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Complex Regional Pain Syndrome in Cancer Cases: Current Knowledge and Perspectives.

BACKGROUND: Complex regional pain syndrome (CRPS) is a disabling painful disorder caused by many different and poorly understood mechanisms. It often affects the distal limbs and usually happens as consequence of a trauma. Its severity can remarkably affect patients' quality of life. When this painful complication happens in a cancer patient, the impact may be exponential. To date, there is limited knowledge of the surrounding circumstances of CRPS cases in this population. METHODS: We present two clinical cases of patients diagnosed with cancer-related pain presenting with symptoms and signs

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… He agreed to a trial of adding night-time 50 mg nortriptyline, along with tramadol 37.5 mg plus acetaminophen 325 mg as breakthrough medication. Interventional options including selective nerve root block and stellate ganglion block were offered, but the patient declined. …

Methadone rotation versus other opioid rotation for refractory cancer induced bone pain: protocol of an exploratory randomised controlled open-label study.

BACKGROUND: A third of patients with advanced cancer and bone metastasis suffer from cancer induced bone pain (CIBP), impeding quality of life, psychological distress, depression and anxiety. This study will evaluate the impact of an opioid rotation, comparing methadone rotation with other opioid rotation in patients with refractory CIBP. METHODS: This open-label randomised controlled trial will recruit cancer patients with CIBP and inadequate pain control despite established baseline opioid and/or intolerable opioid side effects from cancer and palliative care services. Participants will be

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… Use of adjuvant co-analgesic medications such as NSAID, trazodone, acetaminophen, or Tramadol [ 15 ] are permitted but titration of these medications will be restricted during the study period to ensure the observed changes in pain intensity is attributable only to the study intervention. …

A practical approach to joint pain in primary care.

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… start at 100 mg BD, up to maximum dose of 400 mg/day Etoricoxib: start at 60 mg OD, up to maximum dose of 120 mg OD Topical NSAIDs | Ketoprofen/diclofenac plaster: one plaster BD PRN Ketoprofen/diclofenac gel: one application BD/TDS PRN | • Usually safe with no/minimal systemic side effects Opioids | Tramadol …

Influence of Metamizole on Antitumour Activity of Risedronate Sodium in In Vitro Studies on Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines.

The availability of metamizole varies greatly around the world. There are countries such as the USA, UK, or Australia where the use of metamizole is completely forbidden, and there are also countries where this drug is available only on prescription (e.g., Greece, Italy, Spain, etc.) and those in which it is sold OTC-over the counter (e.g., most Asian and South American countries). Metamizole, as a drug with a strong analgesic effect, is used as an alternative to other non-steroidal anti-inflammatory drugs, alone or in combination with opioid drugs. Risedronate sodium is a third-generation bis

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… These drugs can be administered alone or in a combination with opioid analgesics (tramadol, butorphanol, or fentanyl). Metamizole, sometimes called dipyrone, is a non-steroidal anti-inflammatory drug belonging to the group of pyrazolones and the WHO “analgesic ladder” [ 23 ]. …

Effectiveness of ondansetron as an adjunct to lidocaine intravenous regional anesthesia on tourniquet pain and postoperative pain in patients undergoing elective hand surgery: a systematic review protocol.

REVIEW QUESTION/OBJECTIVE: The objective of this quantitative systematic review is to determine the effects of ondansetron as an adjunct to … viewed to include various adjuncts to LA in IVRA. Adjuncts studied in this review included opioids, tramadol, non-steroidal anti-inflammatory drugs (NSAIDs), clonidine, muscle relaxants, sodium bicarbonate and potassium. The results of this systematic review suggest that NSAIDs have the most potential to offer as adjuncts to IVRA, while opioid adjuncts to …

The Association Between Anticholinergic Burden and Treatment-Related Complications in Older Adults with Cancer.

BackgroundOlder adults constitute more than 50% of newly diagnosed cancer cases and polypharmacy is highly prevalent in this population. The Anticholinergic Burden (ACB) score quantifies the cumulative anticholinergic effects of all medications. Few studies link high ACB to adverse health outcomes in this population, and its effect on treatment outcomes remains largely unknown.ObjectiveThis study investigates the association between the ACB-score and treatment-related toxicity (grade ≥ 3), functional decline, and emergency room (ER) visits or hospitalization in older adults with cancer receivi

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… Gastric reflux | 20.5 Metformin | 1 | Diabetes type 2 | 15.9 Oxycodone | 1 | Pain | 5.5 Tiotropium | 1 | Chronic obstructive pulmonary disease | 3.9 Isosorbide mononitrate | 1 | Cardiovascular disease | 3.0 Fentanyl | 1 | Pain | 3.0 Desloratadine | 1 | Allergy | 2.1 Paroxetine | 3 | Depression | 2.1 Tramadol …

Comparison of the Efficacy of Zoledronate and Denosumab in Patients with Acute Osteoporotic Vertebral Compression Fractures: A Randomized Controlled Trial.

Background: The comparison of the efficacy of zoledronate and denosumab for treating osteoporosis is controversial, and few randomized controlled trials have compared these two drugs in practical patients with acute osteoporotic vertebral compression fractures (OVCFs). We conducted a randomized controlled study to compare the efficacy of zoledronate and denosumab in patients with acute OVCF, with a focus on the occurrence of new OVCF. Methods: We enrolled 206 subjects who had their first acute OVCF, without any previous history of osteoporosis medication. The patients were randomly assigned to

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… For conservative treatment, conventional analgesics, such as nonsteroidal anti-inflammatory drugs, tramadol, or opioids, were prescribed to control pain in an outpatient setting, and bed rest for 1–2 weeks was recommended. If pain relief was observed, conservative treatment was continued. …

Pamidronate-induced irreversible symptomatic hypocalcemia in a dog with hypercalcemia after glucocorticoid withdrawal: a case report.

BACKGROUND: Pamidronate is used for the treatment of hypercalcemia. However, a rare but potential adverse event of pamidronate treatment is hypocalcemia. This report describes an unusual case of severe, irreversible hypocalcemia after a single injection of pamidronate for the treatment of hypercalcemia due to glucocorticoid withdrawal in a dog. CASE PRESENTATION: An 11-year-old castrated male Maltese dog presented with anorexia, vomiting, and diarrhea (day 0). The patient had calcinosis cutis throughout the body, calcification of intraabdominal organs, mild azotemia, and severe hypercalcemia.

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… At discharge, the patient was prescribed oral administration of cyclosporin 5 mg/kg bid, amlodipine 0.4 mg/kg bid, famotidine 1 mg/kg bid, maropitant 1 mg/kg sid (Cerenia, Zoetis, USA), tramadol 4 mg/kg bid (Shinpoong Pharmaceutical, Seoul, Republic of Korea), silymarin 20 mg/kg bid, ursodeoxycholic …

Side effects of analgesia may significantly reduce quality of life in symptomatic multiple myeloma: a cross-sectional prevalence study.

BACKGROUND: Pain is a common symptom in patients with multiple myeloma (MM). Many patients are dependent on analgesics and in particular opioids, but there is limited information on the impact of these drugs and their side effects on health-related quality of life (HRQoL). METHOD: In a cross-sectional study, semi-structured interviews were performed in 21 patients attending the hospital with symptomatic MM on pain medications. HRQoL was measured using items 29 and 30 of the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30. RESULTS: Patients were able to recall a med

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… Cumulative n | % | n | % | n | % Paracetamol | 15 | 71 | 4 | 19 | 19 | 90 Fentanyl (patch) | 10 | 48 | 1 | 5 | 11 | 52 Morphine | 3 | 14 | 7 | 33 | 10 | 48 Oxycodone | 7 | 33 | 2 | 10 | 9 | 43 Gabapentin | 3 | 14 | 6 | 29 | 9 | 43 Codeine | 3 | 14 | 6 | 29 | 9 | 43 Bisphosphonates | 7 | 33 | 1 | 5 | 8 | 38 Tramadol …

Оценка и лечение мужской сексуальной дисфункции в болезни Паркинсона: клиническая дорожная карта.

Болезнь Паркинсона (PD) является прогрессивным нейродегенеративным заболеванием с множественными проявлениями, включая как моторные, так и немоторные симптомы. Одним из проявлений PD, который часто игнорируется, является сексуальная дисфункция (SD), которую могут испытывать пациенты. У лиц с ОВП могут быть дефекты сексуального желания, возбуждения или смазки, оргазма, эякуляции, боли и физических аспектов близости. Цель этой статьи состоит в том, чтобы дать общее представление о нынешней практике оценки и лечения сексуальной дисфункции у мужчин в контексте ПР. Следует отметить, что в этой стат

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… first line pharmacologic treatment. 56 , 133 Topical anesthetics are also considered as a first line pharmacotherapy in patients with premature ejaculation. 134 Other medications have been studied and may play a role in pharmacologic treatment for various ejaculatory related symptoms, such as tramadol …

Bilateral Pathological Femoral Fractures Secondary to Long-Term Tenofovir Disoproxil Fumarate-Induced Osteomalacia in a Woman Living with HIV: A Case Report.

BACKGROUND: People living with HIV on long-term antiretroviral therapy (ART) face increased risks of bone loss and fragility fractures, partly due to tenofovir disoproxil fumarate (TDF), a commonly used nucleoside reverse transcriptase inhibitor. TDF is associated with proximal tubular dysfunction, renal phosphate wasting, osteomalacia, and pathological fractures. This case highlights severe, bilateral femoral fractures as a rare but debilitating manifestation of chronic TDF-induced osteomalacia in a postmenopausal woman. CASE PRESENTATION: A 43-year-old African woman with HIV (diagnosed >15

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… Supplementation continued for several months and was tapered once phosphate and alkaline phosphatase levels normalized and remained stable Multimodal analgesia was administered throughout the hospital stay, incorporating paracetamol, weak opioids such as tramadol, and nonsteroidal anti-inflammatory drugs …

Initial management and disposition of metastatic spinal cord compression in the emergency department: a review of the literature.

BACKGROUND: Metastatic spinal cord compression (MSCC) is a serious medical emergency that can complicate the course of various malignancies, including prostate, breast, and lung cancers. Appropriate evaluation and effective management of MSCC early in the emergency department are necessary to minimize neurologic deterioration and optimize the trajectory of patient recovery. METHODS: This literature review examines and summarizes current evidence surrounding the emergency department approach for timely recognition, initial evaluation, and management of MSCC. RESULTS: A comprehensive clinical

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… NSAIDs and paracetamol), mild opioids (codeine, tramadol) for mild to moderate breakthrough pain, and strong opioids (morphine, oxycodone, hydromorphone, transdermal fentanyl) for severe breakthrough pain [ 44 ]. …

Determination of drug-related problems in the hematology service: a prospective interventional study.

BackgroundPatients with hematological malignancies often require multidrug therapy using a variety of antineoplastic agents and supportive care medications. This increases the risk of drug-related problems (DRPs). Determining DRPs in patients hospitalized in hematology services is important for patients to achieve their drug treatment goals and prevent adverse effects. This study aims to identify DRPs by the clinical pharmacist in the multidisciplinary team in patients hospitalized in the hematology service of a university hospital in Turkey.MethodsThis study was conducted prospectively betwee

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… Drug dose of a single active ingredient too high | Tramadol-Since the patient had CrCL < 30, it was recommended not to exceed 200 mg daily. Dosage regimen too frequent | Amicasin - Due to renal dysfunction, it was recommended to give the dose every 48 h. …

Retrospective assessment of tolerability and efficacy of zoledronate in the palliative treatment of cancer-bearing dogs.

Zoledronate is a bisphosphonate frequently used for the treatment of hypercalcaemia of malignancy and tumour-associated bone pain in dogs, however, there is a paucity of information regarding its use in veterinary medicine. The aim of this retrospective study was to report the tolerability of zoledronate in the palliative treatment of cancer-bearing dogs and secondarily to to assess the efficacy of zoledronate for the treatment of hypercalcaemia of malignancy. Thirty-seven dogs (22 with tumour-associated bone pain and 15 with hypercalcaemia of malignancy) that received 114 zoledronate infusion

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… Other concurrent medications included non‐steroidal anti‐inflammatory drugs (NSAIDs) in 27 dogs (73%), corticosteroids in six dogs (16%) and other pain relief medication in 26 dogs (70%) (paracetamol, gabapentin, tramadol, buprenorphine, methadone). …

Pamidronate disodium for palliative therapy of feline bone-invasive tumors.

This study sought to quantify in vitro antiproliferative effects of pamidronate in feline cancer cells and assess feasibility of use of pamidronate in cats by assessing short-term toxicity and dosing schedule in cats with bone-invasive cancer. A retrospective pilot study included eight cats with bone invasive cancer treated with intravenous pamidronate. In vitro, pamidronate reduced proliferation in feline cancer cells (P < 0.05). One cat treated with pamidronate in combination with chemotherapy and two cats treated with pamidronate as a single agent after failing prior therapy had subjective

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… All cats received chronic oral analgesics including one or more of piroxicam, meloxicam, tramadol, buprenorphine, butorphanol, and gabapentin For clinical administration, pamidronate was reconstituted in sterile water per manufacturer's recommendations and diluted into 40–60 mL 0.9% saline. …

Nurse-Administered Auricular Point Acupressure for Cancer-Related Pain.

PurposeThe study aimed to (1) examine the feasibility of providing a training course on auricular point acupressure (APA) for clinical oncology nurses to integrate APA into real-world nursing care settings, and (2) examine the effectiveness of APA on cancer-related pain (CRP) under usual inpatient oncology ward conditions.MethodsThis was a 2-phase feasibility study. Phase 1, an in-person, 8 hour training program was provided to oncology nurses. Phase 2, a prospective and feasibility study was conducted to evaluate the integration of APA into nursing care activities to manage CRP. Oncology pati

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… (0) (0, 200) | 0 (0) (0, 200) Fentanyl transdermal patch n (%) of subjects | 3 (9) | 4 (12) | 4 (12) | 4 (12) Dosage, mean (SD) | 67.50 (381.84) | 69.68 (387.95) | 69.68 (387.95) | 69.68 (387.95) Dosage, median (IQR) (min, max) | 0 (0) (0, 2160) | 0 (0) (0, 2160) | 0 (0) (0, 2160) | 0 (0) (0, 2160) Tramadol …

Последние достижения в лечении и профилактике периферической нейропатии после многократного лечения миеломы.

Заболеваемость множественной миеломой (ММ) из года в год увеличивается, и для контроля за состоянием требуется химиотерапия. С появлением новых протеиновых ингибиторов, иммуномодуляторов и моноклональных антител, прогнозы пациентов значительно улучшились. Однако периферическая нейропатия, вызванная лекарственными препаратами, ограничивает дозу и продолжительность лечения, что серьезно сказывается на качестве жизни пациентов и результатах лечения. Несмотря на то, что нейропатии, вызванные химиотерапией, привлекли к себе большое внимание, их механизм и эффективные профилактические и лечебные мер

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… treatments such as exercise, acupuncture, nerve blocks, and electrical stimulation, are effective in the prevention and treatment of CIPN, but there are no highly recommended therapies for the prevention or treatment of CIPN (Figure 2 ). 31 Various opioids (including oxycodone, morphine, fentanyl, and tramadol …

Differences in the Analgesic Effect of Opioids on Pain in Cancer Patients With Spinal Metastases.

BACKGROUND: Spinal metastasis pain includes both inflammatory and neuropathic pain, and opioids, which have only a μ-opioid receptor-stimulating effect, are generally less effective in neuropathic pain. However, no previous study has been conducted for the comparisons of the efficacy of opioids in treating spinal metastasis pain. OBJECTIVE: To compare the efficacy of tapentadol and methadone with other opioids for back pain caused by a metastatic spinal tumor. DESIGN: Retrospective cohort study. SETTING/SUBJECTS: A total of 274 patients were enrolled, who started a tapentadol extended-relea

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… Fentanyl | 12 (23.1) | 14 (26.4) | 12 (20.0) | 14 (27.5) | — | Hydromorphone | 10 (19.2) | 11 (20.8) | — | 8 (15.7) | 6 (10.9) | Morphine | 3 (5.8) | 6 (11.3) | 10 (16.7) | 9 (17.6) | 6 (10.9) | Tapentadol | — | 5 (9.4) | 6 (10.0) | 3 (5.9) | 4 (7.3) | Tramadol | 9 (17.3) | 1 (1.9) | 7 (11.7) | 9 …

Minimally Invasive Surgical Techniques for Management of Painful Metastatic and Primary Spinal Tumors.

Patients with metastatic spinal disease are affected by disabling pain. The treatment of spinal metastases is focused on pain reduction and improvement in quality of life. Until recently, many patients with metastatic spinal disease did not qualify as surgical candidates due to the risks of surgery and length of recovery period. However, recent advances in minimally invasive surgery such as kyphoplasty and vertebroplasty allow patients to safely undergo surgery for pain relief with a short recovery period. The studies reviewed here suggest that vertebral augmentation is successful in reducing

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… Mild pain is managed with nonopioid analgesics such as nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen, while moderate pain is managed with weak opioids such as dihydrocodone or tramadol. NSAIDs may be added at any level on the analgesic ladder. …

Выявляется высокий уровень использования медицинских услуг после операции на шейном позвоночнике с использованием комплексных методов прогнозирования.

Расходы на медицинское обслуживание пациентов с хроническими заболеваниями позвоночника и пациентов, проходящих хирургическую операцию, продолжают расти заметными темпами. Таким образом, выявление пациентов, подверженных риску в плане более широкого использования послеоперационного медицинского обслуживания, имеет решающее значение для оптимизации результатов медицинского обслуживания и распределения ресурсов. Цель нашего исследования заключается в использовании целого ряда предоперабельных характеристик пациентов, включая всеобъемлющую медицинскую, хирургическую и социальную историю, для разр

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… diflunisal”, “etodolac”, “flurbiprofen”, “ibuprofen”, “ketoprofen”, “meloxicamnabumetone”, “naproxen”, “piroxicam”, “sulindac”, “ibuprofen”, “indomethacin”, “ketorolac” | Opioids | “hydromorphone”, “oxycodone”, “hydrocodone”, “fentanyl”, “methadone”, “morphine”, “codeine”, “butorphanol”, “nalbuphine”, “tramadol …