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Adaptive intrapatient dose escalation of cisplatin in patients with advanced head and neck cancer.

The purpose of this study was to explore the feasibility and toxicity of intrapatient dose adjustment using predefined levels of exposure to … e defined target levels by modest dose increases of 10-20% during course 2. Relevant but reversible ototoxicity (temporary grade 3 in two patients) and renal toxicity (temporary grade 2 in two other patients) were observed. The pattern and severity of the toxicity was comparable to that encountered in the previous phase II study in H/N cancer patients. We con …

Secondary Raynaud's phenomenon and other late vascular complications following chemotherapy for testicular cancer.

182 patients treated with cisplatin-based chemotherapy for testicular cancer at Hannover University Medical School who were in complete remi … after chemotherapy or a history of smoking. RP was not associated with the occurrence of neuro- or ototoxicity. All 7 patients with hypertensive blood pressure before chemotherapy developed RP. Furthermore, the median postchemotherapy diastolic blood pressure had increased by 8 mmHg compared to prechemotherapy values, leading to significant hypertension in 8 …

Empiric antibiotic therapy for granulocytopenic cancer patients.

Many cancer patients become granulocytopenic as a result of therapy and, as such, are likely to have fever during neutropenic episodes. Appr … icillin or a cephalosporin. In patients for whom concern about aminoglycoside-associated nephro- or ototoxicity is high, a double beta-lactam combination has been considered. Also, with the introduction of increasingly active, exceptionally broad-spectrum antimicrobials, empiric therapy with single agents has been considered. Beta-lactam/aminoglycoside combin …

Salicylate Induced GABAAR Internalization by Dopamine D1-Like Receptors Involving Protein Kinase C (PKC) in Spiral Ganglion Neurons.

BACKGROUND Sodium salicylate (SS) induces excitotoxicity of spiral ganglion neurons (SGNs) by inhibiting the response of γ-aminobutyric acid type A receptors (GABAARs). Our previous studies have shown that SS can increase the internalization of GABAARs on SGNs, which involves dopamine D1-like receptors (D1Rs) and related signaling pathways. In this study, we aimed to explore the role of D1Rs and their downstream molecule protein kinase C (PKC) in the process of SS inhibiting GABAARs. MATERIAL AND METHODS The expression of D1Rs and GABARγ2 on rat cochlear SGNs cultured in vitro was tested by im

Proton versus photon radiotherapy in adults with primary brain tumors evaluating functional survival: a phase 3 randomized controlled trial study protocol (PRIDE).

BACKGROUND: Radiation therapy (RT) plays a significant role in the multimodal management of primary brain tumors, improving oncological outc … survival, defined as survival without functional deterioration (neurocognitive decline, significant ototoxicity, new or worsening endocrine dysfunction, neurological impairment, severe radio-necrosis, disease progression, or death). Secondary endpoints include patient-reported quality of life and health economic analysis. Survival outcomes will be analyzed us …

Combined hearing screening and genetic screening of deafness among Sanya newborns in Hainan Province.

OBJECTIVE: To conduct combined hearing and genetic screening for hearing impairment in newborns in Sanya City, and to characterize the distr … early the identification of infants at risk for hereditary hearing loss and aminoglycoside-induced ototoxicity. Large-scale implementation of combined hearing and genetic screening improves the overall detection of at-risk newborns, thereby facilitating prevention strategies and early clinical intervention to mitigate hearing impairment hearing impairment.

A disproportionality analysis of adverse events associated with loop diuretics in the FDA Adverse Event Reporting System (FAERS).

BACKGROUND: Loop diuretics, including furosemide, torsemide, and bumetanide, are widely utilized in the management of volume overload-related conditions. Although previous studies have extensively documented risks such as electrolyte imbalances, ototoxicity, and nephrotoxicity, real-world evidence regarding novel or underrecognized adverse event (AE) signals remains limited and underexplored. METHODS: Using data from the Food and Drug Administration Adverse Event Reporting System (FAERS) from the first quarter of 2004 to the third quarter of 2024, we conducted a disproportionality analysis in…

Patterns of Vestibular Impairment in Bilateral Vestibulopathy and Its Relation to Etiology.

OBJECTIVE: This study aimed to investigate (1) the patterns of vestibular impairment in bilateral vestibulopathy (BVP) and subsequently, the … lar evoked myogenic potentials (c- and oVEMPs). The etiologies were split into idiopathic, genetic, ototoxicity, infectious, Menière's Disease, (head)trauma, auto-immune, neurodegenerative, congenital, and mixed etiology. RESULTS: The caloric test and horizontal vHIT more often indicated horizontal semicircular canal impairment than the torsion swing test. T …

Age-related hearing loss was accelerated by apoptosis of spiral ganglion and stria vascularis cells in ApoE KO mice with hyperglycemia and hyperlipidemia.

Age-related hearing loss (ARHL) is associated with diabetes and/or dyslipidemia in humans. However, the detailed mechanism for the developme … uted to the damage to the SGN and stria vascularis in the cochlea. Thus, our results indicated that ototoxicity by diabetes and/or dyslipidemia accelerated ARHL in ApoE KO mice, thereby suggesting the importance of appropriate treatment of patients with diabetes and/or dyslipidemia to prevent ARHL.

Combined antioxidants and anti-inflammatory therapies fail to attenuate the early and late phases of cyclodextrin-induced cochlear damage and hearing loss.

Niemann-Pick C1 (NPC1) is a fatal neurodegenerative disease caused by aberrant cholesterol metabolism. The progression of the disease can be … roles in mediating the first or second phase of HPβCD-induced cochlear damage. Thus, HPβCD-induced ototoxicity must be mediated by some other unknown cell-death pathway possibly involving loss of trophic support from damaged support cells or disrupted cholesterol metabolism.

Perfluoroalkyl substances exposure and hearing impairment in US adults.

BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are widely applied in consumer and industrial products such as nonstick cookware, wat … pounds in adults ≥70 years. CONCLUSIONS: Our study does not provide strong evidence to support the ototoxicity of PFAS exposure. Non-linear threshold dose-response associations between serum concentrations of PFNA and PFDA and HFHI need further investigation.

[Validation of a immunoassay for the determination of vancomycin in cerebospinal fluid].

INTRODUCTION: Vancomycin (VAN) is an antibiotic used to treat serious infections. Its use is related to adverse effects such as acute facial hyperemia, nephrotoxicity and ototoxicity. By having a very narrow therapeutic range, its monitoring is necessary to maximize efficiency and minimize toxic effects. It is estimated that its concentration in CSF is approximately 10% of the plasma level in patients who receive intravenous treatment and who have meninges inflammation. Plasma concentrations of VAN are not a reliable indicator of those present in CSF. The aim of this study was to validate an i…

Auditory Impairments in HIV-Infected Children.

OBJECTIVES: In a cross-sectional study of human immunodeficiency virus (HIV)-infected adults, the authors showed lower distortion product ot … ) even when corrected for confounders DPOAEs were lower in the HIV+ group. Previous studies suggest ototoxicity from antiretroviral drugs is an unlikely cause of the reduced DPOAE magnitudes. Other possibilities include effects on efferent pathways connecting to outer hair cells or a direct effect of HIV on the cochlea.

Vancomycin-induced thrombocytopenia in a 60-year-old man: a case report.

INTRODUCTION: Vancomycin, a glycopeptide antibiotic, is used to treat resistant gram-positive infections. There has been a 10- to 20-fold increase in its use over the past 25 years. Although ototoxicity and nephrotoxicity are well known side effects of vancomycin, it can also induce platelet reactive antibodies leading to life-threatening thrombocytopenia. Vancomycin is often clinically overlooked as a cause of thrombocytopenia, especially in a scenario of sepsis or when there is use of heparin. We report a proven case of vancomycin-induced thrombocytopenia and its reversal after discontinuati…

Gender effects on high frequency distortion product otoacoustic emissions in humans.

OBJECTIVE: Gender has been reported to affect many tests of the auditory system, including distortion product otoacoustic emission (DPOAE) g … frequency DPOAEs in clinical protocols, such as for auditory neuropathy/dys-synchrony diagnosis and ototoxicity monitoring, DPOAEs elicited with conventional and higher frequency stimuli must be understood, including the role of gender to determine if an effect on clinical protocols would exist.

Tandem high dose chemotherapy with autologous bone marrow transplantation for initial relapse of testicular germ cell cancer.

BACKGROUND: The purpose of this study was to evaluate the use of two cycles of high dose chemotherapy with autologous bone marrow transplant … rade 3-4 stomatitis in 17 of 25 patients, Grade 3-4 nausea/emesis in 12 of 25 patients, and Grade 3 ototoxicity in 3 of 25 patients. At the completion of therapy, nine patients were in complete remission, six had only teratoma found at resection, one had carcinoma resected, six were in partial remission, two had stable disease, and one had progressive disease …

Torasemide. An update of its pharmacological properties and therapeutic efficacy.

The pharmacological properties and therapeutic use of the high-ceiling loop diuretic torasemide (torsemide) were previously reviewed in Drug … failure. Adverse effects due to torasemide are usually mild and transient in nature. No evidence of ototoxicity has been demonstrated in humans, and torasemide does not appear to affect blood glucose levels, serum uric acid concentrations, or serum potassium levels at dosages below 5 mg/day. Thus, additional evidence has accumulated for the clinical efficacy …

Неврологические проявления и токсичность антитуберкулезных препаратов. Обзор.

Рассматриваются неврологические проявления и токсичность 12 антитуберкулезных препаратов [исониазид, рифампицин (рифампин), этимбутол, паминосалициловая кислота, пиразинамид, стрептомицин, канамицин, этионамид, циклозерин, капреомицин, вомицин и тиацезона]. Изучаются их воздействие на центральную нервную систему, краниальные нервы, периферийные нервы и нейромускульное соединение, а также кратко обсуждаются взаимосвязи между лекарственными средствами, вызывающими неврологическую обеспокоенность. Изониазид хорошо известен тем, что он увеличивает концентрации гамма-аминобутирной кислоты в нейронн

Совпадение в аннотации оригинала
The neurological manifestations and toxicities of 12 antituberculosis drugs [isoniazid, rifampicin (rifampin), ethambutol, p-aminosalicylic … arked loss of colour discrimination, constricted visual fields, and central and peripheral scotoma. Ototoxicity is a well known problem caused by streptomycin, kanamycin, capreomycin and viomycin. The use of streptomycin in pregnant mothers is associated with congenital deafness in newborns in certain cases. The aminoglycoside antibiotics are also associated …

[Netilmicin in refractory urinary tract infections. Good therapeutic effect in spite of long dosage intervals].

Aminoglycoside antibiotics are useful--despite potential toxicity--for treating urinary tract infection when other antibacterial agents have … and in one transplanted patient by infection localized to her own shrunken kidneys. No instance of ototoxicity or nephrotoxicity due to netilmicin could be detected. Netilmicin administered according to the dosage schedule described can be recommended for ambulatory treatment of tenacious, recurring urinary tract infections due to gram-negative bacteria and …

Uncharted territory - an audiometric surveillance program for seafarers.

BACKGROUND: Occupational noise exposure causes noise-induced hearing loss (NIHL). The International Maritime Organization Code on Noise Levels on Board Ships includes audiometric surveillance as an optional measure for monitoring auditory thresholds over time. The Occupational Safety and Health Administration (OSHA) standard threshold shift (STS) criterion is widely used for surveillance. A standard threshold shift can occur due to aging, illness, cumulative exposure to noise and ototoxic agents, or test-retest variability. To the authors' knowledge, this is the first service implementation an