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Malnutrition and Geriatric Vulnerability Are Independently Associated With Short-Term Mortality in Older Emergency Department Patients in Taiwan.

BACKGROUND: Malnutrition is common among older adults and is associated with adverse outcomes, yet its impact and relationship with geriatric vulnerability in emergency department (ED) patients remain underrecognized. OBJECTIVES: To determine the prevalence, associated factors, and prognostic impact of malnutrition in noncritically ill older adults in the ED. METHODS: We conducted an observational study of patients aged ≥ 65 years presenting to the ED. Nutritional status was assessed using the Mini Nutritional Assessment-Short Form (MNA-SF) and categorized as normal, at risk of malnutrition,

Analysis of the implementation of nutritional care in the context of Primary Health Care.

OBJECTIVE: To evaluate the implementation of nutritional care within the Primary Health Care (PHC) system in Brazilian municipalities and to identify the association between the degree of implementation and aspects of the sociodemographic and political-organizational context. METHODS: This is an evaluative study with a quantitative approach that examined the responsibility of municipal managers in ensuring conditions and implementing interventions, based on the analysis of 17 indicators grouped into the dimensions of management and care. The municipalities were classified according to the deg

High-flux hemodialysis combined with nutritional intervention: Effects on the nutritional status and clinical outcomes of patients with renal failure.

BACKGROUND: To evaluate the association between high-flux-based hemodialysis prescription combined with nutritional intervention and nutriti … redictors of poor outcomes (P < 0.05). CONCLUSIONS: High-flux-based hemodialysis prescription with nutritional support was associated with more effective clearance of uremic markers, improvements in nutritional status and inflammatory response, as well as better survival in renal failure patients. Elevated IL-6 and TNF-α levels were identified as significant predict …

Clinical characteristics and nutritional profiles of children with different irritable bowel syndrome subtypes: a retrospective hospital-based study.

BACKGROUND: Irritable bowel syndrome (IBS) is a common disorder of gut‑brain interaction (DGBI) in children, but data on its clinical heterogeneity and nutritional profiles across different IBS subtypes remain limited. This study aimed to characterize the clinical features of IBS subtypes and assess variations in nutritional status across subtypes and sexes in hospitalized children. METHODS: Children hospitalized with an initial diagnosis of IBS at the Children's Hospital, Zhejiang University School of Medicine (January 2020 to October 2025) were enrolled. Demographic and clinical data regard

Malnutrition in head and neck cancer patients: Impacts and indications of a prophylactic percutaneous endoscopic gastrostomy.

INTRODUCTION: Head and neck cancer (HNC) patients often experience malnutrition before and during treatment. Prophylactic gastrostomy has em … trition. RESULTS: Forty-one patients received prophylactic gastrostomy whereas 111 patients had no nutritional support. Prophylactic gastrostomy placement was associated with a lower initial body mass index, with severe malnutrition, and with initial oral intake disorder. Patients who did not experienced prophylactic gastrostomy had much worse outcomes such as hospi …

An investigation to determine the nutritional adequacy and individuals experience of a very low fat diet used to treat type V hypertriglyceridaemia.

BACKGROUND: The management of Type V hypertriglyceridaemia at some centres involves the use of a very low fat diet (15% energy as fat). There is no published research examining compliance with, or nutritional adequacy, of this treatment. This study assesses the nutritional adequacy of the diet and examines barriers and enablers to adherence. METHODS: Fifty-four eligible patients were invited to take part. Eight males and one female agreed to participate. One male later withdrew. The mean age of participants was 49.4 years (SD 12.9 years), their mean BMI was 30.4 kg m(-2) (SD 3.4 kg m(-2)) and

Evaluating swallowing capacity in older adults with dysphagia: high protein, low carbohydrate smoothie formulas versus commercial formula.

BACKGROUND: Dysphagia is a common problem in older adults that can lead to nutritional deficiencies. Oral nutritional supplements (ONS) are products used for oral nutrition support as an alternative nutritional therapy, specifically manufactured for the older individuals at risk of dysphagia. This study aimed to develop four high protein (23-34% energy ratio) and low carbohydrate (25-38% energy ratio) smoothie formulas (white sesame (WS) vs. white sesame and low carbohydrate (WSLC) vs. black sesame and low carbohydrate (BSLC) vs. chicken shitake (CS); 1 kcal/ml) for the older people with dysph

Metabolic response and parenteral nutrition in trauma, sepsis, and burns.

Trauma, sepsis, and burns cause abnormal manifestations in the body. These manifestations can cause alterations in body metabolism, which complicates nutritional management. Goals of nutrition support with assessment modifications for a constantly changing population are reviewed. Patients in such stress states as burns, trauma, and sepsis many times need altered nutrition. This article outlines guidelines for total parenteral formula modification and monitoring, and discusses other complications such as drug interactions with parenteral formulas.

Moderate Water Deficit Improves Tomato Fruit Nutritional Quality Through SlNAP2-Mediated Transcriptional Activation of Lycopene and Ascorbic Acid Biosynthesis Genes.

Moderate water deficit is an effective strategy to improve fruit nutritional quality, yet the underlying molecular mechanism remains largely elusive, limiting its application in high-quality crop cultivation. Here, we report that moderate water deficit simultaneously elevates the contents of α-carotene, β-carotene, lutein, lycopene, soluble solids, soluble protein, and ascorbic acid in tomato (Solanum lycopersicum L.) fruits, with no significant reduction in fruit yield under our experimental conditions. Through transcriptome analysis and RT-qPCR, we identified SlNAP2 as a central transcriptio

Development of a nutritional management protocol for patients with severe traumatic brain injury: a Delphi study.

BACKGROUND: Patients with severe traumatic brain injury (sTBI) commonly experience hypermetabolism, catabolism, and feeding intolerance, making nutritional management an essential part of clinical care. However, there is still a lack of standardized and integrated protocols to guide nutritional management in this population. AIMS: To develop an evidence-based nutrition management protocol for patients with sTBI. METHODS: An evidence-based approach was adopted to formulate the protocol. Relevant evidence was identified through systematic retrieval, followed by quality appraisal, evidence synt

Nutritional Intake in Oropharyngeal Dysphagia: A Retrospective Comparison of Traditional Homogenized and Density-Enriched Prepared Diets.

Oropharyngeal dysphagia is prevalent in hospitalized geriatric and neurological populations and constitutes a major driver of disease-related malnutrition. Conventional texture-modified diets frequently rely on diluting solid foods with liquid agents to achieve safe swallowing consistency, a process that reduces caloric and protein density per gram and creates a so-called volume paradox, whereby large meal volumes deliver inadequate nutrients. This retrospective observational study, conducted at the Fondazione Policlinico Gemelli IRCCS in Rome, compared nutritional intake in 208 hospitalized d

Factors affecting oral frailty and nutritional status in older adults living alone.

INTRODUCTION: The global aging population is rapidly increasing, with South Korea experiencing the fastest aging rate among the OECD countries. Consequently, the number of older adults living alone is sharply increasing, creating an urgent social issue that necessitates comprehensive and systematic care service policies. Frailty is a key indicator of the overall health status of older adults, and because oral health and nutrition are closely linked, continuous monitoring is essential in this population. METHODS: This study aimed to analyze the factors influencing oral frailty and nutritional

Предварительная обработка сигнатуры эндокринного недоедания прогнозируют клиническую пользу от PD-1/PD-L1 Блокирование гематологовых магнатов.

Гематологические заболевания создают значительное бремя для здоровья людей во всем мире, а запрограммированная клеточная смертность protein-1 (В тыс.PD-1)/запрограммированный смертельный лиганж клеток 1 (В тыс.PD-L1) ингибиторы, революционизирующие лечение в подтипах, таких, как классическая лимфома Ходжкина (cHL) и первичная медистинальная лимфома В-клеток (PMBCL), достигающая высоких объективных показателей ответов (ORR). Однако эффективность варьируется в широких пределах, при этом успех в множестве миеломы ограничен.< 10% ORR) и лейкемии, подчеркивая необходимость лучшего прогнозирования,

Совпадение в аннотации оригинала
Hematologic malignancies pose significant global health burdens, with programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 … ior prognostic value, enabling targeted interventions like vitamin D supplementation, metformin, or nutritional support to enhance immune checkpoint inhibitor efficacy. Mechanistic insights reveal convergence on mTOR/IFN-γ pathways and microbiome modulation. Translating these to clinical panels could personalize immunotherapy, addressing gaps in hematologic malignanc …

Association between muscle quality and nutritional status among community-dwelling older adults: A cross-sectional study.

Background: Decline in muscle quality is associated with poorer health in community-dwelling older adults. Although there is evidence that m … , 95% confidence interval: 0.01-0.62). Conclusion: The observed association suggests that providing nutritional support for older adults living in the community may be a useful strategy to maintain muscle quality.

Metabolic and Nutritional Issues after Lower Digestive Tract Surgery: The Important Role of the Dietitian in a Multidisciplinary Setting.

Many patients undergo small bowel and colon surgery for reasons related to malignancy, inflammatory bowel disease (IBD), mesenteric ischemia … ctional changes resulting from surgery can affect either nutritional status due to malabsorption or nutritional support (NS) pathways. The dietitian providing NS to these patients needs to understand the pathophysiology underlying these sequelae and collaborate with other professionals, including surgeons, internists, nurses, and pharmacists. The aim of this review i …

Review article: the diagnostic approach and current management of chylous ascites.

BACKGROUND: Chylous ascites is rare, accounting for less than 1% of cases. An appropriate and stepwise approach to its diagnosis and managem … dL is consistent with chylous ascites. Treatment is based on management of the underlying cause and nutritional support. CONCLUSIONS: Chylous ascites is mostly due to malignancy and cirrhosis in adults, and congenital lymphatic disorders in children. Treatment with nutritional optimization and management of the underlying etiology are the cornerstones of therapy. Wh …

Listeria monocytogenes cells under nutrient deprivation showed reduced ability to infect the human intestinal cell line HT-29.

PURPOSE: This study aimed to evaluate the effect of two types of stress, cold and nutritional, on the viability and the in vitro virulence of the foodborne pathogenic bacteria Listeria monocytogenes. METHODOLOGY: Ten diverse isolates were kept in phosphate-buffered saline (PBS) at optimal (37 °C) or at refrigeration temperature (7 °C), for 1 and 7 days. The viability of the cells [log colony-forming units (c.f.u.)/ml] and their in vitro virulence, before and after storage in these conditions, were investigated. In vitro virulence (log PFA) was evaluated using the human intestinal epithelial c

Mental development and growth in children with chronic liver disease of early and late onset.

Comparison was made of the mental function and physical growth of 21 children in whom liver disease occurred in the first year of life with … Careful monitoring of nutritional status of children with early-onset liver disease and aggressive nutritional support beginning at the time of diagnosis may help reduce delays in growth and mental development.

Vitamin D Intake in Very Low Birth Weight Infants in Neonatal Intensive Care Unit.

It is unknown how often preterm infants in neonatal intensive care units achieve the American Academy of Pediatrics-recommended daily intake of 400 international units of Vitamin D. We studied 378 preterm infants with birth weight 1500 g or less admitted to our neonatal intensive care unit, 151 infants before and 227 infants after daily vitamin D-intake monitoring was introduced. Infants were stratified into 2 groups: extremely low birth weight (<1000 g) and Very low birth weight (1000-1500 g). Monitoring of daily intake coincided with significant improvement in vitamin D intake in both extrem

Nutritional treatment in inflammatory bowel disease. An update.

BACKGROUND AND AIMS: enteral (EN) and parenteral (TPN) nutrition exert variable therapeutic effects on the induction and maintenance of remission in inflammatory bowel disease (IBD). This review aims to provide an updated discussion on the complex relationship between diet and IBD. METHODS: medline, Cochrane and Scopus database searches were conducted. Sources cited in the articles obtained were also searched to identify other potential sources of information. RESULTS: nutritional status is significantly compromised in IBD patients, especially those with Crohn's disease (CD). Apart from rest