment in hospitalized patients with renal impairment at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia.

BACKGROUND: Dose adjustment for certain drugs is required in patients with reduced renal function to avoid toxicity as many drugs are eliminated by the kidneys. The aim of this study was to assess whether appropriate dosage adjustments were made in hospitalized patients with renal impairment. METHODS: A prospective cross-sectional study was carried out in the internal medicine wards of Tikur Anbessa Specialized Hospital. All patients with creatinine clearance ≤ 59 ml/min admitted to hospital between April and July, 2013 were included in the analysis. Data regarding serum creatinine level, age

Scaling the side effects: A case of apalutamide-induced ichthyosis.

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… ichthyosis (AI) may be a result of malignancy (Hodgkin’s, multiple myeloma), nutritional diseases (celiac disease, pancreatic insufficiency), metabolic disease (chronic hepatic or renal failure), infectious disease (acquired immunodeficiency syndrome, leprosy), or the use of certain medications, like cimetidine …

Pharmacological interventions for acute pancreatitis.

BACKGROUND: In people with acute pancreatitis, it is unclear what the role should be for medical treatment as an addition to supportive care … ts assessed in these 78 trials included antibiotics, antioxidants, aprotinin, atropine, calcitonin, cimetidine, EDTA (ethylenediaminetetraacetic acid), gabexate, glucagon, iniprol, lexipafant, NSAIDs (non-steroidal anti-inflammatory drugs), octreotide, oxyphenonium, probiotics, activated protein C, somatostatin, somatostatin plus omeprazole, somatostatin plu …

Acute interstitial nephritis - a reappraisal and update.

Acute interstitial nephritis (AIN) is an under recognized and under diagnosed cause of acute kidney injury (AKI). It is estimated to account for 15 - 20% of cases of AKI; it is the reported diagnosis in 2.8% of all kidney biopsies, and 13.5% of biopsies done specifically for acute renal failure. Considerable evidence implicates antigen initiated cell-mediated injury in the pathogenesis of AIN. Drugs account for 70% of all cases, with over 150 different agents incriminated. The remaining cases are due to infections, autoimmune diseases, and rarely idiopathic. The central component of renal inju

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… flurbiprofen, mefenamate, phenazone, phenylbutazone, noramidopyrine, nimesulide, prioxicam, sulindac, tolmentin, zomepirac Drug-induced: proton-pump inhibitors & H 2 -Antagonists Incidence > 50 cases reported Omeprazole Other PPIs: lansoprazole > pantoprazole > esmoprazole > rabeprazole; H2 Antagonists: cimetidine … flurbiprofen, mefenamate, phenazone, phenylbutazone, noramidopyrine, nimesulide, prioxicam, sulindac, tolmentin, zomepirac Drug-induced: proton-pump inhibitors & H 2 -Antagonists | Incidence > 50 cases reported Omeprazole Other PPIs: lansoprazole > pantoprazole > esmoprazole > rabeprazole; H2 Antagonists: cimetidine …

Исследование безопасности фамфридина у пациентов с различными стадиями множественного склероза.

Fampridine является единственным лекарственным средством, утвержденным Администрацией США по контролю за продуктами питания и лекарствами для лиц с множественным склерозом (MS) в целях улучшения их передвижения и продемонстрировал клинически существенное улучшение функции похода в группе пациентов с повышенным уровнем инвалидности (ESDSS) из группы MS. 4 в адрес 7. Тем не менее, согласно сообщениям, это лекарство имеет некоторые неблагоприятные последствия (АЭ), такие, как припадок из-за его фармакологических свойств. Цель этого исследования заключалась в оценке распространенности побочных эфф

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… Patients using metformin, cimetidine, and quinidine were not included in the study due to the contraindication of these drugs with fampridine. …

How to calculate the dose of chemotherapy.

Body surface area-dosing does not account for the complex processes of cytotoxic drug elimination. This leads to an unpredictable variation in effect. Overdosing is easily recognised but it is possible that unrecognised underdosing is more common and may occur in 30% or more of patients receiving standard regimen. Those patients who are inadvertently underdosed are at risk of a significantly reduced anticancer effect. Using published data, it can be calculated that there is an almost 20% relative reduction in survival for women receiving adjuvant chemotherapy for breast cancer as a result of u

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… Inhibition of CYP enzymes and MDR1 and probably other efflux pumps can occur with drugs such as cyclosporin, HMGCoA reductase inhibitors, verapamil, omeprazole and cimetidine. However, few clinically significant interactions have been documented or examined for cytotoxic chemotherapy. …

Hydroxychloroquine efficacy and safety in preventing SARS-CoV-2 infection and COVID-19 disease severity during pregnancy (COVID-Preg): a structured summary of a study protocol for a randomised placebo controlled trial.

OBJECTIVES: The primary objectives of the study are: 1. To assess the effect of hydroxychloroquine (HCQ) in reducing SARS-CoV-2 viral sheddi … ine compounds • History of retinopathy of any aetiology • Concomitant use of digoxin, cyclosporine, cimetidine • Known liver disease • Clinical history of cardiac pathology including known long QT syndrome • Unable to cooperate with the requirements of the study • Participating in other intervention studies • Delivery onset (characterized by painful uterine …

Efficacy of hydroxychloroquine for post-exposure prophylaxis to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among adults exposed to coronavirus disease (COVID-19): a structured summary of a study protocol for a randomised controlled trial.

OBJECTIVES: Primary Objective • To test the efficacy of Hydroxychloroquine (HCQ) (400 mg orally daily for 3 days then 200 mg orally daily fo … honuclear leukocytes <1500) or thrombocytopenia (<100 K)10.Concomitant use of digoxin, cyclosporin, cimetidine, amiodarone, or tamoxifen11.Known moderate or severe liver disease12.Known long QT syndrome13.Severe renal impairment14.Use of any investigational or non-registered drug or vaccine within 30 days preceding the first dose of the study drugs or planne …

Marketed nonsteroidal anti-inflammatory agents, antihypertensives, and human immunodeficiency virus protease inhibitors: as-yet-unused weapons of the oncologists' arsenal.

Experimental data indicate that several pharmacological agents that have long been used for the management of various diseases unrelated to cancer exhibit profound in vitro and in vivo anticancer activity. This is of major clinical importance, since it would possibly aid in reassessing the therapeutic use of currently used agents for which clinicians already have experience. Further, this would obviate the time-consuming process required for the development and the approval of novel antineoplastic drugs. Herein, both pre-clinical and clinical data concerning the antineoplastic function of dist

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… treatment with ACEIs or sartans prolongs life expectancy of advanced lung cancer patients receiving conventional platinum drugs. 119 A Phase II clinical trial indicated remarkable benefits of receiving low-dose (4 mg) candesartan or perindopril in combination with IFN-α, the COX-2 inhibitor meloxicam, and cimetidine … blockers on survival in patients with advanced non-small-cell lung cancer undergoing first-line platinum-based chemotherapy Cancer Res Clin Oncol 2009 135 10 1429 1435 10.1007/s00432-009-0587-3 PMC12160257 19399518 120 Tatokoro M Fujii Y Kawakami S Phase-II trial of combination treatment of interferon-α, cimetidine …

Intestinal/Multivisceral Transplantation

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… metronidazole, penicillins, rifampicin, trimethoprim–sulfamethoxazole, valganciclovir, vancomycin Anticonvulsants Phenytoin, valproic acid Cardiovascular drugs and diuretics Acetazolamide, coumarins, hydralazine, metolazone, nifedipine, propranolol, spironolactone, thiazides, ticlopidine Gastrointestinal drugs Cimetidine … penicillins, rifampicin, trimethoprim–sulfamethoxazole, valganciclovir, vancomycin Anticonvulsants | Phenytoin, valproic acid Cardiovascular drugs and diuretics | Acetazolamide, coumarins, hydralazine, metolazone, nifedipine, propranolol, spironolactone, thiazides, ticlopidine Gastrointestinal drugs | Cimetidine …

Pharmacological treatment options for mast cell activation disease.

Mast cell activation disease (MCAD) is a term referring to a heterogeneous group of disorders characterized by aberrant release of variable subsets of mast cell (MC) mediators together with accumulation of either morphologically altered and immunohistochemically identifiable mutated MCs due to MC proliferation (systemic mastocytosis [SM] and MC leukemia [MCL]) or morphologically ordinary MCs due to decreased apoptosis (MC activation syndrome [MCAS] and well-differentiated SM). Clinical signs and symptoms in MCAD vary depending on disease subtype and result from excessive mediator release by MC

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… cell activation syndrome Compound | Number of patients included in the study or case series | References H 1 -antihistamines Rupatadine | 30 | Siebenhaar et al. 2013 Azelastine vs. chlorpheniramine | 15 | Friedman et al. 1993 Ketotifen vs. hydroxyzine | 8 | Kettelhut et al. 1989 Chlorpheniramine plus cimetidine … Metcalfe DD Comparison of azelastine and chlorpheniramine in the treatment of mastocytosis J Allergy Clin Immunol 1993 92 520 526 10.1016/0091-6749(93)90076-R 8104966 Frieri M Alling DW Metcalfe DD Comparison of the therapeutic efficacy of cromolyn sodium with that of combined chlorpheniramine and cimetidine …

The Evaluation of Melatonin Effects on Mobilization and Engraftment in Autologous Hematopoietic Stem Cell Transplant Recipients; A Randomized, Double-blind and Placebo-controlled Trial.

Mobilization and engraftment of Hematopoietic Stem Cells (HSCs) are challenging issues in Autologous HSC transplantation (AHSCT) so several attempts such as colony-stimulating factors (CSF) and plerixafor have been used for enhancement of HSCs mobilization and engraftment. In this randomized, double-blind and placebo-controlled study, we evaluated the melatonin's efficacy and safety, as endogenous CSF inducer, co-administered with Filgrastim in mobilizing and engraftment of HSC. AHSCT patients were randomized to receive either Melatonin or placebo plus filgrastim. Of Fifty-one patients, 26 pat

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… Moreover, the exclusion criteria were as follows: 1) inability to use sublingual tablets, 2) regular use of ≥ two antidepressants, 3) receiving hypnotic and sedative medicines for more than one week, 4) taking medicines with melatonin major interactions with such as fluvoxamine, cimetidine, and benzodiazepines …

Predictive Modeling of Pharmacokinetic Drug-Drug and Herb-Drug Interactions in Oncology: Insights From PBPK Studies.

Physiologically based pharmacokinetic (PBPK) modeling is increasingly used to anticipate, quantify, and strategically manage drug-drug (DDI) and herb-drug (HDI) interactions that can alter the exposure of chemotherapy agents together with co-administered phytochemicals or nutraceuticals. To evaluate current knowledge, we performed a comprehensive Google Scholar search (2003-2024) and selected studies that employed PBPK platforms, reported quantitative validation, and focused on chemotherapy-related interactions. From these reports, key modeling parameters, validation metrics, and clinically re

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… Ni et al, 2023 36 Rifampicin Potent CYP3A4 induction 0.26 0.12 0.11 0.04 2.36 3.00 Clarithromycin Potent time-dependent CYP3A4 inhibitor 3.69 12.9 N/A N/A N/A N/A Erythromycin Moderate CYP3A4 inhibitor 2.74 6.64 N/A N/A N/A N/A Fluvoxamine Moderate to weak CYP3A4 inhibitor 1.37 1.59 N/A N/A N/A N/A Cimetidine … 0.26 | 0.12 | 0.11 | 0.04 | 2.36 | 3.00 Clarithromycin | Potent time-dependent CYP3A4 inhibitor | 3.69 | 12.9 | N/A | N/A | N/A | N/A Erythromycin | Moderate CYP3A4 inhibitor | 2.74 | 6.64 | N/A | N/A | N/A | N/A Fluvoxamine | Moderate to weak CYP3A4 inhibitor | 1.37 | 1.59 | N/A | N/A | N/A | N/A Cimetidine …

Pruritus in Systemic Diseases: A Review of Etiological Factors and New Treatment Modalities.

Pruritus is the most frequently described symptom in dermatology and can significantly impair the patient's quality of life. In 10-50% of adults with persistent pruritus, it can be an important dermatologic clue for the presence of a significant underlying systemic disease such as renal insufficiency, cholestasis, hematologic disorder, or malignancy (Etter and Myers, 2002; Zirwas and Seraly, 2001). This review describes the presence of pruritus in different systemic diseases. It is quite important to discover the cause of pruritus for providing relief for the patients experiencing substantial

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… Pruritus in Hodgkin's disease is thought to be caused by release of histamine, since it responds to histamine blockers like cimetidine. …

A review on in silico virtual screening methods in COVID-19 using anticancer drugs and other natural/chemical inhibitors.

The present coronavirus disease 2019 (COVID-19) pandemic scenario has posed a difficulty for cancer treatment. Even under ideal conditions, malignancies like small cell lung cancer (SCLC) are challenging to treat because of their fast development and early metastases. The treatment of these patients must not be jeopardized, and they must be protected as much as possible from the continuous spread of the COVID-19 infection. Initially identified in December 2019 in Wuhan, China, the contagious coronavirus illness 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (S

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… 6.05 and –11.23 | S-protein (S-RBD) | Anti-SARS-CoV-2 activity | [ 54 ] ACE2 Bedaquiline | - | Mpro | Inhibitors against the SARS-CoV-2 | [ 76 ] Glibenclamide Miconazole 7 Drugs | - | Mpro | Inhibitors against the SARS-CoV-2 | [ 55 ] Vaborbactam | Below –5.40 | Mpro | Anti-SARS-CoV-2 activity | [ 56 ] Cimetidine … A combined structure-based VS technique may uncover possible irreversible Mpro inhibitors, which can be employed in creating antiviral medicines and potentially vaccinations using bioinformatics tools (FDA-approved drugs including vaborbactam, cimetidine, ixazomib, scopolamine, bicalutamide, and riociguat …

Interventions for postburn pruritus.

BACKGROUND: Postburn pruritus (itch) is a common and distressing symptom experienced on healing or healed burn or donor site wounds. Topical … trical nerve stimulation, transcranial direct current stimulation), and other therapies (cetirizine/cimetidine combination, lemon balm tea). Most RCTs were conducted at academic hospitals and were at a high risk of performance, attrition, and detection bias. While 24 out of 25 included studies reported change in burn-related pruritus, secondary outcomes such …

Кислотная терапия и риск излечения в случае воспламенительной болезни лопатки: сравнительное исследование в целях информирования о личностном лечении в мире.

Предыстория/цели: Известно, что ингибиторы протонных насосов (ИПЦ) изменяют состав кишечника микробиота; однако их связь с курсами заболеваний и результатами у пациентов с воспалительным кишечным заболеванием (ИБД) остается неопределенной. Наши цели заключались в оценке связи между использованием ИЦП и эскалацией лечения, диффицией Клостридиодов и использованием медицинских услуг в ИБД. Методы: Мы провели ретроспективное когортное исследование на платформе TriNetX. Пациенты IBD с ИЦП или histamine-2 Совпадали антагонисты рецептора (H2RA) one- чтобы...one с помощью баллов склонности. Итогом это

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… Patients were required to have a documented diagnosis of IBD, including ulcerative colitis (UC, ICD-10 code K51) or Crohn’s disease (CD, ICD-10 code K50), and subsequent exposure to either PPI (omeprazole, pantoprazole, esomeprazole, lansoprazole, or rabeprazole) or H2RAs (cimetidine, famotidine, nizatidine …

Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance.

Chemotherapy is an effortless and frequently used approach in cancer therapy. However, in most cases, it can only prolong life expectancy and does not guarantee a complete cure. Furthermore, chemotherapy is associated with severe adverse effects, one of the major complications of effective cancer therapy. In addition, newly published research outputs show that cancer stem cells are involved in cancer disease progression, drug resistance, metastasis, and recurrence and that they are functional in the trans-differentiation capacity of cancer stem cells to cancer cells in response to treatments.

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… signaling 191 , 192 7 | Brexpiprazole | Anti-psychotic | Pancreatic, non-small cell | Affect the self-renewal ability of CSCs by reducing the sphere formation ability of CSCs 193 8 | Brivudine | Anti-viral | Pancreatic cancer | Showed anti-cancer properties by suppressing the chemoresistance 194 9 | Cimetidine …

Voltage-gated sodium channel as a target for metastatic risk reduction with re-purposed drugs.

ObjectiveTo determine the exact role of sodium channel proteins in migration, invasion and metastasis and understand the possible anti-invasion and anti-metastatic activity of repurposed drugs with voltage gated sodium channel blocking properties.Material and methodsA review of the published medical literature was performed searching for pharmaceuticals used in daily practice, with inhibitory activity on voltage gated sodium channels. For every drug found, the literature was reviewed in order to define if it may act against cancer cells as an anti-invasion and anti-metastatic agent and if it w

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… Many other compounds have also been identified as possessing anti-metastatic effects, including increases in NO 12 , cimetidine, doxycycline, heparin and low molecular heparins, and metapristone 13 . High creativity has been employed in the search for anti-metastatic compounds. …