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Pentalogy of Fallot: A case report.

We report the case of a 45-year-old woman with pentalogy of Fallot, a severe and complicated cyanotic congenital heart disease. Congenital anomalies of pentalogy of Fallot include ventricular septal defect, right ventricular hypertrophy, saddle aorta, pulmonary ostium stenosis, atrial septal defect, and patent foramen ovale. Pentalogy of Fallot is less common than triplet and tetralogy of Fallot and can affect children's physical development. Approximately 95% of patients with pentalogy of Fallot die before the age of 40 years, and early surgical radical surgery is recommended. However, the pa

Photo-Catalyzed Acyl Azolium Promoted Selective α-C(sp3 )-H Acylation of Acetone via HAT: Access to Thermodynamically Less Favoured (Z)-α,β-Unsaturated Ketones.

Mono α-acylation of acetone has been achieved for the first time by reacting with bench-stable acyl azolium salts under violet-LED light at room temperature. The intermolecular hydrogen atom transfer (HAT) from acetone to triplet state of azolium salts under violet LED irradiation resulted in thermodynamically less favourable (Z)-α,β-unsaturated ketones with up to 99 : 1 selectivity via C-C bond formation. This compelling protocol access the desired α-C(sp3 )-H acylation product under metal-, ligand- and oxidant-free conditions on a wide range of substrates.

Atomic versus molecular Auger decay in CH2Cl2 and CD2Cl2 molecules.

Autoionization spectra of CH2Cl2 and CD2Cl2 molecules after Cl 2p excitation are studied. The two molecular and atomic Auger transitions are examined and assigned. The contribution of atomic Auger transitions is lower in the deuterated molecule. In addition, to support the presence of the ultrafast dissociation mechanism in the dichloromethane molecule, a series of high-level ab initio quantum mechanical calculations were performed at multiconfigurational self-consistent field (MCSCF) and multireference configuration interaction (MRCI) levels of theory. Minimum energy pathways for the dissocia

Photophysics and electrochemistry of a platinum-acetylide disubstituted perylenediimide.

The synthesis and photophysical study of a perylene diimide (PDI) functionalised with platinum acetylide units of the type, trans{-C≡C-Pt(PBu3)2-C≡C-Ph} and comparison with a phenylacetylide substituted model compound are reported. The model compound demonstrates typical perylene absorption and photoluminescence spectra characteristic of singlet excited state formation and decay. The Pt-substitution, however, appears to induce spin-orbit coupling into the chromophore and giving rise to a triplet excited state which was confirmed by transient absorption measurements. This excited state is quenc

Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics.

Fragile X syndrome (FXS) is the most frequent form of inherited intellectual disability and is also linked to other neurologic and psychiatric disorders. FXS is caused by a triplet expansion that inhibits expression of the FMR1 gene; the gene product, FMRP, regulates mRNA metabolism in the brain and thus controls the expression of key molecules involved in receptor signaling and spine morphology. While there is no definitive cure for FXS, the understanding of FMRP function has paved the way for rational treatment designs that could potentially reverse many of the neurobiological changes observ

Efficient red-emitting cyclometalated Iridium(III) complexes containing lepidine-based ligands.

Heteroleptic cyclometalated iridium(III) complexes featuring lepidine-based ligands and acetyl acetone auxiliary ligand are synthesized. Multiple lowest energy absorption bands are observed for these complexes indicating substantial mixing of the singlet and triplet levels. All the complexes emit orange or red color in dichloromethane solutions with lifetimes in the range 1.6-3.7 micros. The emission in the complexes probably originates from the (3)MLCT state. The complexes are applied as emitting guests in LED devices of the structure ITO/HTL(BPAPF or NPB)/6% Ir in CBP/BCP/Alq(3)/LiF/Al. They

[Positive troponin T in a chagasic patient with sustained ventricular tachycardia and no obstructive lesions on cine coronary angiography].

The assessment and stratification of patients with chest pain in the emergency unit may indicate the appropriate therapy for each patient based on the probability of the presence of acute coronary artery disease and on the risk of its major cardiac events. That assessment is based on the triplet: clinical setting, electrocardiographic findings, and markers of myocardial lesion. We report the case of a 58-year-old male chagasic patient admitted to the emergency unit due to chest pain and palpitations, with an electrocardiogram showing sustained ventricular tachycardia and positive troponin meas

Cloning, chromosomal localization and identification of polymorphisms in the human thyroid transcription factor 2 gene (TITF2).

The human gene encoding the thyroid transcription factor 2 (TTF-2) was cloned and mapped to human chromosome 9q22. Three polymorphisms were identified in the gene by SSCP and direct sequencing: two consist of a third base substitution in the triplet encoding Leu129 and Ser273, and the third is an alanine stretch that varies from 12 to 17 residues. TTF-2 plays a critical role during thyroid morphogenesis in mice, and in man the TITF2 gene is associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The polymorphisms identified in this study can be used as markers to st

Characterization of a processed pseudogene of human FAU1 on chromosome 18.

A member of the human FAU (Finkel-Biskis-Reilly murine sarcoma virus-associated ubiquitously expressed) gene subfamily, encoding the ribosomal protein S30 fused in frame to an ubiquitin-like protein, was cloned, sequenced and analysed. This clone, FAU1P, is a processed pseudogene with a completely intact, although transcriptionally silent, open reading frame of 137 codons. FAU1P exhibits an amplification of the (AAG) triplet repeat present in the S30 coding part of FAU. FAU1P is integrated in an antisense orientation within a sequence homologous to the promoter of the islet amyloid polypeptide

The oxidation of cyclic sulfides by tetramethyldioxetane and the isobutanal/O2/peroxidase system: oxygen transfer versus electron transfer.

The oxidation of chlorpromazine (CPZ) by tetramethyldioxetane (TMD) and isobutanal (IBAL)/O2/horseradish peroxidase (HRP) system was investigated. The reaction with TMD proved to be of the oxygen transfer type, generating chlorpromazine-5-oxide (CPZO) and tetramethylethylene-oxide, and not by single-electron transfer, as previously reported. In contrast, the reaction of CPZ with IBAL/O2/HRP leads to formation of chlorpromazine cation radical, through reaction with active intermediates Compound I and II, following its dismutation and hydrolysis to CPZO. For comparison, 10-methylphenothiazine wa

Retrospective analysis of transarterial chemoembolization or hepatic arterial infusion chemotherapy combined with lenvatinib with or without PD-1 inhibitor as first-line therapy for unresectable hepatocellular carcinoma with high tumor burden: a propensity score-matched study.

PURPOSE: To compare the efficacy, safety, and hepatic impact of TACE or HAIC plus lenvatinib with or without PD-1 inhibitors in unresectable hepatocellular carcinoma with high tumor burden (HTB-uHCC). PATIENTS AND METHODS: This retrospective study (2019-2023) included 278 HTB-uHCC patients (defined as tumors exceeding the up-to-11 criteria or exhibiting Vp4 portal vein tumor thrombus) receiving either doublet therapy (TACE or HAIC + lenvatinib, THL) or triplet therapy (TACE or HAIC + lenvatinib + PD-1 inhibitor, THLP) (139 per cohort after 1:1 propensity score matching; caliper=0.2). Primary

Spin-orbit effects on the molecular properties of Group 14 tetracoordinate compounds TX4 (T = Ge, Sn, and Pb; X = H, F, Cl, Br, and I): Natural electron configuration-based rationalization of structural variations.

The spin-orbit (SO) effects on the molecular properties of Group 14 tetracoordinate compounds TX4 (T = Ge, Sn, and Pb; X = H, F, Cl, Br, and I) were systematically investigated using two-component spin-orbit density functional theory with the PBE0 and MN15 functionals. The spin-orbit coupling (SOC)-induced changes in the T-X equilibrium bond lengths exhibit a non-monotonic pattern across the 15 TX4 compounds, governed by the competition between central-atom p1/2 contraction and ligand p3/2 elongation. The natural electron configuration-based spinor occupation inference (NSOI) framework, extend

Quantum Mechanics/Molecular Mechanics Study on the Excited-State Relaxation Pathways of 2'-Deoxy-5-Fluorocytidine in Aqueous Solution.

We have employed a high-level QM(CASPT2//CASSCF)/MM approach to investigate the excited-state properties and decay mechanism of 2'-deoxy-5-fluorocytidine (5FdCyd) in aqueous solution. The S1(ππ*) and S2(nπ*) states are the lowest spectroscopically bright and dark states in the Franck-Condon region with the predicted vertical excitation energies of 99.0 [4.29] and 117.3 kcal/mol [5.09 eV], respectively, at the QM(CASPT2)/MM level. Four feasible excited-state nonradiative relaxation pathways are also suggested for the initially populated S1(ππ*) state. The photoexcited 1ππ* state undergoes a bif

SOHO State of the Art Updates and Next Questions | Late/Deferred ASCT in Myeloma.

High-dose melphalan with autologous stem cell transplant (HDM-ASCT) remains a standard-of-care for transplant-eligible patients with newly diagnosed multiple myeloma (NDMM), with data from randomized studies demonstrating progression-free survival (PFS) benefit with transplant versus nontransplant approaches. However, with increasing overall survival (OS) in this setting, associated with the substantial efficacy of triplet and quadruplet regimens and multiple novel treatment approaches, strategic considerations are key, together with a holistic approach taking into account patients' preference

Клинические результаты лечения пожилых людей за пределами клинических исследований: уделение особого внимания октогеническому опыту.

При стареющем населении множественная миелома (ММ) оказывает все большее воздействие на октогенариев (Octos; возраст ≥80 В то же время данные об их управлении и результатах, особенно в случае лечения за пределами клинических испытаний, остаются ограниченными. Это ретроспективное исследование проанализировано 652 больные в возрасте ≥70 годами, с диагнозом активного MM между 2014 и 2023, идентифицируется в медицинских картах службы здравоохранения Маккаби. Характеристики пациента, лечение, время до следующего лечения (TTNT), общее выживание (OS) и факторы, влияющие на результаты, были сопоставле

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… Of note, triplets/quadruplets containing Dara provided longer TTNT than non-Dara triplets; being not reached vs 28.3 months ( P = .05). … Interestingly, the use of Dara-based triplet therapy appeared to extend TTNT compared with other triplets, with the median TTNT not yet reached within the 24-month FU period. …

Toxicity-benefit analysis of advanced prostate cancer trials using weighted toxicity scoring.

OBJECTIVE: The weighted toxicity score (WTS) is a metric suitable for comparing the toxicity burden in experimental versus control arms of randomized controlled trials (RCTs). When paired with clinical endpoints, the WTS offers a framework to evaluate the toxicity-benefit profile of anti-cancer agents. This study applied the WTS to phase III advanced prostate cancer (PC) clinical trials. DESIGN: Select phase III PC RCTs with adverse event (AE) data were compiled. The WTS was calculated for each trial arm using 2 approaches: (1) all AEs (A-WTS) and (2) symptomatic AEs (S-WTS). Percent change i

The effect of heavy atoms on the deactivation of electronic excited states of dye molecules near the surface of metal nanoparticles.

The influence of a heavy atom and the plasmon field on the efficiency of populating the lowest triplet state (T1) and on the phosphorescence intensity has been studied for fluorescein, 2Br-fluorescein, eosin and erythrosine, which have an increasing number of substituted heavy atoms. We show that the heavy atoms affect not only the rate constant of intersystem crossing (kISC) but also the rate constant of internal conversion (kIC). The calculations show that the C-H bonds in the meso position are the primary acceptors of the excitation energy of the lowest excited electronic singlet state (S1)

Sterically Encumbered Aryl Isocyanides Extend Excited-State Lifetimes and Improve the Photocatalytic Performance of Three-Coordinate Copper(I) β-Diketiminate Charge-Transfer Chromophores.

Copper(I) complexes are prominent candidates to replace noble metal-based photosensitizers. We recently introduced a three-coordinate design for copper(I) charge-transfer chromophores that pair β-diketiminate ligands with aryl isocyanides. The excited-state lifetime in these compounds can be extended using a bichromophoric "triplet reservoir" strategy, which comes at the expense of a decrease in excited-state energy and reducing power. In this work, we introduce a complementary, sterically driven strategy for increasing the excited-state lifetimes of these photosensitizers, which gives a highe

Defining the clinical benefits of adding a neurokinin-1 receptor antagonist to control chemotherapy-induced nausea and vomiting in moderately emetogenic chemotherapy: a systematic review and meta-analysis of the clinical practice guidelines for antiemesis 2023 from the Japan society of clinical oncology.

BACKGROUND: Chemotherapy-induced nausea and vomiting (CINV) commonly affects patient quality of life and the overall effectiveness of chemotherapy. This study aimed to evaluate whether adding neurokinin-1 receptor antagonists (NK1RAs) to 5-hydroxytryptamine-3 receptor antagonists (5-HT3RAs) and corticosteroids provides clinically meaningful benefits in preventing CINV in patients receiving moderately emetogenic chemotherapy (MEC). METHODS: We conducted a systematic review of PubMed, Cochrane Library, and Ichushi-Web to identify clinical studies evaluating NK1RAs combined with 5-HT3RAs and dex