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Expanding your use of silicone hydrogel contact lenses: using lotrafilcon A for daily wear.

OBJECTIVE: The purpose of this study was to profile contact lens (CL) experience among patients in eyecare practitioner (ECP) offices and th … line had less frequent early removal during the day, burning or stinging, uncomfortable lenses, and photophobia while reporting more problems inserting and removing lenses. No adverse events were reported with lotrafilcon A CLs. Adapted CL wearers showed improved clinical signs, subjective symptoms, and comfort when changed to lotrafilcon A for DW. New or for …

Clinical characteristics and patterns of medication use of migraneurs in Latin America from 12 cities in 6 countries.

OBJECTIVE: The objective of this study was to document the clinical characteristics of migraine and patterns of medication use in residents … the migraineurs, 94.2% reported moderate to severe pain. Associated symptoms of nausea or vomiting, photophobia, phonophobia, and osmophobia were common during migraine attacks in 30.3, 76.4, 85.1, and 47.7% of subjects, respectively. The majority of subjects suffered between one and eight migraines each month. Although no previous diagnosis of migraine was r …

Oral magnesium oxide prophylaxis of frequent migrainous headache in children: a randomized, double-blind, placebo-controlled trial.

OBJECTIVE: To assess whether, in children, oral magnesium oxide reduces migrainous headache frequency, severity, and associated features com … ate-to-severe headache with a throbbing or pulsatile quality, associated anorexia/nausea, vomiting, photophobia, sonophobia, or relief with sleep, but no fever or evidence of infection. Subjects were randomly assigned to receive either magnesium oxide (9 mg/kg per day by mouth divided 3 times a day with food) (n = 58) or matching placebo (n = 60) for 16 weeks …

Comparison of preference for rizatriptan 10-mg wafer versus sumatriptan 50-mg tablet in migraine.

Rizatriptan (MAXALT, a registered trademark of Merck & Co. Inc.) is a selective 5-HT(1B/1D) receptor agonist with rapid oral absorption and … also superior to sumatriptan in terms of the proportions of patients with no nausea, phonophobia or photophobia, and patients with normal function 2 h after treatment intake (p < 0.05). More patients were (completely, very or somewhat) satisfied 2 h after treatment with rizatriptan (73.3%) than 2 h after treatment with sumatriptan (59.0%) (p < or = 0.001). Ad …

Cloning of a human homologue of the Xenopus laevis APX gene from the ocular albinism type 1 critical region.

Ocular albinism type 1 (OA1) is an X-linked recessive disorder characterized by a major impairment of visual acuity, nystagmus, strabismus, photophobia and retinal hypopigmentation. From the analysis of patients carrying deletions and translocations involving the distal short arm of the X chromosome (Xp22.3) we have identified a region of approximately 110 kb in which the OA1 gene must lie. We have extensively searched for genes in this region using a variety of techniques which included exon amplification, cDNA selection and direct hybridization of cosmid inserts to cDNA libraries. Putative e…

Aseptic meningitis associated with high-dose intravenous immunoglobulin therapy: frequency and risk factors.

OBJECTIVE: Intravenous immunoglobulin is widely used to treat various autoimmune disorders. After observing instances of aseptic meningitis … completion of the infusions. Symptoms, lasting 3 to 5 days, included severe headache, meningismus, photophobia, and fever. Cerebrospinal fluid showed pleocytosis in 4 patients (leukocyte count as high as 1169 x 10(6)/L in one patient), eosinophilia in 3 patients, and IgG elevation in all patients (as great as 7 times the upper limit of normal in one patient) …

Neuro-ophthalmic presentation of cone dysfunction syndromes in the adult.

Cone dysfunction syndromes are probably part of the spectrum of cone-rod degenerations and can present with widely varying clinical pictures … ion in twilight or under dim illumination. Patients may falsely describe hemeralopia as "glare" or "photophobia." Careful testing of color vision, a meticulous tangent screen examination, and specifically looking for diffuse narrowing of retinal arterioles in a patient with an otherwise normal fundus appearance will usually suffice to prompt the clinician to …

Genistein mitigates nitroglycerine-induced migraine: modulation of nitric oxide-mediated vasodilation and oxidative stress.

Migraine is a widespread brain condition described by frequent, recurrent episodes of incapacitating, moderate-to-severe headaches with thro … el. Genistein (20 mg/kg) significantly mitigated the facial-unilateral head pain, spontaneous pain, photophobia, and anxiety-like behavior induced by nitroglycerine. Biochemical analysis showed that genistein (20 mg/kg) significantly abrogated the nitroglycerine-induced lipid peroxidation and increased serum TNF-α level. Genistein treatment also upregulated t …

Pineal germ cell tumors: review.

BACKGROUND: Primary intracranial germ cell tumors represent a rare category of neoplasms, which occur in children and young adults. The WHO … erved in a 26-year-old male with presentation of an eye-sight disorder with focusing difficulty and photophobia, accompanied by intensive fatigue and sleepiness, nausea with occasional vomiting, intermittent headaches and Parinauds syndrome. MRI examination of the brain showed tumor expansion in the pineal region and in the right part of the mesencephalon. Ra …

Botulinum toxin in migraine prophylaxis.

Migraine is a chronic headache disorder manifesting in attacks lasting 4-72 hours. Characteristics of headache are unilateral location, pulsating quality, moderate or severe intensity, aggravation by routine physical activity, and association with nausea, photophobia and phonophobia. The migraine aura is a complex of neurological symptoms, which occurs just before or at the onset of migraine headache. Botulinum toxin A represents a completely new option for patients with chronic pain conditions. Numerous retrospective open-label chart reviews and 4 double-blind, placebo-controlled studies have…

Clinical features of abdominal migraine: a systematic review and summary of data from 662 patients.

BACKGROUND: Abdominal migraine (AM) is an episodic syndrome characterized by recurrent, self-limiting episodes of abdominal pain with autono … while nausea (66.1%), vomiting (53.6%), and headache (47.1%) were common in a cohort of 448 cases. Photophobia, pallor, and anorexia were also frequently observed. Triptans showed the highest acute efficacy (98.04%, 50/51), versus 62.5% (5/8) for NSAIDs. Prophylactics were highly effective: anticonvulsants (95.0%, 19/20), beta-blockers (100%, 12/12), and ant …

The impact of vision impairment on living with congenital aniridia: a pan-European survey study.

BACKGROUND: Congenital aniridia is a rare but severe eye disease stemming from genetic variants in PAX6 or related genes and affecting all e … tative statistical comparisons. RESULTS: Of 295 survey respondents (age range 0-79, 58.3% female), photophobia was the most prevalent symptom experienced daily by 83%, followed by 42% experiencing daily dryness, 34% reporting unstable vision daily and 20% experiencing daily ocular pain. 51% of those aged 19 years or younger experienced ocular pain once or mo …

Photobiomodulation therapy for children's eye and vision conditions.

BACKGROUND: Photobiomodulation (PBM) is a non-invasive, light-based technology that stimulates cellular mechanisms, with therapeutic effect … arly myopia and blepharitis. It appears generally safe, with transient adverse effects such as mild photophobia and dry eye. CONCLUSIONS: Further research is needed to optimise protocols and assess sustained efficacy and safety for widespread clinical adoption.

Expanding the clinical spectrum: A case report of the first Jordanian presentation of KID syndrome with neurological and skeletal anomalies beyond the classical triad.

RATIONALE: Keratitis-ichthyosis-deafness (KID) syndrome is a rare ectodermal disorder caused by pathogenic mutations in GJB2 gene, which enc … t 31 weeks of gestation presented with a history of global developmental delay, recurrent seizures, photophobia, and thick hyperkeratotic skin changes. At birth, she was encased in a collodion membrane and exhibited bilateral eyelid malposition. Her development was marked by delayed milestones, joint stiffness, and poor weight gain. DIAGNOSES: Clinical findi …

Emergent Meningoencephalitis Following Spinal Anesthesia: A Case Report.

Background: Iatrogenic meningitis is a rare but increasingly reported condition, particularly following invasive spinal procedures. The inci … se Presentation: A 32-year-old previously healthy male presented with severe headache, phonophobia, photophobia, nuchal rigidity, and fever, one day after undergoing anterior cruciate ligament (ACL) reconstructive surgery under spinal anesthesia. Initial evaluation revealed a Glasgow Coma Scale (GCS) score of 11, leukocytosis with neutrophilia, and turbid CSF …

Evaluating associations of migraine-related vertigo.

OBJECTIVE: We set out to examine detailed phenotypic data from our clinic for associations of vertigo in chronic migraine. BACKGROUND: Vert … (n = 562), potential associations of interest for the presence of vertigo (gender, allodynia, aura, photophobia, phonophobia and osmophobia, baseline headache frequency, number of premonitory symptoms, presence of cranial autonomic symptoms, and age) were analyzed using a regression model (IBM SPSS v 29). Missing data were excluded (final n = 435). RESULTS: …

Безопасность неураксиальной анестезии у пациентов с множественным склерозом: систематический обзор результатов наблюдений.

ВВЕДЕНИЕ: Безопасность неураксиальной анестезии у пациентов с множественным склерозом (МС) является одним из важнейших вопросов для обсуждения в рамках клинической практики. Цель этого обзора состоит в том, чтобы оценить безопасность нервной анестезии у пациентов с НР путем изучения случаев возникновения неблагоприятных неврологических последствий, включая частотность рецидивов и появление новых неврологических симптомов. МЕТОДЫ: Со времени создания нескольких баз данных, включая PubMed, Embase, Cochrane Bibrary, Web of Science, Scopus и CINAHL, до ноября 2024 года был проведен всесторонний по

Совпадение в аннотации оригинала
INTRODUCTION: The safety of neuraxial anesthesia in patients with multiple sclerosis (MS) is a critical area of discussion within clinical p … Complications were reported in 15 studies (44.2 %), with six case reports detailing issues such as photophobia and neurological deficits that could worsen MS symptoms. While six case series noted complications like postpartum relapses, retrobulbar neuritis, and dysesthesia, most patients did not experience significant adverse effects. Among cohort studies in …

Cohort profile: migraine exposures and cardiovascular health in Hong Kong Chinese women (MECH-HK).

PURPOSE: Evidence about the associations of migraine features with cardiovascular risk profiles in Chinese population is lacking. The Migrai … nd stress (54.0%) were the top triggers, while prevalent accompanying symptoms were nausea (67.4%), photophobia (39.9%), phonophobia (30.0%) and vomiting (26.2%). Migraine auras included blurred visions (59.6%), flashing lights (41.3%), blind spots (33.0%), pins and needles (6.4%) and halo (1.8%). FUTURE PLANS: The follow-up for the cohort will be implemente …

Photokeratitis in Outdoor Event Participants Exposed to UV Radiation Display.

IMPORTANCE: While UV radiation displays may be used for recreational purposes at outdoor events, unprotected eyes have been reported to have … ilaterally. All patients experienced eye pain, 6 experienced red eye, and 5 experienced tearing and photophobia. Mean (SD) presenting visual acuity was logMAR 0.10 (0.14) (approximate Snellen equivalent, 20/25) for right eyes and 0.06 (0.89) (approximate Snellen equivalent, 20/25) for left eyes. On examination, there were findings of cornea and conjunctival i …

Acute Pain Transfusion Reaction: A Case Report.

Transfusion-related adverse events involving packed red blood cells (PRBCs) and fresh frozen plasma (FFP) are not unusual. Reactions can happen at any time during the transfusion, as well as hours or days later. An acute pain transfusion reaction (APTR) is defined as sudden, intense joint pain, usually in the back and trunk, that appears right after transfusion after all other potential causes of transfusion reactions have been eliminated. The present article discusses two similar cases. A 38-year-old female presented with complaints of right-sided headache and photophobia for four days, assoc…