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Treating Primary Aldosteronism-Induced Hypertension: Novel Approaches and Future Outlooks.

Primary aldosteronism (PA) is the most common cause of secondary hypertension and is associated with increased morbidity and mortality when compared with blood pressure-matched cases of primary hypertension. Current limitations in patient care stem from delayed recognition of the condition, limited access to key diagnostic procedures, and lack of a definitive therapy option for nonsurgical candidates. However, several recent advances have the potential to address these barriers to optimal care. From a diagnostic perspective, machine-learning algorithms have shown promise in the prediction of P

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… Similarly, the gold standard status of confirmatory testing has recently been called in to question in a comprehensive meta-analysis (55 studies; 7357 patients) of the 4 commonly used investigations (SIT, salt-loading test, fludrocortisone suppression test, and captopril challenge test) ( 63 ). … Acknowledging the limitations highlighted within this metanalysis, the fludrocortisone challenge test demonstrated the best performance as a confirmatory test, followed by the recumbent SIT and the captopril challenge test. …

Gestational Pityriasis Rosea: Suggestions for Approaching Affected Pregnant Women.

Dear Editor, Pityriasis rosea is a common, acute, and self-limiting dermatosis, which is associated with the endogenous systemic reactivatio … ors should be excluded: a. Exposure to drugs prior to the development of the rash (biologic agents, captopril, clonidine, hydrochlorothiazide, atenolol, lamotrigine, nortriptyline, barbiturates, metronidazole, terbinafine, omeprazole, non-steroidal anti-inflammatory drugs, and isotretinoin), which are capable of inducing a pityriasis rosea-like eruption (6) …

Alpha-lipoic acid as a trigger of insulin autoimmune syndrome: Current evidence, a case-based approach, diagnostic pitfalls, and practical management.

Insulin autoimmune syndrome (IAS), also known as Hirata disease, is a rare immune-mediated cause of endogenous hyperinsulinemic hypoglycemia characterized by circulating insulin autoantibodies (IAAs). It typically develops in individuals without prior exposure to exogenous insulin. Although IAS has been associated with viral infections and, less commonly, with autoimmune and hematologic disorders, medications and dietary supplements are considered the most frequent precipitating factors. Sulfhydryl-containing compounds are the most commonly implicated triggers. Methimazole represents the class

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… Among the medications evaluated, captopril demonstrated the strongest association with IAS, followed by methimazole and clopidogrel. … Furthermore, a particularly strong association was observed between captopril-associated IAS and the HLA-DRB1*04:06 genotype. …

Необычный случай тромбоцитопенсии и ренального провала, возрождающего злодеяние - ассоциированная тромботическая микроангиопатия.

Тромботическая микроангиопатия (TMA) — процесс, характеризующийся тромбоцитопенией, микроангиопатичной гемолитической анемией и конечной травмой. ТМА, связанная с злоумышленностью, встречается редко и может быть похожа на первичные синдромы ТМА, особенно в тех случаях, когда преобладает почечная дисфункция, а периферийные мазки ограничены. Мы представляем случай биопсии, подтвержденной почечной ТМА, при установлении недавно диагностированной метастатической скучной клеточной карциномы (SCC) после значительной диагностической неопределенности. 59-летний мужчина с сахарным диабетом, зависящим от

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… A tunneled dialysis catheter (PermCath) was placed in the right internal jugular vein on hospital day 15 for continued hemodialysis, and captopril 12.5 mg daily was started for blood pressure control. …

Acute interstitial nephritis - a reappraisal and update.

Acute interstitial nephritis (AIN) is an under recognized and under diagnosed cause of acute kidney injury (AKI). It is estimated to account for 15 - 20% of cases of AKI; it is the reported diagnosis in 2.8% of all kidney biopsies, and 13.5% of biopsies done specifically for acute renal failure. Considerable evidence implicates antigen initiated cell-mediated injury in the pathogenesis of AIN. Drugs account for 70% of all cases, with over 150 different agents incriminated. The remaining cases are due to infections, autoimmune diseases, and rarely idiopathic. The central component of renal inju

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… chlorthalidone, ethacrynic acid, furosemide, hydrochlorothiazide, indapamide, tienilic acid, triamterene Other drugs Incidence >10 cases reported Allopurinol, 5-Aminosalicylic acid Others: acetaminophen, anisoindione, aminopyrine, amidopyrine, amphetamine, aristolochic acid, armodafinil, aspirin, azathioprine, captopril … , ethacrynic acid, furosemide, hydrochlorothiazide, indapamide, tienilic acid, triamterene Other drugs | Incidence >10 cases reported Allopurinol, 5-Aminosalicylic acid Others: acetaminophen, anisoindione, aminopyrine, amidopyrine, amphetamine, aristolochic acid, armodafinil, aspirin, azathioprine, captopril …

HDAC Inhibitors: Therapeutic Potential in Fibrosis-Associated Human Diseases.

Fibrosis is characterized by excessive deposition of the extracellular matrix and develops because of fibroblast differentiation during the process of inflammation. Various cytokines stimulate resident fibroblasts, which differentiate into myofibroblasts. Myofibroblasts actively synthesize an excessive amount of extracellular matrix, which indicates pathologic fibrosis. Although initial fibrosis is a physiologic response, the accumulated fibrous material causes failure of normal organ function. Cardiac fibrosis interferes with proper diastole, whereas pulmonary fibrosis results in chronic hypo

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… Unlike captopril, an ACE inhibitor, HDACI significantly suppressed the fibrotic changes in the right ventricle. There is limited evidence on right ventricular hypertrophy and fibrosis, and more detailed studies are required. … Sodium valproate, a histone deacetylase inhibitor, but not captopril, prevents right ventricular hypertrophy in rats Circ. J. 2010 74 760 770 10.1253/circj.CJ-09-0580 20208383 44. Liu F. Levin M.D. Petrenko N.B. Lu M.M. Wang T. Yuan L.J. Stout A.L. Epstein J.A. Patel V.V. …

Paradoxical Left Ventricular Hypertrophy by Echocardiogram and Low Voltage ECG: A Key Clue in the Diagnostic Workup of Two Distinct Presentations of Cardiac AL Amyloidosis.

Cardiac amyloidosis remains a rare disease caused by the extracellular deposition of abnormal proteins-amyloids in the myocardium. These protein structures in the myocardium are associated with high morbidity and mortality, with prognosis hinging on early detection and treatment. Three main types of cardiac amyloidosis have been identified: light chain (AL), familial or senile (ATTR), and secondary amyloidosis which is associated with chronic inflammation. Cardiac amyloidosis classically presents as diastolic heart failure with symptoms of volume overload low voltage on electrocardiogram (ECG)

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… Captopril is preferred if a RAAS blockade is to be started due to its shorter duration of action and must be gradually introduced [ 11 ]. …

Hirata Syndrome Clinical Presentation and Management: A Single-Centre Experience.

BackgroundHirata syndrome, or Insulin Autoimmune Syndrome (IAS), is a rare condition characterized by hyperinsulinemic hypoglycemia due to autoantibodies targeting endogenous insulin. Its rarity and unique presentation make diagnosis and management challenging.ObjectiveTo analyze the clinical presentation, diagnostic methods, and management of IAS based on a single-center experience.MethodologyThis was a case series, conducted at a tertiary care center in northeast India, involving six cases diagnosed between January 2022 and April 2024. Clinical histories, including drug use and comorbidities

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… Other implicated medications include captopril, d-penicillamine, propranolol, and α-lipoic acid. Furthermore, genetic predisposition, particularly HLA associations such as HLA-DRB1 *0406, DQB1 *0302, DQA1 *0301, DRB1 *0415, and DRB1 *13:01, have been observed in the majority of IAS cases. …

The prince and the pauper. A tale of anticancer targeted agents.

Cancer rates are set to increase at an alarming rate, from 10 million new cases globally in 2000 to 15 million in 2020. Regarding the pharmacological treatment of cancer, we currently are in the interphase of two treatment eras. The so-called pregenomic therapy which names the traditional cancer drugs, mainly cytotoxic drug types, and post-genomic era-type drugs referring to rationally-based designed. Although there are successful examples of this newer drug discovery approach, most target-specific agents only provide small gains in symptom control and/or survival, whereas others have consiste

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… Among ACE-I, at least nine agents are commonly used, including benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, quinapril, ramipril , and trandolapril . The majority of these agents are taken orally once a day. … The idea that ACE inhibitors might play a protective role in cancer was suggested by observations of reduced incidence of breast and lung cancer in patients undergoing long-term treatment with the captopril, lisinopril, or enalapril [ 85 ]. …

Unlocking Novel Therapeutic Potential of Angiotensin II Receptor Blockers.

Pharmaceutical companies keep producing novel drugs and drug treatments for improving the life of every sick individual, most often following a pattern; a specific drug for a specific condition. Evidence suggests that different medications can have a positive effect on different pathological conditions. The full potential of existing therapies can be revealed through drug repurposing-also referred to as drug repositioning, reprofiling, or re-tasking-which involves identifying new therapeutic uses for approved or investigational drugs beyond their original indications. One significant target in

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… In animal models of PD, neuroprotective effects have been demonstrated with the angiotensin-converting enzyme (ACE) inhibitors captopril and perindopril, as well as the AT1 receptor antagonists losartan, candesartan, and telmisartan. …

Radioprotectors & mitigators in radiation therapy: Harnessing diverse pathways for optimizing clinical outcomes.

Radioprotectors are agents that protect normal tissues from the harmful effects of radiation during cancer treatment. Combining these protective agents with advanced radiotherapy techniques such as stereotactic body radiotherapy (SBRT) and proton therapy offers a promising strategy to enhance therapeutic efficacy while minimizing normal tissue toxicity. However, despite extensive research and the identification of numerous potential radioprotectors, only a few have made it into clinical practice. It is primarily because the transition from laboratory research to clinical application faces sign

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… whole-body irradiation (various doses, e.g. , 8 Gy) | Reduces DNA damage, with Taurine demonstrating antioxidative & detoxification properties, while L-carnitine synergistically inhibits proliferation & osteoblastic differentiation of vascular smooth muscle cells | DMF: Not known | 51 Radiation Mitigators Captopril … Effects of captopril against radiation injuries in the Göttingen minipig model of hematopoietic-acute radiation syndrome. PLoS One. 2021;16:e0256208. doi: 10.1371/journal.pone.0256208. 53. Medhora M, Phadnis P, Narayanan J, Gasperetti T, Zielonka J, Moulder JE, et al. …

Частота и факторы риска в случае вновь диагностированной гиперкалемии после выписки из больницы пациентов, не зависящих от диализа, которые лечатся ингибиторами RAS.

ВВЕДЕНИЕ: Ингибиторы системы " ренин-ангиотенсин " (РАС) все чаще предписываются в силу их позитивного воздействия на систему " конечная организация " . Иатрогенная гиперкалемия представляет собой хорошо известное опасное для жизни осложнение использования ингибитора RAS у пациентов, страдающих хроническим заболеванием почек (CKD). Мы предположили, что у пациентов, проходящих курс лечения с помощью ингибиторов RAS, часто возникает гиперкалемия после выписки из больницы, даже если во время госпитализации у них была нормальная оклемия, так как их образ жизни существенно измен

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… Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both. N Engl J Med. 2003;349: 1893–906. doi: 10.1056/NEJMoa032292 2. ONTARGET Investigators; Yusuf S, Teo KK, Pogue J, Dyal L, Copland I, et al. …

Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer.

The strategy of using existing drugs originally developed for one disease to treat other indications has found success across medical fields. Such drug repurposing promises faster access of drugs to patients while reducing costs in the long and difficult process of drug development. However, the number of existing drugs and diseases, together with the heterogeneity of patients and diseases, notably including cancers, can make repurposing time consuming and inefficient. The key question we address is how to efficiently repurpose an existing drug to treat a given indication. As drug efficacy rem

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… (Antabuse TM ) | Aldehyde dehydrogenase inhibitor | Alcoholism | + | | | | | | + | [ 64 , 65 ] Ivermectin (Stromectol TM ) | Anthelmintic drug | Parasite infections | + | + | | | + | | | [ 66 ] Diclofenac (Voltaren TM ) | NSAID | Pain | | + | | | | + | + | [ [67] , [68] , [69] , [70] ] Captopril … potrace 1.16, written by Peter Selinger 2001-2019 </metadata><g transform="translate(1.000000,15.000000) scale(0.019444,-0.019444)" fill="currentColor" stroke="none"><path d="M0 440 l0 -40 480 0 480 0 0 40 0 40 -480 0 -480 0 0 -40z M0 280 l0 -40 480 0 480 0 0 40 0 40 -480 0 -480 0 0 -40z"/></g></svg> O)O Captopril …

Oxyphenbutazone ameliorates carfilzomib induced cardiotoxicity in rats via inhibition of oxidative free radical burst and NF-κB/IκB-α pathway.

Carfilzomib (CFZ), a chemotherapeutic agent used for multiple myeloma treatments reported to cause high incidence of cardiac events either new onset and/or exacerbate formerly diagnosed heart failure with ventricular and myocardial dysfunction. Purpose: Current research designed to explore and examine the preventive effect of oxyphenbutazone in the CFZ -instigated cardiotoxicity. Methodology: Female Wistar Rats weighing 200-250 g selected randomly and grouped as follows: Group 1 designated as the Normal control and receive normal saline only. Group 2 served toxic control and exposed to CFZ (4

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… Captopril ameliorates myocardial and hematological toxicities induced by adriamycin Biochem. and Mol. Biol International 45 1998 419 427 10.1080/15216549800202802 9678264 Behairy, A., Elkomy, A., Elsayed, F. et al., 2023. …

Heart Failure in Older Patients: An Update.

Heart failure (HF) is a clinical syndrome with high incidence and prevalence and high morbidity and death rate, even in the short term, representing a serious public health issue, mainly in older people. It is a growing cause for hospital admission in this age group, being frequently associated with several comorbidities, further aggravating the disease's course. Moreover, older HF patients are usually affected by clinical conditions, like frailty, malnutrition, and cachexia, which significantly impact the overall management of HF and need to be properly identified and treated. Diagnosing and

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… Randomised Trial of Losartan versus Captopril in Patients over 65 with Heart Failure (Evaluation of Losartan in the Elderly Study, ELITE) Lancet 1997 349 747 752 10.1016/S0140-6736(97)01187-2 9074572 80. Pitt B. Poole-Wilson P.A. Segal R. Martinez F.A. Dickstein K. Camm A.J. Konstam M.A. … Effect of Losartan Compared with Captopril on Mortality in Patients with Symptomatic Heart Failure: Randomised Trial—The Losartan Heart Failure Survival Study ELITE II Lancet 2000 355 1582 1587 10.1016/S0140-6736(00)02213-3 10821361 81. Barywani S.B. Ergatoudes C. Schaufelberger M. Petzold M. …

Carfilzomib-induced sinus bradycardia: A case report and literature review.

Carfilzomib is a second-generation irreversible proteasome inhibitors commonly used in the treatment of relapsed or refractory multiple myeloma. However, cardiac toxicity (heart failure, hypertension, coronary heart disease, etc.) has become the main factor leading to its reduction or withdrawal. We report a case of a 55-year-old female patient with multiple myeloma who developed sinus bradycardia following the administration of carfilzomib, along with a review of the relevant literature. The correlation between carfilzomib and cardiotoxicity was assessed by reviewing the medical history, appl

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… Biventricular heart failure | None | Tachypneic | Bilevel-positive air pressure, furosemide 20 mg intravenous injections; symptomatic improvement | Discontinued Alali and Baljevic 31 | Female/40 | Bortezomib | 5 times, 22 days | Perimyocarditis | None | Ventricular tachycardia, syncope | Spironolactone, captopril …

Vasodilators for primary Raynaud's phenomenon.

BACKGROUND: Numerous agents have been suggested for the symptomatic treatment of primary Raynaud's phenomenon. Apart from calcium channel bl … ee studies revealed a possible small increase in the frequency of attacks per week after treatment (captopril or enalapril) compared to placebo (mean difference [MD] 0.79, 95% confidence interval [CI] 0.43 to 1.17; low-certainty evidence). There was no evidence of a difference between groups in severity of attacks (MD -0.17, 95% CI -4.66 to 4.31; 34 partici …

Novel Therapeutics for Anthracycline Induced Cardiotoxicity.

Anthracyclines remain an essential component of the treatment of many hematologic and solid organ malignancies, but has important implications on cardiovascular disease. Anthracycline induced cardiotoxicity (AIC) ranges from asymptomatic LV dysfunction to highly morbid end- stage heart failure. As cancer survivorship improves, the detection and treatment of AIC becomes more crucial to improve patient outcomes. Current treatment modalities for AIC have been largely extrapolated from treatment of conventional heart failure, but developing effective therapies specific to AIC is an area of growing

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… DOX (weekly ×5) | Enalapril | ↑ | ↓ | NA | NA | NA | ↑ Activation PI3K/AKT/mTOR Hiona et al. ( 12 ) | Rat model Chronic DOX (weekly ×6) | Enalapril | ↑ | NA | NA | ↓ | ↔ | ↑ Mitochondrial function | | | | | | | | ↑ %Fractional shortening Abd El-Aziz et al. ( 121 ) | Rat model Acute DOX (×1) | Captopril …

Interpreting Randomized Controlled Trials.

This article describes rationales and limitations for making inferences based on data from randomized controlled trials (RCTs). We argue that obtaining a representative random sample from a patient population is impossible for a clinical trial because patients are accrued sequentially over time and thus comprise a convenience sample, subject only to protocol entry criteria. Consequently, the trial's sample is unlikely to represent a definable patient population. We use causal diagrams to illustrate the difference between random allocation of interventions within a clinical trial sample and tru

FDA-Approved Drugs Containing Amide Functionality in the Last Five Years (2021-2025): Pharmaceutical Use, Trends and Synthetic Approaches.

The amide functional group remains a cornerstone of medicinal chemistry, serving as an indispensable scaffold in the design of modern therapeutics. This review presents an analysis of FDA-approved drugs (small molecules and peptides with MW ®), amides form the structural backbone of peptidomimetics, enabling high-affinity binding to a viral protease. In precision oncology, as seen with adagrasib (Krazati®), the amide acts as a critical, metabolically stable linker that positions a covalent warhead for selective inhibition of a mutant kinase. This analysis underscores that amide's unique combin

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… stability, binding to target proteins, and mimicry of peptide bonds, helping these compounds act effectively as analgesics, antibiotics, anesthetics, CNS drugs, cardiovascular agents, and agrochemicals, as demonstrated by paracetamol ( 8 ), lidocaine ( 9 ), amoxicillin ( 10 ), diazepam ( 11 ), and captopril … Captopril is an ACE inhibitor medication used to treat high blood pressure (hypertension), heart failure, and damage after a heart attack by relaxing blood vessels [ 21 ]. …