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Bridging the Gap in Understanding Bone Metastasis: A Multifaceted Perspective.

The treatment of patients with advanced cancer poses clinical problems due to the complications that arise as the disease progresses. Bone metastases are a common problem that cancer patients may face, and currently, there are no effective drugs to treat these individuals. Prostate, breast, and lung cancers often spread to the bone, causing significant and disabling health conditions. The bone is a highly active and dynamic tissue and is considered a favorable environment for the growth of cancer. The role of osteoblasts and osteoclasts in the process of bone remodeling and the way in which th

Совпадение в полном тексте источника
… Minimally invasive techniques such as radiofrequency ablation and percutaneous vertebroplasty are employed by surgeons for vertebral collapse. Surgical options range from simple decompression to en bloc resection and fixation, tailored to the region involved and patient factors [ 176 ]. 9.9. …

Rapid Fire Presentations

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Bone-modifying therapy in multiple myeloma: a comprehensive review.

Multiple myeloma (MM) is a clonal hematologic malignancy characterized by plasma cell proliferation in the bone marrow. One of the most common clinical presentations is skeletal-related events (SREs), characterized by osteolysis of the bone, leading to a significant morbidity and mortality. The main aim of this review article is to provide an overview of the pathogenesis and evidence-based, guideline-recommended treatment of SREs. MM bone homeostasis is altered by numerous pathways and cytokines, leading to the pathogenesis of bone and osteolytic lesions. Historically, bisphosphonates were the

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… . - consider vertebroplasty or kyphoplasty +/- radiofrequency ablation for symptomatic vertebral compression fractures which are refractory to medical management. - attention should be placed on any potential impending fractures or structural instabilities of the spinal column, and appropriate ancillary …

Bone metastases in thyroid cancer.

Whereas preemptive screening for the presence of lymph node and lung metastases is standard-of-care in thyroid cancer patients, bone metastases are less well studied and are often neglected in thyroid cancer patient surveillance. Bone metastases in thyroid cancer are, however, independently associated with poor/worse prognosis with a median overall survival from detection of only 4 years despite an otherwise excellent prognosis for the vast majority of thyroid cancer patients. In this review we summarize the state of current knowledge as pertinent to bony metastatic disease in thyroid cancer,

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… In patients with pain but without neurological damage or spinal instability, less invasive techniques such as percutaneous vertebroplasty and kyphoplasty may be considered. …

Intelligence Architectures and Machine Learning Applications in Contemporary Spine Care.

The rapid evolution of artificial intelligence (AI) and machine learning (ML) technologies has initiated a paradigm shift in contemporary spine care. This narrative review synthesizes advances across imaging-based diagnostics, surgical planning, genomic risk stratification, and post-operative outcome prediction. We critically assess high-performing AI tools, such as convolutional neural networks for vertebral fracture detection, robotic guidance platforms like Mazor X and ExcelsiusGPS, and deep learning-based morphometric analysis systems. In parallel, we examine the emergence of ambient clini

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… For example, Yang et al. (2025) analyzed postoperative spine CT scans of patients treated with vertebroplasty and found that a model combining CT-radiomic features with clinical factors predicted adjacent-level fracture (AUC ≈ 0.86) [ 40 ]. …

Oral Presentations

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Oral Presentations

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Hematology

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Всемирный конгресс по болезням остеопороза, остеоартрита и мускулоскелета 2025).

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Hematology

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Emerging advances in drug delivery systems (DDSs) for optimizing cancer complications.

The management and treatment of tumor complications pose continuous challenges due to the inherent complexity. However, the advent of drug delivery systems (DDSs) brings promising opportunities to address the tumor complications using innovative technological approaches. This review focuses on common oncological complications, including cancer thrombosis, malignant serous effusion, tumor-associated infections, cancer pain, and treatment-related complications. Emphasis was placed on the application and potential of DDSs in mitigating and treating these tumor complications, and we delved into th

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… Italy | University Hospital Padova NCT06115330 | Completed | Gynecologycal Cancer | Battlefield acupuncture | NA | Indonesia | Indonesia University NCT06073496 | Completed | Gynecologycal Cancer | Electroacupuncture | NA | Indonesia | Indonesia University NCT05317026 | Recruiting | Spine Metastases | Vertebroplasty …

Oral Presentations

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Abstract Book for the 3rd European Myeloma Network Meeting

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… Balloon kyphoplasty and vertebroplasty are recommended for patients with painful vertebral compression fractures. Radiotherapy should be considered for uncontrolled pain due to impeding or symptomatic spinal cord compression and due to pathological fractures. …

ROS 2020 Abstract

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The leptomeninges as a critical organ for normal CNS development and function: First patient and public involved systematic review of arachnoiditis (chronic meningitis).

BACKGROUND & IMPORTANCE: This patient and public-involved systematic review originally focused on arachnoiditis, a supposedly rare "iatrogenic chronic meningitis" causing permanent neurologic damage and intractable pain. We sought to prove disease existence, causation, symptoms, and inform future directions. After 63 terms for the same pathology were found, the study was renamed Diseases of the Leptomeninges (DLMs). We present results that nullify traditional clinical thinking about DLMs, answer study questions, and create a unified path forward. METHODS: The prospective PRISMA protocol is pu

Устные доклады

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Abstracts from the 37th Annual Meeting of the Society of General Internal Medicine, 2014, San Diego, CA, USA.

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Abstracts of the 19th International Congress on Neuromuscular Diseases 7th – 11th July 2026

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