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Different attitudes towards estimating indirect costs of disease: The example of cancer.

GoalCost estimations in healthcare are crucial to make sound and adequate economic evaluations and assessments. The concept of indirect costs' estimation seems to be still not very well developed and systematized. This article is dedicated to the problem of indirect costs estimation of different types of cancer. The main aim of the article is to analyse the frequency of usage of different methods used for estimating indirect costs in economic analysis.MethodsThere are discussed various methods used for indirect costs' estimations. Among them, in details, there are described: human capital appr

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… Author | Country | Type of cancer | Method Bencina et al. 37 | Hungary, Poland, and Romania | Head and neck cancer | HCA Bencina et al. 38 – 40 | Belgium, Poland, the Netherlands | Lung cancer | HCA Bencina et al. 39 | Portugal, Greece | Kidney cancer | HCA Bencina et al. 40 | Bulgaria, Croatia, Czech … guidelines available Netherlands | | X | | Switzerland | | | X | Finland | | | | X | National Healthcare – traditionally shaped systems England | X | | | Ireland | | | | X Bulgaria | No guidelines available | Universal Health Insurance – transformed systems Czech Republic | X | | | Croatia …

Research trends and hotspots of CAR-T cell therapy for acute lymphoblastic leukemia: A bibliometric analysis.

This study aims to analyze the global research patterns and emerging trends in CAR-T cell therapy for ALL through a bibliometric analysis. Publications were retrieved from the Web of Science Core Collection database. The bibliometric analysis utilized VOSviewer, CiteSpace, and the R package "bibliometrix" to visualize collaborations, keyword co-occurrences, and emerging research trends. A total of 844 articles from 253 journals by 6,459 authors across 44 countries were analyzed, showing an annual growth rate of 40.08%. The USA (372 articles, 38,065 citations) and China (275 articles, 5,636 cit

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… Nodes include USA, China, Germany, Italy, Spain, France, UK, Netherlands, Canada, Australia, Japan, Belgium, Norway, Switzerland, Israel, Poland, Sweden, Denmark, Ireland, Czech Republic, Croatia, Finland, Russia, Thailand, India, Iran, Brazil, Singapore. … Nodes include USA, China, Germany, Italy, Spain, France, UK, Netherlands, Canada, Australia, Japan, Belgium, Norway, Switzerland, Israel, Poland, Sweden, Denmark, Ireland, Czech Republic, Croatia, Finland, Russia, Thailand, India, Iran, Brazil, Singapore. …

49th ESCP virtual symposium on clinical pharmacy 19.10.2021-21.10.2021 Clinical pharmacy, working collaboratively in mental health care.

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… The aim of our study was to explore various risk factors (sociodemographic, clinical and medication-related) that significantly correlate with self-reported poor health status in community-residing older patients in Croatia. … Method: 210 patients aged 65 years and older attending community pharmacies in 3 different regions of Croatia (Zagreb, Istria and Slavonia) were prospectively assessed using method of comprehensive geriatric assessment with the EUROAGEISM H2020 ESR7 study protocols (Jun2019–Jan2020). …

Cancer burden in Europe: a systematic analysis of the GLOBOCAN database (2022).

BackgroundCancer remains a significant public health challenge in Europe, with substantial regional disparities in incidence, mortality, and access to healthcare. This study analyses cancer patterns across Eastern, Northern, Southern, and Western Europe in 2022, highlighting key public health implications and gaps in prevention and treatment.MethodsUsing data from GLOBOCAN 2022, this study assessed total new cancer cases, age-standardized incidence and mortality rates (ASRs) per 100,000, and cumulative cancer risk at age 75. The top three cancers by sex and region were also analysed to identif

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… For mortality, Hungary recorded the highest rate (143.7 per 100,000), followed by Croatia (125.7), Lithuania (125.0), and Latvia (122.9). Conversely, the lowest mortality rates were observed in Switzerland (78.8), Luxembourg (77.3), and Iceland (79.8). … Population(s) included: Albania, Bosnia Herzegovina, Croatia, Cyprus, Greece, Italy, North Macedonia, Malta, Montenegro, Portugal, Serbia, Slovenia, Spain, Andorra, Gibraltar, Holy See*, San Marino Fig. 8 Top 5 most frequent cancers in Southern Europe 2022, all sexes, all ages. …

ECC-4 Abstracts

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Prevalence and determinants of polypharmacy among cancer patients: a systematic review and meta-analysis.

BACKGROUND: Polypharmacy (PP) is a rising clinical challenge among patients with a cancer diagnosis. Uncertainty remains regarding its exact burden, exact prevalence estimates, and definitional themes in this vulnerable cohort of patients. METHODS: We searched PubMed, EMBASE, Scopus, the Cochrane Database of Systematic Reviews (CDSR), and Google Scholar, for studies published between 2000 and 2025 for eligible studies reporting on polypharmacy in cancer patients. These were critically appraised for eligibility and inclusion by two independent reviewers. Using quality and random effect models,

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… Single studies were reported from Denmark [ 22 ] the Netherlands [ 16 ] Australia [ 18 ], Qatar [ 20 ], and Croatia [ 10 ]. Most included studies employed observational designs, predominantly retrospective cohort or cross-sectional analyses [ 10 , 14 – 16 , 18 , 19 , 21 , 22 , 26 , 27 , 31 ]. … Outpatient | 881 | 630 (71.5%) | 495 (56.2%) | 67.8 (22.5–94.4) a | Solid & hematological | ≥ 5 medications M.Castro-Manzanares 2019 [ 13 ] | Observational | Spain | Outpatient | 273 | 203 (74.3%) | 159 (58.2%) | 61 (18) d | Solid & hematological | ≥ 4 medications IVAN KRECAK 2023 [ 10 ] | Observational | Croatia …

Cancer mortality by country of birth and cancer type in Sweden: A 25-year registry-based cohort study.

Numerous studies have reported lower overall cancer mortality rates among immigrants compared to native populations. However, limited information exists regarding cancer mortality among immigrants based on specific birth countries and cancer types. We used population-based registries and followed 10 million individuals aged 20 years or older in Sweden between 1992 and 2016. The Cox proportional hazard model was used to explore the disparities in cancer mortality by country of birth and cancer type, stratified by gender. Age-standardized mortality rates were also computed using the world standa

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… Immigrants were stratified into the largest immigrant groups in Sweden to ensure a sufficiently large analytical sample size: Nordic (Finland, Norway, Denmark), Non‐Nordic Europe (Turkey, Germany, Austria, Netherlands, France, former Yugoslavia, Bosnia‐Hercegovina, Italy, Spain, Greece, Croatia, Poland … 91.4 | 1.17 | 1.09 | 1.25 *** Italy | 423 | 0.9 | 124.6 | 1.08 | 0.98 | 1.19 | 140 | 0.5 | 88.6 | 0.99 | 0.83 | 1.17 Spain | 155 | 0.6 | 104.6 | 0.92 | 0.78 | 1.07 | 69 | 0.4 | 64 | 0.71 | 0.56 | 0.90 ** Greece | 316 | 1.4 | 95.5 | 0.76 | 0.68 | 0.85 *** | 133 | 0.9 | 57.5 | 0.61 | 0.52 | 0.73 *** Croatia …

Частота и распространенность множественных склерозов в Венгрии на основе рекордной увязки общенациональных многочисленных административных данных в области здравоохранения.

ЦЕЛИ: Поскольку в Венгрии проводились лишь региональные исследования по вопросу о распространенности множественного склероза (МС), мы стремились оценить его эпидемиологические особенности с использованием данных венгерской системы медицинского страхования с одним плательщиком. МЕТОДЫ: Псевудонимная база данных о жалобах, представленных больницами и амбулаторными службами в период между 2004-2016 был проанализирован и увязан с независимой базой данных о заправке амбулаторными аптеками 2010-2016. Мы установили административное определение MS и подтвердили его на медицинских записях 309 Последова

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… In Croatia, after merging 3 databases of public health care and that of the MS-patient society, the crude prevalence was found to be 143.8/100,000 in 2015, much higher than previously estimated [ 30 ]. … Prevalence of multiple sclerosis in Croatia: data from national and non-governmental organization registries. Croat Med J. 2018;59:65–70. 10.3325/cmj.2018.59.65 31. Daltrozzo T, Hapfelmeier A, Donnachie E, Schneider A, Hemmer B. …

Unexpected and Deadly: Three Cases of Bone Marrow Necrosis.

Bone marrow necrosis (BMN) is a rare pathological diagnosis, with an incidence of 0.3% to 2%. It is most often associated with hematological malignancies and less commonly due to solid tumors, infections, medications, sickle cell disease, chemotherapy, radiotherapy, or idiopathic causes. We reviewed bone marrow biopsies performed in our institution from 2009 to 2019 and found three cases of BMN. Two cases were secondary to neoplastic causes, while the third one was possibly from alcohol abuse.

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… Croatia: Intech; 2016. Disorders mimicking myelodysplastic syndrome and difficulties in its diagnosis; pp. 45–94. …

COVID-19 burden of illness in people who are immunocompromised due to cancer: an expert opinion review.

From the beginning of the pandemic, people with cancer have experienced a high burden from COVID-19 compared with the general population, both in terms of severe COVID-19-related outcomes and reduced health-related quality of life and mental health. This review presents and discusses expert views on the burden of COVID-19 in individuals with cancer throughout the pandemic. The literature suggests that early in the pandemic, people with cancer had a disproportionately high risk of COVID-19-related hospitalization compared with the general population. This trend continued throughout the pandemic

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… Contributor Information Igor Aurer, University Hospital Centre Zagreb, 10000 Zagreb, Croatia; Department of Internal Medicine, Medical School, University of Zagreb, 10000 Zagreb, Croatia. …

Nanotherapeutics in the EU: an overview on current state and future directions.

The application of nanotechnology in areas of drug delivery and therapy (ie, nanotherapeutics) is envisioned to have a great impact on public health. The ability of nanotherapeutics to provide targeted drug delivery, improve drug solubility, extend drug half-life, improve a drug's therapeutic index, and reduce a drug's immunogenicity has resulted in the potential to revolutionize the treatment of many diseases. In this paper, we review the liposome-, nanocrystal-, virosome-, polymer therapeutic-, nanoemulsion-, and nanoparticle-based approaches to nanotherapeutics, which represent the most suc

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… Austria; BE, Belgium; BG, Bulgaria; CH, Switzerland; -CMS, concerned member state; CP, centralized procedure; CY, Cyprus; CZ, Czech Republic; DE, Germany; DK, Denmark; EE, Estonia; EL, Greece; EMA, European Medicines Agency; ES, Spain; FI, Finland; FR, France; HMA, Heads of Medicines Agencies; HR, Croatia … , Cyprus; CZ, Czech Republic; DE, Germany; DK, Denmark; EE, Estonia; EL, Greece; EMA, European Medicines Agency; ES, Spain; Fab, fragment antigen binding; Fl, Finland; FR, France; Glu, glutamic acid; HIV, human immunodeficiency virus; HGH, human growth hormone; HMA, Heads of Medicines Agencies; HR, Croatia …

Ocular manifestations in leukemia and myeloproliferative disorders and their association with hematological parameters.

ObjectivesTo study the ocular manifestations in patients diagnosed with leukemia or myeloproliferative disorders and to derive an association between the ocular manifestations and hematological parameters of the patients.Materials and methodsThis observational and descriptive study was conducted in a Tertiary Care Center of Dehradun, North India over a period of 1 year. All the diagnosed cases of leukemia and myeloproliferative diseases attending the Oncology Department were included. Patients underwent a detailed ocular examination. The hematological parameters were also recorded including he

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… Croatia, European Union: InTech 2011 Last accessed on 2016 Feb 02 Available from: http://www. intechopen.com/ books/novel-aspects-in-acute-lymphoblastic-leukemia/ophthalmologicalmanifestations- in-acutelymphoblastic-leukemia 7 Reddy SC Jackson N Menon BS Ocular involvement in leukemia - A study of 288 …

Technology forecast: advanced therapies in late clinical research, EMA approval or clinical application via hospital exemption.

Background: The umbrella term ATMPs (Advanced Therapy Medicinal Products) comprises cell therapies, gene therapeutics and tissue engineered products. After implementation of the Regulation 1394/2007, only a couple of products have obtained a centralized European marketing authorisation. Objectives: The aim of the presented study is to give an overview on ATMPs available within the European Union either via centralized marketing authorisation or via national Hospital exemption. Additionally, a forecast on innovative ATMPs in the process of EMA approval as well as in phase III and IV clinical tr

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… Croatia no ? Cyprus no ? Czech Republic no yes Chondrocytes Denmark yes ? Estonia no no Finland no ? France yes ? Germany yes yes Cytokine induced killer cells, dendritic cells, chondrocytes, mesenchymal stroma cells, engineered oral mucosa, bone marrow derived progenitor cells Greece no ? … | Croatia | no | ? | Cyprus | no | ? | Czech Republic | no | yes | Chondrocytes Denmark | yes | ? | Estonia | no | no | Finland | no | ? | France | yes | ? …

Резюме книги: Тема: 13th Международный симпозиум на тему " Ходжкин лимфома " ; октябрь 2024

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Global perspectives on lupus nephritis: a review of clinical trials and therapeutic innovations.

BACKGROUND AND OBJECTIVES: Lupus nephritis (LN) remains a leading cause of morbidity and mortality in systemic lupus erythematosus (SLE). Although recent years have witnessed the approval of several targeted therapies, achieving long-term, drug-free remission remains challenging. This commentary evaluates the global landscape of interventional LN clinical trials from 2001 to 2026 to identify emerging trends and strategic gaps in drug development. METHODS: We analyzed 200 interventional pharmacological trials retrieved from three major global registries: ClinicalTrials.gov, Chinadrugtrials.org

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… United Kingdom | NCT03174587 (Completed) | Phase I | 2017 | CS20AT04 Inj (allogenic bone marrow-derived mesenchymal stem cells) | South Korea | III, IV, V NCT03021499 (Completed) | Phase III | 2017 | Voclosporin | United States, Argentina, Belarus, Brazil, Bulgaria, Canada, Chile, Colombia, Costa Rica, Croatia … 2020 | BMS-986165 | China, Argentina, Australia, Belgium, Brazil, Czech, Germany, Israel, Italy, Mexico, Holland, Russia, United Kingdom, | III+/- V, IV +/- V, V NCT04181762 (Terminated) | Phase III | 2020 | Secukinumab | United States, Argentina, Australia, Brazil, Canada, Chile, China, Colombia, Croatia …

Outcomes and Risk Factors of Critically Ill Patients with Hematological Malignancy. Prospective Single-Centre Observational Study.

Background and Objectives: Oncohematological patients have a high risk of mortality when they need treatment in an intensive care unit (ICU). The aim of our study is to analyze the outcomes of oncohemathological patients admitted to the ICU and their risk factors. Materials and Methods: A prospective single-center observational study was performed with 114 patients from July 2017 to December 2019. Inclusion criteria were transfer to an ICU, hematological malignancy, age >18 years, a central line or arterial line inserted or planned to be inserted, and a signed informed consent form. Univariate

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… mortality is lower than it was in multicenter retrospective study of 200 patients with hematological malignancies made in Poland (ICU mortality, 67%; hospital mortality, 78.8%) [ 10 ] and single center prospective observational study of 170 patients with hematological malignancies treated in ICU in Croatia …

Case Report: Gastrointestinal cancer initially presenting as postmenopausal osteoporosis.

BACKGROUND: Gastric cancer usually presents late with nonspecific symptoms such as epigastric discomfort, anorexia, weight loss, nausea, anemia, or gastrointestinal bleeding. Initial presentation with osteoporosis-like manifestations and multiple bone metastases in the absence of gastrointestinal symptoms is rare. CASE PRESENTATION: We report a 59-year-old postmenopausal woman who presented with thoracolumbar back pain after routine activity. Bone mineral density assessment showed osteoporosis, but laboratory evaluation revealed markedly increased bone turnover markers, including alkaline pho

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… Edited by: Tan-Huy Chu , Tam Anh Research Institute, Vietnam Reviewed by: Branko Bakula , University Hospital Sveti Duh, Croatia Neha Aggarwal , Vardhman Mahavir Medical College & Safdarjung Hospital, India Data availability statement The raw data supporting the conclusions of this article will be …

Распространение и распространенность множественных склерозов в Болгарии.

Множественный склероз (MS) является хроническим, подстрекательским, аутоиммунным, демиелинизирующим и нейродегенеративным заболеванием центральной нервной системы, которое в первую очередь затрагивает молодых, активных людей и является одной из основных причин нетравматического и необратимого неврологического дефицита. Множественный склероз one из наиболее изученных заболеваний в нейроэпидемиологии, для которых характерно неравномерное географическое распределение по всему миру. ЦЕЛЬ: Оценить распространенность и распространенность множественных склерозов в Болгарии и их распределение по возра

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… High values and a sustained upward trend in epidemiological indicators are reported for Bosnia and Herzegovina with a prevalence rate of 91/100,000 ( 9 , 15 , 16 ), Serbia with prevalence of 136/100,000 an incidence of 3.4/100,000 ( 9 , 17–19 ), and Croatia—143.8/100,000 ( 20 ). …

High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease.

AimTo determine the frequency and the characteristics of cutaneous manifestations, especially vitiligo and alopecia areata, in patients with chronic graft-vs-host disease (cGVHD).Methods50 patients with cGVHD were prospectively enrolled in the observational study protocol and evaluated by an experienced dermatologist. The evaluation was focused on the clinical spectrum of skin and adnexal involvement, and the cutaneous GVHD score was determined according to National Institutes of Health (NIH) Consensus criteria. The presence of vitiligo, alopecia, xerosis, nail changes, and dyspigmentation was

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… Ethical approval All patients or their parents (for pediatric patients) signed informed consent approved by ethical committees of the UHC and Medical School University of Zagreb, Zagreb, Croatia. Declaration of authorship RČ and LD contributed to conception and design of the study. …

Outcomes of Ixazomib Treatment in Relapsed and Refractory Multiple Myeloma: Insights from Croatian Cooperative Group for Hematologic Diseases (KROHEM).

Background and Objectives: Ixazomib, used in combination with lenalidomide and dexamethasone (IRd), has shown efficacy in clinical trials for relapsed/refractory multiple myeloma (RRMM). Materials and Methods: This study evaluates the real-world effectiveness and safety of IRd in Croatian RRMM patients. A retrospective analysis was conducted on 164 RRMM patients treated with ixazomib at nine Croatian haematology centres from November 2016 to February 2023. Data on patient demographics, treatment regimens, and outcomes were collected and analysed using Kaplan-Meier survival curves and Cox propo…