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Interpreting abdominal fluid in colic horses: Understanding and applying peritoneal fluid evidence.

BACKGROUND: Interpreting changes in peritoneal fluid helps clinicians manage colic and other diseases in horses. During abdominal problems in the horse, abdominal fluid characteristics such as color, turbidity, total nucleated and red blood cell counts, cytology, total protein, and l-lactate change in predictable ways, helping the clinician characterize the disease. DESCRIPTION: Normal abdominal fluid in horses is odorless, clear to light yellow in color, and transparent. Peritoneal fluid becomes more turbid with increasing levels of protein, number of WBCs or RBCs, or with gross contaminatio

Ruptured cerebral pseudoaneurysm in an adolescent as an early onset of COVID-19 infection: case report.

The clinical manifestations of coronavirus disease 2019 (COVID-19) are non-specific and multi-inflammatory. They vary from mild to severe manifestations that can be life-threatening. The association of SARS-CoV-2 infection and pseudoaneurysm formation or rupture of an already existing aneurysm is still unexplored. Several mechanisms may be involved, including the direct destruction to the artery by the viral infection or through the release of the inflammatory cytokines. We are presenting a case of a 13-year-old girl with a ruptured cerebral pseudoaneurysm of the left middle cerebral artery (M

Gastrointestinal complications of cocaine use: a narrative literature review.

BACKGROUND: Cocaine is the second most widely used illicit substance worldwide and exerts potent sympathomimetic effects by inhibiting the reuptake of norepinephrine, dopamine, and serotonin. While cardiovascular and neurological complications are well recognized, gastrointestinal (GI) manifestations are increasingly reported. These arise from multifactorial mechanisms including vasospasm, endothelial dysfunction, thrombosis, ischemia, and direct mucosal toxicity, often with severe clinical consequences. OBJECTIVE: This narrative review summarizes the mechanisms, pharmacokinetics, pharmacodyn

[Application of channel screw combined with skin-stretching technique in treatment of pelvic fracture with severe Morel-Lavallée lesion].

OBJECTIVE: To investigate the effectiveness of channel screw combined with skin-stretching technique in treatment of pelvic fracture with se … ocks in 8 cases, hips in 2 cases, and thigh in 1 case. There was 1 case of rectal injury, 1 case of splenic rupture, 3 cases of craniocerebral injury, 2 cases of chest injury, 4 cases of spinal fracture, and 6 cases of sacral nerve injury. X-ray films were performed to observe reduction and healing of fracture. The quality of fracture reduction was evaluated by M …

Nonparasitic splenic cysts in children: Current status.

BACKGROUND: at present, the management of nonparasitic splenic (NPS) cysts in children is not well described in literature. The aim of this study was to evaluate the current status of NPS cysts in the world literature and develop some higher level of evidence in the management of this disease entity. In this study, we have also included our experience with NPS cysts. METHODS: a systematic study of NPS cysts published in the English literature, between the periods of 1989-2008, was performed. The data were analyzed with respect to the type of cysts, mode of presentation, patient's demography,

Reinterventions after fenestrated and branched endografting for degenerative aortic aneurysms.

OBJECTIVE: Fenestrated/branched endovascular abdominal aortic aneurysm repair (F/B-EVAR) is widely accepted technique to treat juxta/pararenal abdominal aortic aneurysms (J/P-AAAs) and thoracoabdominal aortic aneurysms (TAAAs) for patients at high-surgical risk. However, the follow-up results should be carefully evaluated, especially in terms of the reintervention rate. The aim of the present study was, therefore, to evaluate the early and mid-term reinterventions after FB-EVAR for J/P-AAAs and TAAAs and their effects on follow-up survival. METHODS: From 2006 to 2019, all consecutive patients

Vertebral fracture and splenomegaly in a head and neck cancer producing granulocyte colony-stimulating factor: A case report of systemic complications associated with a cytokine-producing solid tumor.

Granulocyte colony-stimulating factor (G-CSF)-producing tumors are rare and are associated with a poor prognosis when they occur in the lungs and the head and neck region. Positron emission tomography/computed tomography has been reported to show systemic specific accumulation of fluorodeoxyglucose in these cases, but the systemic complications associated with the cytokines produced are not well known. We herein present the case of a G-CSF-producing maxillary sinus squamous cell carcinoma in a 73-year-old Japanese woman with a vertebral fracture and splenomegaly. These findings are known sever

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… The adverse events of recombinant human G-CSF (rhG-CSF) administered to mobilize peripheral blood stem cells include spinal bone pain and osteoporosis (with vertebral fractures in severe cases), myocardial infarction, stroke and splenomegaly (with splenic rupture in severe cases). … Aubrey-Bassler FK, Sowers N. 613 cases of splenic rupture without risk factors or previously diagnosed disease: A systematic review. BMC Emerg Med. 2012;12(11) doi: 10.1186/1471-227X-12-11. 16. Alshamrani MA, Al-Foheidi M, Abdulrahim AH. …

Приобретенный изолированный фактор VII Недостаток в ячейке Плазмы: краткое представление Two Дела, связанные с Плазмой-Келл-Леукемией, и обзор литературы.

Приобретенный изолированный фактор VII (FVII) недостаток является редким, но важным открытием у пациентов с расстройствами плазменных клеток, имеющими значительные терапевтические и прогнозные последствия. Цель настоящего анализа и обзора случаев, о которых сообщается в литературе, состоит в том, чтобы высветить связанные с болезнями характеристики, связанные с этим редким свертываемым дефектом, клиническими проявлениями и результатами, а также потенциальными основополагающими механизмами и дать руководящие указания в отношении методов лечения этих пациентов с точки зрения профилактических и т

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… Overall, in six out of nine cases, including the three personal cases reported here, hepatosplenomegaly has been documented, in two cases evolving to splenic rupture. … Case of factor VII deficiency with systemic amyloidosis having a unique clinical course such as splenic rupture Nihon Naika Gakkai Zasshi 1997 86 314 316 9139071 13. Hu H. Wang L. Xu H. Peng J. Jia Y. …

Efficacy and Safety of Pegfilgrastim in Patients With Severe Congenital Neutropenia.

BACKGROUND: Severe congenital neutropenia (SCN) is commonly treated with granulocyte colony-stimulating factor (G-CSF) to reduce neutropenia and the associated risk of infections. Pegfilgrastim, a long-acting form of G-CSF, provides the benefit of less frequent dosing; however, its application in SCN has not been extensively studied. This study aims to assess the long-term safety and effectiveness of transitioning SCN patients from standard G-CSF therapy to pegfilgrastim. METHODS: We followed eight patients with severe congenital neutropenia (five males, average age 17.8 years) who had been o

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… No cases of acute respiratory distress syndrome (ARDS), thrombocytopenia, splenic rupture, skin rash, or headache were reported. Furthermore, no malignancies or cancers were observed in any of the patients. … Idress , “ Splenic Rupture, Secondary to G‐CSF Use for Chemotherapy Induced Neutropenia: A Case Report and Review of Literature ,” Cases Journal 1 ( 2008 ): 418 , 10.1186/1757-1626-1-418 . 19108744 PMC2615768 24 D. C. Dale , T. E. Cottle , C. J. …

[Collection of hematopoietic progenitor cells from healthy donors].

Allogeneic hematopoietic progenitor cell (HPC) transplantation is an established therapy for many hematologic disorders. HPCs may be collect … ild side effects, moderate to life-threatening complications are sporadically observed. Spontaneous splenic rupture, acute lung injury, acute iritis, severe pyogenic infections, and anaphylactoid reactions were reported in healthy donors after G-CSF administration. Adverse effects of apheresis for PBPC collection are the same as for other apheresis procedure and …

Review of oncological emergencies in small animal patients.

Oncological emergencies can occur at any time during the course of a malignancy and need to be recognized promptly to maximize successful outcomes. Emergencies are characterized as chemotherapy-induced, paraneoplastic syndromes, or directly related to the neoplasm. Prompt identification with treatment of these emergencies can prolong survival and improve quality of life, even in the setting of terminal illness. This review aims to educate the reader on the pathophysiology, clinical presentation and treatment of some of these emergencies, and to review the current veterinary literature to help

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… For dogs and cats presenting with haemorrhagic peritoneal effusion, malignancy is the most common cause, usually secondary to splenic ruptures (Mandell & Drobatz 1995 ; Pintar et al . 2003 ). …

Theatrical fire pursuant exploratory laparotomy.

Fire in the operating theater is a rare but potentially fatal complication. We report igniting an intraperitoneal fire while preforming an exploratory laparotomy for perforated viscus. Fortunately, the patient suffered no injuries as a result.

Infarcts and ischemia in the abdomen: an imaging perspective with an emphasis on cross-sectional imaging findings.

Infarcts and ischemia of abdominal organs may present with acute abdominal pain, and early diagnosis is crucial to prevent morbidity and mortality. Unfortunately, some of these patients present in poor clinical conditions to the emergency department, and imaging specialists are crucial for optimal outcomes. Although the radiological diagnosis of abdominal infarcts is often straightforward, it is vital to use the appropriate imaging modalities and correct imaging techniques for their detection. Additionally, some non-infarct-related abdominal pathologies may mimic infarcts, cause diagnostic con

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… Parenchymal abscesses, pseudocyst formations, splenic rupture, and hemorrhage are among the potential complications of SIs [ 48 , 49 ]. … However, this approach has largely been abandoned in modern practice due to several severe complications associated with the procedure, such as abscess formation, splenic rupture, and life-threatening sepsis. …

Adverse Reaction to COVID-19 mRNA Vaccination in a Patient With VEXAS Syndrome.

VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a rare genetic disorder originating from a somatic mutation in the hematopoietic stem cells. This syndrome was first described in 2020 and carries many clinical features that other conditions cannot explain. Widespread autoinflammation is the primary process the disease presents, with high morbidity and mortality in those who show signs of bone marrow failure. Treatment is complex, and response to current therapies is poor. Long-term prognosis carries a mortality of 50%. In addition, the advancement of new-generation

Is It Better to Mobilize Hematopoietic Stem Cells With Pegfilgrastim in Healthy Donors During Allogeneic Hematopoietic Stem Cell Transplantation?

The mobilization of hematopoietic stem cells (HSCs) using granulocyte colony-stimulating factor is a classic method. Recently, a single injection of pegfilgrastim was used to mobilize CD34+ cells in some small-sample studies. To confirm the efficacy and safety of pegfilgrastim in the mobilization of CD34+ cells from healthy donors, we conducted a retrospective multicenter study. A total of 146 healthy donors who all received subcutaneous pegfilgrastim (12 mg) on day 1 were enrolled in our study. Donor HSC apheresis was conducted on day 5. The primary endpoint was the percentage of donors from

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… There was no cases of splenic rupture or thrombosis in our study or in other pegfilgrastim-induced mobilization studies. Splenomegaly was not detected after PEG mobilization in our observation. … Spontaneous splenic rupture in a healthy allogeneic donor of peripheral-blood stem cell following the administration of granulocyte colony-stimulating factor (g-csf). A case report and review of the literature. Haematologica. (2006) 91:ECR08. 30. Hunter MG, Druhan LJ, Massullo PR, Avalos BR. …

Prolonged Cytopenia with CAR-T Cell Therapy and Management Recommendations.

Chimeric antigen receptor T-cell (CAR T-cell) therapy has revolutionized the treatment of lymphoid malignancies. Prolonged cytopenias, though poorly understood, have emerged as important considerations in the treatment process. In this review, we classified cytopenias into early (< 30 days post CAR T infusion), and late-occurring (after day 30 post infusion). We identified previous chemotherapy and lymphodepletion chemotherapy as the major risk factors contributing to early cytopenia. Product characteristics, such as costimulatory domains, and side effects of therapy such as cytokine release s

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… Spontaneous splenic rupture in a healthy allogeneic donor of peripheral-blood stem cell following the administration of granulocyte colony-stimulating factor (g-csf). A case report and review of the literature. Nuamah N. M., Goker H., Kilic Y. A.., et al. 2006Haematologica. 91(5 Suppl):Ecr08. … Splenic rupture, secondary to G-CSF use for chemotherapy induced neutropenia: a case report and review of literature. Masood N., Shaikh A. J., Memon W. A.., et al. 2008Cases J. 1(1):418. doi: 10.1186/1757-1626-1-418. …

Hematopoietic stem cell transplantation.

More than 25,000 hematopoietic stem cell transplantations (HSCTs) are performed each year for the treatment of lymphoma, leukemia, immune-deficiency illnesses, congenital metabolic defects, hemoglobinopathies, and myelodysplastic and myeloproliferative syndromes. Before transplantation, patients receive intensive myeloablative chemoradiotherapy followed by stem cell "rescue." Autologous HSCT is performed using the patient's own hematopoietic stem cells, which are harvested before transplantation and reinfused after myeloablation. Allogeneic HSCT uses human leukocyte antigen (HLA)-matched stem

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… haematoma in a multiple myeloma patient receiving pegfilgrastim support Clin Lab Haematol 2006 28 416 418 17105496 10.1111/j.1365-2257.2006.00819.x 43 Masood N Shaikh AJ Memon WA Idress R Splenic rupture, secondary to G-CSF use for chemotherapy induced neutropenia: a case report and review of literature … Cases J 2008 1 418 19108744 10.1186/1757-1626-1-418 PMC2615768 44 Nuamah NM Goker H Kilic YA Dagmoura H Cakmak A Spontaneous splenic rupture in a healthy allogeneic donor of peripheral-blood stem cell following the administration of granulocyte colony-stimulating factor (g-csf). …

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