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Результаты перкутановой вертебропластики в множестве миеломы: опыт третичной нейрофизики в долгосрочной последующей деятельности.

Множественная миелома диагностируется в 5,800 ежегодно в Соединенном Королевстве (Соединенном Королевстве) 64% - иметь переломы позвоночника при диагностике. Больные переломы позвоночника могут нанести значительный ущерб качеству жизни пациентов. Перкутанная вертебропластика направлена на обеспечение долгосрочного обезболивания и стабилизацию перелома позвонков. МЕТОДЫ И МАТЕРИАЛЫ: Данные были собраны по всем случаям перкутановой вертебропластики, выполненной пациентами с множественной миеломой с ноября 2017 по январь 2019. Показатели боли измерялись по шкале Визуального Аналога (VAS) и предпр

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… Examples of the changes of analgesic requirements include one patient who required a 100-μg/h fentanyl patch pre-procedure, reduced to only requiring 100 mg of tramadol twice daily post-procedure (reduction of strength, i.e., a step down the analgesic ladder); one patient who required 10 mg of oxycodone …

Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor.

The purpose of this study was to investigate the application of bromelain in the treatment of pain, swelling, and limited mouth opening in patients with hematologic tumor after extraction of the third molar during chemotherapy. We recruited 72 patients with hematologic tumor who were treated by oral and maxillofacial surgery in our hospital, and third molar extraction was performed under local anesthesia. After extraction, patients in the control group were treated with cold - hot compress and patients in the experimental group were treated by oral administration of bromelain. One, three, and

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… Analgesic efficacy and safety of single-dose tramadol and non-steroidal anti-inflammatory drugs in operations on the third molars: A systematic review and meta-analysis. Br J Oral Maxillofac Surg. 2014;52:775–783. doi: 10.1016/j.bjoms.2014.05.005. 14. …

NLRP3 inflammasome: a key driver of neuroinflammation and a novel therapeutic target for neuropathic pain.

Neuropathic pain represents a serious complication arising from a spectrum of disorders that precipitate lesions within the central and peripheral nervous systems. This disabling pain can persist for years, severely diminishing the quality of life of the affected individuals. The treatment options available for neuropathic pain at present have limited efficacy. Moreover, the adverse effects associated with these options restrict their application. The exact etiological mechanisms underlying the pathogenesis of neuropathic pain remain unclear. However, neuroinflammatory processes mediated by th

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… Neuropathic pain was alleviated through the genetic knockout of NLRP1 [ 52 ] or inhibition of its activity by curcumin [ 52 ], tramadol [ 54 ], or aspirin [ 53 ] inducing neuroprotective and anti-inflammatory effects in these studies. … The role of NLRP1 inflammasome and interleukin 1β in experimental neuropathic pain model in rat and the effect of tramadol treatment. Turk Neurosurg. 2024;34:856–64. doi: 10.5137/1019-5149.JTN.43768-23.3. 55. Li Q, Liu S, Zhu X, Mi W, Maoying Q, Wang J, et al. …

Risk Factors and Impact on Survival of Pathological Fractures in Patients With Humeral Metastasis.

Background Bone metastases often cause pathological fractures and impair patients' quality of life and survival. Although several studies have been conducted on pathological fractures in the femur and spine, limited research has been done on the upper limbs. This study aimed to reveal the risk factors and determine how pathological fractures impact survival in patients with humeral metastasis. Methods This retrospective study was based on patients with humerus metastasis treated in the Nagoya-City University Hospital from 2010 to 2020. Patient characteristics, including sex, age at diagnosis o

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… Loxoprofen 60 mg×3 71 | Male | Lung | No | B+C | 12 | No rehabilitation | Acetoaminophen 400 mg×3 80 | Female | Myeloma | No | B+C | 25 | Anterior elevation 90 | Oxycodone 5 mg 60 | Male | Kidney | No | B+C | 49 | No rehabilitation | None 82 | Female | Myeloma | No | B+C | 24 | Anterior elevation 60 | Tramadol …

Effect of Acupuncture in Pain Management of Head and Neck Cancer Radiotherapy: Prospective Randomized Unicentric Study.

This prospective randomized open-label trial aimed to evaluate the role of acupuncture in the treatment of pain related to curative and adjuvant (chemo)radiotherapy of head and neck cancer. Patients in two arms (30 patients in each arm) underwent standard oncology therapy and standard supportive care with or without acupuncture. The stratification factors were the type of treatment and chemotherapy indication. The toxicity assessed was represented by pain rated on a 10-point pain scale and analgesic use. Average pain (AP) and the worst pain during the day (WP) were significantly lower in the a

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… Thus, the therapy ranged from non-opioids (metamizole and paracetamol) through weak opioids (tramadol or codeine) to strong opioids (fentanyl, buprenorphine, or morphine). 2.3. Acupuncture Acupuncture was carried out by a certified physician (R.D. …

The assessment of surgical and non-surgical treatment of stage II medication-related osteonecrosis of the jaw.

BACKGROUND: Non-surgical treatment has generally been recommended for stage II medication-related osteonecrosis of the jaw (MRONJ) in preference to surgery. However, non-surgical treatment is not empirically effective. The aim of this study was to evaluate whether surgical or non-surgical treatment leads to better outcomes for stage II MRONJ. MATERIAL AND METHODS: In this retrospective study, surgery was performed in a total of 28 patients while 24 patients underwent non-surgical treatment. The outcomes of both treatment approaches after 6 months were evaluated and statistically compared. In

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… When swelling and pain were exacerbated, we administered effective antibiotics (amoxicillin, ceftriaxone, clindamycin, and/or cefcapene pivoxil) and analgesics (loxoprofen, acetaminophen, and/or tramadol hydrochloride) accompanied by incisional drainage. …

Repetitive Transcranial Magnetic Stimulation: Is it an Effective Treatment for Cancer Pain?

Cancer is a major public health issue, with an estimated 20 million new cases and 9.7 million cancer-related deaths worldwide in 2022. Approximately 44.5% of patients experience cancer pain, significantly impacting their quality of life and causing physical and psychological burdens. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive neuromodulation technique, shows potential in managing cancer pain. This review summarizes current research on rTMS for cancer pain, focusing on pain directly caused by tumors, pain from cancer treatments, postoperative pain, and cancer-related sy

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… All patients followed the same regimen and were required not to change during the study: tramadol hydrochloride 100 mg twice daily, scopolamine 20 mg three times per day, and amitriptyline 25 mg twice daily. … All patients used the same and unchangeable treatment regimen: tramadol hydrochloride 100 mg twice daily, pregabalin 75 mg twice daily, gabapentin 400 mg twice daily, and amitriptyline 25 mg twice daily. …

Pain Management in Patients with Multiple Myeloma: An Update.

Most patients with multiple myeloma (MM) suffer from chronic pain at every stage of the natural disease process. This review focuses on the most common causes of chronic pain in MM patients: (1) pain from myeloma bone disease (MBD); (2) chemotherapy-induced peripheral neuropathy as a possible consequence of proteasome inhibitor therapy (i.e., bortezomib-induced); (3) post-herpetic neuralgia as a possible complication of varicella zoster virus reactivation because of post-transplantation immunodepression; and (4) pain in cancer survivors, with increasing numbers due to the success of antiblasti

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… When these drugs do not provide adequate analgesia, weak opioids such as tramadol are recommended. … There is insufficient evidence to support or refute the use of other opioids, such as oxycodone, buprenorphine, and tramadol, which have been shown to provide clinically relevant pain relief in highly selected patients with neuropathic pain syndromes [ 94 ]. …

Using antipsychotic agents in older patients.

OBJECTIVES: Antipsychotics are widely used in geriatric psychiatric disorders. A growing number of atypical antipsychotics are available, ex … prazole, risperidone, or a high-potency conventional plus valproate) or with codeine, phenytoin, or tramadol. CONCLUSIONS: The experts reached a high level of consensus on many of the key treatment questions. Within the limits of expert opinion and with the expectation that future research data will take precedence, these guidelines provide direction for …

Biological implant-associated granulomatous inflammation resulting in secondary hypercalcemia and azotemia in a dog.

Implant associated granulomatous inflammation causing hypercalcemia can occur following use of commercial xenogeneic pericardial tissue patches in dogs. Removal of the implant can result in resolution of the hypercalcemia, suggesting a causal relationship between the tissue reaction to a xenogeneic implant and development of hypercalcemia.

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… The patient recovered uneventfully from surgery and was sent home the following day on standard doses of carprofen, tramadol and a 2‐week course of cefpodoxime. It was recommended that the previously prescribed oclacitinib for atopy be discontinued during the 2‐week post‐operative period. …

A randomized controlled trial to compare the efficacy of bisphosphonates in the management of painful bone metastasis.

IntroductionThe prospective interventional single-institution randomized control study was carried out to compare the pain relieving efficacy among different bisphosphonates at the cost of incidence of skeletal-related events (SRE).Materials and methodsDuring June 2008 and May 2011, 256 patients with painful bone metastasis in solid tumors with a pain score of at least 5 were randomized into three arms: zoledronic acid (4 mg, i.v.), ibandronate (6 mg, i.v.) and pamidronate (90 mg, i.v.). Radiation was given to all patients, either 800 cGy single fraction or 20 Gy in five fractions. The ANOVA t

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… The narcotic score was calculated by multiplying pain medication [none = 0, analgesic = 1 (paracetamol, ibuprofen), mild narcotic = 2 (dextropropoxyphene), moderate narcotic =3 (tramadol) and strong narcotic = 4 (morphine)] and frequency of medication administration [none = 0, less than daily = 1 (p.r.n …

Gabapentinoids and unexplained death in general practice: Case series and feasibility study arising from a critical incident.

BACKGROUND: Prescribing epidemiology in general practice shows gabapentinoid drugs to be independently associated with unexpected, drug-related death. There is an increasing trend of gabapentinoid deaths throughout Europe and North America. OBJECTIVES: The overall aim of this study was to assess how patient, practice and health system factors might be associated with gabapentinoid prescribing in primary care. METHODS: Case series following a critical incident of an unexpected death in a patient prescribed a gabapentinoid drug in a single general practice. Unexpected and expected deaths in pa

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… Sciatica | Pain Yes | No | No | Zolpidem 10 mg | No | Metastatic Colorectal Carcinoma 8 | 80–89 | F | 8 | 13 | Gabapentin 300 mg TDS | Tempero-Mandibular Pain | Pain Yes | Yes | No | Zopiclone 7.5 mg | No | COPD 9 | 30–39 | F | 2 | 8 | Gabapentin 100 mg TDS | Neuropathic cancer pain | Oncology Yes | No | Tramadol …

What Changes Have Occurred in Opioid Prescriptions and the Prescribers of Opioids Before TKA and THA? A Large National Registry Study.

BACKGROUND: Opioid use before TKA or THA is linked to a higher risk of revision surgery and less functional improvement. In Western countrie … CI 2.6 to 4.7]; p < 0.001, respectively). For TKA, but not for THA, there was a monthly decrease in tramadol prescriptions (-0.6 MME [95% CI -1.0 to -0.2]; p = 0.006). Regarding the opioids prescribed in the year before surgery, there was a mean increase of 48 MME (95% CI 39.3 to 56.7 MME; p < 0.001) for TKA between 10 and 12 months and the last 3 months b …

Bortezomib-induced peripheral neuropathy: from molecular mechanisms to clinical management.

Bortezomib (BTZ) is a first-generation proteasome inhibitor that has shown significant efficacy in the treatment of multiple myeloma (MM), providing significant therapeutic benefits without severely compromising overall patient health. However, one of the most common and debilitating side effects associated with BTZ therapy is bortezomib-induced peripheral neuropathy (BIPN). This condition is the leading complication observed in patients undergoing BTZ treatment and has a profound impact on treatment regimens, often necessitating dose reductions or alterations in the dosing schedule. Despite t

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… The mechanical hypersensitivity caused by BTZ can be substantially reduced through the use of Ca 2+ channel blockers, such as tramadol, pregabalin, and ethosuximide ( Duggett and Flatters, 2017 ; Yamamoto et al., 2015 ). … Therapeutic: A single administration of Gabapentin (30 and 100 mg/kg, i.g. or 30 and 100 μg/site, i.c.) was performed on 12 days after BTZ injection. | Activated the descending noradrenergic system | Reduced neural excitability and inhibited BTZ-induced mechanical allodynia | Kitamura et al. (2014) Tramadol …

Comparative Long-Term Outcomes of Vertebroplasty Versus Kyphoplasty for Osteoporotic Vertebral Compression Fractures: A Propensity-Matched Analysis.

Introduction Vertebroplasty and kyphoplasty are widely performed for osteoporotic vertebral compression fractures (VCFs). The objective of this study was to compare long-term clinical outcomes between patients undergoing vertebroplasty and kyphoplasty for osteoporotic VCFs. Methods We used the TriNetX US Collaborative Research Platform to identify adults aged ≥50 years with osteoporotic VCFs treated with vertebroplasty or kyphoplasty between 2000 and 2025. Patients with malignancy were excluded. Cohorts were propensity-matched 1:1 (7,528 per cohort) on demographic, comorbidity, and bone health

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… 22515 | Kyphoplasty, 1 vertebral body; each additional vertebral body Laminectomy | 63046 | Laminectomy, facetectomy and foraminotomy, single vertebral segment; thoracic 63047 | Laminectomy, facetectomy and foraminotomy, single vertebral segment; lumbar Opioid Prescriptions | RxNorm Code | 10689 | Tramadol …

Impact of discontinuing 5 years of enzyme replacement treatment in a cohort of 6 adults with hypophosphatasia: A case series.

Asfotase alfa is a human recombinant enzyme replacement therapy for hypophosphatasia. We describe 6 adults who were treated with asfotase alfa for 61-68 months in a clinical trial (NCT01163149), after which asfotase alfa was discontinued for 15-48 months. The patients experienced clinical deterioration and, when treatment was restarted, showed improvement. Patients with hypophosphatasia should be closely monitored if asfotase alfa is stopped as clinical decline is likely. Clinical practice guidelines are needed.

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… at the time of the other assessments Concomitant medications Study baseline | Acetaminophen, amoxicillin, codeine, menthol with methyl salicylate cream, methylprednisolone, morphine, oxycodone | Acetaminophen, codeine, gabapentin, ibuprofen, methocarbamol, mineral supplements, naproxen, prednisone, tramadol …

Acupuncture combined with methylcobalamin for the treatment of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma.

BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) seriously affects the quality of life of patients with multiple myeloma (MM) as well as the response rate to chemotherapy. Acupuncture has a potential role in the treatment of CIPN, but at present there have been no randomized clinical research studies to analyze the effectiveness of acupuncture for the treatment of CIPN, particularly in MM patients. METHODS: The MM patients (104 individuals) who met the inclusion criteria were randomly assigned into a solely methylcobalamin therapy group (500 μg intramuscular methylcobalamin injec

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… First line treatments of neuropathic pain includes gabapentin, 5% lidocaine patches and opioid analgesics such as tramadol hydrochloride. Second line drugs include lamotrigine, carbamazepine and amitriptyline, as well as other antidepressants [ 5 ]. …

Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model.

BACKGROUND: Bisphosphonate-related osteonecrosis of the jaw is a pathological condition without effective established treatment and preventive strategies. The aim of this study was to analyse the effect of adipose-derived stem cells (ASC) in an experimental murine model of osteonecrosis. MATERIAL AND METHODS: 38 Wistar rats were injected intraperitoneally with zoledronic acid. After treatment, upper jaw molars were extracted. The animals were randomly assigned to one of two groups. In the control group, saline solution was applied over the alveolar sockets after the tooth extractions. In the

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… Tramadol was administered once preoperatively, and daily subcutaneously for 3 postoperative days. Intraperitoneal general anaesthesia (ketamine 100 mg/kg + diazepam 8 mg/kg + atropine 0.4 mg/kg) was first used; however, 9 rats (all controls) died during the procedure or on the postoperative days. …

Adefovir dipivoxil-induced hypophosphatemic osteomalacia and osteoporosis: a case report and literature review.

The nephrotoxicity of adefovir dipivoxil (ADV) can induce Fanconi syndrome, which causes hypophosphatemic osteomalacia. We report a case of a 67-year-old postmenopausal woman who had been receiving long-term adefovir dipivoxil therapy for chronic hepatitis B. She presented with severe bone pain and multiple pseudofractures, and was diagnosed with drug-induced hypophosphatemic osteomalacia. Following discontinuation of adefovir and supplementation with vitamin D and phosphate, her biochemical parameters normalized and bone pain significantly improved, indicating that osteomalacia had been essen

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… The Orthopedics department initiated management with calcium and vitamin D supplementation, tramadol for analgesia, and denosumab 60 mg for osteoporosis. However, her generalized bone pain persisted despite this treatment, prompting her transfer to our department on January 5, 2024. …

Localized fungal osteomyelitis caused by Aspergillus sp. in the ilium and acetabulum of a dog with disseminated aspergillosis: A case report.

BACKGROUND: Osteomyelitis caused by Aspergillus sp. is uncommon in dogs and cats and may occur in cases of disseminated aspergillosis, a rare and poorly described condition in veterinary medicine. CASE DESCRIPTION: Due to the scarcity of reports documenting this disease, particularly with localized involvement of the pelvic bones, the present case report aimed to describe the condition in an 8-year-old mixed-breed dog presenting with severe pain and lameness of the right pelvic limb. Radiographic examination revealed marked periosteal bone proliferation and osteolysis extending from the right

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… Postoperative medications included dipyrone (25 mg/kg PO q12 hours for 7 days), tramadol hydrochloride (5 mg/kg PO q12 hours for 7 days), meloxicam (0.1 mg/kg PO q24 hours for 5 days), and cephalexin (30 mg/kg PO q12 hours for 10 days). …