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Intrauterine insemination performance characteristics and post-processing total motile sperm count in relation to live birth for couples with unexplained infertility in a randomised, multicentre clinical trial.

STUDY QUESTION: Are intrauterine insemination (IUI) performance characteristics and post-processing total motile sperm count (TMC) related t … ts from Merck and support from Taylor and Frances and from Springer, outside the submitted work. Dr Diamond reports grants from NIH/NICHD, Yale University, during the conduct of the study and support from Advanced Reproductive Care AbbVie, Bayer and ObsEva, outside the submitted work. Dr Legro reports support from Bayer, Kindex, Odega, Millendo and AbbVie …

Safety and efficacy of the selective progesterone receptor modulator asoprisnil for heavy menstrual bleeding with uterine fibroids: pooled analysis of two 12-month, placebo-controlled, randomized trials.

STUDY QUESTION: Can asoprisnil, a selective progesterone receptor modulator, provide clinically meaningful improvements in heavy menstrual b … G, Gynesonics, and Welltwigs. She received royalties from UpToDate and the Med Learning Group. M.P. Diamond received research funding for the conduct of the studies paid to the institution and consulted for AbbVie. He is a stockholder and board and director member of Advanced Reproductive Care. He has also received funding for study conduct paid to the in …

A 12-month extension study to evaluate the safety and efficacy of asoprisnil in women with heavy menstrual bleeding and uterine fibroids.

STUDY QUESTION: What is the safety and efficacy profile during long-term (12-24 months) uninterrupted treatment with the selective progester … t. Financial support for medical writing and editorial assistance was provided by AbbVie Inc. M. P. Diamond received research funding for the conduct of the study paid to the institution and is a consultant to AbbVie. He is a stockholder and board and director member of Advanced Reproductive Care. He has also received funding for study conduct paid to the …

Chemokine receptors as important regulators of pathogenesis during arboviral encephalitis.

The central nervous system (CNS) is a highly complex network comprising long-lived neurons and glial cells. Accordingly, numerous mechanisms have evolved to tightly regulate the initiation of inflammatory responses within the brain. Under neuroinflammatory conditions, as in the case of viral encephalitides, the infiltration of leukocytes is often required for efficient viral clearance and recovery. The orchestration of leukocyte migration into the inflamed CNS is largely coordinated by a large family of chemotactic cytokines and their receptors. In this review, we will summarize our current un

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… , 2005 ; Diamond and Gale, 2012 ). … Diamond M. S. ( 2005 ). Alpha/Beta interferon protects against lethal West Nile Virus infection by restricting cellular tropism and enhancing neuronal survival. J. Virol. 79 13350 – 13361 10.1128/JVI.79.21.13350-13361.2005 16227257 PMC1262587 Samuel M. A. Diamond M. S. ( 2006 ). …

" Nucleolus in Human Beasons: Ribosome Biogenesis " , " Nucleolar Survey " и " Terrapeutic Opportunities " .

Nucleolus превратился в динамичную и многофункциональную субядерную органилию, интегрирующую рибосомный биогенез с клеточным ростом и сигнализацией стресса. Регулирование нуклеолярной функции все чаще признается в качестве главного движителя человеческих заболеваний, связывающего изменённое рибосомное производство и нуклеолярное наблюдение с раком, рибосомопатиями, синдромами преждевременного старения, нейродегенерацией и иммунными расстройствами. В этом обзоре мы интегрируем структурные, молекулярные и болезнетворные перспективы нуклеолярной биологии для определения того, как рипосомный биоге

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… Diamond–Blackfan Anaemia Syndrome (DBAS), a ribosomopathy first described almost a century ago, is predominantly caused by RP haploinsufficiency, most commonly in RPS19 (~25% of cases), with biallelic variants in HEATR3 recently identified as an additional causative lesion [ 33 , 258 , 259 ]. … Shwachman–Diamond Syndrome: Given the high prevalence of nonsense mutations in SBDS , Ataluren, a small-molecule that promotes ribosomal read-through of premature stop codons, was administered to three SDS patients carrying nonsense mutations under a compassionate use program [ 421 ]. …

Ribosome Biogenesis and Function in Cancer: From Mechanisms to Therapy.

Ribosome biogenesis is a highly coordinated, multi-step process that assembles the ribosomal machinery responsible for translating mRNAs into proteins. It begins with the rate-limiting step of RNA polymerase I (Pol I) transcription of the 47S ribosomal RNA (rRNA) genes within a specialised nucleolar region in the nucleus, followed by rRNA processing, modification, and assembly with ribosomal proteins and the 5S rRNA produced by Pol III. The ribosomal subunits are then exported to the cytoplasm to form functional ribosomes. This process is tightly regulated by the PI3K/RAS/MYC oncogenic network

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… HEATR3 variants impair nuclear import of uL18 (RPL5) and drive Diamond-Blackfan anemia Blood 2022 139 3111 3126 10.1182/blood.2021011846 35213692 PMC9136880 103. Vlachos A. Muir E. How I treat Diamond-Blackfan anemia Blood 2010 116 3715 3723 10.1182/blood-2010-02-251090 20651069 PMC2981532 104. … Incidence of neoplasia in Diamond Blackfan anemia: A report from the Diamond Blackfan Anemia Registry Blood 2012 119 3815 3819 10.1182/blood-2011-08-375972 22362038 PMC3335385 109. Vlachos A. Rosenberg P.S. Atsidaftos E. Kang J. Onel K. Sharaf R.N. Alter B.P. Lipton J.M. …

Hallmarks of ribosomopathies.

Ribosomopathies are diseases caused by defects in ribosomal constituents or in factors with a role in ribosome assembly. Intriguingly, congenital ribosomopathies display a paradoxical transition from early symptoms due to cellular hypo-proliferation to an elevated cancer risk later in life. Another association between ribosome defects and cancer came into view after the recent discovery of somatic mutations in ribosomal proteins and rDNA copy number changes in a variety of tumor types, giving rise to somatic ribosomopathies. Despite these clear connections between ribosome defects and cancer,

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… Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome . Genes Dev. 2011 ; 25 : 917 – 929 . 21536732 10.1101/gad.623011 PMC3084026 21. … Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia . J. Clin. Invest. 2012 ; 122 : 2439 – 2443 . 22706301 10.1172/JCI63597 PMC3386831 81. …

Use of Curcumin in Multiple Myeloma patients intolerant of steroid therapy.

Curcumin, when used in a combination regimen in multiple myeloma patients, has comparable progression-free survival without the adverse effects of steroid-based combination therapies that is curcumin may be a viable alternative to corticosteroids in combination with an immunomodulatory drug or proteasome inhibitor.

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… Wong R, Golombick T, Diamond TH, Ramakrishna R, Manoharan A. Curcumin enhances the cytotoxic and chemo‐sensitising effects of Lenalidomide in human myeloma cells. J Haematol Malign. 2013;3:2. 17. Zhu YX, Braggio E, Shi C‐X, et al. … Golombick T, Diamond T, Manoharan A. ,Response to Vermorken et al. – curcumin and free light chains. Am J Hematol. 2012;87:E80‐E81. 23. Golombick T, Diamond T, Manoharan A, Ramakrishna R. Long term use of curcumin in two smoldering multiple myeloma (SMM) patients. …

Long-term stabilisation of myeloma with curcumin.

Myeloma is a haematological malignancy which typically follows a relapsing-remitting course. While treatment can control the myeloma and improve quality of life for given periods of time, remissions generally become progressively shorter with subsequent relapses, and patients ultimately enter a final refractory phase. To help control symptoms and enhance quality of life, some patients use complementary therapies as an adjunct to their conventional therapy. Here, we describe a myeloma patient who started a daily dietary supplement of curcumin when approaching her third relapse. In the absence o

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… Mol Cancer Ther 2009 ; 8 : 959 – 70 . 10.1158/1535-7163.MCT-08-0905 19372569 PMC2694943 11 Wong R , Golombick T , Diamond TH , et al Curcumin enhances the cytotoxic and chemo-sensitising effects of lenalidomide in human multiple myeloma cells . … Blood 2007 ; 110 : 1177 . 14 Golombick T , Diamond TH , Badmaev V , et al The potential role of curcumin in patients with monoclonal gammopathy of undefined significance—its effect on paraproteinemia and the urinary N-telopeptide of type I collagen bone turnover marker . …

Chemokine analysis as a novel diagnostic modality in the early prediction of the outcome of non-union therapy: a matched pair analysis.

BACKGROUND: Despite the regenerative capability of skeletal tissue fracture, non-union is common. Treatment of non-unions remains challenging, and early determination of the outcome is impossible. Chemokines play an important role in promoting the formation of new bone and remodeling existing bone. Despite their importance regarding the regulation of bone biology, the potential of chemokines as biological markers reflecting osseous regeneration is unknown. The purpose of this study was to determine (1) if serum chemokine expression levels correlate with the outcome of non-union surgery and (2)

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… Thereby, the Masquelet therapy provides all factors necessary for bone healing according to the “diamond concept.” … Marsh David Fracture healing: The diamond concept Injury 2007 38 S3 S6 10.1016/S0020-1383(08)70003-2 18224731 16. …

Centralised treatment, entry to trials and survival.

A review was carried out of the published literature on survival rates for cancer in relation to patterns of organisation of medical care, specifically treatment at specialist centres or at hospitals treating larger numbers of patients and treatment by protocol, usually within the context of a clinical trial. Centralised referral or entry to trials was frequently associated with a higher survival rate, particularly for the less common cancers, and was never found to be associated with a lower survival rate. Few studies were identified for any one cancer site and some antedated current methods

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… Participants in prospective, randomized clinical trials for resected non-small cell lung cancer have improved survival compared with nonparticipants in such trials. 56 7 1 10 1985 1710 1718 Cancer 3896460 10.1002/1097-0142(19851001)56:7<1710::aid-cncr2820560741>3.0.co;2-t Diamond J. J. … Diamond J. J. Davis L. W. Rominger C. J. An outcome study of the RTOG Cancer Control program. 12 12 12 1986 2157 2163 Int J Radiat Oncol Biol Phys 3539898 10.1016/0360-3016(86)90015-5 Gillis C. R. Hole D. J. Still R. M. Davis J. Kaye S. B. …

Факторы риска, выходящие за рамки воздействия химиотерапии на вторичные миелоидные неоплазмы после рака гематологов: исследование на основе СЭЭУ.

UNLABELLED. По мере того, как показатели выживаемости лимфоидных магнатов продолжают улучшаться, для выживших людей все большее значение приобретает понимание поздних последствий после лечения, таких, как вторичные миелоидные новообразования (SMN). В этом крупномасштабном исследовании населения (SEER-Medicare) были изучены факторы риска и кумулятивная распространенность SMN у пациентов с диагнозом диффузной большой лимфомы B-клеток (DLBCL), фолликулярной лимфомы (FL) и множественной миеломы между 2000 и 2011, с последующими мерами 2015. Пациенты с ПЛ постоянно увеличивают совокупное число НРМ

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… Forest plot depicting factors associated with increased risk of sMNs in patients with FL( green diamond), multiple myeloma (MM, blue diamond), and DLBCL (red diamond). Chemo, chemotherapy; CVD, cardiovascular disease. … Jonsdottir G , Björkholm M , Turesson I , Hultcrantz M , Diamond B , Porwit A , . Cumulative exposure to melphalan chemotherapy and subsequent risk of developing acute myeloid leukemia and myelodysplastic syndromes in patients with multiple myeloma . …

Ангина из-за обструкционистской болезни коронарной артерии в сочетании с периферической болезнью артерии.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… His optimal medical therapy was managed based on the ‘diamond approach’ to the personalized treatment of angina in case of the presence of peripheral arterial disease. 1–3 This case emphasized the complexity of managing refractory angina and the underlying causes of angina and how to treat them to prevent … Expert consensus document: a ‘diamond’ approach to personalized treatment of angina. Nat Rev Cardiol 2018;15:120–132. 2. Ambrosio G, Mugelli A, Lopez-Sendón J, Tamargo J, Camm J.. Management of stable angina: a commentary on the European Society of Cardiology guidelines. …

Zoledronic acid in metastatic castrate-sensitive prostate cancer: A state-of-the-art review.

Prostate cancer is the most common cancer in men in developed countries. Despite its slow growing pattern, metastatic disease to bone occurs and results in a significant number of deaths. Since more than eight decades, the classical androgen deprivation therapy (ADT) leads to clinical response in most patients with metastatic castration-sensitive prostate cancer (mCSPC). Moving backward docetaxel and androgen receptor pathway inhibitors (ARPI) from castrate-resistant setting to castrate sensitive setting improves overall survival (OS) compared to ADT alone. Recently, studies suggested that tri

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… Diamond et al. with the pamidronate group compared to placebo showed an increase in LS and femoral neck BMD in the zoledronic acid group [ 37 , 38 ]. … Cancer Res. 29 14 2023 2702 2713 37126020 10.1158/1078-0432.CCR-22-3394 PMC12211896 37 Diamond T.H. Winters J. Smith A. De Souza P. Kersley J.H. Lynch W.J. …

Safety of totally implantable venous access devices and peripherally inserted central catheters in hematological malignancies patients: a meta-analysis.

BackgroundThe use of totally implantable venous access devices (TIVADs) and peripherally inserted central catheters (PICCs) are the two options for patients receiving chemotherapy for hematologic malignancies. However, it remains unclear which approach yields superior patient outcomes. This meta-analysis aimed to compare the efficacy of TIVAPs and PICCs in patients undergoing chemotherapy for hematologic malignancies.MethodsA comprehensive literature search was conducted in PubMed, Embase, Cochrane Library, Wanfang, and China National Knowledge Infrastructure (CNKI) to identify available artic

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… Each study shows varied ORs with confidence intervals, marked by black diamonds and horizontal lines. A red dashed line marks the reference line at one. The overall effect size is indicated at the bottom with a blue diamond, showing OR 0.21 and I-squared 0.0%. Table 2 The main results. … The overall effect is depicted by a diamond, with an OR of 0.16 (CI: 0.06, 0.42). The plot assesses heterogeneity with I-squared at 0.0% and p-value at 0.907. Phlebitis Seven studies reported phlebitis data. …

Understanding Rare Anemias: Emerging Frontiers for Diagnosis and Treatment.

Background-This review provides a comprehensive overview of rare anemias, emphasizing their hereditary and acquired causes, diagnostic advancements, and evolving treatment strategies. It outlines the significance of rare anemias within public health, historical challenges in recognition and treatment, and the role of European initiatives like ENERCA and EuroBloodNet in advancing care. Content-This document discusses diagnostic technologies like next-generation sequencing and the impact of artificial intelligence, alongside the promising avenues of gene therapy, targeted drug treatments, and st

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… Conversely, a minor proportion of cases exhibits X-linked inheritance, as seen in sideroblastic anemia and dyskeratosis congenita, or an autosomal dominant pattern, exemplified by Diamond-Blackfan anemia. 2.1.1. … However, its specific role in Diamond–Blackfan anemia (DBA) warrants further clinical investigation and validation [ 59 ]. 6.2.2. …

Clinical Trial Evidence Supporting US Food and Drug Administration Approval of Novel Cancer Therapies Between 2000 and 2016.

IMPORTANCE: Clinical trial evidence used to support drug approval is typically the only information on benefits and harms that patients and clinicians can use for decision-making when novel cancer therapies become available. Various evaluations have raised concern about the uncertainty surrounding these data, and a systematic investigation of the available information on treatment outcomes for cancer drugs approved by the US Food and Drug Administration (FDA) is warranted. OBJECTIVE: To describe the clinical trial data available on treatment outcomes at the time of FDA approval of all novel c

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… Diamonds represent the pooled mean with the points of the diamonds representing 95% CIs. HR indicates hazard ratio. Table 3. … Diamonds represent the pooled mean with the points of the diamonds representing 95% CIs. RR indicates relative risk. …

Efficacy, safety and economy of denosumab and zoledronic acid in the treatment of bone metastases of solid tumors and multiple myeloma: a systematic review and meta-analysis.

ObjectiveTo conduct a comprehensive comparison of the efficacy, safety, and cost-effectiveness of denosumab versus zoledronic acid in patients with bone metastases from solid tumors and multiple myeloma.MethodsA systematic search of PubMed, Web of Science, Embase, and major Chinese databases was performed for studies published up to 30 September 2025. Eligible evidence included randomized controlled trials, cohort studies, and pharmacoeconomic analyses. Random-effects models were applied for quantitative synthesis. The certainty of evidence for key outcomes was assessed using the GRADE framewo

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… Diamonds indicate confidence intervals, with subgroups favoring the experimental group. Overall heterogeneity and effect tests are provided. However, subgroup analysis revealed significant heterogeneity driven by tumor type (P = 0.04). … Diamonds represent overall effects for each subgroup and the total. Summary statistics show heterogeneity and overall test effects, with lines indicating the experimental and control boundaries. …

Геномика определяет злонамеренную трансформацию в условиях Миеломы.

Множественной миеломе (ММ) последовательно предшествует моноклонная гаммопатия неопределённого значения (МГУС) и множественная миелома (ШМ). Хотя эти прекурсоры являются асимптоматическими, они не являются полностью доброкачественными и сопряжены с риском продвижения к MM на протяжении всей жизни. В отличие от других раковых заболеваний, определяемых патологией, злокачественная трансформация от MGUS или SMM до MM до сих пор основывалась на демонстрации клинического ущерба конечной организации, поскольку морфология и цитогенетика не могут надежно их отличить. В настоящем исследовании используют

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… Kazandjian D, Diamond B, Papadimitriou M, et al. : Genomic profiling to contextualize the results of intervention for smoldering multiple myeloma. Clin Cancer Res 30:4482-4490, 2024 22. … Diamond B, Yellapantula V, Rustad EH, et al. : Positive selection as the unifying force for clonal evolution in multiple myeloma. Leukemia 35:1511-1515, 2021 51. …

Мультиэнштейная геномная ассоциация и мультиомикальный анализ позволяют выявить специфичные особенности многоклерозной генетики.

Множественный склероз (MS) — хроническое воспалительное заболевание центральной нервной системы, характеризующееся обезвоживанием, распространяющимся в пространстве и во времени. Здесь мы провели исследование ассоциации генома (GWAS) с использованием 688 Количество дел, связанных с НР и 205,199 :: контроль со стороны японского населения и выявление важных связей в основном сложном регионе, связанном с гистокомпьютерностью, и в 11q24 году вариант риска, учитывающий специфику населения. С помощью межнаселенных метаанализов GWAS с использованием всего 29,374 случаи и случаи 1,843,563 контроля с 4

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… Diamonds are colored by heterogeneity I 2 . b , Comparison of effect sizes between our GWAS meta-analysis and Patsopoulos et al. 10 (IMSGC2019). … Diamonds are colored by significance in the Japanese meta-analysis (left) and by heterogeneity I 2 (right). Error bars indicate 95% confidence Intervals. …