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Идентификация и каталог регуляторов вирусной транскрипции заболеваний человека.

Вирусные геномы кодируют регуляторы вирусной транскрипции (vTRs), которые манипулируют экспрессией гена хоста, чтобы облегчить воспроизведение и избежать иммунной обнаружения. Тем не менее их роль в нераковых болезнях по-прежнему в значительной степени недооценивается. Здесь мы представили 268 новых кандидатов в VTR из 14 из 20 вирусных семей, которые мы расследовали. Мы картировали связующие профили генома VTR и определили их потенциальные цели человека, которые были обогащены иммунно-посредованными путями, нейродегенеративными расстройствами и раком. На основе анализа предпочтений VTR, имеющ

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… -Downloading-SRA-Toolkit Diamond BLASTP (v2.1.8) Buchfink et al. 62 https://github.com/bbuchfink/diamond MMseqs2 (v16.747c6) Steinegger et al. 63 https://github.com/soedinglab/MMseqs2 HMMER (v3.4) Finn et al. 64 http://hmmer.org HHblits (v3.3.0) Remmert et al. 65 https://github.com/soedinglab/hh-suite … The homologs of these 7,329 sequences were assessed within the same dataset using the abovementioned five tools with following parameters, --query-cover 50; --id 50; --evalue 1e −6 for Diamond BLASTP, and e-value 1e −6 for other four tools. …

Воздействие питательных микроэлементов на результаты беременности в развивающихся странах: систематический обзор и метаанализ.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: В развивающихся странах по-прежнему относительно высоки показатели низкой беременности. Недостаток питательных микроэлементов относится к числу факторов, которые играют определенную роль в определении негативных последствий беременности. Цель настоящего исследования заключается в изучении роли дефицита питательных микроэлементов в неудовлетворительных результатах беременности и их связи с здоровьем новорожденных.МЕТОД: Для этого обзора был проведен систематический поиск с использованием программы " Харзинг периш " и публикация программного обеспечения, а также

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… The diamond at the bottom indicates the pooled overall effect size using a random-effects model. B Funnel plot used to evaluate publication bias for studies assessing the association between maternal vitamin D levels and LBW. … The diamond at the bottom indicates the pooled overall effect size using a random-effects model. B Funnel plot used to evaluate publication bias for studies assessing the association between maternal vitamin D levels and LBW. …

Тип 1 Диабет и многоразовый склероз делятся общей генной переменой автономного иммунитета.

Справочная информация/цели: тип 1 диабет (T1D) и множественный склероз (MS) являются аутоиммунными, многофакторными, специфическими для органов расстройствами, обусловленными иммунными клетками. Их соучастие отчасти объясняется общими генетическими и экологическими факторами. Мы стремились расчленить общую генетическую архитектуру между T1D и MS с использованием крупномасштабных исследований по общегеномной ассоциации (GWAS) и анализа совместной локализации. Методы: Мы применили Байесовскую систему совместной локализации к two Крупномасштабные наборы данных GWAS: исследование T1D, включающее 1

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… The lead variant is shown as a purple diamond, while surrounding variants are colored based on their linkage disequilibrium (r 2 ) with the lead variant, calculated using European samples from the 1000 Genomes Project. Recombination rates (cM/Mb) are shown as a blue line on the secondary y -axis. … The lead variant is shown as a purple diamond, while surrounding variants are colored based on their linkage disequilibrium (LD; r 2 ) with the lead variant, calculated using European samples from the 1000 Genomes Project. …

Case Report: Application of ex-vivo drug sensitivity testing to identify personalized treatment options for an adolescent with diffuse midline glioma.

Diffuse midline glioma (DMG) is a pediatric brain cancer that has a dismal prognosis with limited treatment options. We present the treatment course and outcome of an adolescent male diagnosed with a thalamic DMG carrying a histone H3.3 K27M (H3K27M) alteration. Tumor biopsies were taken at diagnosis for histological analysis, molecular profiling, and ex vivo drug sensitivity testing (DST). Seven months after diagnosis, the patient had recurrent/progressive disease after radiotherapy and an ineffective molecular-guided therapy based on tumor molecular profiling. The patient then started a nove

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… Surgeries are indicated by diamonds: blue diamond, external shunt placement and septostomy (day 1); yellow diamond, external shunt removal and third ventriculostomy (day 7); red diamond, internal shunt placement and septostomy (day 226). …

Inflammatory markers from routine blood tests predict survival in multiple myeloma: a Systematic Review and meta-analysis.

BACKGROUND: Multiple myeloma (MM) is an incurable hematologic malignancy marked by abnormal plasma cell proliferation. Inflammatory indices derived from routine blood tests-such as neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), red cell distribution width (RDW), RDW-to-platelet ratio (RPR), and hemoglobin-to-RDW ratio (HRR)-have shown prognostic value across cancers. This meta-analysis aimed to evaluate their prognostic significance in MM. METHODS: Following PRISMA guidelines, a systematic search of PubMed, Embase, and Web of Scie

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… Red squares represent individual study estimates, and diamonds represent pooled estimates, all with confidence intervals. Each plot includes heterogeneity statistics and overall effect tests. … Each dot represents individual study results with 95% confidence intervals, and diamonds represent the overall effect. Heterogeneity is minimal across all panels. …

Sclerotic prostate cancer bone metastasis: woven bone lesions with a twist.

Bone metastases are the most severe and prevalent consequences of prostate cancer (PC), affecting more than 80% of patients with advanced PC. PCBMs generate pain, pathological fractures, and paralysis. As modern therapies increase survival, more patients are suffering from these catastrophic consequences. Radiographically, PCBMs are predominantly osteosclerotic, but the mechanisms of abnormal bone formation and how this pathological increase in bone density is related to fractures are unclear. In this study, we conducted a comprehensive analysis on a cohort of 76 cadaveric PCBM specimens and 1

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… The transverse surface of the embedded bone sections underwent grinding using a series of decreasing grit carbide papers and subsequently polished using a 1 μm diamond suspension. … This irregular sclerotic bone protruded from the trabecular surface into, and often occupied most of, the intertrabecular/medullary space (diamonds). …

Acupuncture for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis with Trial Sequential Analysis.

BACKGROUND: Effective options for managing chemotherapy-induced peripheral neuropathy (CIPN) remain limited. Evidence supporting acupuncture for CIPN continues to accumulate, warranting a comprehensive synthesis to clarify its effects. METHODS: We searched eight databases and extracted study characteristics from the included studies. We assessed risk of bias using the Cochrane RoB 2 tool and graded the certainty of evidence using the GRADE framework. Meta-analyses evaluated CIPN symptoms, clinical effectiveness rate (ER), nerve conduction study (NCS) parameters, and quantitative sensory testi

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… Image C includes 9 studies, x-axis from -4 to 2, with a pooled diamond at -0.97 (95% CI: -1.35 to -0.60). Image D features 10 studies, x-axis from -4 to 2, with a pooled diamond at -1.34 (95% CI: -1.96 to -0.71). … Image C includes 9 studies, x-axis from -4 to 2, with a pooled diamond at -0.97 (95% CI: -1.35 to -0.60). Image D features 10 studies, x-axis from -4 to 2, with a pooled diamond at -1.34 (95% CI: -1.96 to -0.71). …

Смертельная диспропорция фусариоза во время вводного терапия для взрослой острой лимфоболической лейкемии у пациента с приорной множественной миеломой.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Bars indicate the duration of continuous treatments, whereas single markers indicate one-off administrations, treatment initiations, or discrete clinical events; downward triangles denote single administrations and the start of systemic antibacterial therapy, and diamonds denote clinical milestones, … The diagnosis of invasive fusariosis (D21) is highlighted by a star and by a vertical orange dashed line spanning both panels, with the open diamond indicating the onset of skin lesions two days earlier (D19); the shaded orange area delimits the interval of targeted antifungal therapy. …

Idiotypic DNA vaccination for the treatment of multiple myeloma: safety and immunogenicity in a phase I clinical study.

We report on the safety and immunogenicity of idiotypic DNA vaccination in a phase I, non-randomised, open-label study in patients with multiple myeloma. The study used DNA fusion gene vaccines encoding patient-specific single chain variable fragment, or idiotype (Id), linked to fragment C (FrC) of tetanus toxin. Patients in complete or partial response following high-dose chemotherapy and autologous stem cell transplant were vaccinated intramuscularly with 1 mg DNA on six occasions, beginning at least 6 months post-transplant; follow-up was to week 52. Fourteen patients were enrolled on study

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… ), MM11 ( open circles ), MM17 ( open squares ), MM19 ( open triangles ) and MM21 ( open diamonds ). … ), MM07 ( open circles ), MM10 ( open squares ), MM11 ( open triangles ), MM17 ( open diamonds ) and MM21 ( closed stars ). c One of 13 patients (MM19) generated an anti-Id IgG Ab response following vaccination, detectable against scFv ( closed circles ), but not paraprotein ( open circles ). …

Immediate and short-term effect of physical exercise on BDNF in multiple sclerosis patients: a systematic review and meta-analysis.

Low brain-derived neurotrophic factor (BDNF) concentrations have been found in individuals with multiple sclerosis (MS). Physical exercise is an effective strategy for acutely increasing the levels of this neurotrophin in various populations; nevertheless, definitive results are still required for individuals with MS. Thus, this systematic review with meta-analysis aimed to analyze the acute and short-term effects of physical exercise on BDNF concentrations in MS patients. In this pre-registered systematic review (PROSPERO; ID: CRD42024505920), six electronic databases (PubMed-Medline, Scopus,

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… Black diamonds represent the overall effect of physical exercise session in people with MS. Immediate after session, Total: 1.52% (95% CI 0.11, 2.93, p = < 0.01); 30 min after session, Total: 0.45% (95% CI −2.17, 3.07, p = < 0.01). … Black diamonds represent the overall effect of physical exercise session in people with MS. 3-weeks of physical exercise, Total: 0.27% (95% CI 0.00, 0.54, p = < 0.40). …

Pancreatitis: TIGAR-O Version 2 Risk/Etiology Checklist With Topic Reviews, Updates, and Use Primers.

The Toxic-metabolic, Idiopathic, Genetic, Autoimmune, Recurrent and severe acute pancreatitis and Obstructive (TIGAR-O) Pancreatitis Risk/Etiology Checklist (TIGAR-O_V1) is a broad classification system that lists the major risk factors and etiologies of recurrent acute pancreatitis, chronic pancreatitis, and overlapping pancreatic disorders with or without genetic, immunologic, metabolic, nutritional, neurologic, metaplastic, or other features. New discoveries and progressive concepts since the 2001 TIGAR-O list relevant to understanding and managing complex pancreatic disorders require an up

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… Shwachman-Diamond syndrome. Shwachman-Diamond syndrome (SDS) is characterized by exocrine pancreatic insufficiency with hematologic abnormalities (e.g., cyclic neutropenia), skeletal defects, and short stature ( 118 ). … Diagnosis, treatment, and molecular pathology of shwachman-diamond syndrome. Hematol Oncol Clin North Am 2018;32:687–700. 119. Boocock GR, Morrison JA, Popovic M, et al. Mutations in SBDS are associated with Shwachman-Diamond syndrome. Nat Genet 2003;33:97–101. 120. …

Use of bisphosphonates in prostate cancer: Current status.

Bisphosphonates are a relatively newer class of drugs which have been used for the prevention of skeletal related complications of age related osteoporosis or metastatic disease from carcinoma breast or multiple myeloma. Their role in the management of prostate cancer is still under evolution. We hereby review the ongoing and some published randomized trials to define the role of bisphosphonates in various stages of prostate cancer.

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… Siddiqui NA Shetty KR Duthie EH Jr Osteoporosis in older men: Discovering when and how to treat it Geriatrics 1994 54 20 2 27 8 30 10494225 6 Oefelein MG Resnick MI The impact of osteoporosis in men treated for prostate cancer Urol Clin North Am 2004 31 313 9 15123410 10.1016/j.ucl.2004.02.002 7 Diamond … aid-cncr17>3.0.co;2-3 9 Shahinian VB Kuo YF Freeman JL Goodwin JS Risk of fracture after androgen deprivation for prostate cancer N Engl J Med 2005 352 154 64 15647578 10.1056/NEJMoa041943 10 Stock H Schneider A Strauss E Osteoporosis: A disease in men Clin Orthop Relat Res 2004 425 143 51 15292799 11 Diamond …

Diagnosis and management of neutropenia in adults: Expert guidance.

Neutropenia in general is defined as a blood neutrophil count of less than 1.5 × 109/L, in severe neutropenia counts drop to less than 0.5 × 109/L, but the definition of neutropenia varies according to the patient's ethnic origin and age. For Caucasian adults, the absolute neutrophil count (ANC) threshold of 1.8 × 109/L is adopted for the definition of neutropenia according to the World Health Organization (see Fioredda et al. (1)). It can be inherited or acquired, and it is an uncommon haematological finding in adult outpatient clinics. Neutropenia can result from decreased production of neut

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… Shwachman‐diamond syndrome: a review of the clinical presentation, molecular pathogenesis, diagnosis, and treatment. Hematol Oncol Clin North Am. 2009;23(2):233–248. 10.1016/j.hoc.2009.01.007 13. Reilly CR, Shimamura A. … Predisposition to myeloid malignancies in Shwachman‐diamond syndrome: biological insights and clinical advances. Blood. 2023;141:1513–1523. 14. Freedman MH, Bonilla MA, Fier C, Bolyard AA, Scarlata D, Boxer LA, et al. …

Impairment of vocational activities and financial problems are frequent among German blood cancer survivors.

Little is known about changes in the personal living conditions of long-term blood cancer survivors in Germany. To gather information about social relationships, work life, overall well-being, and religion, we performed a questionnaire-based retrospective study on 1551 survivors who had been on follow-up for ≥ 3 years (median, 9 years). Most survivors reported that marital status and relationships with relatives and friends remained constant before and after blood cancer. Vocational activities were temporarily impaired for 47.5%, with a median time of 11 months to return to work. More than a t

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… Box, range between the 25th and 75th percentile; whiskers, upper quartile with maximum and lower quartile with minimum, respectively; horizontal line, median; diamond, mean. … Box, range between the 25th and 75th percentile; whiskers, upper quartile with maximum and lower quartile with minimum, respectively; horizontal line, median; diamond, mean. …

Symptoms, unmet needs, and quality of life in Erdheim-Chester disease: a longitudinal registry-based analysis.

AbstractMeasurement of patient-reported outcomes (PROs) and health-related quality of life (HrQOL) are crucial for comprehensive, patient-centered cancer care. Both PROs and HrQOL have been understudied in patients with Erdheim-Chester disease (ECD), a rare cancer with protean manifestations, dense symptomatology, and frequent diagnostic delay. We sought to evaluate the longitudinal evolution of symptom burden and unmet supportive care needs in patients with ECD, and to identify associations between these PROs and HrQOL. A registry-based cohort of patients with ECD completed a PRO battery incl

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… Diamond EL, Durham BH, Haroche J, et al. Diverse and targetable kinase alterations drive histiocytic neoplasms. Cancer Discov. 2016;6(2):154–165. doi: 10.1158/2159-8290.CD-15-0913. 20. Goyal G, Heaney ML, Collin M, et al. … Diamond EL, Reiner AS, Buthorn JJ, et al. A scale for patient-reported symptom assessment for patients with Erdheim-Chester disease. Blood Adv. 2019;3(7):934–938. doi: 10.1182/bloodadvances.2018030502. 29. Mitchell HR, Applebaum AJ, Lynch KA, et al. …

The effectiveness of continuous subcutaneous insulin pumps with continuous glucose monitoring in outpatient adolescents with type 1 diabetes: A systematic review.

REVIEW QUESTION/OBJECTIVE: The review question is: Are metabolic outcomes improved in outpatient adolescents (aged 13 to 19 years) with type … 999, the World Health Organization (WHO) launched the Multinational Project for Childhood Diabetes (DIAMOND), which was tasked with assessing type 1 diabetes in those 14 years or younger worldwide . Finland was discovered to have the highest age-adjusted incidence at 40.9 cases per 100,000/year. The lowest age-adjusted incidence is in China and Venezuela …

Investigation of the Effectiveness of Surgical Treatment on Maxillary Medication-Related Osteonecrosis of the Jaw: A Literature Review.

AIM: Medication-related osteonecrosis of the jaw (MRONJ) occurs after exposure to medication (antiresorptive or antiangiogenic agents) for bone-related complications. It is more common in the mandible than in the maxilla. The present study investigated maxillary MRONJ in elderly patients through a meta-analysis. METHODS: Keywords, including "MRONJ", "maxilla", and "surgery", were entered into databases, including Embase, PubMed/MEDLINE, Cochrane Library, and ProQuest, which were searched systematically. RESULTS: Investigating 77 studies, we found that 18 (2 case reports and 16 case series) p

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… The pooled estimate is marked with an unfilled diamond at the bottom of the forest plot. CIs of pooled estimates are displayed as a horizontal line through the diamond, where the line might be contained within the diamond if the CI is narrow. …

Patterns and perceptions of supplement use among patients with plasma cell disorders.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Golombick T, Diamond TH, Manoharan A, Ramakrishna R. … Diamond T, Manoharan A, Ramakrishna R Long-term follow-up of curcumin treated MGUS/SMM patients – an updated single centre experience. Hematol Med Oncol. 2017;2. 10.15761/hmo.1000125 17. …

Непрозрачная онтология: нейроимAGING классификация групп диагнозов ICD-10 в UK Biobank.

Фон. Использование машинного обучения для классификации диагностических случаев по сравнению с контролем, определенным на основе диагностических онтологий, таких как десятая редакция Международной классификации болезней (ICD-10), на основе нейровизуальных признаков, сейчас является распространенной практикой в широком спектре диагностических областей. Однако сравнения, которые пересекают диагностику (transdiagnostic), таких классификаций отсутствуют. Такие трансдиагностические сравнения важны для определения специфичности классификационных моделей, установления бенчмарков и оценки ценности диа

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… The red diamond marks the mean classification accuracy obtained from random forest classification using StratifiedShuffleSplit cross-validation as a comparison. … Large red diamonds show mean classification accuracy of the best-performing classifier, while large black diamonds show mean classification accuracy across all classifiers. All classification results across different models are reported in Supplementary Table S8 . …

Всеобъемлющий и систематический обзор по вопросу о добавке ресвератрола в качестве перспективного кандидата в отношении болезни сетчатки сетчатки: акцент на механизмах действий на основе доклинических исследований.

Resveratrol — естественный полифенолический соединение, демонстрирующее большой потенциал нейрозащиты, борьбы с воспалением и антиоксидацией. Предыдущие исследования показали, что ресвератрол может эффективно лечить различные животные модели болезней сетчатки. ПУРПОСЕ: Цель исследования состояла в том, чтобы использовать экспериментальную модель животных для оценки эффективности лечения заболеваний, связанных с сетчаткой, в рамках различных видов заболеваний, связанных с животным, таких, как ишемия-реперциозная травма, диабетическая ретинопатия, глаукома, хроническая окулярная гипертония, опти

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… Horizontal lines represent confidence intervals, and all individual study results combine into a diamond at the bottom, indicating the overall effect size, favoring the experimental group. The heterogeneity statistics are provided below the plot. … Confidence intervals and mean differences are visualized as green squares with horizontal lines for CI, and black diamonds for overall effect, indicating directional favor towards experimental or control groups. …