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Real-Life Use of Ceftolozane/Tazobactam for the Treatment of Bloodstream Infection Due to Pseudomonas aeruginosa in Neutropenic Hematologic Patients: a Matched Control Study (ZENITH Study).

We sought to assess the characteristics and outcomes of neutropenic hematologic patients with Pseudomonas aeruginosa (PA) bloodstream infection (BSI) treated with ceftolozane-tazobactam (C/T). We conducted a multicenter, international, matched-cohort study of PA BSI episodes in neutropenic hematologic patients who received C/T. Controls were patients with PA BSI treated with other antibiotics. Risk factors for overall 7-day and 30-day case fatality rates were analyzed. We compared 44 cases with 88 controls. Overall, 91% of episodes were caused by multidrug-resistant (MDR) strains. An endogenou

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… This was a prospective/retrospective, international, multicenter matched control study of neutropenic hematologic patients with BSI due to PA from 1 January 2016 to 30 June 2020 across 17 centers from 4 countries: Spain, United States, Italy, and Croatia. …

Development of a Health-Related Quality of Life Tool for Adolescents and Young Adults With Cancer.

ImportanceA diagnosis of cancer during adolescence and young adulthood disrupts key developmental stages, affecting multiple domains of health-related quality of life (HRQOL). To provide a comprehensive assessment of the HRQOL issues of adolescents and young adults (AYAs) with cancer, a questionnaire dedicated to this age group is needed.ObjectiveTo develop an HRQOL questionnaire, as a supplement to the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30, that measures issues of relevance and importance to AYAs with cancer.Design, setting, and participantsThis survey stu

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… . (%) (N = 253) Country | Australia | 4 (2) Croatia | 16 (6) Cyprus | 7 (3) Denmark | 25 (10) Germany | 7 (3) Greece | 4 (2) Israel | 22 (9) India | 10 (4) Italy | 3 (1) Japan | 19 (8) Jordan | 25 (10) Netherlands | 12 (5) Norway | 8 (3) Poland | 10 (4) Spain | 9 (4) Sweden | 6 (2) Switzerland | 6 ( …

First-year treatment response predicts the following 5-year disease course in patients with relapsing-remitting multiple sclerosis.

Predicting long-term prognosis and choosing the appropriate therapeutic approach in patients with Multiple Sclerosis (MS) at the time of diagnosis is crucial in view of a personalized medicine. We investigated the impact of early therapeutic response on the 5-year prognosis of patients with relapsing-remitting MS (RRMS). We recruited patients from MSBase Registry covering the period between 1996 and 2022. All patients were diagnosed with RRMS and actively followed-up for at least 5 years to explore the following outcomes: clinical relapses, confirmed disability worsening (CDW) and improvement

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… 3.3) 34 (0.9) Netherlands 257 (3.2) 137 (3.6) Portugal 157 (2.0) 107 (2.8) Lebanon 156 (2.0) 72 (1.9) United States 153 (1.9) 35 (0.9) Switzerland 141 (1.8) 14 (0.4) Egypt 92 (1.2) 1 (0.0) Argentina 86 (1.1) 35 (0.9) United Kingdom 73 (0.9) 18 (0.5) Tunisia 67 (0.8) 19 (0.5) Ireland 61 (0.8) 1 (0.0) Croatia …

Prevalence and prognostic value of baseline sarcopenia in hematologic malignancies: a systematic review.

BackgroundThe correlation between sarcopenia and hematological malignancy prognosis is still controversial. Design: A systematic review and meta-analysis. Objectives: To explore sarcopenia's prevalence and prognostic value in hematologic malignancies.Data sources and methodsWe searched Embase, MEDLINE, and Cochrane Library through Ovid SP using an appropriate search strategy on August 28, 2022, and updated the search results on January 9, 2023. Study quality was assessed using the Newcastle-Ottawa scale. The pooled prevalence of sarcopenia was calculated with a 95% confidence interval (CI). Re

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… (PETCT) | 65.9% Sun, 2022 | China | 02/2012-08/2021 | 227 (48.0%) | median 64 (range 24-87) | AML | LMM (BIA) | 18.1% | >60 years old, 21.0% (32/152) Albano, 2022 | Italy | 01/2010-12/2020 | 53 (74.0%) | mean 72.7 (SD 5.6, range 66–88) | Mantle Cell Lymphoma | LMM (PETCT) | 60.4% Lucijanić, 2021 | Croatia …

Bortezomib (PS-341) treatment decreases inflammation and partially rescues the expression of the dystrophin-glycoprotein complex in GRMD dogs.

Golden retriever muscular dystrophy (GRMD) is a genetic myopathy corresponding to Duchenne muscular dystrophy (DMD) in humans. Muscle atrophy is known to be associated with degradation of the dystrophin-glycoprotein complex (DGC) via the ubiquitin-proteasome pathway. In the present study, we investigated the effect of bortezomib treatment on the muscle fibers of GRMD dogs. Five GRMD dogs were examined; two were treated (TD- Treated dogs) with the proteasome inhibitor bortezomib, and three were control dogs (CD). Dogs were treated with bortezomib using the same treatment regimen used for multip

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… Rijeka, Croatia: InTech; 2012. pp. 535–544. doi: 10.5772/30329 63. Yang HT, Shin JH, Hakim CH, Pan X, Terjung RL, et al. (2012) Dystrophin deficiency compromises force production of the extensor carpi ulnaris muscle in the canine model of duchenne muscular dystrophy. …

Mortality-Related Risk Factors in Patients with Hematologic Neoplasm Admitted to the Intensive Care Unit: A Systematic Review.

BackgroundHematooncology patients admitted to intensive care units (ICUs) are at high risk for mortality due to the severity of their critical illness. Such complications can develop into complex clinical management, thus signaling an urgent need to identify mortality-related factors to improve interventions and outcomes for these patients.MethodsA systematic review of studies published between 2012 and 2023 in databases such as PubMed, Scopus, and Web of Science was conducted, following the PRISMA guidelines. A meta-analysis was carried out to determine the significance of mortality-related f

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… Marion Cornish, et al. [ 18 ] | 2016 | Canada | 206 | Observational retrospective cohort | ICU: 45.6% 30 Days: 59.2% 60 Days: 62.6% 12 Months: 74.3% 5 | Enas Abd El motlb, et al. [ 19 ] | 2017 | Egypt | 448 | Observational prospective cohort | ICU: 78% 6 | Marijana Grgić Medić, et al. [ 20 ] | 2015 | Croatia …

Business Risk Mitigation in the Development Process of New Monoclonal Antibody Drug Conjugates for Cancer Treatment.

Recent developments aim to extend the cytotoxic effect and therapeutic window of mAbs by constructing antibody-drug conjugates (ADCs), in which the targeting moiety is the mAb that is linked to a highly toxic drug. According to a report from mid of last year, the global ADCs market accounted for USD 1387 million in 2016 and was worth USD 7.82 billion in 2022. It is estimated to increase in value to USD 13.15 billion by 2030. One of the critical points is the linkage of any substituent to the functional group of the mAb. Increasing the efficacy against cancer cells' highly cytotoxic molecules (

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… Risk Assessment of Innovations in The Biopharmaceutical Industry/Book 2 IntechOpen Rijeka, Croatia 2012 85 104 80. Baah S. Laws M. Rahman K.M. Antibody–Drug Conjugates—A Tutorial Review Molecules 2021 26 2943 10.3390/molecules26102943 34063364 PMC8156828 81. Fu Z. Li S. Han S. Shi C. Zhang Y. …

Comparing the efficacy of different dexamethasone regimens for maintenance treatment of multiple myeloma in standard-risk patients non-eligible for transplantation.

BackgroundMultiple myeloma (MM) is a plasma cell malignancy, while MM outcomes have significantly improved due to novel agents and combinations, MM remains an incurable disease. The key goal of treatment in MM is to achieve a maximal response and the subsequent consolidation of response after initial therapy. Many studies analyzed an improved progression-free survival (PFS) following lenalidomide alone maintenance versus placebo or observation after autologous stem cell transplant (ASCT) in patients with NDMM. In the SWOG S0777 clinical trial, patients newly diagnosed with MM (NDMM) without AS

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… in press: October 18, 2022 Specialty type: Hematology Country/Territory of origin: China Peer-review report’s scientific quality classification Grade A (Excellent): 0 Grade B (Very good): B, B Grade C (Good): 0 Grade D (Fair): 0 Grade E (Poor): 0 P-Reviewer: Arunachalam J, India; Glumac S, Croatia …

Специальный выпуск: резюме 11th Конгресс Европейской академии неврологии, Хельсинки, Финляндия.

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Burden of non-communicable diseases among adolescents aged 10-24 years in the EU, 1990-2019: a systematic analysis of the Global Burden of Diseases Study 2019.

BackgroundDisability and mortality burden of non-communicable diseases (NCDs) have risen worldwide; however, the NCD burden among adolescents remains poorly described in the EU.MethodsEstimates were retrieved from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Causes of NCDs were analysed at three different levels of the GBD 2019 hierarchy, for which mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) were extracted. Estimates, with the 95% uncertainty intervals (UI), were retrieved for EU Member Stat

Acute lymphoblastic leukemia: an update on treatment and Brazilian perspective.

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, representing a major global health concern, particularly in developing countries. This review provides an updated overview of the epidemiology, diagnosis, prognosis, treatment, and a Brazilian perspective for ALL. Despite advances in chemotherapy and immunotherapy, survival disparities remain challenging, driven by socioeconomic and healthcare access inequalities. Present diagnosis incorporates immunophenotyping, cytogenetics, and molecular biology for precise stratification and treatment planning. Treatment has evolved fr

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… A different study involving patients from Argentina, Bulgaria, Cuba, Chile, Croatia, Greece, Hungary, Poland, Serbia, Slovakia, Slovenia, and Uruguay has shown that 84.1% of childhood patients had B-type ALL, and 11.1% were classified as T-type ALL ( 37 ). …

Liposomal Drug Delivery Systems and Anticancer Drugs.

Cancer is a life-threatening disease contributing to ~3.4 million deaths worldwide. There are various causes of cancer, such as smoking, being overweight or obese, intake of processed meat, radiation, family history, stress, environmental factors, and chance. The first-line treatment of cancer is the surgical removal of solid tumours, radiation therapy, and chemotherapy. The systemic administration of the free drug is considered to be the main clinical failure of chemotherapy in cancer treatment, as limited drug concentration reaches the tumour site. Most of the active pharmaceutical ingredien

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… InTech Rijeka, Croatia 2017 57. Maeda H. The enhanced permeability and retention (EPR) effect in tumor vasculature: The key role of tumor-selective macromolecular drug targeting Adv. Enzyme Regul. 2001 41 189 207 10.1016/S0065-2571(00)00013-3 11384745 58. Kunjachan S. Ehling J. Storm G. …

Abstracts from the 8th Drug Hypersensitivity Meeting (DHM)

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15th Конгресс Европейской ассоциации клинической фармакологии и терапии (ЕАКПТ)

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… Amsterdam, Netherlands 3 European Association for Clinical Pharmacology and Therapeutics (EACPT) Education Working Group 4 Aristotle University of Thessaloniki, Faculty of Health Sciences, Thessaloniki, Greece 5 University of Zagreb School of Medicine and Clinical Hospital Centre Zagreb, Zagreb, Croatia …

Facial expression deep learning algorithms in the detection of neurological disorders: a systematic review and meta-analysis.

BackgroundNeurological disorders, ranging from common conditions like Alzheimer's disease that is a progressive neurodegenerative disorder and remains the most common cause of dementia worldwide to rare disorders such as Angelman syndrome, impose a significant global health burden. Altered facial expressions are a common symptom across these disorders, potentially serving as a diagnostic indicator. Deep learning algorithms, especially convolutional neural networks (CNNs), have shown promise in detecting these facial expression changes, aiding in diagnosing and monitoring neurological condition

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… . | 2024 | Bosnia Herzegovina Croatia Serbia | CNN | Facial movements | neurological impairment disorder cerebral palsy pilepsy autism spectrum disorder Tanaka et al. | 2022 | Japan | ASEA (Assessment Scale for Engagement in Activities) Kokoro sensor | Anger Contempt Disgust Engagement Fear Joy Sadness …

37th International Symposium on Intensive Care and Emergency Medicine (part 1 of 3) : Brussels, Belgium. 21–24 March 2017

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… 11 Policlinico di Modena, Modena, Italy; 12 Azienda Ospedaliero-Universitaria di Parma, Parma, Italy; 13 Ospedale Citta di Sesto San Giovanni, Sesto San Giovanni, Italy; 14 Policlinico Gemelli, Roma, Italy; 15 University Hospital Frankfurt, Frankfurt, Germany; 16 University Hospital Zagreb, Zagreb, Croatia … 11 Policlinico di Modena, Modena, Italy; 12 Azienda Ospedaliero-Universitaria di Parma, Parma, Italy; 13 Ospedale di Sesto San Giovanni, Sesto San Giovanni, Italy; 14 Policlinico Gemelli, Rome, Italy; 15 University Hospital Frankfurt, Frankfurt, Germany; 16 University Hospital Center Zagreb, Zagreb, Croatia …

Overview of dyslipidemia and metabolic syndrome in myeloproliferative neoplasms.

Myeloproliferative neoplasms (MPNs) occur due to the abnormal proliferation of one or more terminal myeloid cell lines in peripheral blood. Subjects suffering from MPNs display a high burden of cardiovascular risk factors, and thrombotic events are often the cause of death in this population of patients. Herein, we provide a brief overview of dyslipidemia and metabolic syndrome and their epidemiology in MPNs and examine the common molecular mechanisms between dyslipidemia, metabolic syndrome, and MPNs, with a special focus on cardiovascular risk, atherosclerosis, and thrombotic events. Further

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… Specialty type: Oncology Country of origin: Romania Peer-review report’s classification Scientific Quality: Grade C Novelty: Grade B Creativity or Innovation: Grade C Scientific Significance: Grade B P-Reviewer: Cigrovski Berkovic M, Croatia S-Editor: Li L L-Editor: Filipodia P-Editor: Zhao YQ …

The prevalence of obstructive sleep apnea-hypopnea syndrome in patients with multiple sclerosis: a systematic review and meta-analysis.

OBJECTIVE: Obstructive sleep apnea-hypopnea syndrome is the most common respiratory disorder in patients with multiple sclerosis. The purpose of this meta-analysis was to evaluate the prevalence of OSAHS in MS patients and to analyze their sleep monitoring indicators of patients. METHODS: Online databases such as PubMed, EMBASE, Web of Science, CNKI, and WanFang were used to review the Chinese and English literature about OSAHS in MS patients in detail. Two researchers analyzed the Quality of included studies based on the Quality Assessment of Diagnostic Accuracy Studies. The prevalence and s

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… | 103 | STOP-BANG questionnaire Sparasci D | 2022 | Switzerland | CSS | 50.60 ± 8.20 | 25.40 ± 5.30 | 20 | 27 | 67 | PSG Singh M | 2022 | USA | CC | 48.80 ± 10.90 | 31.60 ± 7.20 | 62 | 156 | 200 | PSG Hensen HA | 2022 | Australia | – | 54.00 ± 8.00 | 29.00 ± 6.00 | 4 | 11 | 11 | – Mihalj M | 2022 | Croatia …

Abstract

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… Roganovic Clinical Hospital Centre Rijeka, Rijeka, Primorsko‐Goranska, Croatia Background : Acquired haemophilia A is a rare but potentially life‐threatening haemorrhagic disorder caused by autoantibodies directed mostly against coagulation factor VIII. …

Global inequalities in tracheal, bronchus, and lung cancer care quality from 1990 to 2021.

Tracheal, bronchus, and lung cancer remains a major global cancer burden, but cross-national comparisons using composite proxy indicators are limited. Using Global Burden of Disease 1990-2021 estimates, we constructed a quality-of-care index (QCI) from incidence, mortality, prevalence, and disability outcomes; assessed temporal and geographic patterns; modeled associations with linear mixed models; and compared older adults with the overall population. Age-standardized incidence and death rates declined globally, but QCI remained highly unequal across 204 countries. QCI was higher in high-deve

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… Additionally, countries showing the highest AQCI change ratios included New Zealand (6.42), Czechia (5.49), and Croatia (5.08), while the lowest were Republic of Korea (−12.75), Japan (−10.32), and France (−9.31), all six countries from high and high-middle SDI groups ( Figure 4 B). …