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Minimal Residual Disease-Adapted Therapy in Multiple Myeloma: Current Evidence and Opinions.

Purpose of reviewMultiple myeloma (MM) is a biologically heterogeneous malignancy with relatively uniform treatment paradigms. This review aims to assess the growing role of Minimal Residual Disease (MRD) assessment in facilitating response-adapted therapeutic decision making to individualize therapy in MM.Recent findingsMRD has been repeatedly demonstrated to provide strong prognostic information, superseding traditional IMWG response criteria. The use of MRD to modulate therapy remains controversial. Here, we review the existing landscape of MRD-adapted trial designs in both induction/consol

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… Diamond BT Defining the undetectable: the current landscape of minimal residual disease assessment in multiple myeloma and goals for future clarity Blood Rev 2021 46 100732 10.1016/j.blre.2020.100732 32771227 PMC9928431 4. … Diamond B Tracking the evolution of therapy-related myeloid neoplasms using chemotherapy signatures Blood 2023 141 19 2359 2371 10.1182/blood.2022018244 36626250 PMC10273163 52. …

Спасение гиппокампальной синаптической пластичности и эффективности памяти Финголимода (FTY720) в модели APP/PS1 болезни Альцгеймера сопровождается коррекцией метаболизма финголипидов, полиаминов и фосфолипидного насыщенного состава.

Ранее, наши метаболомические, транскриптомные и геномные исследования характеризовали путь церамида/шфингомилена как терапевтическую цель в болезни Альцгеймера, и мы показали, что FTY720, фингозин-1-фосфахатный рецептор, утвержденный для лечения множественных склерозов, восстанавливает синаптическая пластичность и память в мышах APP/PS1. Для дальнейшего изучения того, как FTY720 спасает патологию, мы провели метаболический анализ мозга, плазмы и печени обученных APP/PS1 и диких мышей. APP/PS1 мыши продемонстрировали локальные нарушения мозга в полиаминах, фосфолипидах и сфинголипидах. Большинс

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… The normalized regression coefficients are shown on the x axis as points, with the shape denoting the statistical significance (diamond – FDR ≤ 0.05; square – FDR > 0.05 and p ≤ 0.05; circle – p > 0.05), located in the middle of a horizontal line depicting 95% confidence intervals, with lower opacity … The normalized regression coefficients are shown on the x axis as points, with the shape denoting the statistical significance (diamond – FDR ≤ 0.05; square – FDR > 0.05 and p ≤ 0.05; circle – p > 0.05), located in the middle of a horizontal line depicting 95% confidence intervals, with lower opacity …

Spectrum of histiocytic neoplasms associated with diverse haematological malignancies bearing the same oncogenic mutation.

Histiocytic disorders are a spectrum of rare diseases characterised by the accumulation of macrophage-, dendritic cell-, or monocyte-differentiated cells in various tissues and organs. The discovery of recurrent genetic alterations in many of these histiocytoses has led to their recognition as clonal neoplastic diseases. Moreover, the identification of the same somatic mutation in histiocytic lesions and peripheral blood and/or bone marrow cells from histiocytosis patients has provided evidence for systemic histiocytic neoplasms to originate from haematopoietic stem/progenitor cells (HSPCs). H

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… Papo M, Diamond EL, Cohen‐Aubart F, et al High prevalence of myeloid neoplasms in adults with non‐Langerhans cell histiocytosis. Blood 2017; 130 : 1007–1013. 24. … Diamond EL, Subbiah V, Lockhart AC, et al Vemurafenib for BRAF V600‐mutant Erdheim–Chester disease and Langerhans cell histiocytosis. JAMA Oncol 2018; 4 : 384–388. 76. Bhatia A, Ulaner G, Rampal R, et al Single‐agent dabrafenib for BRAFV600E‐mutated histiocytosis. …

Effect of prophylactic low level laser therapy on oral mucositis: a systematic review and meta-analysis.

BackgroundObjective was to determine whether prophylactic low level laser therapy (LLLT) reduces the risk of severe mucositis as compared to placebo or no therapy.MethodsMEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials were searched until February 2014 for randomized controlled trials (RCTs) comparing prophylactic LLLT with placebo or no therapy in patients with cancer or undergoing hematopoietic stem cell transplantation (HSCT). All analyses used random effects models.ResultsEighteen RCTs (1144 patients) were included. Prophylactic LLLT reduced the overall risk of severe mu

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… The size of the squares reflects each study's relative weight, and the diamond represents the aggregate risk ratio and 95% CI. Secondary Outcomes Table 2 summarizes the secondary outcomes of the analysis. … The size of the squares reflects each study's relative weight, and the diamond represents the aggregate risk ratio and 95% CI. (TIF) Click here for additional data file. …

Dexametasone для управления CRS в связи с teclistamab у пациентов с повторной/редактированной множественной миеломой.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Kowalski A Lykon JL Diamond B Coffey D Kaddoura M Maura F Tocilizumab prophylaxis for patients treated with teclistamab: a single-center experience Blood 2023 142 4709 10.1182/blood-2023-187086 Kowalski A, Lykon JL, Diamond B, Coffey D, Kaddoura M, Maura F, et al. …

Стратегия выбора субстрата, взаимно исключающаяся, у человека m3C RNA трансферазы METTL2A и METTL6.

tRNAs содержат наиболее разнообразные посттранскрипционные модификации. 3-метилцитидин (m3C) широко распределяется на позиции C32 (m3C32) у эукариотических tRNAThr и tRNASer. m3C32 модифицируется единственным метилтрансферазой Trm140 у дрожжей-попыток; однако для его биогенеза участвуют два (Trm140 и Trm141 у деления дрожжей) или три энзима (METTL2A, METTL2B и METTL6 у млекопитающих). До сих пор неизвестно обоснование существования нескольких метилтрансфераз m3C32 и их механизм дифференциации по субстрату. Здесь мы обнаружили, что оба METTL2A и METTL2B выражены в живых организмах. Мы выделили

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… construction of five Ec tRNA Thr mutants and one hctRNA Thr (AGU) mutant. m 3 C modification levels of t 6 A- Ec tRNA Thr (UGU) (black filled circles) and t 6 A- Ec tRNA Thr :hc-1 (blue filled squares), :hc-3 (green filled triangles), :hc-4 (orange filled inverted triangles) and :hc-5 (purple filled diamond … ) and -ΔUe3 (red hollow circle) ( H ); of hctRNA Ser (GCU) transcript (black filled circles) and hctRNA Ser (GCU)-Ue1G (blue filled squares), -Ce2A (green filled triangles), -Ue3G (orange filled inverted triangles), -e12 (A-U) (purple filled diamond) and -e12 (G-C) (red hollow circle) ( I ); of hctRNA …

Протокол для оценки региональной патологии оптического нерва грызунов с использованием продольных криосекций и поперечной электронной микроскопии.

Визуальная патология была установлена в качестве одной из главных особенностей демиелинизирующих заболеваний, таких, как множественный склероз (MS). Здесь мы представляем протокол для оценки региональной патологии оптического нерва грызунов с использованием продольных криосекций и поперечной электронной микроскопии. Мы описываем шаги для оптического диссекции нерва, постфиксации, обнаружения миелина, сканирования слайда основного белка миелина и анализа демиелинации. Затем мы подробно описываем процедуры пятна антителных флуоресцирующих веществ, анализ микроскопии для передачи электронов (ТЕА)

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… Using a microtome with a diamond blade, cut ultrathin 85-nm section. g. Stain sections with 10% uranyl acetate and lead citrate. h. Mount sections onto an EM grid for imaging. Cut optic nerve from the eye. Post-fix optic nerve in 1% osmium tetroxide in water for 60 min. at 4°C. i. … Using a microtome with a diamond blade, cut ultrathin 85-nm section. Stain sections with 10% uranyl acetate and lead citrate. Mount sections onto an EM grid for imaging. …

Predicting biomarkers in laryngeal squamous cell carcinoma based on the cytokine-cytokine receptor interaction pathway.

ObjectiveTo analyze and validate differential genes in the cytokine-cytokine receptor interaction CCRI pathway in laryngeal squamous cell carcinoma (LSCC) using bioinformatics and Mendelian randomization (MR) to find potential biomarkers for LSCC.MethodsFive sets of LSCC-related gene chips were downloaded from the GEO database, and four sets of combined datasets were randomly selected as the test set and one set as the validation set to screen for differential genes in the CCRI pathway; two-way Mendelian randomization was performed to analyze the causal relationship between cytokine receptor a

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… In this network, as shown in Fig. 7 , key gene mRNAs are represented by red elliptical nodes, miRNAs by green triangular nodes, and lncRNAs by purple diamond-shaped nodes. … The red nodes represent pathway gene mRNAs, the green nodes represent miRNAs, and the purple diamonds represent lncRNAs. Each line indicates the interaction between mRNA and miRNA, as well as between miRNA and lncRNA. …

Study of a novel Ca/P/S-based cement implanted in the osteoporotic goat spine and its clinical application in preventing adjacent vertebral fractures.

Osteoporotic vertebral compression fracture (OVCF) has been increasing over the last decades. In addition to primary OVCF, the adjacent vertebral fracture (AVF) is a frequent serious complication in OVCF patients receiving percutaneous vertebroplasty or kyphoplasty, resulting in poor long-term outcome and recurrent symptoms. The aim of the present study is to investigate the bone regeneration behavior of a novel Ca/P/S-based resorbable cement (Ezechbone® Cement CBC-400) implanted into surgically created vertebral defects of ovariectomized (OVX) goats. Furthermore, the present study provides a

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… Samples were sectioned into four thick slices using a Buehler low-speed diamond blade (IsoMet Blade, Buehler, Illinois, USA). … The diamonds indicate the means of the average values for the four sections with standard deviations. …

Comorbidities and mortality rate in COVID-19 patients with hematological malignancies: A systematic review and meta-analysis.

IntroductionThe global pandemic of coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It seems that there is an association between blood cancer and an increased risk of severe COVID-19. This study aimed to review the literature reporting the COVID-19 outcomes in patients with hematological malignancies.Material and methodsIn this systematic review and meta-analysis, Pubmed, Embase, and Web of Science databases were searched using the following keywords: COVID-19, SARS-CoV-2, blood cancer, myeloma, lymphoma, and leukemia. All the

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… Each line segment's midpoint shows the percent estimate, length of line segment indicates 95% CI in each study, and diamond mark illustrates the pooled estimate in each subgroup FIGURE 3 Pooled prevalence with 95% CI and heterogeneity indices of different comorbidity percent in patients with COVID‐19 … The diamond mark illustrates the pooled percent, and the length of the diamond indicates the 95% CI. N is the number of the study in the analysis FIGURE 4 Association among death rate and Median of age by means of meta‐regression. The size of circles indicates the precision of each study. …

Prognostic disclosure in cancer care: a systematic literature review.

BackgroundCollusion in cancer care is the diplomatic concealment of information between a triad of the health care professional (HCP), patient, and caregiver. Free and expressive communication is determined by multiple factors, which establishes a healthy balance between 'patient-centric' and 'family-centric' decision making. The lack of a universal approach to prognostic disclosure techniques emphasizes the need for a systematic review of contemporary practice.MethodsA systematic review of the literature was conducted till June 2020 using themes based on cancer, communication, prognostic disc

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… This was supported by nearly two-thirds of patients and one-fourth of caregivers who reported that prognostic information was important according to Diamond et al. 23 Disclosing more detailed information to terminally ill cancer patients contributed to a better quality of communication, irrespective … Diamond EL, Prigerson HG, Correa DC, et al. Prognostic awareness, prognostic communication, and cognitive function in patients with malignant glioma. Neuro Oncol 2017; 19: 1532–1541. 24. Nakajima N, Kusumoto K, Onishi H, et al. …

Лучшие достижения года: Биотипные антитела на ранних линиях терапии в множестве миеломы.

После их введения в качестве терапии для сильного рефрактного множества миэломы, лица, занимающиеся диагностикой двух клеток, недавно получили исключительно глубокие и долговременные ответные реакции на ранние линии терапии, включая ранние данные о новых диагностированных болезнях. Сохраняется множество проблем, включая оптимальную обстановку и сочетание, смягчение токсичности и уточнение оптимальной продолжительности терапии.

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… Kazandjian D, Diamond B, Hoffman J, et al. A phase 2 trial of abbreviated fixed‐duration (Default 4 Cycles) linvoseltamab immuno‐consolidation to deepen responses post newly diagnosed multiple myeloma combination therapy for minimal residual disease positivity (the IMMUNOPLANT Study). … Kowalski A, Lykon J, Diamond B, et al. Tocilizumab prophylaxis for patients with multiple myeloma treated with bispecific antibodies. Blood Adv. 2025;9(19):4979‐4986. doi: 10.1182/bloodadvances.2025016911 31. Zamagni E, Silzle T, Špička I, et al. …

The association between financial toxicity and mortality in hematologic malignancies: a systematic review and meta-analysis.

BackgroundHematologic malignancies impose substantial economic burdens, but the quantitative association between financial toxicity and overall survival remains poorly defined across diverse clinical settings and disease lineages.MethodsAdhering to PRISMA and MOOSE guidelines, we searched electronic databases through January 2026 for studies reporting multivariable-adjusted hazard ratios (aHRs) for the association between financial toxicity and mortality in adults diagnosed with hematologic malignancies. A random-effects model with Hartung-Knapp adjustment was used for data synthesis. Small-st

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… The diamond denotes the overall pooled aHR, and the solid orange bar at the bottom indicates the 95% prediction interval. … For each subgroup, diamonds represent the pooled adjusted hazard ratio under a random-effects model with Hartung–Knapp adjustment. Statistical heterogeneity within each subgroup is reported via the I 2 statistic. …

Analysis of the most influential publications on vertebral augmentation for treating osteoporotic vertebral compression fracture: A review.

This study aimed to analyze the most influential publications on vertebral augmentation for treating osteoporotic vertebral compression fracture. The Web of Science database was searched using the key words "percutaneous vertebroplasty," "percutaneous kyphoplasty," "balloon kyphoplasty," "vertebroplasty," "kyphoplasty," and "vertebral augmentation." The top 100 publications were arranged by citations per year and descriptively and visually analyzed. The top 100 publications were cited 25,482 times, with an average of 14.4 citations per paper per year. The corresponding authors of the publicati

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… [16] Diamond TH, Bryant C, Browne L, et al. Clinical outcomes after acute osteoporotic vertebral fractures: a 2-year non-randomised trial comparing percutaneous vertebroplasty with conservative therapy. Med J Aust. 2006;184:113–7. [17] McGuire R. … [22] Diamond TH, Champion B, Clark WA. Management of acute osteoporotic vertebral fractures: a nonrandomized trial comparing percutaneous vertebroplasty with conservative therapy. Am J Med. 2003;114:257–65. [23] Blasco J, Martinez-Ferrer A, Macho J, et al. …

Эффективность и безопасность терапии клеток CAR-T и биконкретных антител в повторной/отредактированной миеломе с повреждением ренальности: анализ пропенсиентности.

Иммунотерапия с перенаправкой Т, включая химериковую антигенную рецепторную терапию T-клеток (CAR-T) и биконкретные антитела (BSAbs), изменила лечение повторной/охлажденной миеломы (RRMMM). В то же время в ходе важнейших регистрационных испытаний, как правило, исключались пациенты с существенными почечными нарушениями (РИ), что создавало критический разрыв в данных о населении, в котором болезни почек 20-50% пациентов с диагнозом. Прямого сопоставления результатов по расчетному спектру широтной фильтрации (eGFR) для обоих вариантов не проводится.МЕТОДЫ: Мы провели ретроспективное когортное исс

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… Diamond markers denote statistically significant comparisons ( p < 0.05); circle markers denote non-significant comparisons. Supplementary Figure S2: Safety Outcomes After CAR-T Cell Therapy in Patients With eGFR 30–60 vs. eGFR >60 mL/min/1.73 m 2 ( n = 878 Propensity-Matched Pairs). … Diamond markers denote statistically significant comparisons ( p < 0.05); circle markers denote non-significant comparisons. Supplementary Table S1: Diagnosis, Procedure, Medication, and Laboratory Codes Used in This Study. …

ASH Highlights and Commentary: Multiple Myeloma

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… As many of you are aware, MRD negativity in newly diagnosed myeloma is a surrogate marker for progression-free survival and overall survival (Avet-Loiseau et al., 2020; Diamond et al., 2020). … Clinical Lymphoma Myeloma and Leukemia, 20 (1), e30–e37. https://doi.org/10.1016/j.clml.2019.09.622 Diamond, B. T., Rustad, E., Maclachlan, K., Thoren, K., Ho, C., Roshal, M.,…Landgren, C. O. (2020). …

Pathologic and prognostic impacts of FGFR2 amplification in gastric cancer: a meta-analysis and systemic review.

Fibroblast growth factor receptor-2 (FGFR2) gene is amplified in up to 15% of patients with gastric cancer (GC). However, the prognostic significance of FGFR2 amplification has been controversial. This meta-analysis was conducted to evaluate the clinicopathological impacts of FGFR2 amplification in patients with GC. We performed a systematic computerized search of the electronic databases of PubMed, PMC, EMBASE, Web of Science, and Google Scholar and selected studies assessing the correlation of FGFR2 amplification with pathologic features and/or prognosis in gastric adenocarcinoma. From eight

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… Outcomes are provided as forest plots with diamonds representing the estimate of the pooled effect. The line of no effect is number one for binary outcomes, which depicts statistical significance if not crossed by the diamond 29 . …

Complications of vertebral augmentation in metastatic spinal fractures: a systematic review of multiple study designs.

BACKGROUND: Vertebral augmentation techniques, including vertebroplasty and kyphoplasty, are widely used to relieve pain and restore spinal stability in patients with metastatic vertebral lesions. Despite their widespread use, the full spectrum and clinical significance of procedure-related complications remain incompletely characterised. This systematic review aims to summarise and characterise all reported complications associated with vertebral augmentation for metastatic thoracolumbar disease. METHODS: A comprehensive search of PubMed/MEDLINE, Scopus, and Web of Science databases was perf

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… Diamond, TH et al. Vertebroplasty * 7 patients * 14 vertebrae Fluoroscopy * No post-op CT 1–6 mL / vertebra 0% 0% – 12. … Diamond, TH et al. | Vertebroplasty * 7 patients * 14 vertebrae | Fluoroscopy * No post-op CT | 1–6 mL / vertebra | 0% | 0% | – 12. …

The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation.

The human microbiota heavily influences most vital aspects of human physiology including organ transplantation outcomes and transplant rejection risk. A variety of organ transplantation scenarios such as lung and heart transplantation as well as hematopoietic stem cell transplantation is heavily influenced by the human microbiotas. The human microbiota refers to a rich, diverse, and complex ecosystem of bacteria, fungi, archaea, helminths, protozoans, parasites, and viruses. Research accumulating over the past decade has established the existence of complex cross-species, cross-kingdom interac

Upfront or Deferred Autologous Stem Cell Transplantation for Newly Diagnosed Multiple Myeloma in the Era of Triplet and Quadruplet Induction and Minimal Residual Disease/Risk-Adapted Therapy.

The standards of care for the initial treatment of patients with newly diagnosed multiple myeloma (NDMM) who are eligible for high-dose melphalan and autologous stem cell transplantation (HDM-ASCT) include highly active triplet and quadruplet regimens based on proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies. These regimens are resulting in improved outcomes and increasingly high rates of minimal residual disease (MRD)-negative responses without HDM-ASCT as part of the upfront therapy. Furthermore, recent randomized studies have shown that, while transplant-based approa

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… Diamond B. Lesokhin A.M. Mailankody S. Hassoun H. Tan C. Shah U.A. Lu S.X. Salcedo M. … Diamond B.T. Rustad E.H. Maclachlan K.H. Gundem G. Medina-Martinez J. Ossa J.A. Levine M.F. Zhou Y. Accelerated Single Cell Seeding in Relapsed Multiple Myeloma Nat. Commun. 2020 11 3617 10.1038/s41467-020-17459-z 32680998 PMC7368016 57. Misund K. Bruinink D.H.O. Coward E. Hoogenboezem R.M. …