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Sarcoidosis within a pituitary adenoma.

A 54 year old man presented with frontal headaches for one year. A CT scan of the head revealed a pituitary mass. He denied a change in visi … 1,25-dihydroxyvitamin D, 69 pg/ml. These results were felt to be consistent with a non-PTH-mediated hypercalcemia, such as humoral hypercalcemia of malignancy, or a vitamin D-mediated hypercalcemia, such as lymphoma, sarcoidosis or tuberculosis. Head MRI demonstrated a 3.5 x 3.5 x 2.5 cm heterogeneous mass enlarging the sella, deforming the clivus and compressi …

Management of asymptomatic hyperparathyroidism.

From January 1, 1971, to December 31, 1982, 242 patients with uncomplicated biochemical or asymptomatic hyperparathyroidism underwent operat … ith protracted but temporary postoperative hypocalcemia. Four patients (1.7 percent) had persistent hypercalcemia and therefore, must be considered treatment failures. The procedure resulted in normocalcemia in 238 of the patients (98.3 percent). The mean serum calcium level decreased from a preoperative value of 11.1 to 8.9 mg/100 ml the serum phosphorus level …

Tender skin nodules in a newborn.

Subcutaneous fat necrosis of infancy is a rare disorder of subcutaneous adipose tissue that is sometimes complicated by hypercalcemia. Complete resolution is common. From the pediatrician's point of view, the disease is a rare but important cause of inconsolable cry in a newborn.

Primary hyperparathyroidism: is there anything new?

Primary hyperparathyroidism remains the most common cause of hypercalcemia encountered in outpatient practice. Management of the asymptomatic patient with mild disease remains controversial. Surgery is the only curative therapy, and minimally invasive procedures are now possible.

Acute adult T-cell leukemia/lymphoma presenting with florid cutaneous disease.

Adult T-cell leukemia/lymphoma (ATLL) is characterized by cutaneous disease, hypercalcemia, associated HTLV-I infection, and a fulminant course refractory to therapy. A patient with acute ATLL is described, and the natural history of ATLL is reviewed.

Parathyroid carcinoma in a child: unusual presentation with seizures.

The second reported case of carcinoma of the parathyroid gland in a child 15 years of age or younger is presented. This case is also remarkable in its extremely unusual presentation with seizures, theorized to be associated with hypercalcemia and/or a negative magnesium balance.

Transient neonatal hyperparathyroidism associated with maternal hypoparathyroidism.

The newborn infant of a mother with hypoparathyroidism following thyroidectomy showed transient hypercalcemia and hypermagnesemia. Hypophosphatemia, as found in adult hyperparathyroidism, was not noted in this case, or in three of five other reported cases of neonatal hyperparathyroidism secondary to maternal hypoparathyroidism.

Potential Impact of Opportunistic CT for Closing Diagnosis Gaps in Primary Hyperparathyroidism.

OBJECTIVE: Primary hyperparathyroidism (PHPT) is underdiagnosed. Opportunistic assessment for enlarged parathyroid glands on routine CT examinations is a proposed approach to improve diagnosis. However, the proportion of at-risk patients with a relevant CT is unknown. We aimed to determine the proportion of individuals with hypercalcemia untested for PHPT who had CT examinations on which opportunistic screening could have been performed and to assess characteristics associated with imaging availability. METHODS: This retrospective study included adults with hypercalcemia untested for PHPT wit…

[Pattern of biochemical markers of mineral and bone disorders in kidney transplant recipients: real-world data].

BACKGROUND: There is a lack of studies providing comprehensive data on the prevalence of mineral and bone disorders (MBD) laboratory abnorma … our cohort had all laboratory parameters within the target range, whereas persistent HPT along with hypercalcemia was noted in almost one third of the patients (31%). Normal iPTH levels were observed in 13% cases; 84% of the patients had hyperparathyroidism. The fraction of patients with target iPTH did not differ between the groups with normal and decreased es …

Mitigating the Denosumab-Induced Rebound Phenomenon with Alternating Short- and Long-Acting Anti-resorptive Therapy in a Young Boy with Severe OI Type VI.

Osteogenesis imperfecta (OI) type VI, a recessively inherited form of OI caused by mutations in SERPINF1, is a severe form distinguished by osteomalacia on bone histomorphometry. We describe a boy with severe OI type VI who was initially treated with intravenous (IV) zoledronic acid (ZA) at 1.4 years of age; however, a year later he transitioned to denosumab 1 mg/kg sub-cutaneously every three months in an effort to decrease fracture rates. After two years on denosumab, he presented with symptomatic hypercalcemia due to the denosumab-induced, hyper-resorptive rebound phenomenon. Laboratory par…

Health-related quality of life improves 1 year after parathyroidectomy in primary hyperparathyroidism: A prospective cohort study.

OBJECTIVE: Impaired quality of life (QoL) in primary hyperparathyroidism (PHPT) is commonly present. Patients may complain about nonspecific … s of ionized calcium, PHPQoL differed significantly between patients with mild- and moderate-severe hypercalcemia (P = 0.01). Fifty-three patients answered PAS and PHPQoL 12 months after PTX showing an improved QoL at follow-up (Pall  ˂ 0.02). Stratifying patients into groups based on levels of ionized calcium showed a significantly improved PHPQoL score in pat …

Evaluation of total and ionized calcium status in dogs with blastomycosis: 38 cases (1997-2006).

OBJECTIVE: To determine blood ionized calcium (iCa) and serum total calcium (tCa) concentrations in dogs with blastomycosis and to evaluate … e of serum tCa concentration overestimated hypocalcemia in 57.9% (22/38) of dogs and underestimated hypercalcemia in 1 dog. Use of AdjCa-Alb correctly reclassified all dogs as normocalcemic that were classified as hypocalcemic on the basis of serum tCa concentration, but failed to predict hypercalcemia in 1 dog. Use of AdjCa-TP correctly reclassified all but 2 …

Abnormal bone and calcium metabolism in patients after stroke.

OBJECTIVE: To review how mineral stores and endocrine factors affect bone mass in poststroke patients immobilized by hemiparesis. DATA SOURCES: Computer databases and published indexes. STUDY SELECTION: Case-control studies of hemiparetic poststroke patients examined regarding bone metabolism. DATA EXTRACTION: References were obtained from MEDLINE; all data concerning the objective were used. DATA SYNTHESIS: Bone loss occurs in affected extremities after stroke. Immobilization from hemiplegia causes hypercalcemia. Insufficiency or deficiency of 25-hydroxyvitamin D (25-OHD) is very common i…

Therapy of secondary hyperparathyroidism with 19-nor-1alpha,25-dihydroxyvitamin D2.

Secondary hyperparathyroidism contributes to significant morbidity in patients with chronic renal failure. The treatment of this disorder with vitamin D compounds, such as calcitriol, although effective at suppressing parathyroid hormone (PTH) secretion, may promote the development of hypercalcemia and hyperphosphatemia, thus increasing the risk for metastatic calcification. A new vitamin D analogue, 19-nor-1alpha,25-(OH)2D2 (paricalcitol; Zemplar, Abbott Laboratories, Inc, Chicago, IL) has recently been developed for the treatment of secondary hyperparathyroidism, and, in experimental animals…

Exceedingly Hyper-Secreting Parathyroid Adenoma: A Literature Review and Case Series.

BACKGROUND: Hypercalcemia is most commonly caused by hyperparathyroidism, which is often due to the presence of a parathyroid adenoma and more rarely, a parathyroid carcinoma. Distinguishing between the two can be challenging when serum calcium and parathyroid hormone (PTH) levels are severely elevated. Carcinomas classically present with markedly increased values and more severe clinical symptoms. METHODS: Clinical data was obtained via retrospective chart review and literature review. RESULTS: Three cases of female patients with symptomatic hypercalcemia from primary hyperparathyroidism wi…

Множественная миелома с психической нефропатией и негативом Бенса-Джонса Протеинурии: Редкое клиническое представление.

Множественная миелома (MM) — злокачественное расстройство плазменных клеток, которое обычно вызывает анемию, боль в костях, гиперкальцемию и почечную недостаточность. Мы сообщаем о случае 55-year-old Мужчина, у которого были в основном острые повреждения почек (АКИ), пинентопенция и системное воспаление без классических особенностей гиперкальцемии или литических повреждений костей. В частности, мочевые белки Бенса-Джонса были отрицательными, несмотря на заметно повышенную сыворотку каппа и аномальный белковый электрофорез (SPEP). Биопсия костного мозга выявила скромный плазмоцитоз, в то время

Совпадение в аннотации оригинала
Multiple myeloma (MM) is a malignant plasma cell disorder that commonly presents with anemia, bone pain, hypercalcemia, and renal impairment. We report the case of a 55-year-old male who presented primarily with acute kidney injury (AKI), pancytopenia, and systemic inflammation without the classical features of hypercalcemia or lytic bone lesions. Notably, u…

[Sequential autoimmunity? The rare case of MDA5 dermatomyositis and sarcoidosis].

BACKGROUND: Anti-MDA5 positive dermatomyositis is a rare subtype of idiopathic inflammatory myopathies often accompanied by rapidly progressive interstitial lung disease and severe cutaneous ulcerations. It is associated with a high mortality. The simultaneous occurrence of sarcoidosis with multisystemic involvement of myositis has only been described very rarely in the literature to date. CASE REPORT: We report the case of a 39-year-old man with a 3-year history of anti-MDA‑5 positive dermatomyositis who developed a worsening of dyspnea and hypercalcemia with acute kidney injury and a marked…

Chapter 2: Primary Hyperparathyroidism: diagnosis.

Primary hyperparathyroidism is now predominantly an asymptomatic pathology, as blood calcium assay has become systematic. Diagnosis therefor … rathyroid hormone value that is inappropriate to the blood calcium value. The typical form combines hypercalcemia, elevated parathyroid hormone and increased calciuria or calcium excretion fraction. Atypical forms combine either hypercalcemia and normal parathyroid hormone level, or normal calcemia with increased parathyroid hormone level, not necessarily secon …

Coccidioidomycosis as a Potential Trigger for Sarcoidosis: A Case Study.

This study explores the complex interplay between coccidioidomycosis (valley fever) and sarcoidosis through a detailed case study of a 54-year-old male patient. The patient presented with elevated calcium levels, chronic kidney disease (CKD), and unintended weight loss. Interdisciplinary collaboration between nephrologists and pulmonologists played a crucial role in navigating the intricate medical challenges, including hypercalcemia, renal dysfunction, and pulmonary anomalies. The diagnostic journey involved extensive laboratory findings uncovering the involvement of both infectious agents an…

Hepatic Sarcoid-Like Reaction Mimicking Liver Metastases in a 36-Year-Old Female With Rheumatoid Arthritis.

Hepatic and splenic sarcoidosis are still challenging issues for medical imaging, and in many cases, medical images can't exclude the most common mimic of sarcoidosis which is liver metastases; therefore, a liver biopsy is required. A young female patient who had rheumatoid arthritis presented to our hospital with abdominal pain, anorexia, and weight loss for the past three weeks. She was admitted to the acute medical ward and treated with intravenous fluid hydration for hypercalcemia. Her liver function tests were deranged (anicteric cholestasis picture), and her etanercept medication was sto…