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Alternating Current Is More Fatigable Than Pulsed Current in People Who Are Healthy: A Double-Blind, Randomized Crossover Trial.

OBJECTIVE: Tolerance level and rapid fatigue onset are limitations in the use of neuromuscular electrical stimulation (NMES) as an electrotherapeutic resource in rehabilitation and training protocols; however, it is unclear if pulsed current (PC) and alternating current (AC) produce different fatigue levels when applied at submaximal contraction level. The purpose of this study was to compare fatigue and discomfort levels between PC and AC during a submaximal contraction protocol in people who are healthy. METHODS: In this double-blind, randomized crossover trial conducted in a laboratory set

Ca2+ Signaling in Striated Muscle Cells During Intracellular Acidosis.

The cytosolic pH (pHi) of mammalian cells is tightly maintained at values ~7.2. Cytoplasmic acidosis (pHi < 6.8) occurs when the intracellular proton concentration ([H+]i) exceeds the buffering capacity of the cytosol and transport processes to extrude protons are exhausted. During intracellular acidosis, the contractility of cardiac and skeletal muscle cells is strongly reduced, often at sufficient Ca2+ levels. A contraction of striated muscle is achieved when the intracellular calcium (Ca2+) concentration rises above resting levels. The amplitude and kinetics of Ca2+ signals are controlled b

Unraveling the triad of immunotherapy, tumor microenvironment, and skeletal muscle biomechanics in oncology.

The intricate interaction between skeletal muscle biomechanics, the tumor microenvironment, and immunotherapy constitutes a pivotal research focus oncology. This work provides a comprehensive review of methodologies for evaluating skeletal muscle biomechanics, including handheld dynamometry, advanced imaging techniques, electrical impedance myography, elastography, and single-fiber experiments to assess muscle quality and performance. Furthermore, it elucidates the mechanisms, applications, and limitations of various immunotherapy modalities, including immune checkpoint inhibitors, adoptive ce

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… IFN-γ can inhibit respiratory chain complex activity in the mitochondria, reducing ATP production and resulting in muscle fatigue and weakness ( 142 ). … fatigue and soreness. …

Muscle ERRγ mitigates Duchenne muscular dystrophy via metabolic and angiogenic reprogramming.

Treatment of Duchenne muscular dystrophy (DMD) by replacing mutant dystrophin or restoring dystrophin-associated glycoprotein complex (DAG) has been clinically challenging. Instead, identifying and targeting muscle pathways deregulated in DMD will provide new therapeutic avenues. We report that the expression of nuclear receptor estrogen-related receptor-γ (ERRγ), and its metabolic and angiogenic targets are down-regulated (50-85%) in skeletal muscles of mdx mice (DMD model) vs. wild-type mice. Corelatively, oxidative myofibers, muscle vasculature, and exercise tolerance (33%) are decreased in

Effects of Delayed-Onset Muscle Pain on Respiratory Muscle Function.

BACKGROUND: Delayed-onset muscle soreness (DOMS) has been widely examined in the peripheral muscles; however, studies showing the potential effects of DOMS on respiratory function are limited. HYPOTHESIS: DOMS in trunk muscles has a negative effect on respiratory function parameters, respiratory muscle strength, respiratory muscle endurance, and exercise capacity. STUDY DESIGN: Prospective cohort study. LEVEL OF EVIDENCE: Level 2. METHODS: In 24 healthy participants with a mean age of 21 ± 2 years, DOMS was induced for the trunk muscles with a load equal to 80% of the maximum repetitive vo

Comparative efficacy of active recovery and cold water immersion as post-match recovery interventions in elite youth soccer.

The current study compared cold-water immersion (CWI) and active recovery (AR) to static stretching (SS) on muscle recovery post-competitive soccer matches in elite youth players (n = 15). In a controlled crossover design, participants played a total of nine competitive soccer games, comprising three 80 minute games for each intervention (SS, CWI and AR). Muscle oedema, creatine kinase (CK), countermovement jump performance (CMJA) and perceived muscle soreness (PMS) were assessed pre-, immediately post-, and 48 hours post-match and compared across time-intervals and between interventions. Foll

Properties of Paraspinal Muscles in Japanese High School Baseball Players With Terminal-Stage Lumbar Spondylolysis.

BACKGROUND: Lumbar spondylolysis is a defect in the pars interarticularis that is common in young athletes; the stress distribution at the pars interarticularis is the highest in extension and rotation movements. The paraspinal muscles play an important role in stabilization of the lumbar spine; however, no study has assessed the properties of paraspinal muscles in athletes with lumbar spondylolysis. OBJECTIVE: To evaluate the properties of paraspinal muscles in athletes with lumbar spondylolysis. DESIGN: Cross-sectional study. SETTING: Laboratory. PARTICIPANTS: Six high school baseball pl

Post-exercise home-based hot-bathing with/without light exercise: effects on physiological adaptations to short-term high-intensity resistance training in healthy young men.

BACKGROUND: High-intensity resistance training (RT) improves strength via neuromuscular adaptations but also heightens fatigue, potentially limiting gains. Whether post-exercise, home-based hot-bathing, with or without light-exercise, reduces these limitations and enhances neuromuscular adaptations remains unknown. The aims were: 1) to investigate whether home-based hot-bathing improves muscle strength gain and peripheral/central conditions in response to short-term high-intensity RT, and 2) assess whether combining hot-bathing with light exercise augments these benefits, both in healthy young

[Anti-exercise fatigue and mechanism of Keap1/Nrf2 pathway in liver of aqueous extract of aronia melanocarpa].

OBJECTIVE: To investigate the anti-fatigue effect of aqueous extract of aronia melanocarpa on exhausted running mice and its mechanism. METHODS: A mouse model of exhaustive running was used to observe the effects of different doses of aqueous extract of aronia melanocarpa on the time of exhaustive running, and the biochemical indicators such as lactic acid, urea nitrogen and liver/muscle glycogen in the serum of mice were measured to evaluate the anti-exercise-induced fatigue effect in mice. The antioxidant effect of the aqueous extract of aronia melanocarpa was investigated by measuring MDA

Measuring the Effects of the Commonest Exercise Programs on Subjective Fatigue in People with Multiple Sclerosis: A Randomized Effectiveness Trial.

PURPOSE: To test and compare the effects of the four most common exercise-based interventions employed to manage subjective fatigue and functional impairments due to multiple sclerosis. METHODS: Persons with multiple sclerosis complaining of fatigue as a main symptom were enrolled. After a comprehensive baseline assessment evaluating subjective fatigue impact and severity (primary endpoints), quality of life, cardiorespiratory performance, and mobility and motor-functional outcomes, participants were randomly assigned to an 8-wk intervention consisting of strength training (ST) or aerobic tra

Assessment of functional recovery in tennis elbow.

OBJECTIVES: (a) To investigate changes in muscular strength, fatigue and activity in recovered tennis elbow (RTE); (b) to assess the appropr … included metacarpophalangeal (MCP), wrist, shoulder and grip isometric strength and EMG measures of muscle fatigue and activity for five forearm muscles (wrist extensors and flexors). RESULTS: Strength was greater (p<0.05) for all measurements in C compared to RTE and TE except for MCP extension. Only MCP extension was stronger in RTE than TE. EMG revealed incr …

Activity-dependent conduction block in multifocal motor neuropathy: magnetic fatigue test.

BACKGROUND: Multifocal motor neuropathy (MMN) is often misdiagnosed as motor neuron disease, especially when overt evidence of conduction block (CB) is lacking. Activity-dependent CB (ADCB), defined as transient CB induced by brief exercise, has been recently found in MMN but not in ALS. METHODS: To test the diagnostic utility of ADCB for differentiating MMN from ALS, the authors recorded the compound muscle action potentials (CMAPs) from small hand muscles by magnetically stimulating nerve roots before and after 1 minute of maximal voluntary contraction (magnetic fatigue test). They examined

Warming up improves speech production in patients with adult onset myotonic dystrophy.

UNLABELLED: This investigation was conducted to study whether warming up decreases myotonia (muscle stiffness) during speech production or causes adverse effects due to fatigue or exhaustion caused by intensive speech activity in patients with adult onset myotonic dystrophy. Thirty patients with adult onset myotonic dystrophy (MD) and ten healthy controls were examined, using a protocol that requires subjects, to speak continuously for at least 10 min. In MD patients, warming up led to an increase in speech rate and a decrease in speech variability without causing signs of fatigue or exhaustio

[Effects of sheng mai injection on thoracoabdominal motion].

Diaphragmatic muscle fatigue (DMF) has long been recognized as causing and developing respiratory failure in patients with chronic obstructive pulmonary disease (COPD). Paradoxical motion of thoraco-abdomen is one of asynchronous breathing pattern, which is clinical sign of DMF. Thoracoabdominal motion curves were recorded with impedance respirograph (IRG). Indexes, alpha and M on IRG correlated well to the degrees of asynchronous breathing movement. 30 patients with COPD, their IRG showed paradoxical motion of thoraco-abdomen were divided randomly into two groups of 15 cases. Group A was trea…

Polyphenols and post-exercise muscle damage: a comprehensive review of literature.

Recent research highlights the significant role of polyphenols in alleviating post-exercise muscle damage, thus positioning them as a valuab … erefore, we reviewed relevant studies in order to show how efficient polyphenols can be in reducing muscle fatigue and damage and what are the exact mechanisms.

Proteomic analysis reveals that Polygonatum cyrtonema Hua polysaccharide ameliorates mice muscle atrophy in chemotherapy-induced cachexia.

Polygonatum cyrtonema Hua polysaccharide (PCP) is the main bioactive compound derived from the herb Polygonati Rhizoma, known for its anti-fatigue, antioxidant, immunomodulatory, and anti-inflammatory properties. However, its effectiveness on alleviating chemotherapy-induced muscle atrophy has been unclear. In this study, we utilized proteomic analysis to investigate the effects and mechanisms of PCP on gemcitabine plus cisplatin (GC) induced muscle atrophy in mice. Quality control analysis revealed that the functional PCP, rich in glucose, is a heterogeneous polysaccharide comprised of nine m

Rotavirus-Associated Myositis in a 12-Year-Old Child.

Rotavirus infection is a common cause of pediatric gastroenteritis, often self-limited but occasionally associated with extraintestinal complications. This report describes a 12-year-old vaccinated girl who presented with acute gastroenteritis and an incidental elevation of serum creatine kinase (CK). Despite the absence of muscle pain or weakness during hospitalization, laboratory findings indicated skeletal muscle involvement, with elevated CK and aldolase levels, and a predominance of CK-MM isoenzyme. Myocardial involvement and rhabdomyolysis were ruled out. The patient recovered with suppo

Occurrence of butyrylcholinesterase polymorphisms in patients undergoing surgery in Slovakia.

BACKGROUND: Post-operative residual curarization is a persisting problem, characterized by muscle fatigue, exhaustion or paresis, caused by the use of neuromuscular blocking agents with prolonged postoperative effect. Genetically, determined changes in cholinesterase activity can be a major reason for persistent muscle blockade after administration of muscle relaxants. METHODS: Regarding the subsistence of polymorphisms in the plasma cholinesterase gene causing change in enzyme activity and metabolism of applied drugs, we investigated the frequency of two polymorphisms known to reduce its act…