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High Output Heart Failure in Multiple Myeloma: Pathogenetic Considerations.

The high output heart failure is a clinical condition in which the systemic congestion is associated to a high output state, and it can be observed in a non-negligible percentage of hematological diseases, particularly in multiple myeloma, a condition in which the risk of adverse cardiovascular events may increase, with a worse prognosis for patients. For this reason, though an accurate literature search, we provided in this review a complete overview of different pathogenetic mechanisms responsible for high output heart failure in multiple myeloma. Indeed, this clinical finding is present in

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… Splenic rupture secondary to amyloid light-chain (AL) amyloidosis associated with multiple myeloma. J. Surg. Case Rep. 2019;3:rjz021. doi: 10.1093/jscr/rjz021. 17. Tamir R., Lewin R.F., Inbal A., Heller I., Theodor E. High-output cardiac failure as a presenting symptom of plasma cell leukemia. …

Сердечно-сосудистые заболевания

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Complication from Desensitization

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Multiple Extramedullary-Bone Related and/or Extramedullary Extraosseous Are Independent Poor Prognostic Factors in Patients With Newly Diagnosed Multiple Myeloma.

BackgroundExtramedullary (EM) lesions are common in multiple myeloma (MM) and are often related to the poor prognosis of MM but are scarcely understood.MethodsIn this retrospective study, the baseline characteristics of 357 newly diagnosed patients with extramedullary multiple myeloma (EMM) and their impact on the prognosis were analyzed. All patients received first-line treatment with bortezomib-based regimen.ResultsThe overall incidence rate of EM was 22.4%, and the detection rate of PET/CT was significantly higher than other imaging methods (P = 0.015). The cohorts consisted of 10 cases of

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… Splenic Rupture Secondary to Amyloid Light-Chain (AL) Amyloidosis Associated With Multiple Myeloma . J Surg Case Rep ( 2019 ) 2019 ( 3 ): rjz021 . 10.1093/jscr/rjz021 30949329 PMC6439512 17 Chadha J Sahai T Schwimmer J Shani D . A 30-Year-Old Carrier of Gaucher Disease With Multiple Myeloma . …

A Review of Gaucher Disease Pathophysiology, Clinical Presentation and Treatments.

Gaucher disease (GD, ORPHA355) is a rare, autosomal recessive genetic disorder. It is caused by a deficiency of the lysosomal enzyme, glucocerebrosidase, which leads to an accumulation of its substrate, glucosylceramide, in macrophages. In the general population, its incidence is approximately 1/40,000 to 1/60,000 births, rising to 1/800 in Ashkenazi Jews. The main cause of the cytopenia, splenomegaly, hepatomegaly, and bone lesions associated with the disease is considered to be the infiltration of the bone marrow, spleen, and liver by Gaucher cells. Type-1 Gaucher disease, which affects the

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… Splenectomy should only be performed in exceptional circumstances and considered only in rare cases of non-response to well conducted ERT with persistent severe cytopenia (usually related to massive nodular and fibrous splenomegaly) or in cases of splenic rupture. …

Emergency Care

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Imiglucerase in the treatment of Gaucher disease: a history and perspective.

The scientific and therapeutic development of imiglucerase (Cerezyme(®)) by the Genzyme Corporation is a paradigm case for a critical examination of current trends in biotechnology. In this article the authors argue that contemporary interest in treatments for rare diseases by major pharmaceutical companies stems in large part from an exception among rarities: the astonishing commercial success of Cerezyme. The fortunes of the Genzyme Corporation, latterly acquired by global giant Sanofi SA, were founded on the evolution of a blockbuster therapy for a single but, as it turns out, propitious ul

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… Patients may be diagnosed with Gaucher disease after splenectomy carried out either in the course of investigation of suspected hematological malignancy or as a result of splenic rupture. …

Comparative efficacy of moxibustion in chemotherapy-induced leukopenia: A Bayesian network meta-analysis.

BackgroundMoxibustion has been applied in various clinical treatments, including chemotherapy-induced leukopenia. Using a Bayesian network meta-analysis, this study assessed a wide range of published data to identify the most efficient and effective method of moxibustion therapy for treating chemotherapy-induced leukopenia.MethodsPubMed, EMBASE, and eight other databases plus two clinical trial registration platforms were searched from their respective inception date to January 2024. All randomized controlled trials (RCTs) of moxibustion for chemotherapy-induced leukopenia were included. The p

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… For example, primary prophylaxis using granulocyte colony-stimulating factor (G-CSF) can reduce the duration and severity of neutropenia and the risk of febrile neutropenia. 5 However, G-CSF has many adverse effects, including joint pain, flu-like symptoms, aortitis, and splenic rupture, 6 , 7 , 8 , … Splenic rupture in a patient with plasma cell myeloma following G-CSF/GM-CSF administration for stem cell transplantation and review of the literature. Bone Marrow Transplant. 2007;40(4):361–364. doi: 10.1038/sj.bmt.1705736. 10. Dale D.C. …

Biology and Diseases of Dogs

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Extramedullary disease in multiple myeloma.

When clonal plasma cells grow at anatomic sites distant from the bone marrow or grows contiguous from osseous lesions that break through the cortical bone, it is referred to as extramedullary multiple myeloma (EMD). EMD remains challenging from a therapeutic and biological perspective. The pathogenetic mechanisms are not completely understood and it is generally associated with high-risk cytogenetics which portends poor outcomes. There is a rising incidence of EMD in the era of novel agents, likely a reflection of longer OS, with no standard treatment approach. Patients benefit from aggressive

Infection related membranoproliferative glomerulonephritis secondary to anaplasmosis: A case report.

BACKGROUND: Anaplasmosis is a tick-borne disease with a range of clinical manifestations, from a flu-like illness with fever and myalgias to a severe systemic disease with multisystem organ failure. Although renal involvement is not a common presentation, there have been few cases reporting acute kidney injury from Anaplasmosis. CASE SUMMARY: We present a 55-year-old female with anaplasmosis who developed acute kidney injury due to membranoproliferative glomerulonephritis (MPGN). The patient originally presented with cough and shortness of breath. She was admitted to the hospital with a diagn

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… Many complications of Anaplasmosis have been reported, which include end-organ damage such as acute kidney injury, rhabdomyolysis[ 2 ], multiorgan failure, non-traumatic splenic rupture, pancreatitis, secondary hemophagocytic lymphocytosis, and meningoencephalitis. …

2023 Scientific Session of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Montréal, Canada, 19 March–April 1 2023: Posters

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Mechanism and therapeutic potential of traditional Chinese medicine extracts in sepsis.

Sepsis is a complex syndrome characterized by multi-organ dysfunction, due to the presence of harmful microorganisms in blood which could cause mortality. Complications associated with sepsis involve multiple organ dysfunction. The pathogenesis of sepsis remains intricate, with limited treatment options and high mortality rates. Traditional Chinese medicine (TCM) has consistently demonstrated to have a potential on various disease management. Its complements include reduction of oxidative stress, inhibiting inflammatory pathways, regulating immune responses, and improving microcirculation. Tra

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… Hsiao | Patients with traumatic splenic rupture after splenectomy | 20 mL in 250 mL 5% glucose | ↑: CD3 + , CD4 + , CD4 +/CD8+ ↓: CD8 + | NA | NA | Gao et al. (2018) Astragalus granule | Astragalus membranaceus (Fisch.) Bge. or A. membranaceus (Fisch.) Bge. var. mongholicus (Bge.) … Effect of Astragalus injection on T lymphocyte subsets in peripheral blood of patients with traumatic splenic rupture undergoing splenectomy . Mod. J. Integr. Tradit. Chin. West. Med. 27 , 409 – 411 . 10.3969/j.issn.1008-8849.2018.04.021 García de la Cadena S. Massieu L. ( 2016 ). …

The feasibility and efficacy of subcutaneous plerixafor for mobilization of peripheral blood stem cells in allogeneic HLA-identical sibling donors: results of the HOVON-107 study.

BackgroundPlerixafor (PFX) mobilizes CD34+ cells into circulation by disrupting the CXCR4 binding of the hematopoietic stem cell in its bone marrow niche.Study design and methodsin the prospective HOVON-107 study (www.hovon.nl) 23 allogeneic HLA-identical sibling donors received one or two subcutaneous (sc) injections of plerixafor 0.320 mg/kg.The primary endpoint, was defined as feasibility to mobilize a minimum of 2.0 x106 CD34+ cells/kg recipient weight obtained by leukopheresis in at least 90% of the donors.Resultsmedian 3.3 x 106 CD34+ cells/kg (1.9-6.5) were collected after 1 (n=12) or 2

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… Spontaneous splenic rupture following administration of granulocyte colony ‐stimulating factor therapy in an allogeneic blood stem cell donor. Biol Blood Bone Marrow Transplant 1997;3(1):45. 5. Uy G, Rettig MP, Cashen AF. …

Hematopoietic stem and progenitor cell harvesting: technical advances and clinical utility.

Hematopoietic stem and progenitor cell (HSPC) transplantations require prior harvesting of allogeneic or autologous HSPCs. HSPCs are usually present in bone marrow (BM) during the entire life, in cord blood (CB) at birth, or in peripheral blood (PB) under particular circumstances. HSPCs were first harvested in BM and later in CB and PB, as studies showed interesting features of such grafts. All harvesting methods were in use throughout the years, except BM harvesting for HSPC autologous transplantation, which was replaced by PB harvesting. BM, CB, and PB harvesting methods have been developed,

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… Indeed, splenic rupture, which is a rare complication, has been observed in allogeneic and autologous donors. 97 When WBC is higher than 60,000/μL, a GSF dose adaptation can be proposed to prevent vascular complications. The second element concerns the apheresis itself. … post-granulocyte colony-stimulating factor white blood cell counts in predicting the adverse events and yields of stem cell mobilization Int J Hematol 2011 93 5 652 659 21509437 10.1007/s12185-011-0844-5 97 Akyol G Pala C Yildirim A A rare but severe complication of filgrastim in a healthy donor: splenic …

Cardio-cerebral infarction: a narrative review of pathophysiology, treatment challenges, and prognostic implications.

Cardio-cerebral infarction (CCI) is a rare clinical syndrome characterized by the simultaneous or sequential occurrence of acute myocardial infarction (AMI) and acute ischemic stroke (AIS). Despite its complex pathogenesis and more severe prognosis compared to isolated AMI or AIS, no consensus has been established regarding its definition, classification, epidemiology, treatment protocols, or prognostic management. Current research is largely confined to case reports or small case series, and there are no unified diagnostic or treatment guidelines, nor any expert consensus. Consequently, clini

Hematology and Immune-Related Disorders

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2021 Scientific Session of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Las Vegas, Nevada, 31 August–3 September 2021: Video Loops

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A systematic literature review of the efficacy, effectiveness, and safety of filgrastim.

PurposeFilgrastim (NEUPOGEN®) is the originator recombinant human granulocyte colony-stimulating factor widely used for preventing neutropenia-related infections and mobilizing hematopoietic stem cells. This report presents findings of a systematic literature review and meta-analysis of efficacy and safety of originator filgrastim to update previous reports.MethodsA literature search of electronic databases, congress abstracts, and bibliographies of recent reviews was conducted to identify English-language reports of clinical trials and observational studies evaluating filgrastim in its US-app

Amyloidosis in Childhood: A Review of Clinical Features and Comparison with Adult Forms.

Amyloidosis is a rare multisystem disorder characterized by extracellular accumulation of insoluble fibrils in various organs and tissues. The most common subtype in the pediatric population is systemic reactive amyloidosis, typically developing secondary to chronic inflammatory conditions and resulting in deposition of serum amyloid A protein in association with apolipoprotein HDL3. Clinical presentation is highly variable and is mostly influenced by specific organs involved, precursor protein type, and extent of amyloid deposition, often closely reflecting clinical features of the underlying

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… Deposition of amyloid in the liver and spleen in adult causes hepatomegaly and splenomegaly, with elevation of liver enzymes, which can complicate drug management; furthermore, splenomegaly can lead to splenic rupture [ 68 , 69 ]. … Atraumatic Splenic Rupture in Amyloidosis Amyloid 2009 16 47 53 10.1080/13506120802676922 19291515 70. Strauss R.G. Schubert W.K. James MeAdams A. Amyloidosis in Childhood J. Pediatr. 1969 74 272 282 5762889 10.1016/s0022-3476(69)80076-4 71. Baumgart J.-V. Stuhlmann-Laeisz C. Hegenbart U. …