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Spatio-temporal selectivity of loss of colour and luminance contrast sensitivity with multiple sclerosis and optic neuritis.

Colour and luminance-contrast thresholds were measured in the presence of dynamic Random Luminance-contrast Masking (RLM) in individuals who had had past diagnoses of optic neuritis (ON) some of whom have progressed to a diagnosis of multiple sclerosis (MS). To explore the spatio-temporal selectivity of chromatic and luminance losses in MS/ON, thresholds were measured using three different sizes and modulation rates of the RLM displays: small checks modulating slowly, medium-sized checks with moderate modulation and large checks modulating rapidly. The colour of the chromatic stimuli used were…

Long-term brain magnetic resonance imaging changes after optic neuritis in patients without clinically definite multiple sclerosis.

BACKGROUND: Long-term follow-up of the Optic Neuritis Treatment Trial (ONTT) cohort to evaluate brain magnetic resonance imaging (MRI) in patients who have not developed clinically definite multiple sclerosis. OBJECTIVE: To determine the proportion of patients with monosymptomatic optic neuritis who manifest new brain MRI lesions without having developed clinically definite multiple sclerosis 10 to 14 years after enrollment in the ONTT. DESIGN: Observational study. SETTING: Fourteen clinical centers. PARTICIPANTS: One hundred eight ONTT patients who had not developed clinically definite mu…

Aseptic meningitis and optic neuritis preceding varicella-zoster progressive outer retinal necrosis in a patient with AIDS.

Varicella-Zoster Virus (VZV) is the second most common ocular pathogen in patients with HIV infection. VZV retinitis is estimated to occur i … festations such as encephalitis and myelitis in HIV-infected patients. In addition, VZV retrobulbar optic neuritis heralding VZV retinitis has recently been described in HIV-infected patients who had suffered a recent episode of dermatomal herpes zoster. Herein we report the case of an HIV-infected individual who presented with VZV meningitis and retrobulbar opt …

Quality control functions of the Visual Field Reading Center (VFRC) for the Optic Neuritis Treatment Trial (ONTT).

The Visual Field Reading Center (VFRC) was established to assess visual field testing in the Optic Neuritis Treatment Trial (ONTT), to train and certify ONTT technicians, and to monitor the quality of the visual fields through evaluation of the technical aspects of the visual field testing. We describe the functions of the VFRC personnel and the standardized test protocols developed by the VFRC for Humphrey and Goldmann perimetry. We also describe the VFRC procedures for training and certifying visual field technicians, double-checking the eligibility of ONTT patients, assessing the quality of…

Visual loss in multiple sclerosis and its relation to previous optic neuritis, disease duration and clinical classification.

Visual function was investigated in a group of 58 clinically classified cases of multiple sclerosis (MS). Psychophysical measures of luminance and chromatic threshold sensitivity and temporal contrast sensitivity were undertaken, together with visual evoked potentials and Bjerrum screen perimetry. The patient group was divided on the basis of optic neuritis (ON), clinical disease duration and clinical classification. A comparison of the results of all visual measures suggested a nonuniform loss of function in the patient group without ON and a more consistent loss of function in the group with…

Q лихорадочный менингоэнцефалит, связанный с двусторонним параличом нервной системы, двусторонним оптическим невритом и аномальными цереброспиниальными жидкостями.

Q лихорадка - это зооноз, вызванный коксиэллой, клинические особенности которого зачастую не являются конкретными и самоограниченными. Участие центральной нервной системы редкое и обычно рассматривается как осложнение эндокардита, вызванное этим рикетсиальным организмом в хронической болезни. Конкретные неврологические проявления при остром заболевании асептическим менингитом, энцефалитом, токсикозом, внепирамидальными признаками, слабоумием и расстройствами поведения. Мы описываем пациента, разработавшего обратимый двусторонний паралич нервной системы и двусторонний оптический нейрит в ходе о

Совпадение в аннотации оригинала
Q fever is an zoonosis caused by Coxiella burnetti, the clinical features of which are often nonspecific and self-limited. Involvement of th … es. We describe a patient who developed reversible bilateral abducens nerve paralysis and bilateral optic neuritis in the course of acute Q fever meningoencephalitis.

Myelin basic protein in the CSF of patients with multiple sclerosis, optic neuritis and various neurological diseases.

We tested 104 patients for myelin basic protein (MBP) content in the CSF. Of these subjects 14 were selected as control group, 36 were affected by multiple sclerosis (MS), 14 by optic neuritis (ON) and 42 presented other not primarily demyelinating neurological diseases (ND ND). CSF MBP level was significantly higher in the MS group than in the other groups of patients, while no statistical difference was found between the MS patients with acute exacerbation and those in remission.

[Visual evoked potentials, contrast sensitivity and color perception in patients with optic nerve neuritis and multiple sclerosis].

Forty-nine patients with acute optic neuritis (in 21 cases associated with MS) and 26 patients known to have MS but with no history of optic nerve disease underwent visual evoked potential, contrast sensitivity and color vision tests. In patients with optic neuritis the contrast sensitivity was shown to detect optic nerve lesions better than the VEP an often permitted a distinction between acute and past optic neuritis. Combined testing with contrast sensitivity and VEP was superior to the single tests and detected 100% of the acute optic nerve lesions, although in many cases damage was select…

Optic neuritis and chronic relapsing experimental allergic encephalomyelitis: relationship to clinical course and comparison with multiple sclerosis.

Optic nerve tissue from strain 13 guinea pigs sensitized for chronic (relapsing) experimental allergic encephalomyelitis has been examined up to 3 years postinoculation. The changes were compared with the clinical history in each case, with lesions occurring elsewhere in the central nervous system and with optic nerve tissue from a single case of chronic multiple sclerosis. In chronic experimental allergic encephalomyelitis was found that optic neuritis was a consistent finding. Active lesions in the optic nerve were a feature of animals sampled up to 4 months postinoculation. Unlike lesions i…

B and T lymphocytes in cerebrospinal fluid and blood in multiple sclerosis, optic neuritis and mumps meningitis.

B and T cells were defined in cerebrospinal fluid (CSF) and blood of 18 multiple sclerosis (MS), five optic neuritis, and 17 mumps meningitis patients by counting immunoglobulin-bearing lymphocytes for B cells, and the capacity of rosette formation with sheep erythrocytes of T-cell determination. Patients with MS and mumps meningitis had significantly higher T-cell values in CSF compared to blood, while the B cell value was significantly lower in CSF in mumps meningitis only. MS patients also displayed significantly lower B-cell values in blood compared to mumps meningitis patients and blood d…

The prevalence of microcystic macular changes on optical coherence tomography of the macular region in optic nerve atrophy of non-neuritis origin: a prospective study.

BACKGROUND: Microcystic macular changes, also called microcystic macular oedema, have recently been reported in patients with multiple sclerosis, particularly after optic neuritis. But it has since emerged that the finding is not specific for optic neuritis. This study was designed to prospectively investigate the prevalence of microcystic perifoveal changes in patients with optic atrophy not due to optic neuritis. METHODS: A prospective, cross-sectional study including 54 patients with a history of optic atrophy and 54 healthy control subjects. Spectral domain optical coherence tomography (S…

VEP Abnormalities in Treatment-Naïve CIS/Early RRMS Without Prior Optic Neuritis: Clinical, Radiological, and CSF Associations.

Background and Objectives: Visual evoked potentials (VEPs) are a simple, noninvasive method for detecting subclinical visual pathway involvement in multiple sclerosis. This study investigated the frequency of VEP abnormalities and their associations with baseline clinical, radiological, and cerebrospinal fluid (CSF) features in treatment-naïve patients with clinically isolated syndrome (CIS) or early relapsing-remitting multiple sclerosis (RRMS) without prior optic neuritis. Materials and Methods: We retrospectively reviewed newly diagnosed, treatment-naïve CIS/early RRMS patients evaluated be…

Frequency domain analysis of steady-state visual evoked potentials in dogs with optic neuritis: a pilot study.

Visual evoked potentials (VEP) are electrophysiological signals used to assess visual pathway function, with applications in diagnosing optic nerve disorders. This study compared the diagnostic utility of transient VEP (TVEP) and steady-state VEP (SSVEP) in dogs with optic neuritis, focusing on SSVEP's frequency-domain advantages. Seven dogs with optic neuritis and seven controls matched for breed, age, and weight were evaluated. TVEP and SSVEP were recorded without anesthesia using standardized protocols, and parameters were analyzed in time and frequency domains. Significant reductions in SS…

A Case of Recurrent Painful Ophthalmoplegia Following COVID-19: Evolution From Optic Neuritis to Tolosa-Hunt Syndrome.

Tolosa-Hunt syndrome could be considered in patients with painful ophthalmoplegia following COVID-19 infection, but caution should be exercised in attributing causality. Careful exclusion of alternative diagnoses is essential. Corticosteroids usually produce quick clinical relief. Ultimately, any association with COVID-19 is regarded as speculative and unproven.

Are adverse events higher among patients with acute optic neuritis prescribed glucocorticoids? A retrospective, longitudinal cohort study.

OBJECTIVE: Optic neuritis (ON) is an acute focal inflammation of the optic nerve routinely treated with glucocorticoids. We aimed to compare adverse events (AE) among glucocorticoid-treated and untreated patients in the real world to guide clinical decision making about treatment tradeoffs. DESIGN: Retrospective, longitudinal cohort study. SETTING: Claims study from a large, private insurer in the USA (2005-2019). PARTICIPANTS: Adults≥18 years old with ≥1 ICD9/10 ON diagnosis with an evaluation/management visit code, and ≥6 months continuous enrolment prior to and following ON diagnosis. I…

Visualization and analysis of mapping knowledge domains for optic neuritis: a bibliometric research from 2013 to 2022.

PURPOSE: To explore the global research trends, hotspots and frontiers of optic neuritis (ON) over the past decade through qualitative and quantitative analysis of bibliometrics. METHODS: Publications on ON from 2013 to 2022 were retrieved from Web of Science Core Collection (WoSCC). VOSviewer and CiteSpace were mainly used to facilitate bibliometric analysis and visualization. RESULTS: A total of 3027 papers were retrieved from peer-reviewed publications and the annual research output increased over time. Neurosciences neurology was the most published area. The USA was the most productive a…