Результаты поиска

Е-постеры.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Biological and Clinical Aspects of Metastatic Spinal Tumors.

Spine metastases are a common life-threatening complication of advanced-stage malignancies and often result in poor prognosis. Symptomatic spine metastases develop in the course of about 10% of malignant neoplasms. Therefore, it is essential for contemporary medicine to understand metastatic processes in order to find appropriate, targeted therapeutic options. Thanks to continuous research, there appears more and more detailed knowledge about cancer and metastasis, but these transformations are extremely complicated, e.g., due to the complexity of reactions, the variety of places where they oc

Совпадение в полном тексте источника
… CT can be performed to plan a surgical procedure; the imaging helps to select the appropriate access during vertebroplasty [ 129 ]. 4.3. … Currently, compression fractures are considered to be favorable candidates for balloon kyphoplasty or percutaneous vertebroplasty. …

Exploring the applicability, combined strategies, and challenges of ablation in hematology based on its characteristics and immunomodulatory mechanisms.

Malignant hematological diseases, such as lymphoma, leukemia, and multiple myeloma, are frequently accompanied by clinical challenges including local progressive lesions, relapsed/refractory conditions, and poor tolerance to standard treatments in special populations. Systemic therapies represented by chemotherapy and targeted therapy have inherent limitations in addressing local tumor burden, relieving organ compression, and being suitable for frail patients. As a minimally invasive local treatment technology, ablation has been widely used in solid tumor therapy due to its advantages of preci

Совпадение в полном тексте источника
… However, studies by Orgera et al. found that ablation and percutaneous vertebroplasty are comparable in pain relief, improvement of disability scores, stabilization of bone structure, and reduction of analgesic use, providing a minimally invasive option for treatment-resistant pain, especially suitable …

Predictors of quality of life in multiple myeloma patients: a multi-centered cross-sectional study.

BACKGROUND: Multiple myeloma (MM) substantially impairs health-related quality of life (QoL). Evidence from low- and middle-income countries is limited, and identifying reliable predictors of QoL is essential to guide supportive care strategies. METHODS: We conducted a multicenter cross-sectional study of 202 MM patients from six hospitals in the West Bank, Palestine (2018-2025). Patients completed the validated Arabic EORTC QLQ-MY20 questionnaire. Clinical, demographic, and therapeutic variables were collected, and predictors of QoL subscales were analyzed using non-parametric tests and mult

Совпадение в полном тексте источника
… Percutaneous vertebroplasty combined with chemotherapy in the treatment of multiple myeloma patients with vertebral compression fractures. Chin Med J (Engl). 2022;135(18):2242–4. 29. He J, Duenas A, Collacott H, Lam A, Gries KS, Carson R, et al. …

Nontraumatic Spinal Cord Injury: Epidemiology, Etiology and Management.

The spinal cord is a conduit within the central nervous system (CNS) that provides ongoing communication between the brain and the rest of the body, conveying complex sensory and motor information necessary for safety, movement, reflexes, and optimization of autonomic function. After a traumatic spinal cord injury (SCI), supraspinal influences on the peripheral nervous system and autonomic nervous system (ANS) are disrupted, leading to spastic paralysis, sympathetic blunting, and parasympathetic dominance, resulting in cardiac dysrhythmias, systemic hypotension, bronchoconstriction, copious re

Совпадение в полном тексте источника
… Vertebroplasty and kyphoplasty are generally not indicated in the presence of neurological deficits. …

Finite Element Analysis of Osteoporotic and Osteoblastic Vertebrae and Its Association With the Proton Density Fat Fraction From Chemical Shift Encoding-Based Water-Fat MRI - A Preliminary Study.

PurposeOsteoporosis is prevalent and entails alterations of vertebral bone and marrow. Yet, the spine is also a common site of metastatic spread. Parameters that can be non-invasively measured and could capture these alterations are the volumetric bone mineral density (vBMD), proton density fat fraction (PDFF) as an estimate of relative fat content, and failure displacement and load from finite element analysis (FEA) for assessment of bone strength. This study's purpose was to investigate if osteoporotic and osteoblastic metastatic changes in lumbar vertebrae can be differentiated based on the

Совпадение в полном тексте источника
… The first of these patients (ID 4) had previous osteoporotic VFs and vertebroplasty of L2 and L3. The second of these patients (ID 5) had an osteoporotic upper endplate fracture of L4. …

Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel.

Solitary plasmacytoma is an infrequent form of plasma cell dyscrasia that presents as a single mass of monoclonal plasma cells, located either extramedullary or intraosseous. In some patients, a bone marrow aspiration can detect a low monoclonal plasma cell infiltration which indicates a high risk of early progression to an overt myeloma disease. Before treatment initiation, whole body positron emission tomography-computed tomography or magnetic resonance imaging should be performed to exclude the presence of additional malignant lesions. For decades, treatment has been based on high-dose radi

Совпадение в полном тексте источника
… The introduction of modern spinal fixation and stabilization methods, such as vertebroplasty and kyphoplasty, allows for a surgical solution for patients who develop vertebral fractures, vertebral instability, neurological complications, or a combination of these. …

Determinants of Overall and Readmission-Free Survival in Patients with Metastatic Epidural Spinal Cord Compression.

BACKGROUND: The aim of this study was to assess the surgical outcomes and survival of patients surgically treated for metastatic epidural spinal cord compression (MESCC), with a specific focus on identifying factors that influence overall survival and readmission-free survival. METHODS: All patients who underwent surgery for spine metastases at our department in the period 2018-2022 were included in the study. RESULTS: A total of 175 patients (n = 71 females, median age 67.15 years) were included. The most common primary tumors were lung carcinoma (n = 31), prostate carcinoma (n = 31), breas

Совпадение в полном тексте источника
… In a mixed cohort of 197 patients with and without MESCC, vertebroplasty has shown the lowest revision rates followed by decompression alone, with the highest rates in patients who underwent stabilization [ 63 ]. …

Innovative Biomaterials for the Treatment of Bone Cancer.

Bone cancer is a demanding challenge for contemporary medicine due to its high frequency of presentation and significant heterogeneity of malignant lesions developing within the bone. To date, available treatments are rarely curative and are primarily aimed at prolonging patients' survival and ameliorating their quality of life. Furthermore, both pharmacological and surgical therapies are aggravated by a consistent burden of adverse events and subsequent disability due to the loss of healthy bone structural and functional properties. Therefore, great research efforts are being made to develop

Совпадение в полном тексте источника
… Treatment of SREs is multimodal and frequently involves the administration of drugs (i.e., analgesics, bisphosphonates, RANKL inhibitors, radiopharmaceuticals) as well as locoregional (i.e., radiotherapy, vertebroplasty, kyphoplasty) and surgical approaches (i.e., nerve decompression and/or fracture …

The Role of Prognostic Scoring Systems in Assessing Surgical Candidacy for Patients With Vertebral Metastasis: A Narrative Review.

Study designNarrative review.ObjectivesTo review the relevant literature regarding scoring systems for vertebral metastases and quantify their role in contemporary orthopedic practice.MethodsA literature search of PubMed, Google Scholar, and Embase was performed on February 7, 2017. Eight scoring systems were selected for detailed review-7 of which were scores focused solely on patient prognosis (Tokuhashi, Tomita, Bauer, Oswestry Spinal Risk Index, Van der Linden, Rades, and Katagiri). The eighth system reviewed was the Spinal Instability Neoplastic Score, which examines for impending spinal

Совпадение в полном тексте источника
… Br J Neurosurg . 2016 ; 30 : 337 – 344 . doi:10.3109/02688697.2015.1133802 . 26901574 10.3109/02688697.2015.1133802 84 Bae JW Gwak HS Kim S Percutaneous vertebroplasty for patients with metastatic compression fractures of the thoracolumbar spine: clinical and radiological factors affecting functional …

Проблемы с многократной терапией миеломы у пациентов постарше и посторонних.

Каждый год больше, чем 150,000 во всем мире диагностируются случаи множественной миеломы (ММ) и более 100,000 Зарегистрированы случаи смерти в результате этого злонамеренного поведения. Уровень заболеваемости ММ растет во всем мире, особенно в странах с высоким уровнем дохода и среди мужского населения в возрасте ≥ 50. Хотя прогресс в осуществлении стратегий лечения привел к повышению уровня выживания за последние десятилетия, ММ остается неизлечимым во многих случаях. Важно то, что one- треть пациентов с диагнозом MM - >75 возраст и характеризуется относительно низкой трудоспособностью или сл

Совпадение в полном тексте источника
… More specifically, bone-active agents, including bisphosphonates and denosumab, or interventional procedures, such as radiotherapy, vertebroplasty, neurolysis, radiofrequency neurotomy, and spinal cord decompression, should be evaluated [ 85 ]. …

Feasibility of a tailored and virtually supported home exercise program for people with multiple myeloma using a novel eHealth application.

INTRODUCTION: eHealth exercise interventions have the unique ability to leverage the benefits of in-person programming (tailoring and supervision) with the benefits of home programming (flexibility). There may be a role for eHealth-delivered exercise for people with multiple myeloma (MM), as exercise tailoring and supervision are critical for successful outcomes due to the significant impacts/risks of myeloma-related side effects. The purpose of this study was to determine the safety, feasibility, and preliminary efficacy of a 12-week virtually supported eHealth exercise program. METHODS: Par

Совпадение в полном тексте источника
… BMI: body mass index; SCT: stem cell transplantation; MVPA: moderate-to-vigorous physical activity. 1 Includes vertebroplasty, kyphoplasty, or orthopedic surgeries related to myeloma. …

Oral Presentations

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… The fractured vertebra was managed either with Vertebroplasty/kyphoplasty or with cement augmented screws. 6 patients had short segment and 9 patients had long segment fixation. Mean time to follow-up was 14.60 months. …

Mechanisms, Diagnosis and Treatment of Bone Metastases.

Bone and bone marrow are among the most frequent metastatic sites of cancer. The occurrence of bone metastasis is frequently associated with a dismal disease outcome. The prevention and therapy of bone metastases is a priority in the treatment of cancer patients. However, current therapeutic options for patients with bone metastatic disease are limited in efficacy and associated with increased morbidity. Therefore, most current therapies are mainly palliative in nature. A better understanding of the underlying molecular pathways of the bone metastatic process is warranted to develop novel, wel

Совпадение в полном тексте источника
… This technique is known as vertebroplasty in cases involving vertebral involvement, or cementoplasty in cases where long bones are affected. These methods provide pain relief in up to 75% of patients. …

Bone metastasis in colorectal cancer: Pathophysiology, prognostic factors, survival outcomes, and treatment strategies - A comprehensive review.

BackgroundColorectal cancer ranks as the third most prevalent cancer globally, with over 1.9 million new cases and 930,000 deaths in 2020. While the liver and lungs are the most common site of colorectal cancer metastases, bone metastasis is relatively rare but clinically significant. The rarity of bone metastasis in colorectal cancer, early diagnosis challenges, and the poorly understood mechanisms underlying bone metastasis have resulted in lesser research compared to other metastatic sites of colorectal cancer.ObjectiveThe goal of this review is to summarize pathophysiology, clinical presen

Совпадение в полном тексте источника
… Procedures such as vertebroplasty and kyphoplasty can be employed to treat spinal metastasis, providing pain relief from vertebral compression fractures [ 20 ]. …

Diagnosis and Treatment of Bone Metastases in Breast Cancer: Radiotherapy, Local Approach and Systemic Therapy in a Guide for Clinicians.

The standard care for metastatic breast cancer (MBC) is systemic therapies with imbrication of focal treatment for symptoms. Recently, thanks to implementation of radiological and metabolic exams and development of new target therapies, oligometastatic and oligoprogressive settings are even more common-paving the way to a paradigm change of focal treatments role. In fact, according to immunophenotype, radiotherapy can be considered with radical intent in these settings of patients. The aim of this literature review is to analyze available clinical data on prognosis of bone metastases from brea

Совпадение в полном тексте источника
… Percutaneous techniques include vertebroplasty that allow to inject surgical cement in the vertebral body with immediate and analgesic effect in few days—and more recently—cementoplasty, that stabilize also of extraspinal lesion, for example long bone sites. …

Management of skeletal metastases: An orthopaedic surgeon's guide.

Skeletal metastasis is a common cause of severe morbidity, reduction in quality of life (QOL) and often early mortality. Its prevalence is rising due to a higher rate of diagnosis, better systemic treatment, longer lives with the disease and higher disease burden rate. As people with cancer live longer and with rising sensitivity of body imaging and surveillance, the incidence of pathological fracture, metastatic epidural cord compression is rising and constitutes a challenge for the orthopedic surgeon to maintain their QOL. Metastatic disease is no longer a death sentence condemning patients

Совпадение в полном тексте источника
… a decision is made by a multidisciplinary team regarding need for analgesia, radiation, systemic medical treatment (chemotherapy, hormonal therapy, targeted therapy or agents to improve bone strength) and need for intervention either minimally invasive (radiofrequency ablation [RFA], cementoplasty, vertebroplasty …

Quality of Life in Palliative Care: A Systematic Meta-Review of Reviews and Meta-Analyses.

BackgroundThe area of palliative care is a setting in which the evaluation of the quality of life (QoL) is fundamental. However, the topic has been covered from many different points of view, and there is a lack of comprehensive synthesis of the evidence drawn from the available literature.ObjectiveWe carried out a meta-review of all available systematic reviews and meta-analyses that have dedicated part or most of the investigation to the assessment of QoL in palliative care to provide the most updated and comprehensive depiction of all available information about measurement and intervention

Совпадение в полном тексте источника
… Health Quality Ontario Vertebral augmentation involving vertebroplasty or kyphoplasty for cancer-related vertebral compression fractures: A systematic review. Ont. Health Technol. Assess. Ser. 2016;16(11):1–202. 9. Barnes H, McDonald J, Smallwood N, Manser R. …

Sternum Metastases: From Case-Identifying Strategy to Multidisciplinary Management.

We aimed to overview the most recent data on sternal metastases from a multidisciplinary approach (diagnosis strategies, outcome, and histological reports). This narrative review based on a PubMed search (between January 2020 and 22 July 2023) using key words such as "sternal", "manubrium", and "metastasis" within the title and/or abstract only included original papers that specifically addressed secondary sternal spreading of cancer in adults, for a total of 48 original articles (14 studies and 34 single case reports). A prior unpublished case in point is also introduced (percutaneous incisio

Совпадение в полном тексте источника
… Minimally invasive procedures may also include, for example, percutaneous osteoplasty, as similarly seen in percutaneous vertebroplasty (injection of bone cement). …

Prevention and management of adverse events of novel agents in multiple myeloma: a consensus of the European Myeloma Network.

During the last few years, several new drugs have been introduced for treatment of patients with multiple myeloma, which have significantly improved the treatment outcome. All of these novel substances differ at least in part in their mode of action from similar drugs of the same drug class, or are representatives of new drug classes, and as such present with very specific side effect profiles. In this review, we summarize these adverse events, provide information on their prevention, and give practical guidance for monitoring of patients and for management of adverse events.

Совпадение в полном тексте источника
… immunomodulatory agents, INR international normalized ratio, VTE venous thromboembolism a Defined as a body mass index ≥30 kg/m 2 b Comorbidities include diabetes, infections, cardiac diseases, chronic renal disease, and immobilization c Surgical procedures include general surgery, any anesthesia, trauma, vertebroplasty …