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Drug-induced herpes zoster: a pharmacovigilance analysis of FDA adverse event reports from 2004 to 2024.

BACKGROUND: Herpes zoster severely impacts patients' quality of life and therapeutic results. This research utilized data from the FDA Adverse Event Reporting System (FAERS) to examine the prevalence and attributes of drug-induced herpes zoster. METHODS: We analyzed FAERS reports about zoster from Q1 2004 to Q3 2024 and developed a list of possible pathogenic agents. Ranked the 30 medicines with the greatest incidence of reported herpes zoster cases. Statistical disproportionality analysis was employed to identify an elevated reporting frequency of herpes zoster linked to a particular medicat

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… For example, the package insert of tramadol does not mention the risk of hypoglycemia, but both the literature and the study by Juba et al. based on the FAERS database have confirmed this association ( Li et al., 2024 ). This study also presents some limitations that should be acknowledged. …

Overview of Ankle Arthropathy in Hereditary Hemochromatosis.

Hereditary hemochromatosis (HH) is an autosomal recessive bleeding disorder characterized by tissue overload of iron. Clinical systemic manifestations in HH include liver disease, cardiomyopathy, skin pigmentation, diabetes mellitus, erectile dysfunction, hypothyroidism, and arthropathy. Arthropathy with joint pain is frequently reported at diagnosis and mainly involves the metacarpophalangeal and ankle joints, and more rarely, the hip and knee. Symptoms in ankle joints are in most cases non-specific, and they can range from pain and swelling of the ankle to deformities and joint destruction.

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… Opiods : evidence concerning opioid use (such as Tramadol, Morphine, Oxycodone) is weak and not supported by the literature. Currently, their use is contraindicated or accepted only as a third line of treatment [ 62 ]. …

Neurotropin alleviates rat osteocarcinoma pain via P2X3 receptor activation in the midbrain periaqueductal gray.

ObjectivesClinically effective analgesia treatment for patients afflicted with osteocarcinoma lessens the intensity of pain. The midbrain periaqueductal gray (PAG) plays a critical role in pain modulation, and activation of P2X3 receptors in this region mediates pain processing. Neurotropin is a small molecule drug used for analgesic treatment of a number of chronic pain conditions. The present study aims at determining whether P2X3 receptor activation in PAG is responsible for the analgesic effect of neurotropin in rats with osteocarcinoma pain.Materials and methodsThe tibia of female Sprague

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… Activation of the P2X7 receptor in midbrain periaqueductal gray participates in the analgesic effect of tramadol in bone cancer pain rats. Mol Pain. 2018;14:1744806918803039. doi: 10.1177/1744806918803039. 19. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 6st ed. …

Mesenchymal stem cell transplantation plays a role in relieving cancer pain.

Tumors can invade, compress, and damage nerves, leading to persistent pain and seriously affecting the quality of life of patients. However, their treatment is challenging. Sensitization of peripheral receptors, abnormal activity of primary sensory neurons, activation of glial cells, enhanced inflammatory responses, and sensory information transmission contribute towards cancer pain. Therefore, considerable attention has been paid to exploring prospective methods to inhibit the occurrence of these factors and relieve cancer pain. Studies on different types of pains have revealed that the trans

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… The expression of the P2X7 receptor increases in bone cancer pain, and the injection of a P2X7 receptor antagonist in the ventrolateral region of the periaqueductal gray could partially antagonize the analgesic effect of tramadol on bone cancer pain in rats ( Li et al., 2018 ). … Activation of the P2X 7 receptor in midbrain periaqueductal gray participates in the analgesic effect of tramadol in bone cancer pain rats. Mol. Pain 14, 1744806918803039. 10.1177/1744806918803039 Li T., Zhou X., Wang J., Liu Z., Han S., Wan L., et al. (2020). …

Rational treatment of chemotherapy-induced peripheral neuropathy with capsaicin 8% patch: from pain relief towards disease modification.

PurposeChemotherapy-induced peripheral neuropathy (CIPN) with associated chronic pain is a common and disabling condition. Current treatments for neuropathic pain in CIPN are largely ineffective, with unfavorable side-effects. The capsaicin 8% patch (capsaicin 179 mg patch) is approved for the treatment of neuropathic pain: a single topical cutaneous application can produce effective pain relief for up to 12 weeks. We assessed the therapeutic potential of capsaicin 8% patch in patients with painful CIPN, and its mechanism of action.Patients and methods16 patients with chronic painful CIPN (mea

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… All patients reported pain in their feet; most were taking treatment for pain at the start of the study (gabapentin, pregabalin, amitriptyline, duloxetine, tramadol, oxycodone, or a combination of these). …

Efficacy of repetitive transcranial magnetic stimulation on postoperative pain in patients undergoing video-assisted thoracoscopic surgery: study protocol for a prospective, single-center, randomized controlled trial.

BACKGROUND: Video-assisted thoracoscopic surgery (VATS) is a key treatment for many cardiothoracic issues, but intraoperative factors can lead to acute postoperative pain (APSP), impacting recovery and quality of life. While multimodal analgesic methods are used, they have notable side effects. Repetitive transcranial magnetic stimulation (rTMS) offers a non-invasive pain relief option by stimulating the primary motor cortex (M1), effective in chronic pain management. However, its role in preventing and treating APSP after VATS needs confirmation through high-quality clinical trials. METHODS/

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… Rescue analgesia (intravenous tramadol 50 mg) will be administered if the NRS pain score exceeds 4. Study intervention During the morning of the day before surgery, researchers will identify prospective participants based on the surgical schedule. …

Proceedings 27th Symposium ESVN‐ECVN

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… The bladder was emptied with intermittent bladder catheterization, and the animal received analgesia with tramadol, and a muscle relaxant, diazepam. … A: 26 animals, where the cranial tibial reflex was tested in both hindlimbs after anesthetic induction (ketamine‐xylazine‐tramadol) and 15 minutes after epidural anesthetic block with 2% lidocaine (0.22 ml/kg). …

Перспективы Талкетамаба и его полезности в лечении множественной миеломы: безопасность, эффективность и место в терапии.

Несмотря на недавние достижения, большинство пациентов с множественной миэломой в конечном итоге развивают сопротивление имеющимся методам лечения, подчеркивая необходимость новых терапевтических стратегий. G Класс рецептора с протеиновыми соединениями C 5 Член D (GPRC5D) стал жизнеспособной новой терапевтической целью для клеток миэломы, которая привела к клиническому развитию талькетамаба, первого GPRC5D-directed bi специфичный Т-активист (TCE). В августе Талкетамаб получил ускоренное утверждение 2023 Управление по контролю за продуктами питания и лекарствами. Помимо ожидаемой краткосрочной

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… Additionally, tramadol and oxycodone were used for pain management for odynophagia. …

Регулирование пациентов с реанимированными/реферантными миеломами, лечившимися с Талкетамабом: основные моменты из точки зрения фармацевтов.

Talquetamab — семейство рецепторов с белковым белком в классе G. 5 член D (GPRC5D) и CD3-targeting bi специфическая антитела с > 71% :: общее реагирование пациентов с рецидивной или рефрактной множественной миеломой, three другие виды наркотиков. GPRC5D сильно отражается на клетках миэломы, а также некоторое выражение в обычных волосатых фолликах, коже и языке. Его уникальное выражение на этих нормальных тканях приводит к явной структуре неблагоприятных явлений (АЭ), как это было отмечено на этапе I/II. MonumenTAL-1 суд. GPRC5D-related АО включали оральные побочные эффекты (например, дисгейсия

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… For example, analgesics with antipyretic activity (e.g., acetaminophen) can be held during step-up dosing to avoid missing any new fevers; alternate analgesics (e.g., low-dose oxycodone, tramadol) can be utilized as appropriate. …

A novel application perspective of the clinical-used drug verapamil on osteoporosis via targeting Txnip.

BACKGROUND: RANKL and SCLEROSTIN antibodies have provided a strong effective choice for treating osteoporosis in the past years, which suggested novel molecular target identification and therapeutic strategies development are important for the treatment of osteoporosis. The therapeutic effect of verapamil, a drug previously used for cardiovascular diseases, on diabetes was due to the inhibition of TXNIP expression, which has also been reported as a target in mice osteoporosis. Whether verapamil-inhibited TXNIP expression is related to osteoporosis and how it works on the molecular level is wor

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… The post-operative infections and pain of operated mice were prevented by gentamicin ( i.m. , 10 mg/kg) and tramadol ( s.c. , 25 mg/kg) for the initial first three days. The Calcein solution (i.p., 8 mg/kg) (Sigma Aldrich, St. …

Pathological Mechanisms of Bortezomib-Induced Peripheral Neuropathy.

Bortezomib, a first-generation proteasome inhibitor widely used in chemotherapy for hematologic malignancy, has effective anti-cancer activity but often causes severe peripheral neuropathy. Although bortezomib-induced peripheral neuropathy (BIPN) is a dose-limiting toxicity, there are no recommended therapeutics for its prevention or treatment. One of the most critical problems is a lack of knowledge about pathological mechanisms of BIPN. Here, we summarize the known mechanisms of BIPN based on preclinical evidence, including morphological abnormalities, involvement of non-neuronal cells, oxid

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… In addition, it was demonstrated that bortezomib-induced mechanical allodynia could be reversed by systemic administration of gabapentin, tramadol, duloxetine, or mexiletine [ 13 , 18 ]. In contrast, diclofenac or amitriptyline did not exert anti-allodynic effects in a BIPN model [ 13 ]. …

Treatment of Cancer Pain by Targeting Cytokines.

Inflammation is one of the most important causes of the majority of cancer symptoms, including pain, fatigue, cachexia, and anorexia. Cancer pain affects 17 million people worldwide and can be caused by different mediators which act in primary efferent neurons directly or indirectly. Cytokines can be aberrantly produced by cancer and immune system cells and are of particular relevance in pain. Currently, there are very few strategies to control the release of cytokines that seems to be related to cancer pain. Nevertheless, in some cases, targeted drugs are available and in use for other diseas

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… Data in vitro showed that tramadol and ketobemidone and morphine but not fentanyl inhibited the production of TNF and IL-8 mRNA. This was an effect with a significant dose-response relationship (maximum inhibition occurred at millimolar levels) and was not always reversible by naloxone [ 65 ]. …

50th ESCP Symposium on Clinical Pharmacy, Polypharmacy and ageing - highly individualized, interprofessional, person-centered care : 19–21 October 2022, Prague, Czech Republic

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Forecasting drug utilization and expenditure in a metropolitan health region.

BackgroundNew pharmacological therapies are challenging the healthcare systems, and there is an increasing need to assess their therapeutic value in relation to existing alternatives as well as their potential budget impact. Consequently, new models to introduce drugs in healthcare are urgently needed. In the metropolitan health region of Stockholm, Sweden, a model has been developed including early warning (horizon scanning), forecasting of drug utilization and expenditure, critical drug evaluation as well as structured programs for the introduction and follow-up of new drugs. The aim of this

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… The expenditure on analgesics has increased by 5-13% annually the past years due both to increased volumes and increased prescribing of more expensive products such as tramadol and oxycodon. …

Oral Food Supplement with Bio-Activated Silicium and Vitamins D3 and K2 in the Conservative Management of Osteoporotic Vertebral Compression Fractures.

Background: Osteoporotic vertebral compression fractures (OVCFs) are the most prevalent manifestation of osteoporotic skeletal disease, associated with severe pain, functional decline, and elevated risk of subsequent fractures. Conservative management remains the first-line approach for stable fractures, yet pain control is often suboptimal, and vertebral collapse progresses in up to 37% of patients. Bio-activated orthosilicic acid combined with vitamins D3 and K2 (BioSi-DK) may support fracture healing through complementary mechanisms acting on osteoblast differentiation, collagen synthesis,

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… Treatment Protocol All patients received a standardized conservative treatment protocol comprising an initial period of bed rest (one to two weeks, titrated to pain intensity), thoracolumbar orthosis bracing, and analgesic therapy (e.g., tramadol and paracetamol) administered according to the WHO analgesic …

Integrated Medicine for Chemotherapy-Induced Peripheral Neuropathy.

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of typical chemotherapeutics among cancer survivors. Despite the recent progress, the effective prevention and treatment strategies for CIPN remain limited. Better understanding of the pathogenesis of CIPN may provide new niches for developing a new ideal therapeutic strategy. This review summarizes the current understanding of CIPN and current recommendations along with completed/active clinical trials and aims to foster translational research to improve the development of effective strategies for managing CIPN.

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… Opioids, such as tramadol or lidocaine patch, used as the second-tier choices only partially relieved neuropathic pain. The adverse effects such as nausea, dizziness, and somnolence have been observed [ 66 , 67 ]. …

Bone Pain in Cancer Patients: Mechanisms and Current Treatment.

The skeletal system is the third most common site for cancer metastases, surpassed only by the lungs and liver. Many tumors, especially those of the breast, prostate, lungs, and kidneys, have a strong predilection to metastasize to bone, which causes pain, hypercalcemia, pathological skeletal fractures, compression of the spinal cord or other nervous structures, decreased mobility, and increased mortality. Metastatic cancer-induced bone pain (CIBP) is a type of chronic pain with unique and complex pathophysiology characterized by nociceptive and neuropathic components. Its treatment should be

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… Studies have suggested that morphine has the greatest immunosuppressive potential, and fentanyl has intermediate potential, whereas buprenorphine and tramadol have shown the lowest or no immunosuppressive effect [ 67 ]. …

Characterization of a rat model of bortezomib-induced painful neuropathy.

Background and purposeBortezomib (Velcade®) is a breakthrough treatment for multiple myeloma, significantly improving patient survival. However, its use is limited by painful neuropathy often resulting in dose reduction/cessation of first-line treatment due to lack of treatment. The aim of this study was to characterize a clinically relevant rat model of bortezomib-induced painful neuropathy, using established evoked measures and novel ethological techniques, to aid drug discovery.Experimental approachAdult male Sprague-Dawley rats were injected i.p. with 0.1 and 0.2 mg·kg-1 bortezomib, or its

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… The model described by Yamamoto et al . ( 2015 ) showed that administration of tramadol, pregabalin, duloxetine and mexiletine could ameliorate bortezomib‐induced mechanical hypersensitivity, but only the effects of pregabalin exceeded 1 h (up to 3 h; Yamamoto et al., 2015 ). …

RNA therapeutics in targeting G protein-coupled receptors: Recent advances and challenges.

G protein-coupled receptors (GPCRs) are the major targets of existing drugs for a plethora of human diseases and dominate the pharmaceutical market. However, over 50% of the GPCRs remain undruggable. To pursue a breakthrough and overcome this situation, there is significant clinical research for developing RNA-based drugs specifically targeting GPCRs, but none has been approved so far. RNA therapeutics represent a unique and promising approach to selectively targeting previously undruggable targets, including undruggable GPCRs. However, the development of RNA therapeutics faces significant cha

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… overweight) 2020 Eptinezumab-jjmr Vyepti (Lundbeck) CALCRL B, calcitonin migraine (prevention) 2020 Relugolix Orgovyx GnRH A, gonadotrophin-releasing hormone prostate cancer 2020 Amisulpride Barhemsys D2R A, dopamine nausea/vomiting, postoperative 2020 Clascoterone Winlevi mAChR A, acetylcholine acne 2020 Tramadol … Lundbeck) | CALCRL | B, calcitonin | migraine (prevention) | 2020 Relugolix | Orgovyx | GnRH | A, gonadotrophin-releasing hormone | prostate cancer | 2020 Amisulpride | Barhemsys | D2R | A, dopamine | nausea/vomiting, postoperative | 2020 Clascoterone | Winlevi | mAChR | A, acetylcholine | acne | 2020 Tramadol …

Current management of cancer pain in Italy: Expert opinion paper.

IntroductionChronic pain and breakthrough cancer pain (BTcP) have a high prevalence in all cancer types and cancer stages, combined with a significant physical, psychological, and economic burden. Despite efforts to improve appropriate management of cancer pain, a poor assessment and guilty undertreatment are still reported in many countries. The purpose of this expert opinion paper is to contribute to reduce and clarify these issues with a multidisciplinary perspective in order to share virtuous paths of care.MethodsCommon questions about cancer pain assessment and treatment were submitted to

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… WHO cancer pain ladder recommends, for mild to moderate pain, weak opioids such as tramadol and codeine in combination with non-opioid analgesics, but low doses of strong opioids could be an option as an alternative to weak opioids [ 31 , 57 , 58 ]. …